5IHLA

Structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
168
structure length
168
Chain Sequence
PTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSDVSSAFEKCHPWTSCETKDLVVQQAGTDKTDVVCGPQD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
pubmed doi rcsb
molecule tags Immune system/signaling protein
source organism Homo sapiens
molecule keywords Tumor necrosis factor receptor superfamily member 5
total genus 22
structure length 168
sequence length 168
chains with identical sequence D, F, H
ec nomenclature
pdb deposition date 2016-02-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5ihlA01
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 5ihlA02
1FT4A 4E4DR 4M4PA 4RSUD 3U3TA 2X10A 4J6GC 3TJEF 1EXTA 3IJ2X 3ME2R 3U3VA 5DMJA 5IHLA 1DU3A 1D4VA 2HEYR 4MSVB 4MXWR 3THMF 4FHQA 4KGQC 4N90R 4BK5A 1D0GR 4KGGC 3QO4A 1JMAB 5CIRE 3BUKC 3WVTA 3X3FA 3K51B 2HEVR 1ZA3R 4YN0A 3U3SA 3U3PA 3URFZ 1NCFA 4BK4A 5L36B 2H9GR 1TNRR 3MHDD 5BNQR 3QD6R 3U3QA 3ME4A 4M4RA 4I9XC 2UWIA 4GIQR 3FL7A 3MBWA 4OD2S 2AW2B 3QBQB 3MI8D 3ALQR 1SG1X
chains in the Genus database with same CATH superfamily
1FT4A 4E4DR 4M4PA 4RSUD 3U3TA 2X10A 4J6GC 3TJEF 1EXTA 3IJ2X 3ME2R 3U3VA 5DMJA 2E4XA 1DU3A 1D4VA 2HEYR 4MSVB 4MXWR 3THMF 5IHLA 4FHQA 4KGQC 4N90R 4BK5A 1D0GR 4KGGC 3QO4A 1JMAB 5CIRE 3BUKC 3WVTA 3X3FA 3K51B 2HEVR 1ZA3R 2E4VA 4YN0A 3U3SA 3U3PA 3URFZ 1NCFA 4BK4A 5L36B 2H9GR 1TNRR 3MHDD 5BNQR 2E4WA 2QR6A 3QD6R 3U3QA 2E4UA 2E4YA 3ME4A 4M4RA 4I9XC 2UWIA 4GIQR 3FL7A 3MBWA 4OD2S 2AW2B 3QBQB 3MI8D 3ALQR 1SG1X
chains in the Genus database with same CATH topology
1FT4A 4E4DR 4M4PA 4RSUD 3U3TA 2X10A 4J6GC 3TJEF 1EXTA 3IJ2X 3ME2R 3U3VA 5DMJA 5IHLA 1DU3A 1D4VA 2HEYR 4MSVB 4MXWR 3THMF 4FHQA 4KGQC 4N90R 4BK5A 1D0GR 4KGGC 3QO4A 1JMAB 5CIRE 3BUKC 3WVTA 3X3FA 3K51B 2HEVR 1ZA3R 4YN0A 3U3SA 3U3PA 3URFZ 1NCFA 4BK4A 5L36B 2H9GR 1TNRR 3MHDD 5BNQR 3QD6R 3U3QA 3ME4A 4M4RA 4I9XC 2UWIA 4GIQR 3FL7A 3MBWA 4OD2S 2AW2B 3QBQB 3MI8D 3ALQR 1SG1X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FT4 A;  4E4D R;  4M4P A;  4RSU D;  3U3T A;  2X10 A;  4J6G C;  3TJE F;  1EXT A;  3IJ2 X;  3ME2 R;  3U3V A;  5DMJ A;  5IHL A;  1DU3 A;  1D4V A;  2HEY R;  4MSV B;  4MXW R;  3THM F;  4FHQ A;  4KGQ C;  4N90 R;  4BK5 A;  1D0G R;  4KGG C;  3QO4 A;  1JMA B;  5CIR E;  3BUK C;  3WVT A;  3X3F A;  3K51 B;  2HEV R;  1ZA3 R;  4YN0 A;  3U3S A;  3U3P A;  3URF Z;  1NCF A;  4BK4 A;  5L36 B;  2H9G R;  1TNR R;  3MHD D;  5BNQ R;  3QD6 R;  3U3Q A;  3ME4 A;  4M4R A;  4I9X C;  2UWI A;  4GIQ R;  3FL7 A;  3MBW A;  4OD2 S;  2AW2 B;  3QBQ B;  3MI8 D;  3ALQ R;  1SG1 X; 
#chains in the Genus database with same CATH topology
 1FT4 A;  4E4D R;  4M4P A;  4RSU D;  3U3T A;  2X10 A;  4J6G C;  3TJE F;  1EXT A;  3IJ2 X;  3ME2 R;  3U3V A;  5DMJ A;  2E4X A;  1DU3 A;  1D4V A;  2HEY R;  4MSV B;  4MXW R;  3THM F;  5IHL A;  4FHQ A;  4KGQ C;  4N90 R;  4BK5 A;  1D0G R;  4KGG C;  3QO4 A;  1JMA B;  5CIR E;  3BUK C;  3WVT A;  3X3F A;  3K51 B;  2HEV R;  1ZA3 R;  2E4V A;  4YN0 A;  3U3S A;  3U3P A;  3URF Z;  1NCF A;  4BK4 A;  5L36 B;  2H9G R;  1TNR R;  3MHD D;  5BNQ R;  2E4W A;  2QR6 A;  3QD6 R;  3U3Q A;  2E4U A;  2E4Y A;  3ME4 A;  4M4R A;  4I9X C;  2UWI A;  4GIQ R;  3FL7 A;  3MBW A;  4OD2 S;  2AW2 B;  3QBQ B;  3MI8 D;  3ALQ R;  1SG1 X; 
#chains in the Genus database with same CATH homology
 1FT4 A;  4E4D R;  4M4P A;  4RSU D;  3U3T A;  2X10 A;  4J6G C;  3TJE F;  1EXT A;  3IJ2 X;  3ME2 R;  3U3V A;  5DMJ A;  5IHL A;  1DU3 A;  1D4V A;  2HEY R;  4MSV B;  4MXW R;  3THM F;  4FHQ A;  4KGQ C;  4N90 R;  4BK5 A;  1D0G R;  4KGG C;  3QO4 A;  1JMA B;  5CIR E;  3BUK C;  3WVT A;  3X3F A;  3K51 B;  2HEV R;  1ZA3 R;  4YN0 A;  3U3S A;  3U3P A;  3URF Z;  1NCF A;  4BK4 A;  5L36 B;  2H9G R;  1TNR R;  3MHD D;  5BNQ R;  3QD6 R;  3U3Q A;  3ME4 A;  4M4R A;  4I9X C;  2UWI A;  4GIQ R;  3FL7 A;  3MBW A;  4OD2 S;  2AW2 B;  3QBQ B;  3MI8 D;  3ALQ R;  1SG1 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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