4N90R

Crystal structure of ternary complex of trail, dr5, and fab fragment from a dr5 agonist antibody
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
108
structure length
108
Chain Sequence
SSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.
pubmed doi rcsb
molecule keywords Tumor necrosis factor receptor superfamily member 10B
molecule tags Apoptosis/immune system
source organism Homo sapiens
total genus 17
structure length 108
sequence length 108
chains with identical sequence S, T
ec nomenclature
pdb deposition date 2013-10-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 4n90R01
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 4n90R02
1DU3A 4RSUD 3X3FA 3THMF 2H9GR 1TNRR 4M4RA 5L36B 1FT4A 3ME4A 3QD6R 4KGQC 4YN0A 2HEYR 3ALQR 1EXTA 3MHDD 3U3PA 4BK5A 1D4VA 4N90R 4I9XC 1NCFA 5BNQR 3QO4A 4J6GC 3MBWA 1ZA3R 3QBQB 4MSVB 4OD2S 2AW2B 3FL7A 2UWIA 4FHQA 5DMJA 3U3VA 4E4DR 4BK4A 3MI8D 3IJ2X 2HEVR 4M4PA 1SG1X 5IHLA 3URFZ 3U3TA 3TJEF 3BUKC 2X10A 4GIQR 3U3SA 3K51B 3ME2R 1JMAB 3WVTA 4MXWR 1D0GR 4KGGC 5CIRE 3U3QA
chains in the Genus database with same CATH superfamily
1DU3A 4RSUD 3X3FA 3THMF 2H9GR 2E4VA 1TNRR 4M4RA 5L36B 2E4WA 1FT4A 3ME4A 3QD6R 4KGQC 4YN0A 2HEYR 1EXTA 3ALQR 3MHDD 3U3PA 4BK5A 1D4VA 4N90R 4I9XC 1NCFA 5BNQR 3QO4A 3U3QA 4J6GC 3MBWA 1ZA3R 2E4XA 3QBQB 4MSVB 2AW2B 3FL7A 2UWIA 4FHQA 4OD2S 5DMJA 2E4UA 3U3VA 4E4DR 4BK4A 3MI8D 3IJ2X 2HEVR 4M4PA 1SG1X 5IHLA 3URFZ 3U3TA 3TJEF 3BUKC 2X10A 4GIQR 2QR6A 3U3SA 3K51B 3ME2R 1JMAB 3WVTA 4MXWR 1D0GR 4KGGC 5CIRE 2E4YA
chains in the Genus database with same CATH topology
1DU3A 4RSUD 3X3FA 3THMF 2H9GR 1TNRR 4M4RA 5L36B 1FT4A 3ME4A 3QD6R 4KGQC 4YN0A 2HEYR 3ALQR 1EXTA 3MHDD 3U3PA 4BK5A 1D4VA 4N90R 4I9XC 1NCFA 5BNQR 3QO4A 4J6GC 3MBWA 1ZA3R 3QBQB 4MSVB 4OD2S 2AW2B 3FL7A 2UWIA 4FHQA 5DMJA 3U3VA 4E4DR 4BK4A 3MI8D 3IJ2X 2HEVR 4M4PA 1SG1X 5IHLA 3URFZ 3U3TA 3TJEF 3BUKC 2X10A 4GIQR 3U3SA 3K51B 3ME2R 1JMAB 3WVTA 4MXWR 1D0GR 4KGGC 5CIRE 3U3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DU3 A;  4RSU D;  3X3F A;  3THM F;  2H9G R;  1TNR R;  4M4R A;  5L36 B;  1FT4 A;  3ME4 A;  3QD6 R;  4KGQ C;  4YN0 A;  2HEY R;  3ALQ R;  1EXT A;  3MHD D;  3U3P A;  4BK5 A;  1D4V A;  4N90 R;  4I9X C;  1NCF A;  5BNQ R;  3QO4 A;  4J6G C;  3MBW A;  1ZA3 R;  3QBQ B;  4MSV B;  4OD2 S;  2AW2 B;  3FL7 A;  2UWI A;  4FHQ A;  5DMJ A;  3U3V A;  4E4D R;  4BK4 A;  3MI8 D;  3IJ2 X;  2HEV R;  4M4P A;  1SG1 X;  5IHL A;  3URF Z;  3U3T A;  3TJE F;  3BUK C;  2X10 A;  4GIQ R;  3U3S A;  3K51 B;  3ME2 R;  1JMA B;  3WVT A;  4MXW R;  1D0G R;  4KGG C;  5CIR E;  3U3Q A; 
#chains in the Genus database with same CATH topology
 1DU3 A;  4RSU D;  3X3F A;  3THM F;  2H9G R;  2E4V A;  1TNR R;  4M4R A;  5L36 B;  2E4W A;  1FT4 A;  3ME4 A;  3QD6 R;  4KGQ C;  4YN0 A;  2HEY R;  1EXT A;  3ALQ R;  3MHD D;  3U3P A;  4BK5 A;  1D4V A;  4N90 R;  4I9X C;  1NCF A;  5BNQ R;  3QO4 A;  3U3Q A;  4J6G C;  3MBW A;  1ZA3 R;  2E4X A;  3QBQ B;  4MSV B;  2AW2 B;  3FL7 A;  2UWI A;  4FHQ A;  4OD2 S;  5DMJ A;  2E4U A;  3U3V A;  4E4D R;  4BK4 A;  3MI8 D;  3IJ2 X;  2HEV R;  4M4P A;  1SG1 X;  5IHL A;  3URF Z;  3U3T A;  3TJE F;  3BUK C;  2X10 A;  4GIQ R;  2QR6 A;  3U3S A;  3K51 B;  3ME2 R;  1JMA B;  3WVT A;  4MXW R;  1D0G R;  4KGG C;  5CIR E;  2E4Y A; 
#chains in the Genus database with same CATH homology
 1DU3 A;  4RSU D;  3X3F A;  3THM F;  2H9G R;  1TNR R;  4M4R A;  5L36 B;  1FT4 A;  3ME4 A;  3QD6 R;  4KGQ C;  4YN0 A;  2HEY R;  3ALQ R;  1EXT A;  3MHD D;  3U3P A;  4BK5 A;  1D4V A;  4N90 R;  4I9X C;  1NCF A;  5BNQ R;  3QO4 A;  4J6G C;  3MBW A;  1ZA3 R;  3QBQ B;  4MSV B;  4OD2 S;  2AW2 B;  3FL7 A;  2UWI A;  4FHQ A;  5DMJ A;  3U3V A;  4E4D R;  4BK4 A;  3MI8 D;  3IJ2 X;  2HEV R;  4M4P A;  1SG1 X;  5IHL A;  3URF Z;  3U3T A;  3TJE F;  3BUK C;  2X10 A;  4GIQ R;  3U3S A;  3K51 B;  3ME2 R;  1JMA B;  3WVT A;  4MXW R;  1D0G R;  4KGG C;  5CIR E;  3U3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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