1EXTA

Extracellular domain of the 55kda tumor necrosis factor receptor. crystallized at ph3.7 in p 21 21 21.
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
160
structure length
160
Chain Sequence
SVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signalling protein
source organism Homo sapiens
publication title Structures of the extracellular domain of the type I tumor necrosis factor receptor.
pubmed doi rcsb
molecule keywords TUMOR NECROSIS FACTOR RECEPTOR
total genus 29
structure length 160
sequence length 160
chains with identical sequence B
ec nomenclature
pdb deposition date 1996-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA01
1D0GR 3QD6R 4MXWR 4BK5A 3ALQR 5DMJA 1ZA3R 2HEYR 3U3TA 3WVTA 1FT4A 4E4DR 1SG1X 5IHLA 3FL7A 5CIRE 4GIQR 3TJEF 2X10A 3IJ2X 3U3SA 4MSVB 3X3FA 1TNRR 4FHQA 4N90R 1EXTA 2AW2B 4M4RA 1D4VA 1NCFA 2H9GR 3ME4A 3U3VA 2HEVR 3QBQB 4OD2S 4M4PA 2UWIA 3URFZ 3BUKC 3MBWA 3ME2R 4YN0A 5L36B 3MI8D 5BNQR 1DU3A 3THMF 4I9XC 4KGQC 4KGGC 1JMAB 3U3QA 4J6GC 3K51B 4BK4A 3QO4A 3U3PA 3MHDD 4RSUD
chains in the Genus database with same CATH superfamily
1D0GR 3QD6R 4MXWR 4BK5A 3ALQR 5DMJA 1ZA3R 2HEYR 3U3TA 3WVTA 1FT4A 4E4DR 1SG1X 5IHLA 3FL7A 5CIRE 4GIQR 3TJEF 2X10A 3IJ2X 3U3SA 4MSVB 3X3FA 1TNRR 4FHQA 4N90R 1EXTA 2AW2B 4M4RA 1D4VA 1NCFA 2H9GR 3ME4A 3U3VA 2HEVR 3QBQB 4OD2S 4M4PA 2UWIA 3URFZ 3BUKC 2E4VA 3MBWA 3ME2R 2QR6A 4YN0A 3MI8D 5L36B 5BNQR 1DU3A 2E4YA 3THMF 4I9XC 4KGQC 4KGGC 1JMAB 2E4UA 3U3QA 4J6GC 3K51B 2E4WA 4BK4A 2E4XA 3QO4A 3U3PA 3MHDD 4RSUD
chains in the Genus database with same CATH topology
1D0GR 3QD6R 4MXWR 4BK5A 3ALQR 5DMJA 1ZA3R 2HEYR 3U3TA 3WVTA 1FT4A 4E4DR 1SG1X 5IHLA 3FL7A 5CIRE 4GIQR 3TJEF 2X10A 3IJ2X 3U3SA 4MSVB 3X3FA 1TNRR 4FHQA 4N90R 1EXTA 2AW2B 4M4RA 1D4VA 1NCFA 2H9GR 3ME4A 3U3VA 2HEVR 3QBQB 4OD2S 4M4PA 2UWIA 3URFZ 3BUKC 3MBWA 3ME2R 4YN0A 5L36B 3MI8D 5BNQR 1DU3A 3THMF 4I9XC 4KGQC 4KGGC 1JMAB 3U3QA 4J6GC 3K51B 4BK4A 3QO4A 3U3PA 3MHDD 4RSUD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0G R;  3QD6 R;  4MXW R;  4BK5 A;  3ALQ R;  5DMJ A;  1ZA3 R;  2HEY R;  3U3T A;  3WVT A;  1FT4 A;  4E4D R;  1SG1 X;  5IHL A;  3FL7 A;  5CIR E;  4GIQ R;  3TJE F;  2X10 A;  3IJ2 X;  3U3S A;  4MSV B;  3X3F A;  1TNR R;  4FHQ A;  4N90 R;  1EXT A;  2AW2 B;  4M4R A;  1D4V A;  1NCF A;  2H9G R;  3ME4 A;  3U3V A;  2HEV R;  3QBQ B;  4OD2 S;  4M4P A;  2UWI A;  3URF Z;  3BUK C;  3MBW A;  3ME2 R;  4YN0 A;  5L36 B;  3MI8 D;  5BNQ R;  1DU3 A;  3THM F;  4I9X C;  4KGQ C;  4KGG C;  1JMA B;  3U3Q A;  4J6G C;  3K51 B;  4BK4 A;  3QO4 A;  3U3P A;  3MHD D;  4RSU D; 
#chains in the Genus database with same CATH topology
 1D0G R;  3QD6 R;  4MXW R;  4BK5 A;  3ALQ R;  5DMJ A;  1ZA3 R;  2HEY R;  3U3T A;  3WVT A;  1FT4 A;  4E4D R;  1SG1 X;  5IHL A;  3FL7 A;  5CIR E;  4GIQ R;  3TJE F;  2X10 A;  3IJ2 X;  3U3S A;  4MSV B;  3X3F A;  1TNR R;  4FHQ A;  4N90 R;  1EXT A;  2AW2 B;  4M4R A;  1D4V A;  1NCF A;  2H9G R;  3ME4 A;  3U3V A;  2HEV R;  3QBQ B;  4OD2 S;  4M4P A;  2UWI A;  3URF Z;  3BUK C;  2E4V A;  3MBW A;  3ME2 R;  2QR6 A;  4YN0 A;  3MI8 D;  5L36 B;  5BNQ R;  1DU3 A;  2E4Y A;  3THM F;  4I9X C;  4KGQ C;  4KGG C;  1JMA B;  2E4U A;  3U3Q A;  4J6G C;  3K51 B;  2E4W A;  4BK4 A;  2E4X A;  3QO4 A;  3U3P A;  3MHD D;  4RSU D; 
#chains in the Genus database with same CATH homology
 1D0G R;  3QD6 R;  4MXW R;  4BK5 A;  3ALQ R;  5DMJ A;  1ZA3 R;  2HEY R;  3U3T A;  3WVT A;  1FT4 A;  4E4D R;  1SG1 X;  5IHL A;  3FL7 A;  5CIR E;  4GIQ R;  3TJE F;  2X10 A;  3IJ2 X;  3U3S A;  4MSV B;  3X3F A;  1TNR R;  4FHQ A;  4N90 R;  1EXT A;  2AW2 B;  4M4R A;  1D4V A;  1NCF A;  2H9G R;  3ME4 A;  3U3V A;  2HEV R;  3QBQ B;  4OD2 S;  4M4P A;  2UWI A;  3URF Z;  3BUK C;  3MBW A;  3ME2 R;  4YN0 A;  5L36 B;  3MI8 D;  5BNQ R;  1DU3 A;  3THM F;  4I9X C;  4KGQ C;  4KGG C;  1JMA B;  3U3Q A;  4J6G C;  3K51 B;  4BK4 A;  3QO4 A;  3U3P A;  3MHD D;  4RSU D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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