1FT4A

Photochemically-enhanced binding of small molecules to the tumor necrosis factor receptor-1
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
140
structure length
140
Chain Sequence
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
source organism Homo sapiens
publication title Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
pubmed doi rcsb
molecule keywords SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1
total genus 20
structure length 140
sequence length 140
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A01
3MBWA 4RSUD 1NCFA 4I9XC 4J6GC 1ZA3R 4MSVB 3U3VA 3U3TA 4KGGC 4OD2S 3U3SA 2AW2B 2X10A 4BK5A 3MHDD 5L36B 1SG1X 3THMF 3QO4A 1TNRR 3MI8D 3X3FA 3ME4A 1FT4A 5IHLA 3QBQB 4E4DR 3TJEF 4GIQR 3WVTA 2UWIA 3K51B 1DU3A 3U3PA 4BK4A 3ALQR 3URFZ 1D0GR 4M4RA 3IJ2X 2H9GR 4KGQC 3ME2R 4MXWR 3U3QA 3BUKC 1EXTA 4N90R 3QD6R 4FHQA 1D4VA 4YN0A 3FL7A 5DMJA 2HEYR 2HEVR 4M4PA 5BNQR 1JMAB 5CIRE
chains in the Genus database with same CATH superfamily
2E4UA 3MBWA 2QR6A 4RSUD 1NCFA 4I9XC 4J6GC 1ZA3R 4MSVB 3U3VA 3U3TA 2E4VA 4KGGC 4OD2S 3U3SA 2AW2B 2E4YA 2X10A 4BK5A 3MHDD 5L36B 1SG1X 2E4WA 3QO4A 1TNRR 3THMF 3MI8D 3X3FA 3ME4A 1FT4A 5IHLA 3QBQB 4E4DR 3TJEF 4GIQR 3WVTA 2E4XA 2UWIA 3K51B 1DU3A 3U3PA 4BK4A 3ALQR 3URFZ 1D0GR 4M4RA 3IJ2X 2H9GR 4KGQC 3ME2R 4MXWR 3U3QA 3BUKC 1EXTA 4N90R 3QD6R 4FHQA 1D4VA 4YN0A 3FL7A 5DMJA 2HEYR 2HEVR 4M4PA 5BNQR 1JMAB 5CIRE
chains in the Genus database with same CATH topology
3MBWA 4RSUD 1NCFA 4I9XC 4J6GC 1ZA3R 4MSVB 3U3VA 3U3TA 4KGGC 4OD2S 3U3SA 2AW2B 2X10A 4BK5A 3MHDD 5L36B 1SG1X 3THMF 3QO4A 1TNRR 3MI8D 3X3FA 3ME4A 1FT4A 5IHLA 3QBQB 4E4DR 3TJEF 4GIQR 3WVTA 2UWIA 3K51B 1DU3A 3U3PA 4BK4A 3ALQR 3URFZ 1D0GR 4M4RA 3IJ2X 2H9GR 4KGQC 3ME2R 4MXWR 3U3QA 3BUKC 1EXTA 4N90R 3QD6R 4FHQA 1D4VA 4YN0A 3FL7A 5DMJA 2HEYR 2HEVR 4M4PA 5BNQR 1JMAB 5CIRE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MBW A;  4RSU D;  1NCF A;  4I9X C;  4J6G C;  1ZA3 R;  4MSV B;  3U3V A;  3U3T A;  4KGG C;  4OD2 S;  3U3S A;  2AW2 B;  2X10 A;  4BK5 A;  3MHD D;  5L36 B;  1SG1 X;  3THM F;  3QO4 A;  1TNR R;  3MI8 D;  3X3F A;  3ME4 A;  1FT4 A;  5IHL A;  3QBQ B;  4E4D R;  3TJE F;  4GIQ R;  3WVT A;  2UWI A;  3K51 B;  1DU3 A;  3U3P A;  4BK4 A;  3ALQ R;  3URF Z;  1D0G R;  4M4R A;  3IJ2 X;  2H9G R;  4KGQ C;  3ME2 R;  4MXW R;  3U3Q A;  3BUK C;  1EXT A;  4N90 R;  3QD6 R;  4FHQ A;  1D4V A;  4YN0 A;  3FL7 A;  5DMJ A;  2HEY R;  2HEV R;  4M4P A;  5BNQ R;  1JMA B;  5CIR E; 
#chains in the Genus database with same CATH topology
 2E4U A;  3MBW A;  2QR6 A;  4RSU D;  1NCF A;  4I9X C;  4J6G C;  1ZA3 R;  4MSV B;  3U3V A;  3U3T A;  2E4V A;  4KGG C;  4OD2 S;  3U3S A;  2AW2 B;  2E4Y A;  2X10 A;  4BK5 A;  3MHD D;  5L36 B;  1SG1 X;  2E4W A;  3QO4 A;  1TNR R;  3THM F;  3MI8 D;  3X3F A;  3ME4 A;  1FT4 A;  5IHL A;  3QBQ B;  4E4D R;  3TJE F;  4GIQ R;  3WVT A;  2E4X A;  2UWI A;  3K51 B;  1DU3 A;  3U3P A;  4BK4 A;  3ALQ R;  3URF Z;  1D0G R;  4M4R A;  3IJ2 X;  2H9G R;  4KGQ C;  3ME2 R;  4MXW R;  3U3Q A;  3BUK C;  1EXT A;  4N90 R;  3QD6 R;  4FHQ A;  1D4V A;  4YN0 A;  3FL7 A;  5DMJ A;  2HEY R;  2HEV R;  4M4P A;  5BNQ R;  1JMA B;  5CIR E; 
#chains in the Genus database with same CATH homology
 3MBW A;  4RSU D;  1NCF A;  4I9X C;  4J6G C;  1ZA3 R;  4MSV B;  3U3V A;  3U3T A;  4KGG C;  4OD2 S;  3U3S A;  2AW2 B;  2X10 A;  4BK5 A;  3MHD D;  5L36 B;  1SG1 X;  3THM F;  3QO4 A;  1TNR R;  3MI8 D;  3X3F A;  3ME4 A;  1FT4 A;  5IHL A;  3QBQ B;  4E4D R;  3TJE F;  4GIQ R;  3WVT A;  2UWI A;  3K51 B;  1DU3 A;  3U3P A;  4BK4 A;  3ALQ R;  3URF Z;  1D0G R;  4M4R A;  3IJ2 X;  2H9G R;  4KGQ C;  3ME2 R;  4MXW R;  3U3Q A;  3BUK C;  1EXT A;  4N90 R;  3QD6 R;  4FHQ A;  1D4V A;  4YN0 A;  3FL7 A;  5DMJ A;  2HEY R;  2HEV R;  4M4P A;  5BNQ R;  1JMA B;  5CIR E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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