1FHIA

Substrate analog (ib2) complex with the fragile histidine triad protein, fhit
Total Genus 27
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
146
structure length
125
Chain Sequence
SFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDSWRSEEEMAAEAAALRVYFQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
pubmed doi rcsb
molecule tags Nucleotide-binding protein
source organism Homo sapiens
molecule keywords FRAGILE HISTIDINE TRIAD PROTEIN
total genus 27
structure length 125
sequence length 146
ec nomenclature ec 3.6.1.29: Bis(5'-adenosyl)-triphosphatase.
pdb deposition date 1997-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1fhiA00
1EMSA 3KSVA 3O1CA 5IPDA 4NDIA 3FITA 3SPDA 3SPLA 1KPAA 5CS2A 5ED6A 4EGUA 2H39A 3N1TA 3OHEA 5IPCA 1FHIA 4ZGLA 3OJ7A 4NDHA 2Q4HA 1ZWJA 4QDEA 5I2FA 4RHNA 4NDGA 1AV5A 4XBAA 5ED3A 3OMFA 2EO4A 3SP4A 1ST0A 5IN3A 4FITA 1VLRA 5IPEA 4INCA 3IMIA 1KPBA 3BL7A 4NJZA 1KPEA 4NJXA 5I2EA 4EQEA 4INIA 4NDFA 4EQGA 3P0TA 6FITA 4EQHA 3L7XA 4QDVA 1GUPA 5IPBA 3I24A 1KPCA 1HXPA 3R6FA 3RHNA 1KPFA 3WO5A 2OIKA 3I4SA 1ST4A 3QGZA 3SZQA 4NK0A 1XMLA 2FITA 3ANOA 3BL9A 1Y23A 5BV3A 3O0MA 3LB5A 3TW2A 5RHNA 3O1XA 4ZKVA 1RZYA 4ZKLA 1GUQA 6RHNA 3O1ZA 1Z84A 4YKLB 3OXKA 1HXQA 5FITA 1XMMA 3N1SA 3BLAA 5EMTA 2Q4LA 2FHIA 1FITA 3NRDA 4NJYA 4QEBA
chains in the Genus database with same CATH superfamily
4I5WA 1EMSA 3KSVA 3O1CA 5IPDA 4NDIA 3FITA 3SPDA 3SPLA 2R7PA 1KPAA 5CS2A 5ED6A 1L9VA 4EGUA 2H39A 3N1TA 3OHEA 5IPCA 1FHIA 4ZGLA 3OJ7A 4NDHA 2Q4HA 1ZWJA 4QDEA 2POFA 5I2FA 4RHNA 4NDGA 1AV5A 4XBAA 5ED3A 3OMFA 2EO4A 3SP4A 4I5VA 4G0AA 1ST0A 5IN3A 4FITA 2R7JA 1VLRA 5IPEA 4INCA 3IMIA 1KPBA 3BL7A 4NJZA 1KPEA 4NJXA 5I2EA 4EQEA 4INIA 4NDFA 4EQGA 3P0TA 6FITA 2LJWA 4EQHA 3L7XA 4QDVA 1GUPA 5IPBA 3I24A 1KPCA 1HXPA 3R6FA 3RHNA 1KPFA 2R7CA 3WO5A 2OIKA 3I4SA 1ST4A 3QGZA 3SZQA 4NK0A 1XMLA 2FITA 3ANOA 3BL9A 1Y23A 5BV3A 4G0JA 3O0MA 3LB5A 3TW2A 5RHNA 3O1XA 4ZKVA 1RZYA 4ZKLA 1GUQA 6RHNA 2R8FA 3O1ZA 1Z84A 4YKLB 3OXKA 1HXQA 5FITA 1XMMA 3N1SA 3BLAA 5EMTA 2Q4LA 2FHIA 1FITA 3NRDA 2GU0A 4I5TA 4NJYA 4QEBA
chains in the Genus database with same CATH topology
1EMSA 3KSVA 3O1CA 5IPDA 4NDIA 3FITA 3SPDA 3SPLA 1KPAA 5CS2A 5ED6A 4EGUA 2H39A 3N1TA 3OHEA 5IPCA 1FHIA 4ZGLA 3OJ7A 4NDHA 2Q4HA 1ZWJA 4QDEA 5I2FA 4RHNA 4NDGA 1AV5A 4XBAA 5ED3A 3OMFA 2EO4A 3SP4A 1ST0A 5IN3A 4FITA 1VLRA 5IPEA 4INCA 3IMIA 1KPBA 3BL7A 4NJZA 1KPEA 4NJXA 5I2EA 4EQEA 4INIA 4NDFA 4EQGA 3P0TA 6FITA 4EQHA 3L7XA 4QDVA 1GUPA 5IPBA 3I24A 1KPCA 1HXPA 3R6FA 3RHNA 1KPFA 3WO5A 2OIKA 3I4SA 1ST4A 3QGZA 3SZQA 4NK0A 1XMLA 2FITA 3ANOA 3BL9A 1Y23A 5BV3A 3O0MA 3LB5A 3TW2A 5RHNA 3O1XA 4ZKVA 1RZYA 4ZKLA 1GUQA 6RHNA 3O1ZA 1Z84A 4YKLB 3OXKA 1HXQA 5FITA 1XMMA 3N1SA 3BLAA 5EMTA 2Q4LA 2FHIA 1FITA 3NRDA 4NJYA 4QEBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EMS A;  3KSV A;  3O1C A;  5IPD A;  4NDI A;  3FIT A;  3SPD A;  3SPL A;  1KPA A;  5CS2 A;  5ED6 A;  4EGU A;  2H39 A;  3N1T A;  3OHE A;  5IPC A;  