5AO4A

Crystal structure of in vitro phosphorylated human samhd1 (amino acid residues 115-626) bound to gtp
Total Genus 127
50100150200250300350400020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
469
structure length
430
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMHVSFYCKTAPEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
50100150200250300350400400300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI5 (207-210)TIV5 (215-218)S1 (116-120)TIV9 (287-290)S2 (124-128)3H2 (153-155)AH1 (130-136)AH2 (139-142)O1 (136-138)AH3 (164-185)TI2 (148-151)TII'1 (150-153)TIV3 (155-158)TI3 (157-160)AH5 (220-225)3H3 (187-189)AH4 (193-205)AH7 (250-257)TI4 (205-208)AH6 (233-248)TII1 (211-214)AH12 (377-393)TII'2 (213-216)TI6 (214-217)TIV7 (226-229)TI7 (216-219)AH8 (261-273)TII2 (401-404)TIV8 (275-286)3H4 (292-299)TIV10 (299-302)TVIII2 (300-303)TIV12 (304-307)AH9 (310-323)TIV11 (303-306)AH10 (331-337)3H6 (412-414)S3 (338-343)TI10 (394-397)S4 (346-352)TI9 (393-396)AH11 (356-373)AH13 (416-420)S5 (399-400)TI'1 (402-405)TI11 (408-411)AH14 (424-432)TIV1 (120-123)3H5 (353-355)TI8 (373-376)3H1 (143-145)Updating...
connected with : NaN
publication title Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
total genus 127
structure length 430
sequence length 469
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 5ao4A01
4QG4A 3MZOA 4BZCA 2GZ4A 4QG2A 4MLMA 5AO0A 4TNPA 4QFZA 4RXQA 3MEMA 4LRLA 2DQBA 4QFYA 3BG2A 3TM8A 4L1JA 5AO2A 5AO3A 2FLOA 4N71A 3M1TA 3TMBA 4L7WA 4QG0A 3HC1A 3HI0A 3NQWA 5TK9A 3KH1A 1VQRA 2PARA 4RXRA 2PGSA 4N6WA 5TK8A 2PQ7A 1YOYA 4ME4A 3IRHA 4TNYA 2OGIA 2O6IA 4DMBA 4TO4A 5TK6A 4X9EA 4TO2A 1U6ZA 4TNXA 3I7AA 4TO0A 4MCWA 2O08A 4TO5A 2CQZA 3U1NA 5AO1A 2PAUA 2PAQA 4L1JB 2HEKA 4TO3A 4TNZA 2Q14A 4TNQA 5TK7A 4MLNA 3LJXA 4ZWGA 3RF0A 1VJ7A 4TO6A 1YNBA 4R8ZA 3P3QA 3CCGA 4RXOA 4L7EA 1XX7A 4XDSA 4RXSA 3NR1A 4QFXA 4RXPA 4BZBA 4TNRA 5TKAA 4MZ7A 4QG1A 4ZWEA 5AO4A 3TMCA 4MDZA 4TO1A 3TMDA 4Q7HA
chains in the Genus database with same CATH superfamily
