1SG1X

Crystal structure of the receptor-ligand complex between nerve growth factor and the common neurotrophin receptor p75
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
160
structure length
160
Chain Sequence
ETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor/membrane protein
source organism Homo sapiens
publication title Structure of nerve growth factor complexed with the shared neurotrophin receptor p75
pubmed doi rcsb
molecule keywords Beta-nerve growth factor
total genus 27
structure length 160
sequence length 160
ec nomenclature
pdb deposition date 2004-02-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1sg1X02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1sg1X01
5L36B 3URFZ 4N90R 1FT4A 4J6GC 5DMJA 3QO4A 4OD2S 3MI8D 1D4VA 3WVTA 3ME2R 3TJEF 4FHQA 3U3PA 5CIRE 3U3VA 4M4RA 4MXWR 3BUKC 3QD6R 4GIQR 5IHLA 1TNRR 2HEVR 1ZA3R 3QBQB 1JMAB 3THMF 2X10A 4RSUD 4I9XC 1DU3A 4YN0A 2H9GR 1SG1X 3K51B 3U3QA 2UWIA 2HEYR 4BK5A 4BK4A 3U3TA 5BNQR 4E4DR 1NCFA 4KGGC 3ME4A 3MHDD 3MBWA 3X3FA 3U3SA 4MSVB 1D0GR 3FL7A 4M4PA 3IJ2X 1EXTA 4KGQC 2AW2B 3ALQR
chains in the Genus database with same CATH superfamily
5L36B 3URFZ 4N90R 1FT4A 4J6GC 5DMJA 3QO4A 4OD2S 3MI8D 1D4VA 3WVTA 3ME2R 3TJEF 4FHQA 3U3PA 5CIRE 3U3VA 4M4RA 2E4UA 4MXWR 3BUKC 3QD6R 4GIQR 5IHLA 1TNRR 2HEVR 2E4YA 2E4WA 1ZA3R 3QBQB 1JMAB 3THMF 2X10A 4RSUD 4I9XC 1DU3A 4YN0A 2H9GR 1SG1X 3K51B 3U3QA 2UWIA 2HEYR 2E4VA 4BK5A 3U3TA 4BK4A 5BNQR 4E4DR 2E4XA 1NCFA 4KGGC 3ME4A 3MHDD 3MBWA 3X3FA 3U3SA 4MSVB 1D0GR 3FL7A 4M4PA 3IJ2X 2QR6A 1EXTA 4KGQC 2AW2B 3ALQR
chains in the Genus database with same CATH topology
5L36B 3URFZ 4N90R 1FT4A 4J6GC 5DMJA 3QO4A 4OD2S 3MI8D 1D4VA 3WVTA 3ME2R 3TJEF 4FHQA 3U3PA 5CIRE 3U3VA 4M4RA 4MXWR 3BUKC 3QD6R 4GIQR 5IHLA 1TNRR 2HEVR 1ZA3R 3QBQB 1JMAB 3THMF 2X10A 4RSUD 4I9XC 1DU3A 4YN0A 2H9GR 1SG1X 3K51B 3U3QA 2UWIA 2HEYR 4BK5A 4BK4A 3U3TA 5BNQR 4E4DR 1NCFA 4KGGC 3ME4A 3MHDD 3MBWA 3X3FA 3U3SA 4MSVB 1D0GR 3FL7A 4M4PA 3IJ2X 1EXTA 4KGQC 2AW2B 3ALQR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L36 B;  3URF Z;  4N90 R;  1FT4 A;  4J6G C;  5DMJ A;  3QO4 A;  4OD2 S;  3MI8 D;  1D4V A;  3WVT A;  3ME2 R;  3TJE F;  4FHQ A;  3U3P A;  5CIR E;  3U3V A;  4M4R A;  4MXW R;  3BUK C;  3QD6 R;  4GIQ R;  5IHL A;  1TNR R;  2HEV R;  1ZA3 R;  3QBQ B;  1JMA B;  3THM F;  2X10 A;  4RSU D;  4I9X C;  1DU3 A;  4YN0 A;  2H9G R;  1SG1 X;  3K51 B;  3U3Q A;  2UWI A;  2HEY R;  4BK5 A;  4BK4 A;  3U3T A;  5BNQ R;  4E4D R;  1NCF A;  4KGG C;  3ME4 A;  3MHD D;  3MBW A;  3X3F A;  3U3S A;  4MSV B;  1D0G R;  3FL7 A;  4M4P A;  3IJ2 X;  1EXT A;  4KGQ C;  2AW2 B;  3ALQ R; 
#chains in the Genus database with same CATH topology
 5L36 B;  3URF Z;  4N90 R;  1FT4 A;  4J6G C;  5DMJ A;  3QO4 A;  4OD2 S;  3MI8 D;  1D4V A;  3WVT A;  3ME2 R;  3TJE F;  4FHQ A;  3U3P A;  5CIR E;  3U3V A;  4M4R A;  2E4U A;  4MXW R;  3BUK C;  3QD6 R;  4GIQ R;  5IHL A;  1TNR R;  2HEV R;  2E4Y A;  2E4W A;  1ZA3 R;  3QBQ B;  1JMA B;  3THM F;  2X10 A;  4RSU D;  4I9X C;  1DU3 A;  4YN0 A;  2H9G R;  1SG1 X;  3K51 B;  3U3Q A;  2UWI A;  2HEY R;  2E4V A;  4BK5 A;  3U3T A;  4BK4 A;  5BNQ R;  4E4D R;  2E4X A;  1NCF A;  4KGG C;  3ME4 A;  3MHD D;  3MBW A;  3X3F A;  3U3S A;  4MSV B;  1D0G R;  3FL7 A;  4M4P A;  3IJ2 X;  2QR6 A;  1EXT A;  4KGQ C;  2AW2 B;  3ALQ R; 
#chains in the Genus database with same CATH homology
 5L36 B;  3URF Z;  4N90 R;  1FT4 A;  4J6G C;  5DMJ A;  3QO4 A;  4OD2 S;  3MI8 D;  1D4V A;  3WVT A;  3ME2 R;  3TJE F;  4FHQ A;  3U3P A;  5CIR E;  3U3V A;  4M4R A;  4MXW R;  3BUK C;  3QD6 R;  4GIQ R;  5IHL A;  1TNR R;  2HEV R;  1ZA3 R;  3QBQ B;  1JMA B;  3THM F;  2X10 A;  4RSU D;  4I9X C;  1DU3 A;  4YN0 A;  2H9G R;  1SG1 X;  3K51 B;  3U3Q A;  2UWI A;  2HEY R;  4BK5 A;  4BK4 A;  3U3T A;  5BNQ R;  4E4D R;  1NCF A;  4KGG C;  3ME4 A;  3MHD D;  3MBW A;  3X3F A;  3U3S A;  4MSV B;  1D0G R;  3FL7 A;  4M4P A;  3IJ2 X;  1EXT A;  4KGQ C;  2AW2 B;  3ALQ R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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