4N90R

Crystal structure of ternary complex of trail, dr5, and fab fragment from a dr5 agonist antibody
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
108
structure length
108
Chain Sequence
SSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.
pubmed doi rcsb
molecule tags Apoptosis/immune system
source organism Homo sapiens
molecule keywords Tumor necrosis factor receptor superfamily member 10B
total genus 17
structure length 108
sequence length 108
chains with identical sequence S, T
ec nomenclature
pdb deposition date 2013-10-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 4n90R01
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 4n90R02
3X3FA 3U3TA 3ME4A 5L36B 5BNQR 3U3PA 2HEVR 4N90R 2X10A 3U3SA 4FHQA 4J6GC 4M4RA 2H9GR 1D0GR 3IJ2X 5CIRE 1D4VA 3QO4A 3U3VA 1NCFA 4BK4A 4YN0A 4OD2S 4KGQC 1TNRR 2HEYR 4RSUD 4BK5A 1FT4A 4M4PA 5DMJA 3QD6R 3WVTA 4E4DR 1ZA3R 3MHDD 3QBQB 3ALQR 1DU3A 3K51B 4MSVB 5IHLA 3ME2R 3BUKC 4I9XC 3THMF 3MBWA 4MXWR 2AW2B 3URFZ 2UWIA 3FL7A 4GIQR 4KGGC 3TJEF 3U3QA 1JMAB 1SG1X 1EXTA 3MI8D
chains in the Genus database with same CATH superfamily
3X3FA 3U3TA 3ME4A 5L36B 5BNQR 3U3PA 2HEVR 4N90R 2X10A 3U3SA 4FHQA 4J6GC 4M4RA 2H9GR 1D0GR 2E4YA 3IJ2X 5CIRE 1D4VA 3QO4A 3U3VA 1NCFA 4BK4A 4YN0A 4OD2S 3MI8D 1TNRR 2HEYR 4KGQC 4RSUD 1FT4A 2E4XA 4M4PA 5DMJA 4BK5A 3QD6R 3WVTA 4E4DR 1ZA3R 3MHDD 2QR6A 3ALQR 3QBQB 1DU3A 3K51B 4MSVB 5IHLA 3ME2R 2E4VA 3BUKC 4I9XC 3THMF 3MBWA 4MXWR 2AW2B 3URFZ 2UWIA 3FL7A 4GIQR 2E4UA 4KGGC 3TJEF 3U3QA 1JMAB 1SG1X 1EXTA 2E4WA
chains in the Genus database with same CATH topology
3X3FA 3U3TA 3ME4A 5L36B 5BNQR 3U3PA 2HEVR 4N90R 2X10A 3U3SA 4FHQA 4J6GC 4M4RA 2H9GR 1D0GR 3IJ2X 5CIRE 1D4VA 3QO4A 3U3VA 1NCFA 4BK4A 4YN0A 4OD2S 4KGQC 1TNRR 2HEYR 4RSUD 4BK5A 1FT4A 4M4PA 5DMJA 3QD6R 3WVTA 4E4DR 1ZA3R 3MHDD 3QBQB 3ALQR 1DU3A 3K51B 4MSVB 5IHLA 3ME2R 3BUKC 4I9XC 3THMF 3MBWA 4MXWR 2AW2B 3URFZ 2UWIA 3FL7A 4GIQR 4KGGC 3TJEF 3U3QA 1JMAB 1SG1X 1EXTA 3MI8D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3X3F A;  3U3T A;  3ME4 A;  5L36 B;  5BNQ R;  3U3P A;  2HEV R;  4N90 R;  2X10 A;  3U3S A;  4FHQ A;  4J6G C;  4M4R A;  2H9G R;  1D0G R;  3IJ2 X;  5CIR E;  1D4V A;  3QO4 A;  3U3V A;  1NCF A;  4BK4 A;  4YN0 A;  4OD2 S;  4KGQ C;  1TNR R;  2HEY R;  4RSU D;  4BK5 A;  1FT4 A;  4M4P A;  5DMJ A;  3QD6 R;  3WVT A;  4E4D R;  1ZA3 R;  3MHD D;  3QBQ B;  3ALQ R;  1DU3 A;  3K51 B;  4MSV B;  5IHL A;  3ME2 R;  3BUK C;  4I9X C;  3THM F;  3MBW A;  4MXW R;  2AW2 B;  3URF Z;  2UWI A;  3FL7 A;  4GIQ R;  4KGG C;  3TJE F;  3U3Q A;  1JMA B;  1SG1 X;  1EXT A;  3MI8 D; 
#chains in the Genus database with same CATH topology
 3X3F A;  3U3T A;  3ME4 A;  5L36 B;  5BNQ R;  3U3P A;  2HEV R;  4N90 R;  2X10 A;  3U3S A;  4FHQ A;  4J6G C;  4M4R A;  2H9G R;  1D0G R;  2E4Y A;  3IJ2 X;  5CIR E;  1D4V A;  3QO4 A;  3U3V A;  1NCF A;  4BK4 A;  4YN0 A;  4OD2 S;  3MI8 D;  1TNR R;  2HEY R;  4KGQ C;  4RSU D;  1FT4 A;  2E4X A;  4M4P A;  5DMJ A;  4BK5 A;  3QD6 R;  3WVT A;  4E4D R;  1ZA3 R;  3MHD D;  2QR6 A;  3ALQ R;  3QBQ B;  1DU3 A;  3K51 B;  4MSV B;  5IHL A;  3ME2 R;  2E4V A;  3BUK C;  4I9X C;  3THM F;  3MBW A;  4MXW R;  2AW2 B;  3URF Z;  2UWI A;  3FL7 A;  4GIQ R;  2E4U A;  4KGG C;  3TJE F;  3U3Q A;  1JMA B;  1SG1 X;  1EXT A;  2E4W A; 
#chains in the Genus database with same CATH homology
 3X3F A;  3U3T A;  3ME4 A;  5L36 B;  5BNQ R;  3U3P A;  2HEV R;  4N90 R;  2X10 A;  3U3S A;  4FHQ A;  4J6G C;  4M4R A;  2H9G R;  1D0G R;  3IJ2 X;  5CIR E;  1D4V A;  3QO4 A;  3U3V A;  1NCF A;  4BK4 A;  4YN0 A;  4OD2 S;  4KGQ C;  1TNR R;  2HEY R;  4RSU D;  4BK5 A;  1FT4 A;  4M4P A;  5DMJ A;  3QD6 R;  3WVT A;  4E4D R;  1ZA3 R;  3MHD D;  3QBQ B;  3ALQ R;  1DU3 A;  3K51 B;  4MSV B;  5IHL A;  3ME2 R;  3BUK C;  4I9X C;  3THM F;  3MBW A;  4MXW R;  2AW2 B;  3URF Z;  2UWI A;  3FL7 A;  4GIQ R;  4KGG C;  3TJE F;  3U3Q A;  1JMA B;  1SG1 X;  1EXT A;  3MI8 D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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