4QG4A 3MZOA 4BZCA 2GZ4A 4QG2A 4MLMA 5AO0A 4TNPA 4QFZA 4RXQA 3MEMA 3SK9A 4LRLA 2DQBA 3S4LA 4QFYA 4QQZA 3BG2A 3TM8A 4L1JA 5AO2A 5AO3A 2FLOA 4N71A 3M1TA 3TMBA 4L7WA 4QG0A 3HC1A 3HI0A 4Q2DA 3SKDA 4QQXA 3KQ5A 3NQWA 5TK9A 4QQWA 3KH1A 1VQRA 2PARA 4RXRA 2PGSA 4N6WA 5TK8A 2PQ7A 1YOYA 4ME4A 3IRHA 4TNYA 2OGIA 2O6IA 4DMBA 4TO4A 5TK6A 4X9EA 4TO2A 4Q2CA 1U6ZA 4TNXA 3I7AA 4TO0A 4MCWA 4QQYA 2O08A 4TO5A 2CQZA 3U1NA 5AO1A 2PAUA 2PAQA 4L1JB 2HEKA 4TO3A 4TNZA 2Q14A 4TNQA 5TK7A 4MLNA 3LJXA 4ZWGA 3RF0A 1VJ7A 4TO6A 1YNBA 4R8ZA 3P3QA 3GW7A 3CCGA 4RXOA 4L7EA 1XX7A 4XDSA 4RXSA 3NR1A 4QFXA 4RXPA 4BZBA 4TNRA 5TKAA 4MZ7A 4QG1A 4ZWEA 5AO4A 3TMCA 4MDZA 4TO1A 3TMDA 4Q7HA
chains in the Genus database with same CATH topology
4QG4A 3MZOA 4BZCA 2GZ4A 4QG2A 4MLMA 5AO0A 4TNPA 4QFZA 4RXQA 3MEMA 3SK9A 4LRLA 2DQBA 3S4LA 4QFYA 4QQZA 3BG2A 3TM8A 4L1JA 5AO2A 5AO3A 2FLOA 4N71A 3M1TA 3TMBA 4L7WA 4QG0A 3HC1A 3HI0A 4Q2DA 3SKDA 4QQXA 3KQ5A 3NQWA 5TK9A 4QQWA 3KH1A 1VQRA 2PARA 4RXRA 2PGSA 4N6WA 5TK8A 2PQ7A 1YOYA 4ME4A 3IRHA 4TNYA 2OGIA 2O6IA 4DMBA 4TO4A 5TK6A 4X9EA 4TO2A 4Q2CA 1U6ZA 4TNXA 3I7AA 4TO0A 4MCWA 4QQYA 2O08A 4TO5A 2CQZA 3U1NA 5AO1A 2PAUA 2PAQA 4L1JB 2HEKA 4TO3A 4TNZA 2Q14A 4TNQA 5TK7A 4MLNA 3LJXA 4ZWGA 3RF0A 1VJ7A 4TO6A 1YNBA 4R8ZA 3P3QA 3GW7A 3CCGA 4RXOA 4L7EA 1XX7A 4XDSA 4RXSA 3NR1A 4QFXA 4RXPA 4BZBA 4TNRA 5TKAA 4MZ7A 4QG1A 4ZWEA 5AO4A 3TMCA 4MDZA 4TO1A 3TMDA 4Q7HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QG4 A;  3MZO A;  4BZC A;  2GZ4 A;  4QG2 A;  4MLM A;  5AO0 A;  4TNP A;  4QFZ A;  4RXQ A;  3MEM A;  4LRL A;  2DQB A;  4QFY A;  3BG2 A;  3TM8 A;  4L1J A;  5AO2 A;  5AO3 A;  2FLO A;  4N71 A;  3M1T A;  3TMB A;  4L7W A;  4QG0 A;  3HC1 A;  3HI0 A;  3NQW A;  5TK9 A;  3KH1 A;  1VQR A;  2PAR A;  4RXR A;  2PGS A;  4N6W A;  5TK8 A;  2PQ7 A;  1YOY A;  4ME4 A;  3IRH A;  4TNY A;  2OGI A;  2O6I A;  4DMB A;  4TO4 A;  5TK6 A;  4X9E A;  4TO2 A;  1U6Z A;  4TNX A;  3I7A A;  4TO0 A;  4MCW A;  2O08 A;  4TO5 A;  2CQZ A;  3U1N A;  5AO1 A;  2PAU A;  2PAQ A;  4L1J B;  2HEK A;  4TO3 A;  4TNZ A;  2Q14 A;  4TNQ A;  5TK7 A;  4MLN A;  3LJX A;  4ZWG A;  3RF0 A;  1VJ7 A;  4TO6 A;  1YNB A;  4R8Z A;  3P3Q A;  3CCG A;  4RXO A;  4L7E A;  1XX7 A;  4XDS A;  4RXS A;  3NR1 A;  4QFX A;  4RXP A;  4BZB A;  4TNR A;  5TKA A;  4MZ7 A;  4QG1 A;  4ZWE A;  5AO4 A;  3TMC A;  4MDZ A;  4TO1 A;  3TMD A;  4Q7H A; 
