1CA1A

Alpha-toxin from clostridium perfringens
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
370
structure length
370
Chain Sequence
WDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDNSWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTVGCKTNEDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAYISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKLKDENLKIDDIQNMWIRKRKYTAFPDAYKPENIKVIANGKVVVDKDINEWISGNSTYNIK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the key toxin in gas gangrene.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium perfringens
molecule keywords ALPHA-TOXIN
total genus 137
structure length 370
sequence length 370
ec nomenclature ec 3.1.4.3: Phospholipase C.
pdb deposition date 1998-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00882 Zn_dep_PLPC Zinc dependent phospholipase C
A PF01477 PLAT PLAT/LH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.575.10 Mainly Alpha Orthogonal Bundle P1 Nuclease P1 Nuclease 1ca1A01
2.60.60.20 Mainly Beta Sandwich Lipoxygenase-1 PLAT/LH2 domain 1ca1A02
1ROVA 1NO3A 3BNBA 1F8NA 5FBGA 1P5XA 1BU8A 3V99A 4CXPA 3FG1A 3BNEA 3FG4A 3W52A 1CA1A 3PZWA 2PVSA 1OLPA 4DJ4A 3V98A 1N8SA 1P6EA 1FGQA 1Y4KA 3BNCA 1N8QA 4QWTA 2FFZA 1ETHA 1P6DA 1LPAB 1GPLA 2IUKA 4CXVA 3O8YA 1FGOA 2PPLA 1RP1A 3VF1A 1FGTA 5FBDA 1JNQA 5FBAA 5FBCA 1HU9A 3SNGA 4WFOA 1LOXA 5FB9A 2FNQA 1KHOA 2WXTA 3V92A 4WHAA 1LNHA 4CWMA 1LPBB 1FGRA 3BNDA 4JDGA 1QMDA 5FBBA 1RRLA 1AK0A 5FBFA 1W52X 2P0MA 1GYGA 3CWZB 3FG3A 1AH7A 2IUJA 1QM6A 1RRHA 2WY6A 1IK3A 4CXOA 1FGMA 5EEOA 2SBLA 4NREA 2HUCA 2WXUA 1HPLA 1YGEA 2FGNA 2OXEA
chains in the Genus database with same CATH superfamily
1ROVA 1NO3A 3BNBA 2XHJA 1F8NA 4QEYA 5FBGA 1P5XA 1BU8A 3V99A 4CXPA 3FG1A 3BNEA 3FG4A 3W52A 1CA1A 3PZWA 2PVSA 1OLPA 4DJ4A 2XFEA 3V98A 1N8SA 1P6EA 1FGQA 1Y4KA 2XHHA 3BNCA 1N8QA 3IBZA 4QWTA 2FFZA 1ETHA 1P6DA 1LPAB 1GPLA 2IUKA 4CXVA 3O8YA 1FGOA 2PPLA 1RP1A 3VF1A 1FGTA 5FBDA 1JNQA 5FBAA 5FBCA 1HU9A 3SNGA 4WFOA 1LOXA 5FB9A 2QZ7A 2FNQA 1KHOA 2WXTA 3V92A 4WHAA 1LNHA 4CWMA 2KXVA 1LPBB 1FGRA 3BNDA 4JDGA 1QMDA 5FBBA 2LRGA 1RRLA 2LGEA 1AK0A 5FBFA 1W52X 2P0MA 3U6GA 1GYGA 3CWZB 3FG3A 1AH7A 2IUJA 1QM6A 1RRHA 2WY6A 1IK3A 2XFDA 4CXOA 1FGMA 5EEOA 2SBLA 4NREA 2OXEA 2QNGA 2HUCA 2WXUA 1HPLA 2KXTA 1YGEA 2FGNA 2LG7A
chains in the Genus database with same CATH topology
1ROVA 1NO3A 3BNBA 1F8NA 5FBGA 1P5XA 1BU8A 3V99A 4CXPA 3FG1A 3BNEA 3FG4A 3W52A 1CA1A 3PZWA 2PVSA 1OLPA 4DJ4A 3V98A 1N8SA 1P6EA 1FGQA 1Y4KA 3BNCA 1N8QA 4QWTA 2FFZA 1ETHA 1P6DA 1LPAB 1GPLA 2IUKA 4CXVA 3O8YA 1FGOA 2PPLA 1RP1A 3VF1A 1FGTA 5FBDA 1JNQA 5FBAA 5FBCA 1HU9A 3SNGA 4WFOA 1LOXA 5FB9A 2FNQA 1KHOA 2WXTA 3V92A 4WHAA 1LNHA 4CWMA 1LPBB 1FGRA 3BNDA 4JDGA 1QMDA 5FBBA 1RRLA 1AK0A 5FBFA 1W52X 2P0MA 1GYGA 3CWZB 3FG3A 1AH7A 2IUJA 1QM6A 1RRHA 2WY6A 1IK3A 4CXOA 1FGMA 5EEOA 