5I2EA

Human histidine triad nucleotide binding protein 1 (hint1) with bound sulfamate inhibitor 3a:3-(5-o-{[3-(1h-indol-3-yl)propanoyl]sulfamoyl}-beta-d-ribofuranosyl)-3h-imidazo[2,1-i]purine
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Histidine triad nucleotide-binding protein 1
publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
source organism Homo sapiens
total genus 29
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2eA00
3OJ7A 3N1SA 4QDEA 3R6FA 3TW2A 1KPFA 3BLAA 3I24A 3KSVA 3N1TA 3BL7A 3WO5A 3L7XA 4NJXA 4ZKVA 3FITA 2Q4LA 1KPEA 4QDVA 3O0MA 1GUPA 4EQGA 3QGZA 4FITA 1FHIA 1ZWJA 4NJZA 1HXQA 4QEBA 3NRDA 4NJYA 5EMTA 5IPDA 3IMIA 1ST0A 1XMMA 1EMSA 6RHNA 1RZYA 3O1ZA 5BV3A 6FITA 5FITA 1KPBA 3OHEA 3SPDA 2FITA 3SZQA 5I2EA 5IPEA 3OMFA 3P0TA 5I2FA 3SPLA 5ED6A 5ED3A 1XMLA 2EO4A 5IPCA 4NDHA 2Q4HA 5CS2A 1Z84A 1ST4A 1VLRA 4NK0A 4EQEA 5IPBA 4NDGA 1GUQA 4ZKLA 3LB5A 2FHIA 1KPCA 4YKLB 1KPAA 3I4SA 5RHNA 4XBAA 3ANOA 4INIA 1AV5A 4ZGLA 5IN3A 1Y23A 3O1XA 1HXPA 4NDIA 3SP4A 4EGUA 1FITA 4RHNA 4EQHA 4INCA 4NDFA 2H39A 3O1CA 3BL9A 3OXKA 2OIKA 3RHNA
chains in the Genus database with same CATH superfamily
3OJ7A 3N1SA 4QDEA 3R6FA 3TW2A 1KPFA 2R8FA 3BLAA 3I24A 3KSVA 3N1TA 3BL7A 3WO5A 3L7XA 4NJXA 4ZKVA 3FITA 2Q4LA 2R7PA 4I5TA 1KPEA 4QDVA 3O0MA 1GUPA 4EQGA 3QGZA 4FITA 1FHIA 1ZWJA 4NJZA 1HXQA 2GU0A 4QEBA 3NRDA 4NJYA 5EMTA 5IPDA 3IMIA 1ST0A 1XMMA 1EMSA 2POFA 6RHNA 1RZYA 3O1ZA 4I5WA 5BV3A 6FITA 5FITA 1KPBA 3OHEA 3SPDA 4G0JA 2FITA 3SZQA 5I2EA 5IPEA 2R7CA 3OMFA 3P0TA 5I2FA 3SPLA 5ED6A 5ED3A 1XMLA 2EO4A 5IPCA 4NDHA 2Q4HA 2R7JA 1Z84A 5CS2A 1ST4A 1VLRA 4NK0A 4EQEA 5IPBA 4NDGA 1GUQA 4ZKLA 1L9VA 2LJWA 3LB5A 4I5VA 2FHIA 1KPCA 4YKLB 1KPAA 3I4SA 5RHNA 4XBAA 4G0AA 3ANOA 4INIA 1AV5A 4ZGLA 5IN3A 1Y23A 3O1XA 1HXPA 4NDIA 3SP4A 4EGUA 1FITA 4RHNA 4EQHA 4INCA 4NDFA 2H39A 3O1CA 3BL9A 3OXKA 2OIKA 3RHNA
chains in the Genus database with same CATH topology
3OJ7A 3N1SA 4QDEA 3R6FA 3TW2A 1KPFA 3BLAA 3I24A 3KSVA 3N1TA 3BL7A 3WO5A 3L7XA 4NJXA 4ZKVA 3FITA 2Q4LA 1KPEA 4QDVA 3O0MA 1GUPA 4EQGA 3QGZA 4FITA 1FHIA 1ZWJA 4NJZA 1HXQA 4QEBA 3NRDA 4NJYA 5EMTA 5IPDA 3IMIA 1ST0A 1XMMA 1EMSA 6RHNA 1RZYA 3O1ZA 5BV3A 6FITA 5FITA 1KPBA 3OHEA 3SPDA 2FITA 3SZQA 5I2EA 5IPEA 3OMFA 3P0TA 5I2FA 3SPLA 5ED6A 5ED3A 1XMLA 2EO4A 5IPCA 4NDHA 2Q4HA 5CS2A 1Z84A 1ST4A 1VLRA 4NK0A 4EQEA 5IPBA 4NDGA 1GUQA 4ZKLA 3LB5A 2FHIA 1KPCA 4YKLB 1KPAA 3I4SA 5RHNA 4XBAA 3ANOA 4INIA 1AV5A 4ZGLA 5IN3A 1Y23A 3O1XA 1HXPA 4NDIA 3SP4A 4EGUA 1FITA 4RHNA 4EQHA 4INCA 4NDFA 2H39A 3O1CA 3BL9A 3OXKA 2OIKA 3RHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OJ7 A;  3N1S A;  4QDE A;  3R6F A;  3TW2 A;  1KPF A;  3BLA A;  3I24 A;  3KSV A;  3N1T A;  3BL7 A;  3WO5 A;  3L7X A;  4NJX A;  4ZKV A;  3FIT A;  2Q4L A;  1KPE A;  4QDV A;  3O0M A;  1GUP A;  4EQG A;  3QGZ A;  4FIT A;  1FHI A;  1ZWJ A;  4NJZ A;  1HXQ A;  4QEB A;  3NRD A;  4NJY