5CIRE

Crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
102
structure length
102
Chain Sequence
GELCPPGSHRSERPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSTGCPRGMVKVKDCTPWSDIECV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Tumor necrosis factor ligand superfamily member 10
total genus 13
structure length 102
sequence length 102
chains with identical sequence F, G
ec nomenclature
pdb deposition date 2015-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5cirE01
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5cirE02
4M4PA 3ME4A 2AW2B 5DMJA 3QO4A 3BUKC 1FT4A 4J6GC 5L36B 3U3QA 3MBWA 1EXTA 3TJEF 1NCFA 3U3VA 1TNRR 3U3SA 3FL7A 3WVTA 4M4RA 4FHQA 3MI8D 3X3FA 4BK4A 1ZA3R 3ME2R 4MSVB 4E4DR 2X10A 3U3PA 3MHDD 4KGQC 4MXWR 3U3TA 2UWIA 3URFZ 4OD2S 1D0GR 3QD6R 4KGGC 4YN0A 5BNQR 2HEVR 4N90R 1JMAB 3QBQB 4I9XC 5CIRE 1DU3A 4RSUD 3THMF 4BK5A 4GIQR 5IHLA 1SG1X 3IJ2X 3ALQR 3K51B 1D4VA 2H9GR 2HEYR
chains in the Genus database with same CATH superfamily
4M4PA 3ME4A 2AW2B 5DMJA 3QO4A 3BUKC 1FT4A 4J6GC 5L36B 3U3QA 3MBWA 1EXTA 3TJEF 1NCFA 2E4WA 3U3VA 1TNRR 2QR6A 3U3SA 3FL7A 3WVTA 4M4RA 4FHQA 3MI8D 3X3FA 4BK4A 1ZA3R 3ME2R 4MSVB 4E4DR 2X10A 3U3PA 3MHDD 4KGQC 2E4YA 4MXWR 3U3TA 2E4UA 2UWIA 3URFZ 4OD2S 1D0GR 3QD6R 4KGGC 4YN0A 2E4VA 5BNQR 2HEVR 4N90R 1JMAB 3QBQB 2E4XA 4I9XC 5CIRE 1DU3A 4RSUD 3THMF 4BK5A 4GIQR 5IHLA 1SG1X 3IJ2X 3ALQR 3K51B 1D4VA 2H9GR 2HEYR
chains in the Genus database with same CATH topology
4M4PA 3ME4A 2AW2B 5DMJA 3QO4A 3BUKC 1FT4A 4J6GC 5L36B 3U3QA 3MBWA 1EXTA 3TJEF 1NCFA 3U3VA 1TNRR 3U3SA 3FL7A 3WVTA 4M4RA 4FHQA 3MI8D 3X3FA 4BK4A 1ZA3R 3ME2R 4MSVB 4E4DR 2X10A 3U3PA 3MHDD 4KGQC 4MXWR 3U3TA 2UWIA 3URFZ 4OD2S 1D0GR 3QD6R 4KGGC 4YN0A 5BNQR 2HEVR 4N90R 1JMAB 3QBQB 4I9XC 5CIRE 1DU3A 4RSUD 3THMF 4BK5A 4GIQR 5IHLA 1SG1X 3IJ2X 3ALQR 3K51B 1D4VA 2H9GR 2HEYR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M4P A;  3ME4 A;  2AW2 B;  5DMJ A;  3QO4 A;  3BUK C;  1FT4 A;  4J6G C;  5L36 B;  3U3Q A;  3MBW A;  1EXT A;  3TJE F;  1NCF A;  3U3V A;  1TNR R;  3U3S A;  3FL7 A;  3WVT A;  4M4R A;  4FHQ A;  3MI8 D;  3X3F A;  4BK4 A;  1ZA3 R;  3ME2 R;  4MSV B;  4E4D R;  2X10 A;  3U3P A;  3MHD D;  4KGQ C;  4MXW R;  3U3T A;  2UWI A;  3URF Z;  4OD2 S;  1D0G R;  3QD6 R;  4KGG C;  4YN0 A;  5BNQ R;  2HEV R;  4N90 R;  1JMA B;  3QBQ B;  4I9X C;  5CIR E;  1DU3 A;  4RSU D;  3THM F;  4BK5 A;  4GIQ R;  5IHL A;  1SG1 X;  3IJ2 X;  3ALQ R;  3K51 B;  1D4V A;  2H9G R;  2HEY R; 
#chains in the Genus database with same CATH topology
 4M4P A;  3ME4 A;  2AW2 B;  5DMJ A;  3QO4 A;  3BUK C;  1FT4 A;  4J6G C;  5L36 B;  3U3Q A;  3MBW A;  1EXT A;  3TJE F;  1NCF A;  2E4W A;  3U3V A;  1TNR R;  2QR6 A;  3U3S A;  3FL7 A;  3WVT A;  4M4R A;  4FHQ A;  3MI8 D;  3X3F A;  4BK4 A;  1ZA3 R;  3ME2 R;  4MSV B;  4E4D R;  2X10 A;  3U3P A;  3MHD D;  4KGQ C;  2E4Y A;  4MXW R;  3U3T A;  2E4U A;  2UWI A;  3URF Z;  4OD2 S;  1D0G R;  3QD6 R;  4KGG C;  4YN0 A;  2E4V A;  5BNQ R;  2HEV R;  4N90 R;  1JMA B;  3QBQ B;  2E4X A;  4I9X C;  5CIR E;  1DU3 A;  4RSU D;  3THM F;  4BK5 A;  4GIQ R;  5IHL A;  1SG1 X;  3IJ2 X;  3ALQ R;  3K51 B;  1D4V A;  2H9G R;  2HEY R; 
#chains in the Genus database with same CATH homology
 4M4P A;  3ME4 A;  2AW2 B;  5DMJ A;  3QO4 A;  3BUK C;  1FT4 A;  4J6G C;  5L36 B;  3U3Q A;  3MBW A;  1EXT A;  3TJE F;  1NCF A;  3U3V A;  1TNR R;  3U3S A;  3FL7 A;  3WVT A;  4M4R A;  4FHQ A;  3MI8 D;  3X3F A;  4BK4 A;  1ZA3 R;  3ME2 R;  4MSV B;  4E4D R;  2X10 A;  3U3P A;  3MHD D;  4KGQ C;  4MXW R;  3U3T A;  2UWI A;  3URF Z;  4OD2 S;  1D0G R;  3QD6 R;  4KGG C;  4YN0 A;  5BNQ R;  2HEV R;  4N90 R;  1JMA B;  3QBQ B;  4I9X C;  5CIR E;  1DU3 A;  4RSU D;  3THM F;  4BK5 A;  4GIQ R;  5IHL A;  1SG1 X;  3IJ2 X;  3ALQ R;  3K51 B;  1D4V A;  2H9G R;  2HEY R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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