1AV5A

Pkci-substrate analog
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
113
structure length
113
Chain Sequence
GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-based analysis of catalysis and substrate definition in the HIT protein family.
pubmed doi rcsb
molecule tags Protein kinase inhibitor
source organism Homo sapiens
molecule keywords PROTEIN KINASE C INTERACTING PROTEIN
total genus 27
structure length 113
sequence length 113
chains with identical sequence B
ec nomenclature
pdb deposition date 1997-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1av5A00
4INCA 1ST0A 1AV5A 2Q4HA 1KPBA 1GUQA 4NDGA 5RHNA 2Q4LA 3OMFA 3NRDA 3LB5A 3O1CA 4ZGLA 1ZWJA 2EO4A 1GUPA 3IMIA 3P0TA 5EMTA 1VLRA 4NDFA 1KPAA 3TW2A 3RHNA 3OXKA 4QDEA 1RZYA 3WO5A 3O0MA 4EQGA 4NJYA 3ANOA 3I24A 4INIA 3KSVA 5CS2A 3BL7A 1XMLA 3SPDA 3O1ZA 4NJZA 3N1TA 1KPEA 5I2EA 3N1SA 3SZQA 1ST4A 4EQHA 2H39A 2FHIA 3OHEA 3SP4A 4ZKVA 4NDHA 5I2FA 4EQEA 6FITA 5ED3A 2FITA 3QGZA 3OJ7A 5IPDA 1XMMA 5IN3A 4FITA 3L7XA 1HXPA 5IPEA 4NJXA 3BLAA 3I4SA 1Z84A 1Y23A 3O1XA 5ED6A 4RHNA 4NK0A 5IPBA 1KPCA 4NDIA 2OIKA 4XBAA 1EMSA 1HXQA 5FITA 4EGUA 4QDVA 5IPCA 3BL9A 3FITA 1FHIA 4QEBA 6RHNA 1KPFA 4YKLB 4ZKLA 3SPLA 1FITA 5BV3A 3R6FA
chains in the Genus database with same CATH superfamily
4INCA 1ST0A 1AV5A 2Q4HA 1KPBA 1GUQA 4NDGA 5RHNA 2Q4LA 3OMFA 3NRDA 3LB5A 4G0JA 3O1CA 4ZGLA 1ZWJA 2EO4A 1GUPA 3IMIA 3P0TA 5EMTA 1VLRA 4NDFA 1KPAA 3TW2A 2R7CA 3RHNA 3OXKA 4QDEA 1RZYA 3WO5A 3O0MA 4EQGA 4I5VA 4NJYA 3ANOA 3I24A 4INIA 1L9VA 3KSVA 2R8FA 5CS2A 3BL7A 1XMLA 3SPDA 4I5TA 3O1ZA 4NJZA 2GU0A 3N1TA 1KPEA 5I2EA 3N1SA 3SZQA 1ST4A 4EQHA 2H39A 2FHIA 3OHEA 4G0AA 3SP4A 4ZKVA 4NDHA 5I2FA 4EQEA 6FITA 5ED3A 2FITA 2R7JA 3OJ7A 3QGZA 5IPDA 1XMMA 5IN3A 4FITA 3L7XA 1HXPA 5IPEA 4NJXA 3BLAA 4I5WA 3I4SA 1Z84A 1Y23A 3O1XA 5ED6A 4RHNA 4NK0A 5IPBA 1KPCA 4NDIA 2OIKA 4XBAA 1EMSA 1HXQA 5FITA 4EGUA 4QDVA 2POFA 3BL9A 5IPCA 3FITA 1FHIA 4QEBA 6RHNA 1KPFA 4YKLB 2R7PA 2LJWA 4ZKLA 3SPLA 1FITA 5BV3A 3R6FA
chains in the Genus database with same CATH topology
4INCA 1ST0A 1AV5A 2Q4HA 1KPBA 1GUQA 4NDGA 5RHNA 2Q4LA 3OMFA 3NRDA 3LB5A 3O1CA 4ZGLA 1ZWJA 2EO4A 1GUPA 3IMIA 3P0TA 5EMTA 1VLRA 4NDFA 1KPAA 3TW2A 3RHNA 3OXKA 4QDEA 1RZYA 3WO5A 3O0MA 4EQGA 4NJYA 3ANOA 3I24A 4INIA 3KSVA 5CS2A 3BL7A 1XMLA 3SPDA 3O1ZA 4NJZA 3N1TA 1KPEA 5I2EA 3N1SA 3SZQA 1ST4A 4EQHA 2H39A 2FHIA 3OHEA 3SP4A 4ZKVA 4NDHA 5I2FA 4EQEA 6FITA 5ED3A 2FITA 3QGZA 3OJ7A 5IPDA 1XMMA 5IN3A 4FITA 3L7XA 1HXPA 5IPEA 4NJXA 3BLAA 3I4SA 1Z84A 1Y23A 3O1XA 5ED6A 4RHNA 4NK0A 5IPBA 1KPCA 4NDIA 2OIKA 4XBAA 1EMSA 1HXQA 5FITA 4EGUA 4QDVA 5IPCA 3BL9A 3FITA 1FHIA 4QEBA 6RHNA 1KPFA 4YKLB 4ZKLA 3SPLA 1FITA 5BV3A 3R6FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4INC A;  1ST0 A;  1AV5 A;  2Q4H A;  1KPB A;  1GUQ A;  4NDG A;  5RHN A;  2Q4L A;  3OMF A;  3NRD A;  3LB5 A;  3O1C A;  4ZGL A;  1ZWJ A;  2EO4 A;  1GUP A;  3IMI A;  3P0T A;  5EMT A;  1VLR A;  4NDF A;  1KPA A;  