5AO3A

Crystal structure of human samhd1 (amino acid residues 115-626) bound to gtp
Total Genus 146
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
146
sequence length
469
structure length
440
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYNPIDHVSFYCKTAPNRAIEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
pubmed doi rcsb
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
total genus 146
structure length 440
sequence length 469
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 5ao3A01
3M1TA 2Q14A 3BG2A 5AO2A 2PARA 3IRHA 4L1JA 1YNBA 5AO4A 3TMDA 4TNYA 4DMBA 4L7WA 4BZCA 4TO0A 4QG1A 4L7EA 2O08A 4RXSA 3TMCA 3I7AA 3P3QA 4RXPA 4TO4A 5TK8A 4BZBA 4TO1A 2FLOA 4RXQA 4MLMA 3TM8A 4QFXA 1YOYA 5AO0A 4QG4A 4TNZA 1U6ZA 2PAUA 4QG2A 4TNRA 1VJ7A 2OGIA 4QFYA 4R8ZA 3HI0A 1VQRA 3CCGA 4XDSA 4L1JB 2PQ7A 3TMBA 2O6IA 4ME4A 4TO2A 2PGSA 2CQZA 5TK9A 4MLNA 4ZWEA 5TK7A 5AO3A 1XX7A 4Q7HA 2PAQA 4N71A 3RF0A 3KH1A 4TO3A 3MZOA 4MDZA 4TNXA 3LJXA 4RXRA 5TK6A 3U1NA 4X9EA 3NR1A 4N6WA 4TNPA 3NQWA 4TO6A 5TKAA 4TO5A 4ZWGA 4QFZA 4LRLA 3HC1A 4QG0A 5AO1A 4MCWA 2DQBA 3MEMA 2GZ4A 4RXOA 4TNQA 2HEKA 4MZ7A
chains in the Genus database with same CATH superfamily
4QQXA 3M1TA 4QQWA 2Q14A 3BG2A 5AO2A 2PARA 3IRHA 4L1JA 1YNBA 5AO4A 3TMDA 4TNYA 4DMBA 4L7WA 4BZCA 3KQ5A 4TO0A 4QG1A 4L7EA 2O08A 4RXSA 3TMCA 3I7AA 3P3QA 4RXPA 4TO4A 5TK8A 4BZBA 4TO1A 2FLOA 4RXQA 4MLMA 3TM8A 4QFXA 1YOYA 5AO0A 4QG4A 4TNZA 1U6ZA 2PAUA 4QG2A 4TNRA 4Q2DA 1VJ7A 2OGIA 4QFYA 3SK9A 3GW7A 3HI0A 4R8ZA 1VQRA 3CCGA 4L1JB 2PQ7A 4XDSA 3TMBA 2O6IA 4ME4A 4Q2CA 2PGSA 2CQZA 4TO2A 5TK9A 4MLNA 4ZWEA 5TK7A 5AO3A 1XX7A 4Q7HA 2PAQA 4N71A 3RF0A 3KH1A 4TO3A 3S4LA 3MZOA 4MDZA 4TNXA 3LJXA 4RXRA 4QQYA 5TK6A 3U1NA 4X9EA 3NR1A 4N6WA 4TNPA 3NQWA 4TO6A 5TKAA 4QQZA 4TO5A 4ZWGA 4QFZA 3SKDA 4LRLA 3HC1A 4QG0A 5AO1A 4MCWA 2DQBA 3MEMA 2GZ4A 4RXOA 4TNQA 2HEKA 4MZ7A
chains in the Genus database with same CATH topology
4QQXA 3M1TA 4QQWA 2Q14A 3BG2A 5AO2A 2PARA 3IRHA 4L1JA 1YNBA 5AO4A 3TMDA 4TNYA 4DMBA 4L7WA 4BZCA 3KQ5A 4TO0A 4QG1A 4L7EA 2O08A 4RXSA 3TMCA 3I7AA 3P3QA 4RXPA 4TO4A 5TK8A 4BZBA 4TO1A 2FLOA 4RXQA 4MLMA 3TM8A 4QFXA 1YOYA 5AO0A 4QG4A 4TNZA 1U6ZA 2PAUA 4QG2A 4TNRA 4Q2DA 1VJ7A 2OGIA 4QFYA 3SK9A 3GW7A 3HI0A 4R8ZA 1VQRA 3CCGA 4L1JB 2PQ7A 4XDSA 3TMBA 2O6IA 4ME4A 4Q2CA 2PGSA 2CQZA 4TO2A 5TK9A 4MLNA 4ZWEA 5TK7A 5AO3A 1XX7A 4Q7HA 2PAQA 4N71A 3RF0A 3KH1A 4TO3A 3S4LA 3MZOA 4MDZA 4TNXA 3LJXA 4RXRA 4QQYA 5TK6A 3U1NA 4X9EA 3NR1A 4N6WA 4TNPA 3NQWA 4TO6A 5TKAA 4QQZA 4TO5A 4ZWGA 4QFZA 3SKDA 4LRLA 3HC1A 4QG0A 5AO1A 4MCWA 2DQBA 3MEMA 2GZ4A 4RXOA 4TNQA 2HEKA 4MZ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M1T A;  2Q14 A;  3BG2 A;  5AO2 A;  2PAR A;  3IRH A;  4L1J A;  1YNB A;  5AO4 A;  3TMD A;  4TNY A;  4DMB A;  4L7W A;  4BZC A;  4TO0 A;  4QG1 A;  4L7E A;  2O08 A;  4RXS A;  3TMC A;  3I7A A;  3P3Q A;  4RXP A;  4TO4 A;  5TK8 A;  4BZB A;  4TO1 