5DMJA

Structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
165
structure length
165
Chain Sequence
TACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSDVSSAFEKCHPWTSCETKDLVVQQAGTDKTDVVCGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system/signaling protein
source organism Homo sapiens
publication title Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
pubmed doi rcsb
molecule keywords Tumor necrosis factor receptor superfamily member 5
total genus 21
structure length 165
sequence length 165
chains with identical sequence D, F
ec nomenclature
pdb deposition date 2015-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5dmjA01
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5dmjA02
1NCFA 4J6GC 3THMF 1D0GR 5CIRE 3QD6R 3U3TA 3WVTA 3QO4A 1TNRR 3FL7A 5L36B 1DU3A 2HEYR 4M4RA 4FHQA 3U3SA 3U3QA 3U3VA 4E4DR 4YN0A 3QBQB 4OD2S 3BUKC 4RSUD 5IHLA 3MI8D 3K51B 3ME2R 4I9XC 1FT4A 1EXTA 4N90R 2UWIA 3IJ2X 1ZA3R 1SG1X 1JMAB 5BNQR 4KGQC 3ALQR 4BK4A 4KGGC 5DMJA 3MHDD 2HEVR 4M4PA 4GIQR 4BK5A 3TJEF 3MBWA 1D4VA 3X3FA 3URFZ 4MXWR 2H9GR 3ME4A 2X10A 3U3PA 2AW2B 4MSVB
chains in the Genus database with same CATH superfamily
1NCFA 4J6GC 2E4XA 1D0GR 5CIRE 3QD6R 3THMF 3U3TA 3QO4A 1TNRR 3FL7A 5L36B 1DU3A 2HEYR 4M4RA 4FHQA 3U3SA 3U3QA 3U3VA 4E4DR 4YN0A 3QBQB 4OD2S 3BUKC 3WVTA 4RSUD 5IHLA 3MI8D 2E4WA 2E4VA 3K51B 3ME2R 1FT4A 1EXTA 4I9XC 2UWIA 4N90R 2E4UA 3IJ2X 1ZA3R 2E4YA 1SG1X 1JMAB 5BNQR 4KGQC 2QR6A 3ALQR 4BK4A 4KGGC 5DMJA 3MHDD 2HEVR 4M4PA 4GIQR 4BK5A 3TJEF 3MBWA 1D4VA 3X3FA 3URFZ 4MXWR 2H9GR 3ME4A 2X10A 3U3PA 2AW2B 4MSVB
chains in the Genus database with same CATH topology
1NCFA 4J6GC 3THMF 1D0GR 5CIRE 3QD6R 3U3TA 3WVTA 3QO4A 1TNRR 3FL7A 5L36B 1DU3A 2HEYR 4M4RA 4FHQA 3U3SA 3U3QA 3U3VA 4E4DR 4YN0A 3QBQB 4OD2S 3BUKC 4RSUD 5IHLA 3MI8D 3K51B 3ME2R 4I9XC 1FT4A 1EXTA 4N90R 2UWIA 3IJ2X 1ZA3R 1SG1X 1JMAB 5BNQR 4KGQC 3ALQR 4BK4A 4KGGC 5DMJA 3MHDD 2HEVR 4M4PA 4GIQR 4BK5A 3TJEF 3MBWA 1D4VA 3X3FA 3URFZ 4MXWR 2H9GR 3ME4A 2X10A 3U3PA 2AW2B 4MSVB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NCF A;  4J6G C;  3THM F;  1D0G R;  5CIR E;  3QD6 R;  3U3T A;  3WVT A;  3QO4 A;  1TNR R;  3FL7 A;  5L36 B;  1DU3 A;  2HEY R;  4M4R A;  4FHQ A;  3U3S A;  3U3Q A;  3U3V A;  4E4D R;  4YN0 A;  3QBQ B;  4OD2 S;  3BUK C;  4RSU D;  5IHL A;  3MI8 D;  3K51 B;  3ME2 R;  4I9X C;  1FT4 A;  1EXT A;  4N90 R;  2UWI A;  3IJ2 X;  1ZA3 R;  1SG1 X;  1JMA B;  5BNQ R;  4KGQ C;  3ALQ R;  4BK4 A;  4KGG C;  5DMJ A;  3MHD D;  2HEV R;  4M4P A;  4GIQ R;  4BK5 A;  3TJE F;  3MBW A;  1D4V A;  3X3F A;  3URF Z;  4MXW R;  2H9G R;  3ME4 A;  2X10 A;  3U3P A;  2AW2 B;  4MSV B; 
#chains in the Genus database with same CATH topology
 1NCF A;  4J6G C;  2E4X A;  1D0G R;  5CIR E;  3QD6 R;  3THM F;  3U3T A;  3QO4 A;  1TNR R;  3FL7 A;  5L36 B;  1DU3 A;  2HEY R;  4M4R A;  4FHQ A;  3U3S A;  3U3Q A;  3U3V A;  4E4D R;  4YN0 A;  3QBQ B;  4OD2 S;  3BUK C;  3WVT A;  4RSU D;  5IHL A;  3MI8 D;  2E4W A;  2E4V A;  3K51 B;  3ME2 R;  1FT4 A;  1EXT A;  4I9X C;  2UWI A;  4N90 R;  2E4U A;  3IJ2 X;  1ZA3 R;  2E4Y A;  1SG1 X;  1JMA B;  5BNQ R;  4KGQ C;  2QR6 A;  3ALQ R;  4BK4 A;  4KGG C;  5DMJ A;  3MHD D;  2HEV R;  4M4P A;  4GIQ R;  4BK5 A;  3TJE F;  3MBW A;  1D4V A;  3X3F A;  3URF Z;  4MXW R;  2H9G R;  3ME4 A;  2X10 A;  3U3P A;  2AW2 B;  4MSV B; 
#chains in the Genus database with same CATH homology
 1NCF A;  4J6G C;  3THM F;  1D0G R;  5CIR E;  3QD6 R;  3U3T A;  3WVT A;  3QO4 A;  1TNR R;  3FL7 A;  5L36 B;  1DU3 A;  2HEY R;  4M4R A;  4FHQ A;  3U3S A;  3U3Q A;  3U3V A;  4E4D R;  4YN0 A;  3QBQ B;  4OD2 S;  3BUK C;  4RSU D;  5IHL A;  3MI8 D;  3K51 B;  3ME2 R;  4I9X C;  1FT4 A;  1EXT A;  4N90 R;  2UWI A;  3IJ2 X;  1ZA3 R;  1SG1 X;  1JMA B;  5BNQ R;  4KGQ C;  3ALQ R;  4BK4 A;  4KGG C;  5DMJ A;  3MHD D;  2HEV R;  4M4P A;  4GIQ R;  4BK5 A;  3TJE F;  3MBW A;  1D4V A;  3X3F A;  3URF Z;  4MXW R;  2H9G R;  3ME4 A;  2X10 A;  3U3P A;  2AW2 B;  4MSV B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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