1NCFA

A new paradigm for tumor necrosis factor signalling
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
140
structure length
140
Chain Sequence
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signalling protein
source organism Homo sapiens
publication title Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
pubmed doi rcsb
molecule keywords TUMOR NECROSIS FACTOR RECEPTOR
total genus 23
structure length 140
sequence length 140
chains with identical sequence B
ec nomenclature
pdb deposition date 1994-10-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ncfA02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ncfA01
1FT4A 1SG1X 4KGGC 1D4VA 3ALQR 3QD6R 5L36B 3ME2R 1NCFA 3MHDD 5BNQR 4E4DR 3X3FA 4BK4A 4BK5A 2AW2B 3URFZ 1JMAB 4N90R 4J6GC 4KGQC 4OD2S 3U3QA 4M4RA 3THMF 3U3VA 3K51B 3MI8D 3WVTA 2HEVR 1DU3A 3U3SA 3MBWA 4MSVB 3IJ2X 3BUKC 3QBQB 2HEYR 5DMJA 3ME4A 2UWIA 4I9XC 2H9GR 3QO4A 4MXWR 4YN0A 4GIQR 4M4PA 1D0GR 5IHLA 1ZA3R 5CIRE 2X10A 4FHQA 4RSUD 3U3PA 1TNRR 3FL7A 3TJEF 1EXTA 3U3TA
chains in the Genus database with same CATH superfamily
1FT4A 1SG1X 2E4XA 4KGGC 1D4VA 3ALQR 3QD6R 5L36B 3ME2R 1NCFA 3MHDD 5BNQR 4E4DR 3X3FA 4BK4A 4BK5A 2AW2B 3URFZ 1JMAB 4N90R 4J6GC 4KGQC 4OD2S 2QR6A 3U3QA 4M4RA 3THMF 2E4YA 2E4UA 3K51B 3U3VA 3MI8D 3WVTA 2HEVR 1DU3A 3U3SA 3MBWA 4MSVB 3IJ2X 2E4WA 3BUKC 3QBQB 2HEYR 5DMJA 3ME4A 2UWIA 4I9XC 2H9GR 3QO4A 4MXWR 2E4VA 4GIQR 4M4PA 1D0GR 4YN0A 5IHLA 1ZA3R 5CIRE 2X10A 4FHQA 4RSUD 3U3PA 1TNRR 3FL7A 3TJEF 1EXTA 3U3TA
chains in the Genus database with same CATH topology
1FT4A 1SG1X 4KGGC 1D4VA 3ALQR 3QD6R 5L36B 3ME2R 1NCFA 3MHDD 5BNQR 4E4DR 3X3FA 4BK4A 4BK5A 2AW2B 3URFZ 1JMAB 4N90R 4J6GC 4KGQC 4OD2S 3U3QA 4M4RA 3THMF 3U3VA 3K51B 3MI8D 3WVTA 2HEVR 1DU3A 3U3SA 3MBWA 4MSVB 3IJ2X 3BUKC 3QBQB 2HEYR 5DMJA 3ME4A 2UWIA 4I9XC 2H9GR 3QO4A 4MXWR 4YN0A 4GIQR 4M4PA 1D0GR 5IHLA 1ZA3R 5CIRE 2X10A 4FHQA 4RSUD 3U3PA 1TNRR 3FL7A 3TJEF 1EXTA 3U3TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FT4 A;  1SG1 X;  4KGG C;  1D4V A;  3ALQ R;  3QD6 R;  5L36 B;  3ME2 R;  1NCF A;  3MHD D;  5BNQ R;  4E4D R;  3X3F A;  4BK4 A;  4BK5 A;  2AW2 B;  3URF Z;  1JMA B;  4N90 R;  4J6G C;  4KGQ C;  4OD2 S;  3U3Q A;  4M4R A;  3THM F;  3U3V A;  3K51 B;  3MI8 D;  3WVT A;  2HEV R;  1DU3 A;  3U3S A;  3MBW A;  4MSV B;  3IJ2 X;  3BUK C;  3QBQ B;  2HEY R;  5DMJ A;  3ME4 A;  2UWI A;  4I9X C;  2H9G R;  3QO4 A;  4MXW R;  4YN0 A;  4GIQ R;  4M4P A;  1D0G R;  5IHL A;  1ZA3 R;  5CIR E;  2X10 A;  4FHQ A;  4RSU D;  3U3P A;  1TNR R;  3FL7 A;  3TJE F;  1EXT A;  3U3T A; 
#chains in the Genus database with same CATH topology
 1FT4 A;  1SG1 X;  2E4X A;  4KGG C;  1D4V A;  3ALQ R;  3QD6 R;  5L36 B;  3ME2 R;  1NCF A;  3MHD D;  5BNQ R;  4E4D R;  3X3F A;  4BK4 A;  4BK5 A;  2AW2 B;  3URF Z;  1JMA B;  4N90 R;  4J6G C;  4KGQ C;  4OD2 S;  2QR6 A;  3U3Q A;  4M4R A;  3THM F;  2E4Y A;  2E4U A;  3K51 B;  3U3V A;  3MI8 D;  3WVT A;  2HEV R;  1DU3 A;  3U3S A;  3MBW A;  4MSV B;  3IJ2 X;  2E4W A;  3BUK C;  3QBQ B;  2HEY R;  5DMJ A;  3ME4 A;  2UWI A;  4I9X C;  2H9G R;  3QO4 A;  4MXW R;  2E4V A;  4GIQ R;  4M4P A;  1D0G R;  4YN0 A;  5IHL A;  1ZA3 R;  5CIR E;  2X10 A;  4FHQ A;  4RSU D;  3U3P A;  1TNR R;  3FL7 A;  3TJE F;  1EXT A;  3U3T A; 
#chains in the Genus database with same CATH homology
 1FT4 A;  1SG1 X;  4KGG C;  1D4V A;  3ALQ R;  3QD6 R;  5L36 B;  3ME2 R;  1NCF A;  3MHD D;  5BNQ R;  4E4D R;  3X3F A;  4BK4 A;  4BK5 A;  2AW2 B;  3URF Z;  1JMA B;  4N90 R;  4J6G C;  4KGQ C;  4OD2 S;  3U3Q A;  4M4R A;  3THM F;  3U3V A;  3K51 B;  3MI8 D;  3WVT A;  2HEV R;  1DU3 A;  3U3S A;  3MBW A;  4MSV B;  3IJ2 X;  3BUK C;  3QBQ B;  2HEY R;  5DMJ A;  3ME4 A;  2UWI A;  4I9X C;  2H9G R;  3QO4 A;  4MXW R;  4YN0 A;  4GIQ R;  4M4P A;  1D0G R;  5IHL A;  1ZA3 R;  5CIR E;  2X10 A;  4FHQ A;  4RSU D;  3U3P A;  1TNR R;  3FL7 A;  3TJE F;  1EXT A;  3U3T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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