A;  2FLO A;  4RXQ A;  4MLM A;  3TM8 A;  4QFX A;  1YOY A;  5AO0 A;  4QG4 A;  4TNZ A;  1U6Z A;  2PAU A;  4QG2 A;  4TNR A;  1VJ7 A;  2OGI A;  4QFY A;  4R8Z A;  3HI0 A;  1VQR A;  3CCG A;  4XDS A;  4L1J B;  2PQ7 A;  3TMB A;  2O6I A;  4ME4 A;  4TO2 A;  2PGS A;  2CQZ A;  5TK9 A;  4MLN A;  4ZWE A;  5TK7 A;  5AO3 A;  1XX7 A;  4Q7H A;  2PAQ A;  4N71 A;  3RF0 A;  3KH1 A;  4TO3 A;  3MZO A;  4MDZ A;  4TNX A;  3LJX A;  4RXR A;  5TK6 A;  3U1N A;  4X9E A;  3NR1 A;  4N6W A;  4TNP A;  3NQW A;  4TO6 A;  5TKA A;  4TO5 A;  4ZWG A;  4QFZ A;  4LRL A;  3HC1 A;  4QG0 A;  5AO1 A;  4MCW A;  2DQB A;  3MEM A;  2GZ4 A;  4RXO A;  4TNQ A;  2HEK A;  4MZ7 A; 
#chains in the Genus database with same CATH topology
 4QQX A;  3M1T A;  4QQW A;  2Q14 A;  3BG2 A;  5AO2 A;  2PAR A;  3IRH A;  4L1J A;  1YNB A;  5AO4 A;  3TMD A;  4TNY A;  4DMB A;  4L7W A;  4BZC A;  3KQ5 A;  4TO0 A;  4QG1 A;  4L7E A;  2O08 A;  4RXS A;  3TMC A;  3I7A A;  3P3Q A;  4RXP A;  4TO4 A;  5TK8 A;  4BZB A;  4TO1 A;  2FLO A;  4RXQ A;  4MLM A;  3TM8 A;  4QFX A;  1YOY A;  5AO0 A;  4QG4 A;  4TNZ A;  1U6Z A;  2PAU A;  4QG2 A;  4TNR A;  4Q2D A;  1VJ7 A;  2OGI A;  4QFY A;  3SK9 A;  3GW7 A;  3HI0 A;  4R8Z A;  1VQR A;  3CCG A;  4L1J B;  2PQ7 A;  4XDS A;  3TMB A;  2O6I A;  4ME4 A;  4Q2C A;  2PGS A;  2CQZ A;  4TO2 A;  5TK9 A;  4MLN A;  4ZWE A;  5TK7 A;  5AO3 A;  1XX7 A;  4Q7H A;  2PAQ A;  4N71 A;  3RF0 A;  3KH1 A;  4TO3 A;  3S4L A;  3MZO A;  4MDZ A;  4TNX A;  3LJX A;  4RXR A;  4QQY A;  5TK6 A;  3U1N A;  4X9E A;  3NR1 A;  4N6W A;  4TNP A;  3NQW A;  4TO6 A;  5TKA A;  4QQZ A;  4TO5 A;  4ZWG A;  4QFZ A;  3SKD A;  4LRL A;  3HC1 A;  4QG0 A;  5AO1 A;  4MCW A;  2DQB A;  3MEM A;  2GZ4 A;  4RXO A;  4TNQ A;  2HEK A;  4MZ7 A; 
#chains in the Genus database with same CATH homology
 4QQX A;  3M1T A;  4QQW A;  2Q14 A;  3BG2 A;  5AO2 A;  2PAR A;  3IRH A;  4L1J A;  1YNB A;  5AO4 A;  3TMD A;  4TNY A;  4DMB A;  4L7W A;  4BZC A;  3KQ5 A;  4TO0 A;  4QG1 A;  4L7E A;  2O08 A;  4RXS A;  3TMC A;  3I7A A;  3P3Q A;  4RXP A;  4TO4 A;  5TK8 A;  4BZB A;  4TO1 A;  2FLO A;  4RXQ A;  4MLM A;  3TM8 A;  4QFX A;  1YOY A;  5AO0 A;  4QG4 A;  4TNZ A;  1U6Z A;  2PAU A;  4QG2 A;  4TNR A;  4Q2D A;  1VJ7 A;  2OGI A;  4QFY A;  3SK9 A;  3GW7 A;  3HI0 A;  4R8Z A;  1VQR A;  3CCG A;  4L1J B;  2PQ7 A;  4XDS A;  3TMB A;  2O6I A;  4ME4 A;  4Q2C A;  2PGS A;  2CQZ A;  4TO2 A;  5TK9 A;  4MLN A;  4ZWE A;  5TK7 A;  5AO3 A;  1XX7 A;  4Q7H A;  2PAQ A;  4N71 A;  3RF0 A;  3KH1 A;  4TO3 A;  3S4L A;  3MZO A;  4MDZ A;  4TNX A;  3LJX A;  4RXR A;  4QQY A;  5TK6 A;  3U1N A;  4X9E A;  3NR1 A;  4N6W A;  4TNP A;  3NQW A;  4TO6 A;  5TKA A;  4QQZ A;  4TO5 A;  4ZWG A;  4QFZ A;  3SKD A;  4LRL A;  3HC1 A;  4QG0 A;  5AO1 A;  4MCW A;  2DQB A;  3MEM A;  2GZ4 A;  4RXO A;  4TNQ A;  2HEK A;  4MZ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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