1EXTA

Extracellular domain of the 55kda tumor necrosis factor receptor. crystallized at ph3.7 in p 21 21 21.
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
160
structure length
160
Chain Sequence
SVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of the extracellular domain of the type I tumor necrosis factor receptor.
pubmed doi rcsb
molecule tags Signalling protein
source organism Homo sapiens
molecule keywords TUMOR NECROSIS FACTOR RECEPTOR
total genus 29
structure length 160
sequence length 160
chains with identical sequence B
ec nomenclature
pdb deposition date 1996-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA01
3FL7A 1EXTA 4RSUD 1D0GR 4E4DR 2HEVR 5IHLA 4MSVB 1ZA3R 3MBWA 3QO4A 3X3FA 3TJEF 4KGGC 1TNRR 4KGQC 3ME2R 4GIQR 2H9GR 4BK4A 3U3SA 4BK5A 1SG1X 5BNQR 1FT4A 4MXWR 5L36B 1D4VA 1JMAB 3ME4A 5CIRE 2X10A 3IJ2X 4N90R 4J6GC 3QBQB 3ALQR 3BUKC 2AW2B 3U3QA 1NCFA 2HEYR 4M4PA 4OD2S 3U3TA 3MI8D 3K51B 4YN0A 3MHDD 4FHQA 3URFZ 4I9XC 2UWIA 5DMJA 3QD6R 3U3VA 3WVTA 3U3PA 3THMF 4M4RA 1DU3A
chains in the Genus database with same CATH superfamily
3FL7A 1EXTA 4RSUD 1D0GR 4E4DR 2HEVR 5IHLA 4MSVB 1ZA3R 3MBWA 3QO4A 3X3FA 3TJEF 4KGGC 1TNRR 4M4RA 2E4UA 3ME2R 4KGQC 4GIQR 2H9GR 2E4XA 3U3SA 4BK5A 1SG1X 4BK4A 5BNQR 1FT4A 4MXWR 5L36B 1D4VA 1JMAB 3ME4A 5CIRE 2X10A 3IJ2X 4N90R 4J6GC 3QBQB 3ALQR 3BUKC 2AW2B 3U3QA 1NCFA 2HEYR 4M4PA 4OD2S 2E4YA 2QR6A 3U3TA 3MI8D 3K51B 4YN0A 3MHDD 2E4VA 4FHQA 3URFZ 4I9XC 2UWIA 5DMJA 3QD6R 3U3VA 3WVTA 3U3PA 3THMF 2E4WA 1DU3A
chains in the Genus database with same CATH topology
3FL7A 1EXTA 4RSUD 1D0GR 4E4DR 2HEVR 5IHLA 4MSVB 1ZA3R 3MBWA 3QO4A 3X3FA 3TJEF 4KGGC 1TNRR 4KGQC 3ME2R 4GIQR 2H9GR 4BK4A 3U3SA 4BK5A 1SG1X 5BNQR 1FT4A 4MXWR 5L36B 1D4VA 1JMAB 3ME4A 5CIRE 2X10A 3IJ2X 4N90R 4J6GC 3QBQB 3ALQR 3BUKC 2AW2B 3U3QA 1NCFA 2HEYR 4M4PA 4OD2S 3U3TA 3MI8D 3K51B 4YN0A 3MHDD 4FHQA 3URFZ 4I9XC 2UWIA 5DMJA 3QD6R 3U3VA 3WVTA 3U3PA 3THMF 4M4RA 1DU3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FL7 A;  1EXT A;  4RSU D;  1D0G R;  4E4D R;  2HEV R;  5IHL A;  4MSV B;  1ZA3 R;  3MBW A;  3QO4 A;  3X3F A;  3TJE F;  4KGG C;  1TNR R;  4KGQ C;  3ME2 R;  4GIQ R;  2H9G R;  4BK4 A;  3U3S A;  4BK5 A;  1SG1 X;  5BNQ R;  1FT4 A;  4MXW R;  5L36 B;  1D4V A;  1JMA B;  3ME4 A;  5CIR E;  2X10 A;  3IJ2 X;  4N90 R;  4J6G C;  3QBQ B;  3ALQ R;  3BUK C;  2AW2 B;  3U3Q A;  1NCF A;  2HEY R;  4M4P A;  4OD2 S;  3U3T A;  3MI8 D;  3K51 B;  4YN0 A;  3MHD D;  4FHQ A;  3URF Z;  4I9X C;  2UWI A;  5DMJ A;  3QD6 R;  3U3V A;  3WVT A;  3U3P A;  3THM F;  4M4R A;  1DU3 A; 
#chains in the Genus database with same CATH topology
 3FL7 A;  1EXT A;  4RSU D;  1D0G R;  4E4D R;  2HEV R;  5IHL A;  4MSV B;  1ZA3 R;  3MBW A;  3QO4 A;  3X3F A;  3TJE F;  4KGG C;  1TNR R;  4M4R A;  2E4U A;  3ME2 R;  4KGQ C;  4GIQ R;  2H9G R;  2E4X A;  3U3S A;  4BK5 A;  1SG1 X;  4BK4 A;  5BNQ R;  1FT4 A;  4MXW R;  5L36 B;  1D4V A;  1JMA B;  3ME4 A;  5CIR E;  2X10 A;  3IJ2 X;  4N90 R;  4J6G C;  3QBQ B;  3ALQ R;  3BUK C;  2AW2 B;  3U3Q A;  1NCF A;  2HEY R;  4M4P A;  4OD2 S;  2E4Y A;  2QR6 A;  3U3T A;  3MI8 D;  3K51 B;  4YN0 A;  3MHD D;  2E4V A;  4FHQ A;  3URF Z;  4I9X C;  2UWI A;  5DMJ A;  3QD6 R;  3U3V A;  3WVT A;  3U3P A;  3THM F;  2E4W A;  1DU3 A; 
#chains in the Genus database with same CATH homology
 3FL7 A;  1EXT A;  4RSU D;  1D0G R;  4E4D R;  2HEV R;  5IHL A;  4MSV B;  1ZA3 R;  3MBW A;  3QO4 A;  3X3F A;  3TJE F;  4KGG C;  1TNR R;  4KGQ C;  3ME2 R;  4GIQ R;  2H9G R;  4BK4 A;  3U3S A;  4BK5 A;  1SG1 X;  5BNQ R;  1FT4 A;  4MXW R;  5L36 B;  1D4V A;  1JMA B;  3ME4 A;  5CIR E;  2X10 A;  3IJ2 X;  4N90 R;  4J6G C;  3QBQ B;  3ALQ R;  3BUK C;  2AW2 B;  3U3Q A;  1NCF A;  2HEY R;  4M4P A;  4OD2 S;  3U3T A;  3MI8 D;  3K51 B;  4YN0 A;  3MHD D;  4FHQ A;  3URF Z;  4I9X C;  2UWI A;  5DMJ A;  3QD6 R;  3U3V A;  3WVT A;  3U3P A;  3THM F;  4M4R A;  1DU3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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