2SBLA 4NREA 2HUCA 2WXUA 1HPLA 1YGEA 2FGNA 2OXEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ROV A;  1NO3 A;  3BNB A;  1F8N A;  5FBG A;  1P5X A;  1BU8 A;  3V99 A;  4CXP A;  3FG1 A;  3BNE A;  3FG4 A;  3W52 A;  1CA1 A;  3PZW A;  2PVS A;  1OLP A;  4DJ4 A;  3V98 A;  1N8S A;  1P6E A;  1FGQ A;  1Y4K A;  3BNC A;  1N8Q A;  4QWT A;  2FFZ A;  1ETH A;  1P6D A;  1LPA B;  1GPL A;  2IUK A;  4CXV A;  3O8Y A;  1FGO A;  2PPL A;  1RP1 A;  3VF1 A;  1FGT A;  5FBD A;  1JNQ A;  5FBA A;  5FBC A;  1HU9 A;  3SNG A;  4WFO A;  1LOX A;  5FB9 A;  2FNQ A;  1KHO A;  2WXT A;  3V92 A;  4WHA A;  1LNH A;  4CWM A;  1LPB B;  1FGR A;  3BND A;  4JDG A;  1QMD A;  5FBB A;  1RRL A;  1AK0 A;  5FBF A;  1W52 X;  2P0M A;  1GYG A;  3CWZ B;  3FG3 A;  1AH7 A;  2IUJ A;  1QM6 A;  1RRH A;  2WY6 A;  1IK3 A;  4CXO A;  1FGM A;  5EEO A;  2SBL A;  4NRE A;  2HUC A;  2WXU A;  1HPL A;  1YGE A;  2FGN A;  2OXE A; 
#chains in the Genus database with same CATH topology
 1ROV A;  1NO3 A;  3BNB A;  2XHJ A;  1F8N A;  4QEY A;  5FBG A;  1P5X A;  1BU8 A;  3V99 A;  4CXP A;  3FG1 A;  3BNE A;  3FG4 A;  3W52 A;  1CA1 A;  3PZW A;  2PVS A;  1OLP A;  4DJ4 A;  2XFE A;  3V98 A;  1N8S A;  1P6E A;  1FGQ A;  1Y4K A;  2XHH A;  3BNC A;  1N8Q A;  3IBZ A;  4QWT A;  2FFZ A;  1ETH A;  1P6D A;  1LPA B;  1GPL A;  2IUK A;  4CXV A;  3O8Y A;  1FGO A;  2PPL A;  1RP1 A;  3VF1 A;  1FGT A;  5FBD A;  1JNQ A;  5FBA A;  5FBC A;  1HU9 A;  3SNG A;  4WFO A;  1LOX A;  5FB9 A;  2QZ7 A;  2FNQ A;  1KHO A;  2WXT A;  3V92 A;  4WHA A;  1LNH A;  4CWM A;  2KXV A;  1LPB B;  1FGR A;  3BND A;  4JDG A;  1QMD A;  5FBB A;  2LRG A;  1RRL A;  2LGE A;  1AK0 A;  5FBF A;  1W52 X;  2P0M A;  3U6G A;  1GYG A;  3CWZ B;  3FG3 A;  1AH7 A;  2IUJ A;  1QM6 A;  1RRH A;  2WY6 A;  1IK3 A;  2XFD A;  4CXO A;  1FGM A;  5EEO A;  2SBL A;  4NRE A;  2OXE A;  2QNG A;  2HUC A;  2WXU A;  1HPL A;  2KXT A;  1YGE A;  2FGN A;  2LG7 A; 
#chains in the Genus database with same CATH homology
 1ROV A;  1NO3 A;  3BNB A;  1F8N A;  5FBG A;  1P5X A;  1BU8 A;  3V99 A;  4CXP A;  3FG1 A;  3BNE A;  3FG4 A;  3W52 A;  1CA1 A;  3PZW A;  2PVS A;  1OLP A;  4DJ4 A;  3V98 A;  1N8S A;  1P6E A;  1FGQ A;  1Y4K A;  3BNC A;  1N8Q A;  4QWT A;  2FFZ A;  1ETH A;  1P6D A;  1LPA B;  1GPL A;  2IUK A;  4CXV A;  3O8Y A;  1FGO A;  2PPL A;  1RP1 A;  3VF1 A;  1FGT A;  5FBD A;  1JNQ A;  5FBA A;  5FBC A;  1HU9 A;  3SNG A;  4WFO A;  1LOX A;  5FB9 A;  2FNQ A;  1KHO A;  2WXT A;  3V92 A;  4WHA A;  1LNH A;  4CWM A;  1LPB B;  1FGR A;  3BND A;  4JDG A;  1QMD A;  5FBB A;  1RRL A;  1AK0 A;  5FBF A;  1W52 X;  2P0M A;  1GYG A;  3CWZ B;  3FG3 A;  1AH7 A;  2IUJ A;  1QM6 A;  1RRH A;  2WY6 A;  1IK3 A;  4CXO A;  1FGM A;  5EEO A;  2SBL A;  4NRE A;  2HUC A;  2WXU A;  1HPL A;  1YGE A;  2FGN A;  2OXE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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