1AV5A

Pkci-substrate analog
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
113
structure length
113
Chain Sequence
GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein kinase inhibitor
source organism Homo sapiens
publication title Structure-based analysis of catalysis and substrate definition in the HIT protein family.
pubmed doi rcsb
molecule keywords PROTEIN KINASE C INTERACTING PROTEIN
total genus 27
structure length 113
sequence length 113
chains with identical sequence B
ec nomenclature
pdb deposition date 1997-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1av5A00
3KSVA 4QEBA 1EMSA 1KPCA 5RHNA 4QDEA 1FHIA 3I4SA 3LB5A 3N1SA 3SPDA 4FITA 3OJ7A 3NRDA 3O1XA 1KPEA 3I24A 6FITA 1KPBA 3BL9A 4EQGA 5ED6A 4NJXA 3TW2A 1GUPA 1KPFA 4INCA 6RHNA 4NDFA 1VLRA 4NJYA 3O0MA 5IPEA 3RHNA 5FITA 3R6FA 1HXPA 3SP4A 1ST0A 2EO4A 4NJZA 4INIA 4RHNA 2FITA 3OXKA 5CS2A 3IMIA 4NDHA 1RZYA 1Y23A 3N1TA 4NDGA 2OIKA 1ST4A 1FITA 5IPBA 5IN3A 3OMFA 4ZKLA 5I2EA 3SPLA 4EQHA 1AV5A 4ZGLA 3O1CA 1Z84A 1KPAA 3FITA 5IPCA 3ANOA 3QGZA 2Q4HA 4ZKVA 1HXQA 3BL7A 1XMMA 1ZWJA 4EQEA 3BLAA 2FHIA 3L7XA 3OHEA 3WO5A 3P0TA 5EMTA 5IPDA 4QDVA 4YKLB 5I2FA 4NDIA 2Q4LA 1GUQA 4XBAA 3SZQA 2H39A 3O1ZA 5BV3A 5ED3A 1XMLA 4EGUA 4NK0A
chains in the Genus database with same CATH superfamily
4G0AA 3KSVA 4QEBA 1EMSA 1KPCA 5RHNA 4QDEA 1FHIA 3I4SA 3LB5A 3N1SA 3SPDA 4FITA 3OJ7A 3NRDA 2R7JA 4I5TA 3O1XA 1KPEA 3I24A 6FITA 2GU0A 1KPBA 3BL9A 4EQGA 5ED6A 4NJXA 3TW2A 1GUPA 1KPFA 4INCA 6RHNA 4NDFA 1VLRA 4NJYA 3O0MA 5IPEA 2LJWA 3RHNA 5FITA 3R6FA 1HXPA 3SP4A 1ST0A 2EO4A 4NJZA 4INIA 4RHNA 2FITA 3OXKA 5CS2A 3IMIA 2POFA 4NDHA 1RZYA 1Y23A 3N1TA 4NDGA 2OIKA 1ST4A 2R8FA 1FITA 5IPBA 5IN3A 3OMFA 4ZKLA 5I2EA 3SPLA 4EQHA 1AV5A 4ZGLA 3O1CA 1Z84A 1KPAA 2R7CA 3FITA 5IPCA 3ANOA 3QGZA 2Q4HA 4ZKVA 1HXQA 3BL7A 1XMMA 2R7PA 1ZWJA 4EQEA 3BLAA 2FHIA 3L7XA 4I5VA 3OHEA 3WO5A 3P0TA 5EMTA 1L9VA 5IPDA 4QDVA 4YKLB 5I2FA 4NDIA 4G0JA 2Q4LA 4I5WA 1GUQA 4XBAA 3SZQA 2H39A 3O1ZA 5BV3A 5ED3A 1XMLA 4EGUA 4NK0A
chains in the Genus database with same CATH topology
3KSVA 4QEBA 1EMSA 1KPCA 5RHNA 4QDEA 1FHIA 3I4SA 3LB5A 3N1SA 3SPDA 4FITA 3OJ7A 3NRDA 3O1XA 1KPEA 3I24A 6FITA 1KPBA 3BL9A 4EQGA 5ED6A 4NJXA 3TW2A 1GUPA 1KPFA 4INCA 6RHNA 4NDFA 1VLRA 4NJYA 3O0MA 5IPEA 3RHNA 5FITA 3R6FA 1HXPA 3SP4A 1ST0A 2EO4A 4NJZA 4INIA 4RHNA 2FITA 3OXKA 5CS2A 3IMIA 4NDHA 1RZYA 1Y23A 3N1TA 4NDGA 2OIKA 1ST4A 1FITA 5IPBA 5IN3A 3OMFA 4ZKLA 5I2EA 3SPLA 4EQHA 1AV5A 4ZGLA 3O1CA 1Z84A 1KPAA 3FITA 5IPCA 3ANOA 3QGZA 2Q4HA 4ZKVA 1HXQA 3BL7A 1XMMA 1ZWJA 4EQEA 3BLAA 2FHIA 3L7XA 3OHEA 3WO5A 3P0TA 5EMTA 5IPDA 4QDVA 4YKLB 5I2FA 4NDIA 2Q4LA 1GUQA 4XBAA 3SZQA 2H39A 3O1ZA 5BV3A 5ED3A 1XMLA 4EGUA 4NK0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KSV A;  4QEB A;  1EMS A;  1KPC A;  5RHN A;  4QDE A;  1FHI A;  3I4S A;  3LB5 A;  3N1S A;  3SPD A;  4FIT A;  3OJ7 A;  3NRD A;  3O1X A;  1KPE A;  3I24 A;  6FIT A;  1KPB A;  3BL9 A;  4EQG A;  5ED6 A;  4NJX