5BQM | Genus

Total Genus 100

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	100
sequence length	403
structure length	387
Chain Sequence	GSALVLQCIKVKNNRLPYVADKDSISQEIFENKIITDETNVQVPINPEIVDPLLPNVNMEPLNLPGEEIVFYDDITKYVDYLNSYYYLESQKLSNNVENITLTTSVEEALGYSNKIYTFLPSLAEKVNKGVQAGLFLNWANEVVEDFTTNIMKKDTLDKISDVSVIIPYIGPALNIGNSALRGNFNQAFATAGVAFLLEGFPEFTIPALGVFTFYSSIQEREKIIKTIENCLEQRVKRWKDSYQWMVSNWLSRITTQFNHINYQMYDSLSYQADAIKAKIDLEYKKYSGSDKENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNKFDLRTKTELINLIDSHNIILVGEVDRLKAKVNESFENTMPFNIF

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors. pubmed doi rcsb
molecule keywords	Botulinum neurotoxin type D
total genus	100
structure length	387
sequence length	403
chains with identical sequence	D
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2015-05-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
B	PF00123	Hormone_2	Peptide hormone
B	PF07952	Toxin_trans	Clostridium neurotoxin, Translocation domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1120.10	Mainly Alpha	Up-down Bundle	Clostridium botulinum neurotoxin B, "coiled-coil" domain	Clostridium botulinum neurotoxin b, "coiled-coil" domain	5bqmB00

1S0DA 3VUOA 3V0BB 2NZ9A 1I1EA 3ZURA 2NYYA 3V0AB 3FFZA 3ZUSA 1S0BA 1G9BA 3ZUQA 1EPWA 2NP0A 2W2DB 2XHLB 5BQMB 5BQNA 3V0BA 1S0GA 1S0FA 1G9CA 4ZKTB 3V0AA 1F31A 1G9DA 3BTAA 1S0EA 1G9AA 1S0CA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1S0D A;  3VUO A;  3V0B B;  2NZ9 A;  1I1E A;  3ZUR A;  2NYY A;  3V0A B;  3FFZ A;  3ZUS A;  1S0B A;  1G9B A;  3ZUQ A;  1EPW A;  2NP0 A;  2W2D B;  2XHL B;  5BQM B;  5BQN A;  3V0B A;  1S0G A;  1S0F A;  1G9C A;  4ZKT B;  3V0A A;  1F31 A;  1G9D A;  3BTA A;  1S0E A;  1G9A A;  1S0C A; 
#chains in the Genus database with same CATH topology
 1S0D A;  3VUO A;  3V0B B;  2NZ9 A;  1I1E A;  3ZUR A;  2NYY A;  3V0A B;  3FFZ A;  3ZUS A;  1S0B A;  1G9B A;  3ZUQ A;  1EPW A;  2NP0 A;  2W2D B;  2XHL B;  5BQM B;  5BQN A;  3V0B A;  1S0G A;  1S0F A;  1G9C A;  4ZKT B;  3V0A A;  1F31 A;  1G9D A;  3BTA A;  1S0E A;  1G9A A;  1S0C A; 
#chains in the Genus database with same CATH homology
 1S0D A;  3VUO A;  3V0B B;  2NZ9 A;  1I1E A;  3ZUR A;  2NYY A;  3V0A B;  3FFZ A;  3ZUS A;  1S0B A;  1G9B A;  3ZUQ A;  1EPW A;  2NP0 A;  2W2D B;  2XHL B;  5BQM B;  5BQN A;  3V0B A;  1S0G A;  1S0F A;  1G9C A;  4ZKT B;  3V0A A;  1F31 A;  1G9D A;  3BTA A;  1S0E A;  1G9A A;  1S0C A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5BQMB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations