1SG1X

Crystal structure of the receptor-ligand complex between nerve growth factor and the common neurotrophin receptor p75
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
160
structure length
160
Chain Sequence
ETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of nerve growth factor complexed with the shared neurotrophin receptor p75
pubmed doi rcsb
molecule tags Hormone/growth factor/membrane protein
source organism Homo sapiens
molecule keywords Beta-nerve growth factor
total genus 27
structure length 160
sequence length 160
ec nomenclature
pdb deposition date 2004-02-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1sg1X02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1sg1X01
1D0GR 5L36B 2H9GR 5BNQR 4MXWR 5DMJA 4FHQA 3MI8D 3U3TA 3BUKC 5CIRE 4KGGC 3MHDD 3MBWA 2HEVR 1FT4A 4J6GC 3THMF 4OD2S 3U3PA 4M4PA 4M4RA 1D4VA 1DU3A 3U3SA 2UWIA 4N90R 3WVTA 4GIQR 3TJEF 4E4DR 1ZA3R 1NCFA 4KGQC 3ALQR 3X3FA 3IJ2X 3U3VA 1EXTA 4MSVB 4BK4A 5IHLA 3QBQB 4I9XC 3ME2R 1JMAB 3URFZ 3K51B 2AW2B 1TNRR 2HEYR 1SG1X 3QO4A 3QD6R 4RSUD 4BK5A 3ME4A 3U3QA 4YN0A 3FL7A 2X10A
chains in the Genus database with same CATH superfamily
1D0GR 5L36B 2H9GR 5BNQR 4MXWR 5DMJA 4FHQA 3MI8D 3U3TA 3BUKC 5CIRE 4KGGC 3MHDD 2E4YA 2HEVR 1FT4A 3MBWA 4J6GC 4OD2S 3THMF 4M4PA 4M4RA 3U3PA 1D4VA 1DU3A 3U3SA 2UWIA 4N90R 3WVTA 2E4UA 4GIQR 3TJEF 4E4DR 2E4VA 1ZA3R 1NCFA 2E4XA 4KGQC 3ALQR 3X3FA 3IJ2X 3U3VA 2E4WA 1EXTA 4MSVB 4BK4A 3QBQB 4I9XC 3ME2R 5IHLA 1JMAB 3URFZ 3K51B 2AW2B 1TNRR 2HEYR 1SG1X 3QO4A 3QD6R 4RSUD 4BK5A 3ME4A 2QR6A 3U3QA 4YN0A 3FL7A 2X10A
chains in the Genus database with same CATH topology
1D0GR 5L36B 2H9GR 5BNQR 4MXWR 5DMJA 4FHQA 3MI8D 3U3TA 3BUKC 5CIRE 4KGGC 3MHDD 3MBWA 2HEVR 1FT4A 4J6GC 3THMF 4OD2S 3U3PA 4M4PA 4M4RA 1D4VA 1DU3A 3U3SA 2UWIA 4N90R 3WVTA 4GIQR 3TJEF 4E4DR 1ZA3R 1NCFA 4KGQC 3ALQR 3X3FA 3IJ2X 3U3VA 1EXTA 4MSVB 4BK4A 5IHLA 3QBQB 4I9XC 3ME2R 1JMAB 3URFZ 3K51B 2AW2B 1TNRR 2HEYR 1SG1X 3QO4A 3QD6R 4RSUD 4BK5A 3ME4A 3U3QA 4YN0A 3FL7A 2X10A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0G R;  5L36 B;  2H9G R;  5BNQ R;  4MXW R;  5DMJ A;  4FHQ A;  3MI8 D;  3U3T A;  3BUK C;  5CIR E;  4KGG C;  3MHD D;  3MBW A;  2HEV R;  1FT4 A;  4J6G C;  3THM F;  4OD2 S;  3U3P A;  4M4P A;  4M4R A;  1D4V A;  1DU3 A;  3U3S A;  2UWI A;  4N90 R;  3WVT A;  4GIQ R;  3TJE F;  4E4D R;  1ZA3 R;  1NCF A;  4KGQ C;  3ALQ R;  3X3F A;  3IJ2 X;  3U3V A;  1EXT A;  4MSV B;  4BK4 A;  5IHL A;  3QBQ B;  4I9X C;  3ME2 R;  1JMA B;  3URF Z;  3K51 B;  2AW2 B;  1TNR R;  2HEY R;  1SG1 X;  3QO4 A;  3QD6 R;  4RSU D;  4BK5 A;  3ME4 A;  3U3Q A;  4YN0 A;  3FL7 A;  2X10 A; 
#chains in the Genus database with same CATH topology
 1D0G R;  5L36 B;  2H9G R;  5BNQ R;  4MXW R;  5DMJ A;  4FHQ A;  3MI8 D;  3U3T A;  3BUK C;  5CIR E;  4KGG C;  3MHD D;  2E4Y A;  2HEV R;  1FT4 A;  3MBW A;  4J6G C;  4OD2 S;  3THM F;  4M4P A;  4M4R A;  3U3P A;  1D4V A;  1DU3 A;  3U3S A;  2UWI A;  4N90 R;  3WVT A;  2E4U A;  4GIQ R;  3TJE F;  4E4D R;  2E4V A;  1ZA3 R;  1NCF A;  2E4X A;  4KGQ C;  3ALQ R;  3X3F A;  3IJ2 X;  3U3V A;  2E4W A;  1EXT A;  4MSV B;  4BK4 A;  3QBQ B;  4I9X C;  3ME2 R;  5IHL A;  1JMA B;  3URF Z;  3K51 B;  2AW2 B;  1TNR R;  2HEY R;  1SG1 X;  3QO4 A;  3QD6 R;  4RSU D;  4BK5 A;  3ME4 A;  2QR6 A;  3U3Q A;  4YN0 A;  3FL7 A;  2X10 A; 
#chains in the Genus database with same CATH homology
 1D0G R;  5L36 B;  2H9G R;  5BNQ R;  4MXW R;  5DMJ A;  4FHQ A;  3MI8 D;  3U3T A;  3BUK C;  5CIR E;  4KGG C;  3MHD D;  3MBW A;  2HEV R;  1FT4 A;  4J6G C;  3THM F;  4OD2 S;  3U3P A;  4M4P A;  4M4R A;  1D4V A;  1DU3 A;  3U3S A;  2UWI A;  4N90 R;  3WVT A;  4GIQ R;  3TJE F;  4E4D R;  1ZA3 R;  1NCF A;  4KGQ C;  3ALQ R;  3X3F A;  3IJ2 X;  3U3V A;  1EXT A;  4MSV B;  4BK4 A;  5IHL A;  3QBQ B;  4I9X C;  3ME2 R;  1JMA B;  3URF Z;  3K51 B;  2AW2 B;  1TNR R;  2HEY R;  1SG1 X;  3QO4 A;  3QD6 R;  4RSU D;  4BK5 A;  3ME4 A;  3U3Q A;  4YN0 A;  3FL7 A;  2X10 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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