A;  3TW2 A;  1GUP A;  1KPF A;  4INC A;  6RHN A;  4NDF A;  1VLR A;  4NJY A;  3O0M A;  5IPE A;  3RHN A;  5FIT A;  3R6F A;  1HXP A;  3SP4 A;  1ST0 A;  2EO4 A;  4NJZ A;  4INI A;  4RHN A;  2FIT A;  3OXK A;  5CS2 A;  3IMI A;  4NDH A;  1RZY A;  1Y23 A;  3N1T A;  4NDG A;  2OIK A;  1ST4 A;  1FIT A;  5IPB A;  5IN3 A;  3OMF A;  4ZKL A;  5I2E A;  3SPL A;  4EQH A;  1AV5 A;  4ZGL A;  3O1C A;  1Z84 A;  1KPA A;  3FIT A;  5IPC A;  3ANO A;  3QGZ A;  2Q4H A;  4ZKV A;  1HXQ A;  3BL7 A;  1XMM A;  1ZWJ A;  4EQE A;  3BLA A;  2FHI A;  3L7X A;  3OHE A;  3WO5 A;  3P0T A;  5EMT A;  5IPD A;  4QDV A;  4YKL B;  5I2F A;  4NDI A;  2Q4L A;  1GUQ A;  4XBA A;  3SZQ A;  2H39 A;  3O1Z A;  5BV3 A;  5ED3 A;  1XML A;  4EGU A;  4NK0 A; 
#chains in the Genus database with same CATH topology
 4G0A A;  3KSV A;  4QEB A;  1EMS A;  1KPC A;  5RHN A;  4QDE A;  1FHI A;  3I4S A;  3LB5 A;  3N1S A;  3SPD A;  4FIT A;  3OJ7 A;  3NRD A;  2R7J A;  4I5T A;  3O1X A;  1KPE A;  3I24 A;  6FIT A;  2GU0 A;  1KPB A;  3BL9 A;  4EQG A;  5ED6 A;  4NJX A;  3TW2 A;  1GUP A;  1KPF A;  4INC A;  6RHN A;  4NDF A;  1VLR A;  4NJY A;  3O0M A;  5IPE A;  2LJW A;  3RHN A;  5FIT A;  3R6F A;  1HXP A;  3SP4 A;  1ST0 A;  2EO4 A;  4NJZ A;  4INI A;  4RHN A;  2FIT A;  3OXK A;  5CS2 A;  3IMI A;  2POF A;  4NDH A;  1RZY A;  1Y23 A;  3N1T A;  4NDG A;  2OIK A;  1ST4 A;  2R8F A;  1FIT A;  5IPB A;  5IN3 A;  3OMF A;  4ZKL A;  5I2E A;  3SPL A;  4EQH A;  1AV5 A;  4ZGL A;  3O1C A;  1Z84 A;  1KPA A;  2R7C A;  3FIT A;  5IPC A;  3ANO A;  3QGZ A;  2Q4H A;  4ZKV A;  1HXQ A;  3BL7 A;  1XMM A;  2R7P A;  1ZWJ A;  4EQE A;  3BLA A;  2FHI A;  3L7X A;  4I5V A;  3OHE A;  3WO5 A;  3P0T A;  5EMT A;  1L9V A;  5IPD A;  4QDV A;  4YKL B;  5I2F A;  4NDI A;  4G0J A;  2Q4L A;  4I5W A;  1GUQ A;  4XBA A;  3SZQ A;  2H39 A;  3O1Z A;  5BV3 A;  5ED3 A;  1XML A;  4EGU A;  4NK0 A; 
#chains in the Genus database with same CATH homology
 3KSV A;  4QEB A;  1EMS A;  1KPC A;  5RHN A;  4QDE A;  1FHI A;  3I4S A;  3LB5 A;  3N1S A;  3SPD A;  4FIT A;  3OJ7 A;  3NRD A;  3O1X A;  1KPE A;  3I24 A;  6FIT A;  1KPB A;  3BL9 A;  4EQG A;  5ED6 A;  4NJX A;  3TW2 A;  1GUP A;  1KPF A;  4INC A;  6RHN A;  4NDF A;  1VLR A;  4NJY A;  3O0M A;  5IPE A;  3RHN A;  5FIT A;  3R6F A;  1HXP A;  3SP4 A;  1ST0 A;  2EO4 A;  4NJZ A;  4INI A;  4RHN A;  2FIT A;  3OXK A;  5CS2 A;  3IMI A;  4NDH A;  1RZY A;  1Y23 A;  3N1T A;  4NDG A;  2OIK A;  1ST4 A;  1FIT A;  5IPB A;  5IN3 A;  3OMF A;  4ZKL A;  5I2E A;  3SPL A;  4EQH A;  1AV5 A;  4ZGL A;  3O1C A;  1Z84 A;  1KPA A;  3FIT A;  5IPC A;  3ANO A;  3QGZ A;  2Q4H A;  4ZKV A;  1HXQ A;  3BL7 A;  1XMM A;  1ZWJ A;  4EQE A;  3BLA A;  2FHI A;  3L7X A;  3OHE A;  3WO5 A;  3P0T A;  5EMT A;  5IPD A;  4QDV A;  4YKL B;  5I2F A;  4NDI A;  2Q4L A;  1GUQ A;  4XBA A;  3SZQ A;  2H39 A;  3O1Z A;  5BV3 A;  5ED3 A;  1XML A;  4EGU A;  4NK0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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