1FT4A

Photochemically-enhanced binding of small molecules to the tumor necrosis factor receptor-1
Total Genus 20

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
140
structure length
140
Chain Sequence
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
EMPTYTIV2 (22-25)S1 (19-21)O2 (30-43)TIV1 (13-16)TII1 (16-19)S3 (37-41)TIV4 (25-28)TIV3 (23-26)TIV6 (45-48)O4 (55-70)S2 (29-31)TII3 (56-59)S4 (51-54)TIV7 (62-65)O3 (33-52)3H1 (78-80)S9 (102-105)S6 (71-72)O5 (73-88)TIV8 (84-87)S7 (82-86)O6 (76-96)TIV9 (89-92)TIV12 (106-109)TIV15 (118-121)TII4 (120-123)S8 (95-98)TIV10 (98-101)TIV14 (109-112)TIV17 (130-133)S12 (136-139)S10 (113-116)TIV16 (125-128)S11 (123-127)O8 (117-129)TII2 (34-37)Updating...
connected with : NaN
molecule tags Signaling protein
source organism Homo sapiens
publication title Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
pubmed doi rcsb
molecule keywords SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1
total genus 20
structure length 140
sequence length 140
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A01
3ME4A 2AW2B 1NCFA 3ALQR 4RSUD 4YN0A 3U3VA 4GIQR 4I9XC 3U3SA 1DU3A 4FHQA 3U3TA 2HEVR 3BUKC 1TNRR 2HEYR 1D4VA 3MI8D 3QD6R 4BK4A 3TJEF 1JMAB 3K51B 1SG1X 1FT4A 1EXTA 3MHDD 3THMF 5L36B 2X10A 5CIRE 4J6GC 4KGQC 5BNQR 4MXWR 5DMJA 5IHLA 3FL7A 4M4RA 4MSVB 1ZA3R 3ME2R 4N90R 1D0GR 3U3PA 3WVTA 3QBQB 4BK5A 3QO4A 2UWIA 4M4PA 3IJ2X 4KGGC 3URFZ 4OD2S 4E4DR 3U3QA 3X3FA 3MBWA 2H9GR
chains in the Genus database with same CATH superfamily
2E4XA 3ME4A 2AW2B 1NCFA 3ALQR 4RSUD 4YN0A 3U3VA 4GIQR 4I9XC 3U3SA 1DU3A 2E4YA 4FHQA 2HEVR 3U3TA 3BUKC 1TNRR 2HEYR 1D4VA 3MI8D 3QD6R 4BK4A 3TJEF 2QR6A 1JMAB 3K51B 2E4UA 1SG1X 1FT4A 1EXTA 3MHDD 3THMF 5L36B 2X10A 5CIRE 4J6GC 4KGQC 5BNQR 4MXWR 5DMJA 5IHLA 3FL7A 4M4RA 4MSVB 1ZA3R 3ME2R 4N90R 1D0GR 3U3PA 3WVTA 3QBQB 4BK5A 3QO4A 2E4VA 2UWIA 4M4PA 3IJ2X 4KGGC 3URFZ 4OD2S 4E4DR 3U3QA 3X3FA 3MBWA 2E4WA 2H9GR
chains in the Genus database with same CATH topology
3ME4A 2AW2B 1NCFA 3ALQR 4RSUD 4YN0A 3U3VA 4GIQR 4I9XC 3U3SA 1DU3A 4FHQA 3U3TA 2HEVR 3BUKC 1TNRR 2HEYR 1D4VA 3MI8D 3QD6R 4BK4A 3TJEF 1JMAB 3K51B 1SG1X 1FT4A 1EXTA 3MHDD 3THMF 5L36B 2X10A 5CIRE 4J6GC 4KGQC 5BNQR 4MXWR 5DMJA 5IHLA 3FL7A 4M4RA 4MSVB 1ZA3R 3ME2R 4N90R 1D0GR 3U3PA 3WVTA 3QBQB 4BK5A 3QO4A 2UWIA 4M4PA 3IJ2X 4KGGC 3URFZ 4OD2S 4E4DR 3U3QA 3X3FA 3MBWA 2H9GR