3TW2 A;  3RHN A;  3OXK A;  4QDE A;  1RZY A;  3WO5 A;  3O0M A;  4EQG A;  4NJY A;  3ANO A;  3I24 A;  4INI A;  3KSV A;  5CS2 A;  3BL7 A;  1XML A;  3SPD A;  3O1Z A;  4NJZ A;  3N1T A;  1KPE A;  5I2E A;  3N1S A;  3SZQ A;  1ST4 A;  4EQH A;  2H39 A;  2FHI A;  3OHE A;  3SP4 A;  4ZKV A;  4NDH A;  5I2F A;  4EQE A;  6FIT A;  5ED3 A;  2FIT A;  3QGZ A;  3OJ7 A;  5IPD A;  1XMM A;  5IN3 A;  4FIT A;  3L7X A;  1HXP A;  5IPE A;  4NJX A;  3BLA A;  3I4S A;  1Z84 A;  1Y23 A;  3O1X A;  5ED6 A;  4RHN A;  4NK0 A;  5IPB A;  1KPC A;  4NDI A;  2OIK A;  4XBA A;  1EMS A;  1HXQ A;  5FIT A;  4EGU A;  4QDV A;  5IPC A;  3BL9 A;  3FIT A;  1FHI A;  4QEB A;  6RHN A;  1KPF A;  4YKL B;  4ZKL A;  3SPL A;  1FIT A;  5BV3 A;  3R6F A; 
#chains in the Genus database with same CATH topology
 4INC A;  1ST0 A;  1AV5 A;  2Q4H A;  1KPB A;  1GUQ A;  4NDG A;  5RHN A;  2Q4L A;  3OMF A;  3NRD A;  3LB5 A;  4G0J A;  3O1C A;  4ZGL A;  1ZWJ A;  2EO4 A;  1GUP A;  3IMI A;  3P0T A;  5EMT A;  1VLR A;  4NDF A;  1KPA A;  3TW2 A;  2R7C A;  3RHN A;  3OXK A;  4QDE A;  1RZY A;  3WO5 A;  3O0M A;  4EQG A;  4I5V A;  4NJY A;  3ANO A;  3I24 A;  4INI A;  1L9V A;  3KSV A;  2R8F A;  5CS2 A;  3BL7 A;  1XML A;  3SPD A;  4I5T A;  3O1Z A;  4NJZ A;  2GU0 A;  3N1T A;  1KPE A;  5I2E A;  3N1S A;  3SZQ A;  1ST4 A;  4EQH A;  2H39 A;  2FHI A;  3OHE A;  4G0A A;  3SP4 A;  4ZKV A;  4NDH A;  5I2F A;  4EQE A;  6FIT A;  5ED3 A;  2FIT A;  2R7J A;  3OJ7 A;  3QGZ A;  5IPD A;  1XMM A;  5IN3 A;  4FIT A;  3L7X A;  1HXP A;  5IPE A;  4NJX A;  3BLA A;  4I5W A;  3I4S A;  1Z84 A;  1Y23 A;  3O1X A;  5ED6 A;  4RHN A;  4NK0 A;  5IPB A;  1KPC A;  4NDI A;  2OIK A;  4XBA A;  1EMS A;  1HXQ A;  5FIT A;  4EGU A;  4QDV A;  2POF A;  3BL9 A;  5IPC A;  3FIT A;  1FHI A;  4QEB A;  6RHN A;  1KPF A;  4YKL B;  2R7P A;  2LJW A;  4ZKL A;  3SPL A;  1FIT A;  5BV3 A;  3R6F A; 
#chains in the Genus database with same CATH homology
 4INC A;  1ST0 A;  1AV5 A;  2Q4H A;  1KPB A;  1GUQ A;  4NDG A;  5RHN A;  2Q4L A;  3OMF A;  3NRD A;  3LB5 A;  3O1C A;  4ZGL A;  1ZWJ A;  2EO4 A;  1GUP A;  3IMI A;  3P0T A;  5EMT A;  1VLR A;  4NDF A;  1KPA A;  3TW2 A;  3RHN A;  3OXK A;  4QDE A;  1RZY A;  3WO5 A;  3O0M A;  4EQG A;  4NJY A;  3ANO A;  3I24 A;  4INI A;  3KSV A;  5CS2 A;  3BL7 A;  1XML A;  3SPD A;  3O1Z A;  4NJZ A;  3N1T A;  1KPE A;  5I2E A;  3N1S A;  3SZQ A;  1ST4 A;  4EQH A;  2H39 A;  2FHI A;  3OHE A;  3SP4 A;  4ZKV A;  4NDH A;  5I2F A;  4EQE A;  6FIT A;  5ED3 A;  2FIT A;  3QGZ A;  3OJ7 A;  5IPD A;  1XMM A;  5IN3 A;  4FIT A;  3L7X A;  1HXP A;  5IPE A;  4NJX A;  3BLA A;  3I4S A;  1Z84 A;  1Y23 A;  3O1X A;  5ED6 A;  4RHN A;  4NK0 A;  5IPB A;  1KPC A;  4NDI A;  2OIK A;  4XBA A;  1EMS A;  1HXQ A;  5FIT A;  4EGU A;  4QDV A;  5IPC A;  3BL9 A;  3FIT A;  1FHI A;  4QEB A;  6RHN A;  1KPF A;  4YKL B;  4ZKL A;  3SPL A;  1FIT A;  5BV3 A;  3R6F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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