1FHI A;  4ZGL A;  3OJ7 A;  4NDH A;  2Q4H A;  1ZWJ A;  4QDE A;  5I2F A;  4RHN A;  4NDG A;  1AV5 A;  4XBA A;  5ED3 A;  3OMF A;  2EO4 A;  3SP4 A;  1ST0 A;  5IN3 A;  4FIT A;  1VLR A;  5IPE A;  4INC A;  3IMI A;  1KPB A;  3BL7 A;  4NJZ A;  1KPE A;  4NJX A;  5I2E A;  4EQE A;  4INI A;  4NDF A;  4EQG A;  3P0T A;  6FIT A;  4EQH A;  3L7X A;  4QDV A;  1GUP A;  5IPB A;  3I24 A;  1KPC A;  1HXP A;  3R6F A;  3RHN A;  1KPF A;  3WO5 A;  2OIK A;  3I4S A;  1ST4 A;  3QGZ A;  3SZQ A;  4NK0 A;  1XML A;  2FIT A;  3ANO A;  3BL9 A;  1Y23 A;  5BV3 A;  3O0M A;  3LB5 A;  3TW2 A;  5RHN A;  3O1X A;  4ZKV A;  1RZY A;  4ZKL A;  1GUQ A;  6RHN A;  3O1Z A;  1Z84 A;  4YKL B;  3OXK A;  1HXQ A;  5FIT A;  1XMM A;  3N1S A;  3BLA A;  5EMT A;  2Q4L A;  2FHI A;  1FIT A;  3NRD A;  4NJY A;  4QEB A; 
#chains in the Genus database with same CATH topology
 4I5W A;  1EMS A;  3KSV A;  3O1C A;  5IPD A;  4NDI A;  3FIT A;  3SPD A;  3SPL A;  2R7P A;  1KPA A;  5CS2 A;  5ED6 A;  1L9V A;  4EGU A;  2H39 A;  3N1T A;  3OHE A;  5IPC A;  1FHI A;  4ZGL A;  3OJ7 A;  4NDH A;  2Q4H A;  1ZWJ A;  4QDE A;  2POF A;  5I2F A;  4RHN A;  4NDG A;  1AV5 A;  4XBA A;  5ED3 A;  3OMF A;  2EO4 A;  3SP4 A;  4I5V A;  4G0A A;  1ST0 A;  5IN3 A;  4FIT A;  2R7J A;  1VLR A;  5IPE A;  4INC A;  3IMI A;  1KPB A;  3BL7 A;  4NJZ A;  1KPE A;  4NJX A;  5I2E A;  4EQE A;  4INI A;  4NDF A;  4EQG A;  3P0T A;  6FIT A;  2LJW A;  4EQH A;  3L7X A;  4QDV A;  1GUP A;  5IPB A;  3I24 A;  1KPC A;  1HXP A;  3R6F A;  3RHN A;  1KPF A;  2R7C A;  3WO5 A;  2OIK A;  3I4S A;  1ST4 A;  3QGZ A;  3SZQ A;  4NK0 A;  1XML A;  2FIT A;  3ANO A;  3BL9 A;  1Y23 A;  5BV3 A;  4G0J A;  3O0M A;  3LB5 A;  3TW2 A;  5RHN A;  3O1X A;  4ZKV A;  1RZY A;  4ZKL A;  1GUQ A;  6RHN A;  2R8F A;  3O1Z A;  1Z84 A;  4YKL B;  3OXK A;  1HXQ A;  5FIT A;  1XMM A;  3N1S A;  3BLA A;  5EMT A;  2Q4L A;  2FHI A;  1FIT A;  3NRD A;  2GU0 A;  4I5T A;  4NJY A;  4QEB A; 
#chains in the Genus database with same CATH homology
 1EMS A;  3KSV A;  3O1C A;  5IPD A;  4NDI A;  3FIT A;  3SPD A;  3SPL A;  1KPA A;  5CS2 A;  5ED6 A;  4EGU A;  2H39 A;  3N1T A;  3OHE A;  5IPC A;  1FHI A;  4ZGL A;  3OJ7 A;  4NDH A;  2Q4H A;  1ZWJ A;  4QDE A;  5I2F A;  4RHN A;  4NDG A;  1AV5 A;  4XBA A;  5ED3 A;  3OMF A;  2EO4 A;  3SP4 A;  1ST0 A;  5IN3 A;  4FIT A;  1VLR A;  5IPE A;  4INC A;  3IMI A;  1KPB A;  3BL7 A;  4NJZ A;  1KPE A;  4NJX A;  5I2E A;  4EQE A;  4INI A;  4NDF A;  4EQG A;  3P0T A;  6FIT A;  4EQH A;  3L7X A;  4QDV A;  1GUP A;  5IPB A;  3I24 A;  1KPC A;  1HXP A;  3R6F A;  3RHN A;  1KPF A;  3WO5 A;  2OIK A;  3I4S A;  1ST4 A;  3QGZ A;  3SZQ A;  4NK0 A;  1XML A;  2FIT A;  3ANO A;  3BL9 A;  1Y23 A;  5BV3 A;  3O0M A;  3LB5 A;  3TW2 A;  5RHN A;  3O1X A;  4ZKV A;  1RZY A;  4ZKL A;  1GUQ A;  6RHN A;  3O1Z A;  1Z84 A;  4YKL B;  3OXK A;  1HXQ A;  5FIT A;  1XMM A;  3N1S A;  3BLA A;  5EMT A;  2Q4L A;  2FHI A;  1FIT A;  3NRD A;  4NJY A;  4QEB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...