#chains in the Genus database with same CATH topology
 4QG4 A;  3MZO A;  4BZC A;  2GZ4 A;  4QG2 A;  4MLM A;  5AO0 A;  4TNP A;  4QFZ A;  4RXQ A;  3MEM A;  3SK9 A;  4LRL A;  2DQB A;  3S4L A;  4QFY A;  4QQZ A;  3BG2 A;  3TM8 A;  4L1J A;  5AO2 A;  5AO3 A;  2FLO A;  4N71 A;  3M1T A;  3TMB A;  4L7W A;  4QG0 A;  3HC1 A;  3HI0 A;  4Q2D A;  3SKD A;  4QQX A;  3KQ5 A;  3NQW A;  5TK9 A;  4QQW A;  3KH1 A;  1VQR A;  2PAR A;  4RXR A;  2PGS A;  4N6W A;  5TK8 A;  2PQ7 A;  1YOY A;  4ME4 A;  3IRH A;  4TNY A;  2OGI A;  2O6I A;  4DMB A;  4TO4 A;  5TK6 A;  4X9E A;  4TO2 A;  4Q2C A;  1U6Z A;  4TNX A;  3I7A A;  4TO0 A;  4MCW A;  4QQY A;  2O08 A;  4TO5 A;  2CQZ A;  3U1N A;  5AO1 A;  2PAU A;  2PAQ A;  4L1J B;  2HEK A;  4TO3 A;  4TNZ A;  2Q14 A;  4TNQ A;  5TK7 A;  4MLN A;  3LJX A;  4ZWG A;  3RF0 A;  1VJ7 A;  4TO6 A;  1YNB A;  4R8Z A;  3P3Q A;  3GW7 A;  3CCG A;  4RXO A;  4L7E A;  1XX7 A;  4XDS A;  4RXS A;  3NR1 A;  4QFX A;  4RXP A;  4BZB A;  4TNR A;  5TKA A;  4MZ7 A;  4QG1 A;  4ZWE A;  5AO4 A;  3TMC A;  4MDZ A;  4TO1 A;  3TMD A;  4Q7H A; 
#chains in the Genus database with same CATH homology
 4QG4 A;  3MZO A;  4BZC A;  2GZ4 A;  4QG2 A;  4MLM A;  5AO0 A;  4TNP A;  4QFZ A;  4RXQ A;  3MEM A;  3SK9 A;  4LRL A;  2DQB A;  3S4L A;  4QFY A;  4QQZ A;  3BG2 A;  3TM8 A;  4L1J A;  5AO2 A;  5AO3 A;  2FLO A;  4N71 A;  3M1T A;  3TMB A;  4L7W A;  4QG0 A;  3HC1 A;  3HI0 A;  4Q2D A;  3SKD A;  4QQX A;  3KQ5 A;  3NQW A;  5TK9 A;  4QQW A;  3KH1 A;  1VQR A;  2PAR A;  4RXR A;  2PGS A;  4N6W A;  5TK8 A;  2PQ7 A;  1YOY A;  4ME4 A;  3IRH A;  4TNY A;  2OGI A;  2O6I A;  4DMB A;  4TO4 A;  5TK6 A;  4X9E A;  4TO2 A;  4Q2C A;  1U6Z A;  4TNX A;  3I7A A;  4TO0 A;  4MCW A;  4QQY A;  2O08 A;  4TO5 A;  2CQZ A;  3U1N A;  5AO1 A;  2PAU A;  2PAQ A;  4L1J B;  2HEK A;  4TO3 A;  4TNZ A;  2Q14 A;  4TNQ A;  5TK7 A;  4MLN A;  3LJX A;  4ZWG A;  3RF0 A;  1VJ7 A;  4TO6 A;  1YNB A;  4R8Z A;  3P3Q A;  3GW7 A;  3CCG A;  4RXO A;  4L7E A;  1XX7 A;  4XDS A;  4RXS A;  3NR1 A;  4QFX A;  4RXP A;  4BZB A;  4TNR A;  5TKA A;  4MZ7 A;  4QG1 A;  4ZWE A;  5AO4 A;  3TMC A;  4MDZ A;  4TO1 A;  3TMD A;  4Q7H A; 
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