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3ME4 A;  2AW2 B;  1NCF A;  3ALQ R;  4RSU D;  4YN0 A;  3U3V A;  4GIQ R;  4I9X C;  3U3S A;  1DU3 A;  4FHQ A;  3U3T A;  2HEV R;  3BUK C;  1TNR R;  2HEY R;  1D4V A;  3MI8 D;  3QD6 R;  4BK4 A;  3TJE F;  1JMA B;  3K51 B;  1SG1 X;  1FT4 A;  1EXT A;  3MHD D;  3THM F;  5L36 B;  2X10 A;  5CIR E;  4J6G C;  4KGQ C;  5BNQ R;  4MXW R;  5DMJ A;  5IHL A;  3FL7 A;  4M4R A;  4MSV B;  1ZA3 R;  3ME2 R;  4N90 R;  1D0G R;  3U3P A;  3WVT A;  3QBQ B;  4BK5 A;  3QO4 A;  2UWI A;  4M4P A;  3IJ2 X;  4KGG C;  3URF Z;  4OD2 S;  4E4D R;  3U3Q A;  3X3F A;  3MBW A;  2H9G R; 
#chains in the Genus database with same CATH topology
 2E4X A;  3ME4 A;  2AW2 B;  1NCF A;  3ALQ R;  4RSU D;  4YN0 A;  3U3V A;  4GIQ R;  4I9X C;  3U3S A;  1DU3 A;  2E4Y A;  4FHQ A;  2HEV R;  3U3T A;  3BUK C;  1TNR R;  2HEY R;  1D4V A;  3MI8 D;  3QD6 R;  4BK4 A;  3TJE F;  2QR6 A;  1JMA B;  3K51 B;  2E4U A;  1SG1 X;  1FT4 A;  1EXT A;  3MHD D;  3THM F;  5L36 B;  2X10 A;  5CIR E;  4J6G C;  4KGQ C;  5BNQ R;  4MXW R;  5DMJ A;  5IHL A;  3FL7 A;  4M4R A;  4MSV B;  1ZA3 R;  3ME2 R;  4N90 R;  1D0G R;  3U3P A;  3WVT A;  3QBQ B;  4BK5 A;  3QO4 A;  2E4V A;  2UWI A;  4M4P A;  3IJ2 X;  4KGG C;  3URF Z;  4OD2 S;  4E4D R;  3U3Q A;  3X3F A;  3MBW A;  2E4W A;  2H9G R; 
#chains in the Genus database with same CATH homology
 3ME4 A;  2AW2 B;  1NCF A;  3ALQ R;  4RSU D;  4YN0 A;  3U3V A;  4GIQ R;  4I9X C;  3U3S A;  1DU3 A;  4FHQ A;  3U3T A;  2HEV R;  3BUK C;  1TNR R;  2HEY R;  1D4V A;  3MI8 D;  3QD6 R;  4BK4 A;  3TJE F;  1JMA B;  3K51 B;  1SG1 X;  1FT4 A;  1EXT A;  3MHD D;  3THM F;  5L36 B;  2X10 A;  5CIR E;  4J6G C;  4KGQ C;  5BNQ R;  4MXW R;  5DMJ A;  5IHL A;  3FL7 A;  4M4R A;  4MSV B;  1ZA3 R;  3ME2 R;  4N90 R;  1D0G R;  3U3P A;  3WVT A;  3QBQ B;  4BK5 A;  3QO4 A;  2UWI A;  4M4P A;  3IJ2 X;  4KGG C;  3URF Z;  4OD2 S;  4E4D R;  3U3Q A;  3X3F A;  3MBW A;  2H9G R;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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