1FT4A

Photochemically-enhanced binding of small molecules to the tumor necrosis factor receptor-1
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
140
structure length
140
Chain Sequence
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
pubmed doi rcsb
molecule keywords SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1
molecule tags Signaling protein
source organism Homo sapiens
total genus 20
structure length 140
sequence length 140
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A01
3ME4A 1TNRR 3K51B 3FL7A 2UWIA 4RSUD 3X3FA 1ZA3R 3WVTA 3TJEF 4GIQR 1D4VA 3URFZ 3U3VA 5DMJA 3QO4A 1JMAB 4FHQA 4KGQC 3ALQR 4J6GC 3MI8D 1D0GR 2HEVR 4MXWR 3MBWA 3THMF 2AW2B 1EXTA 4OD2S 2H9GR 3ME2R 1FT4A 4YN0A 4BK5A 3MHDD 4M4PA 4BK4A 3U3QA 2X10A 2HEYR 3U3SA 5BNQR 1DU3A 3U3PA 4KGGC 3IJ2X 1NCFA 5CIRE 3U3TA 3BUKC 5L36B 4MSVB 4E4DR 4M4RA 1SG1X 4I9XC 3QBQB 3QD6R 4N90R 5IHLA
chains in the Genus database with same CATH superfamily
3ME4A 1TNRR 3K51B 3FL7A 2UWIA 4RSUD 2QR6A 1ZA3R 3WVTA 3TJEF 4GIQR 1D4VA 3URFZ 3U3VA 5DMJA 3QO4A 1JMAB 4FHQA 4KGQC 3ALQR 4J6GC 3MI8D 1D0GR 2HEVR 4MXWR 3X3FA 3MBWA 3THMF 2AW2B 2E4YA 1EXTA 4OD2S 2H9GR 3ME2R 2E4UA 1FT4A 4YN0A 4BK5A 3MHDD 4M4PA 2E4XA 4BK4A 3U3QA 2X10A 2HEYR 3U3SA 5BNQR 1DU3A 3U3PA 4KGGC 3IJ2X 1NCFA 5CIRE 2E4WA 2E4VA 3BUKC 3U3TA 5L36B 4MSVB 4E4DR 4M4RA 1SG1X 4I9XC 3QBQB 3QD6R 4N90R 5IHLA
chains in the Genus database with same CATH topology
3ME4A 1TNRR 3K51B 3FL7A 2UWIA 4RSUD 3X3FA 1ZA3R 3WVTA 3TJEF 4GIQR 1D4VA 3URFZ 3U3VA 5DMJA 3QO4A 1JMAB 4FHQA 4KGQC 3ALQR 4J6GC 3MI8D 1D0GR 2HEVR 4MXWR 3MBWA 3THMF 2AW2B 1EXTA 4OD2S 2H9GR 3ME2R 1FT4A 4YN0A 4BK5A 3MHDD 4M4PA 4BK4A 3U3QA 2X10A 2HEYR 3U3SA 5BNQR 1DU3A 3U3PA 4KGGC 3IJ2X 1NCFA 5CIRE 3U3TA 3BUKC 5L36B 4MSVB 4E4DR 4M4RA 1SG1X 4I9XC 3QBQB 3QD6R 4N90R 5IHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ME4 A;  1TNR R;  3K51 B;  3FL7 A;  2UWI A;  4RSU D;  3X3F A;  1ZA3 R;  3WVT A;  3TJE F;  4GIQ R;  1D4V A;  3URF Z;  3U3V A;  5DMJ A;  3QO4 A;  1JMA B;  4FHQ A;  4KGQ C;  3ALQ R;  4J6G C;  3MI8 D;  1D0G R;  2HEV R;  4MXW R;  3MBW A;  3THM F;  2AW2 B;  1EXT A;  4OD2 S;  2H9G R;  3ME2 R;  1FT4 A;  4YN0 A;  4BK5 A;  3MHD D;  4M4P A;  4BK4 A;  3U3Q A;  2X10 A;  2HEY R;  3U3S A;  5BNQ R;  1DU3 A;  3U3P A;  4KGG C;  3IJ2 X;  1NCF A;  5CIR E;  3U3T A;  3BUK C;  5L36 B;  4MSV B;  4E4D R;  4M4R A;  1SG1 X;  4I9X C;  3QBQ B;  3QD6 R;  4N90 R;  5IHL A; 
#chains in the Genus database with same CATH topology
 3ME4 A;  1TNR R;  3K51 B;  3FL7 A;  2UWI A;  4RSU D;  2QR6 A;  1ZA3 R;  3WVT A;  3TJE F;  4GIQ R;  1D4V A;  3URF Z;  3U3V A;  5DMJ A;  3QO4 A;  1JMA B;  4FHQ A;  4KGQ C;  3ALQ R;  4J6G C;  3MI8 D;  1D0G R;  2HEV R;  4MXW R;  3X3F A;  3MBW A;  3THM F;  2AW2 B;  2E4Y A;  1EXT A;  4OD2 S;  2H9G R;  3ME2 R;  2E4U A;  1FT4 A;  4YN0 A;  4BK5 A;  3MHD D;  4M4P A;  2E4X A;  4BK4 A;  3U3Q A;  2X10 A;  2HEY R;  3U3S A;  5BNQ R;  1DU3 A;  3U3P A;  4KGG C;  3IJ2 X;  1NCF A;  5CIR E;  2E4W A;  2E4V A;  3BUK C;  3U3T A;  5L36 B;  4MSV B;  4E4D R;  4M4R A;  1SG1 X;  4I9X C;  3QBQ B;  3QD6 R;  4N90 R;  5IHL A; 
#chains in the Genus database with same CATH homology
 3ME4 A;  1TNR R;  3K51 B;  3FL7 A;  2UWI A;  4RSU D;  3X3F A;  1ZA3 R;  3WVT A;  3TJE F;  4GIQ R;  1D4V A;  3URF Z;  3U3V A;  5DMJ A;  3QO4 A;  1JMA B;  4FHQ A;  4KGQ C;  3ALQ R;  4J6G C;  3MI8 D;  1D0G R;  2HEV R;  4MXW R;  3MBW A;  3THM F;  2AW2 B;  1EXT A;  4OD2 S;  2H9G R;  3ME2 R;  1FT4 A;  4YN0 A;  4BK5 A;  3MHD D;  4M4P A;  4BK4 A;  3U3Q A;  2X10 A;  2HEY R;  3U3S A;  5BNQ R;  1DU3 A;  3U3P A;  4KGG C;  3IJ2 X;  1NCF A;  5CIR E;  3U3T A;  3BUK C;  5L36 B;  4MSV B;  4E4D R;  4M4R A;  1SG1 X;  4I9X C;  3QBQ B;  3QD6 R;  4N90 R;  5IHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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