3THMF

Crystal structure of fas receptor extracellular domain in complex with fab ep6b_b01
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
84
structure length
77
Chain Sequence
LHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCGHGLEVEINCTRTQNTKCRCC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Fab EP6b_B01, light chain
total genus 13
structure length 77
sequence length 84
ec nomenclature
pdb deposition date 2011-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 3thmF00
4FHQA 4KGQC 1TNRR 4J6GC 4YN0A 1JMAB 3ME2R 3U3QA 1D0GR 4OD2S 3X3FA 2H9GR 4M4PA 1DU3A 2X10A 3U3PA 4BK4A 5IHLA 5CIRE 5DMJA 3MBWA 3ALQR 4RSUD 3FL7A 3MHDD 1ZA3R 3IJ2X 3K51B 3U3TA 2HEYR 2AW2B 5L36B 2UWIA 4BK5A 1EXTA 3MI8D 4E4DR 3QO4A 3THMF 1SG1X 3QD6R 3U3SA 3TJEF 3URFZ 1D4VA 4MXWR 4KGGC 5BNQR 4MSVB 3WVTA 4GIQR 3ME4A 3BUKC 1NCFA 4M4RA 3QBQB 1FT4A 4I9XC 3U3VA 2HEVR 4N90R
chains in the Genus database with same CATH superfamily
4FHQA 4KGQC 1TNRR 4J6GC 2E4YA 4YN0A 1JMAB 2E4WA 3ME2R 3U3QA 1D0GR 2E4XA 2HEVR 4OD2S 3X3FA 2H9GR 2E4UA 1DU3A 4M4PA 2X10A 3U3PA 4BK4A 5IHLA 5CIRE 5DMJA 3MBWA 3ALQR 4RSUD 3FL7A 3MHDD 1ZA3R 3IJ2X 3K51B 3U3TA 2HEYR 2AW2B 5L36B 2UWIA 4BK5A 1EXTA 3MI8D 4E4DR 3QO4A 3THMF 1SG1X 3QD6R 3U3SA 3TJEF 3URFZ 1D4VA 4MXWR 4KGGC 5BNQR 4MSVB 3WVTA 4GIQR 3ME4A 3BUKC 1NCFA 2QR6A 3QBQB 1FT4A 4I9XC 4M4RA 3U3VA 2E4VA 4N90R
chains in the Genus database with same CATH topology
4FHQA 4KGQC 1TNRR 4J6GC 4YN0A 1JMAB 3ME2R 3U3QA 1D0GR 4OD2S 3X3FA 2H9GR 4M4PA 1DU3A 2X10A 3U3PA 4BK4A 5IHLA 5CIRE 5DMJA 3MBWA 3ALQR 4RSUD 3FL7A 3MHDD 1ZA3R 3IJ2X 3K51B 3U3TA 2HEYR 2AW2B 5L36B 2UWIA 4BK5A 1EXTA 3MI8D 4E4DR 3QO4A 3THMF 1SG1X 3QD6R 3U3SA 3TJEF 3URFZ 1D4VA 4MXWR 4KGGC 5BNQR 4MSVB 3WVTA 4GIQR 3ME4A 3BUKC 1NCFA 4M4RA 3QBQB 1FT4A 4I9XC 3U3VA 2HEVR 4N90R
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FHQ A;  4KGQ C;  1TNR R;  4J6G C;  4YN0 A;  1JMA B;  3ME2 R;  3U3Q A;  1D0G R;  4OD2 S;  3X3F A;  2H9G R;  4M4P A;  1DU3 A;  2X10 A;  3U3P A;  4BK4 A;  5IHL A;  5CIR E;  5DMJ A;  3MBW A;  3ALQ R;  4RSU D;  3FL7 A;  3MHD D;  1ZA3 R;  3IJ2 X;  3K51 B;  3U3T A;  2HEY R;  2AW2 B;  5L36 B;  2UWI A;  4BK5 A;  1EXT A;  3MI8 D;  4E4D R;  3QO4 A;  3THM F;  1SG1 X;  3QD6 R;  3U3S A;  3TJE F;  3URF Z;  1D4V A;  4MXW R;  4KGG C;  5BNQ R;  4MSV B;  3WVT A;  4GIQ R;  3ME4 A;  3BUK C;  1NCF A;  4M4R A;  3QBQ B;  1FT4 A;  4I9X C;  3U3V A;  2HEV R;  4N90 R; 
#chains in the Genus database with same CATH topology
 4FHQ A;  4KGQ C;  1TNR R;  4J6G C;  2E4Y A;  4YN0 A;  1JMA B;  2E4W A;  3ME2 R;  3U3Q A;  1D0G R;  2E4X A;  2HEV R;  4OD2 S;  3X3F A;  2H9G R;  2E4U A;  1DU3 A;  4M4P A;  2X10 A;  3U3P A;  4BK4 A;  5IHL A;  5CIR E;  5DMJ A;  3MBW A;  3ALQ R;  4RSU D;  3FL7 A;  3MHD D;  1ZA3 R;  3IJ2 X;  3K51 B;  3U3T A;  2HEY R;  2AW2 B;  5L36 B;  2UWI A;  4BK5 A;  1EXT A;  3MI8 D;  4E4D R;  3QO4 A;  3THM F;  1SG1 X;  3QD6 R;  3U3S A;  3TJE F;  3URF Z;  1D4V A;  4MXW R;  4KGG C;  5BNQ R;  4MSV B;  3WVT A;  4GIQ R;  3ME4 A;  3BUK C;  1NCF A;  2QR6 A;  3QBQ B;  1FT4 A;  4I9X C;  4M4R A;  3U3V A;  2E4V A;  4N90 R; 
#chains in the Genus database with same CATH homology
 4FHQ A;  4KGQ C;  1TNR R;  4J6G C;  4YN0 A;  1JMA B;  3ME2 R;  3U3Q A;  1D0G R;  4OD2 S;  3X3F A;  2H9G R;  4M4P A;  1DU3 A;  2X10 A;  3U3P A;  4BK4 A;  5IHL A;  5CIR E;  5DMJ A;  3MBW A;  3ALQ R;  4RSU D;  3FL7 A;  3MHD D;  1ZA3 R;  3IJ2 X;  3K51 B;  3U3T A;  2HEY R;  2AW2 B;  5L36 B;  2UWI A;  4BK5 A;  1EXT A;  3MI8 D;  4E4D R;  3QO4 A;  3THM F;  1SG1 X;  3QD6 R;  3U3S A;  3TJE F;  3URF Z;  1D4V A;  4MXW R;  4KGG C;  5BNQ R;  4MSV B;  3WVT A;  4GIQ R;  3ME4 A;  3BUK C;  1NCF A;  4M4R A;  3QBQ B;  1FT4 A;  4I9X C;  3U3V A;  2HEV R;  4N90 R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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