A;  5EMT A;  5IPD A;  3IMI A;  1ST0 A;  1XMM A;  1EMS A;  6RHN A;  1RZY A;  3O1Z A;  5BV3 A;  6FIT A;  5FIT A;  1KPB A;  3OHE A;  3SPD A;  2FIT A;  3SZQ A;  5I2E A;  5IPE A;  3OMF A;  3P0T A;  5I2F A;  3SPL A;  5ED6 A;  5ED3 A;  1XML A;  2EO4 A;  5IPC A;  4NDH A;  2Q4H A;  5CS2 A;  1Z84 A;  1ST4 A;  1VLR A;  4NK0 A;  4EQE A;  5IPB A;  4NDG A;  1GUQ A;  4ZKL A;  3LB5 A;  2FHI A;  1KPC A;  4YKL B;  1KPA A;  3I4S A;  5RHN A;  4XBA A;  3ANO A;  4INI A;  1AV5 A;  4ZGL A;  5IN3 A;  1Y23 A;  3O1X A;  1HXP A;  4NDI A;  3SP4 A;  4EGU A;  1FIT A;  4RHN A;  4EQH A;  4INC A;  4NDF A;  2H39 A;  3O1C A;  3BL9 A;  3OXK A;  2OIK A;  3RHN A; 
#chains in the Genus database with same CATH topology
 3OJ7 A;  3N1S A;  4QDE A;  3R6F A;  3TW2 A;  1KPF A;  2R8F A;  3BLA A;  3I24 A;  3KSV A;  3N1T A;  3BL7 A;  3WO5 A;  3L7X A;  4NJX A;  4ZKV A;  3FIT A;  2Q4L A;  2R7P A;  4I5T A;  1KPE A;  4QDV A;  3O0M A;  1GUP A;  4EQG A;  3QGZ A;  4FIT A;  1FHI A;  1ZWJ A;  4NJZ A;  1HXQ A;  2GU0 A;  4QEB A;  3NRD A;  4NJY A;  5EMT A;  5IPD A;  3IMI A;  1ST0 A;  1XMM A;  1EMS A;  2POF A;  6RHN A;  1RZY A;  3O1Z A;  4I5W A;  5BV3 A;  6FIT A;  5FIT A;  1KPB A;  3OHE A;  3SPD A;  4G0J A;  2FIT A;  3SZQ A;  5I2E A;  5IPE A;  2R7C A;  3OMF A;  3P0T A;  5I2F A;  3SPL A;  5ED6 A;  5ED3 A;  1XML A;  2EO4 A;  5IPC A;  4NDH A;  2Q4H A;  2R7J A;  1Z84 A;  5CS2 A;  1ST4 A;  1VLR A;  4NK0 A;  4EQE A;  5IPB A;  4NDG A;  1GUQ A;  4ZKL A;  1L9V A;  2LJW A;  3LB5 A;  4I5V A;  2FHI A;  1KPC A;  4YKL B;  1KPA A;  3I4S A;  5RHN A;  4XBA A;  4G0A A;  3ANO A;  4INI A;  1AV5 A;  4ZGL A;  5IN3 A;  1Y23 A;  3O1X A;  1HXP A;  4NDI A;  3SP4 A;  4EGU A;  1FIT A;  4RHN A;  4EQH A;  4INC A;  4NDF A;  2H39 A;  3O1C A;  3BL9 A;  3OXK A;  2OIK A;  3RHN A; 
#chains in the Genus database with same CATH homology
 3OJ7 A;  3N1S A;  4QDE A;  3R6F A;  3TW2 A;  1KPF A;  3BLA A;  3I24 A;  3KSV A;  3N1T A;  3BL7 A;  3WO5 A;  3L7X A;  4NJX A;  4ZKV A;  3FIT A;  2Q4L A;  1KPE A;  4QDV A;  3O0M A;  1GUP A;  4EQG A;  3QGZ A;  4FIT A;  1FHI A;  1ZWJ A;  4NJZ A;  1HXQ A;  4QEB A;  3NRD A;  4NJY A;  5EMT A;  5IPD A;  3IMI A;  1ST0 A;  1XMM A;  1EMS A;  6RHN A;  1RZY A;  3O1Z A;  5BV3 A;  6FIT A;  5FIT A;  1KPB A;  3OHE A;  3SPD A;  2FIT A;  3SZQ A;  5I2E A;  5IPE A;  3OMF A;  3P0T A;  5I2F A;  3SPL A;  5ED6 A;  5ED3 A;  1XML A;  2EO4 A;  5IPC A;  4NDH A;  2Q4H A;  5CS2 A;  1Z84 A;  1ST4 A;  1VLR A;  4NK0 A;  4EQE A;  5IPB A;  4NDG A;  1GUQ A;  4ZKL A;  3LB5 A;  2FHI A;  1KPC A;  4YKL B;  1KPA A;  3I4S A;  5RHN A;  4XBA A;  3ANO A;  4INI A;  1AV5 A;  4ZGL A;  5IN3 A;  1Y23 A;  3O1X A;  1HXP A;  4NDI A;  3SP4 A;  4EGU A;  1FIT A;  4RHN A;  4EQH A;  4INC A;  4NDF A;  2H39 A;  3O1C A;  3BL9 A;  3OXK A;  2OIK A;  3RHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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