1FITA

Fhit (fragile histidine triad protein)
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
146
structure length
126
Chain Sequence
SFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDASWRSEEEMAAEAAALRVYFQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.
pubmed doi rcsb
molecule tags Chromosomal translocation
source organism Homo sapiens
molecule keywords FRAGILE HISTIDINE PROTEIN
total genus 32
structure length 126
sequence length 146
ec nomenclature ec 3.6.1.29: Bis(5'-adenosyl)-triphosphatase.
pdb deposition date 1997-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1fitA00
1RZYA 3O1CA 1KPAA 3SPLA 2FITA 4EQHA 4FITA 1GUPA 2FHIA 3BL7A 4YKLB 4INIA 3R6FA 3SPDA 4EQEA 5ED3A 1GUQA 4EGUA 3N1SA 3N1TA 1EMSA 3OJ7A 5IN3A 3O1ZA 1KPBA 3OMFA 3L7XA 1ST0A 4NJZA 4NJYA 3LB5A 2EO4A 4NDHA 3BL9A 5IPBA 3ANOA 4NJXA 3FITA 1ZWJA 1KPEA 6RHNA 1Z84A 3SZQA 3TW2A 5I2EA 5IPCA 1Y23A 3IMIA 5IPEA 5IPDA 1KPCA 4NDIA 4QDVA 4NDGA 4ZKVA 4NK0A 3P0TA 1ST4A 3BLAA 5EMTA 2H39A 1HXPA 3NRDA 1XMMA 5BV3A 4QDEA 1VLRA 3O1XA 3QGZA 5CS2A 6FITA 5ED6A 5FITA 3I4SA 3I24A 3KSVA 4INCA 1FHIA 1FITA 3OXKA 4RHNA 2Q4LA 3O0MA 4ZKLA 1KPFA 1AV5A 3SP4A 2Q4HA 5I2FA 4EQGA 3WO5A 4XBAA 5RHNA 4QEBA 1XMLA 2OIKA 1HXQA 3OHEA 3RHNA 4ZGLA 4NDFA
chains in the Genus database with same CATH superfamily
1RZYA 3O1CA 1KPAA 3SPLA 2FITA 4EQHA 4FITA 1L9VA 1GUPA 2FHIA 3BL7A 4YKLB 4INIA 3R6FA 3SPDA 4EQEA 5ED3A 1GUQA 4EGUA 2R7JA 3N1SA 3N1TA 1EMSA 3OJ7A 5IN3A 4G0JA 3O1ZA 1KPBA 3OMFA 3L7XA 1ST0A 4NJZA 4NJYA 3LB5A 2EO4A 4NDHA 3BL9A 5IPBA 2R8FA 3ANOA 4NJXA 4I5TA 3FITA 1ZWJA 1KPEA 6RHNA 1Z84A 3SZQA 2LJWA 4I5VA 3TW2A 5I2EA 5IPCA 1Y23A 3IMIA 5IPEA 5IPDA 1KPCA 4NDIA 4QDVA 4I5WA 4NDGA 4ZKVA 2R7CA 4NK0A 3P0TA 1ST4A 3BLAA 5EMTA 2H39A 1HXPA 3NRDA 2GU0A 1XMMA 5BV3A 4QDEA 1VLRA 3O1XA 3QGZA 5CS2A 6FITA 5ED6A 5FITA 3I4SA 3I24A 3KSVA 4INCA 1FHIA 1FITA 4G0AA 3OXKA 4RHNA 2R7PA 2Q4LA 3O0MA 4ZKLA 1KPFA 1AV5A 3SP4A 2Q4HA 5I2FA 4EQGA 3WO5A 4XBAA 2POFA 5RHNA 4QEBA 1XMLA 2OIKA 1HXQA 3OHEA 3RHNA 4ZGLA 4NDFA
chains in the Genus database with same CATH topology
1RZYA 3O1CA 1KPAA 3SPLA 2FITA 4EQHA 4FITA 1GUPA 2FHIA 3BL7A 4YKLB 4INIA 3R6FA 3SPDA 4EQEA 5ED3A 1GUQA 4EGUA 3N1SA 3N1TA 1EMSA 3OJ7A 5IN3A 3O1ZA 1KPBA 3OMFA 3L7XA 1ST0A 4NJZA 4NJYA 3LB5A 2EO4A 4NDHA 3BL9A 5IPBA 3ANOA 4NJXA 3FITA 1ZWJA 1KPEA 6RHNA 1Z84A 3SZQA 3TW2A 5I2EA 5IPCA 1Y23A 3IMIA 5IPEA 5IPDA 1KPCA 4NDIA 4QDVA 4NDGA 4ZKVA 4NK0A 3P0TA 1ST4A 3BLAA 5EMTA 2H39A 1HXPA 3NRDA 1XMMA 5BV3A 4QDEA 1VLRA 3O1XA 3QGZA 5CS2A 6FITA 5ED6A 5FITA 3I4SA 3I24A 3KSVA 4INCA 1FHIA 1FITA 3OXKA 4RHNA 2Q4LA 3O0MA 4ZKLA 1KPFA 1AV5A 3SP4A 2Q4HA 5I2FA 4EQGA 3WO5A 4XBAA 5RHNA 4QEBA 1XMLA 2OIKA 1HXQA 3OHEA 3RHNA 4ZGLA 4NDFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RZY A;  3O1C A;  1KPA A;  3SPL A;  2FIT A;  4EQH A;  4FIT A;  1GUP A;  2FHI A;  3BL7 A;  4YKL B;  4INI A;  3R6F A;  3SPD A;  4EQE A;  5ED3 A;  1GUQ A;  4EGU A;  3N1S A;  3N1T A;  1EMS A;  3OJ7 A;  5IN3 A;  3O1Z A;  1KPB A;  3OMF A;  3L7X A;  1ST0 A;  4NJZ A;  4NJY A;  3LB5 A;  2EO4 A;  4NDH A;  3BL9 A;  5IPB A;  3ANO A;  4NJX A;  3FIT A;  1ZWJ A;  1KPE A;  6RHN A;  1Z84 A;  3SZQ A;  3TW2 A;  5I2E A;  5IPC A;  1Y23 A;  3IMI A;  5IPE A;  5IPD A;  1KPC A;  4NDI A;  4QDV A;  4NDG A;  4ZKV A;  4NK0 A;  3P0T A;  1ST4 A;  3BLA A;  5EMT A;  2H39 A;  1HXP A;  3NRD A;  1XMM A;  5BV3 A;  4QDE A;  1VLR A;  3O1X A;  3QGZ A;  5CS2 A;  6FIT A;  5ED6 A;  5FIT A;  3I4S A;  3I24 A;  3KSV A;  4INC A;  1FHI A;  1FIT A;  3OXK A;  4RHN A;  2Q4L A;  3O0M A;  4ZKL A;  1KPF A;  1AV5 A;  3SP4 A;  2Q4H A;  5I2F A;  4EQG A;  3WO5 A;  4XBA A;  5RHN A;  4QEB A;  1XML A;  2OIK A;  1HXQ A;  3OHE A;  3RHN A;  4ZGL A;  4NDF A; 
#chains in the Genus database with same CATH topology
 1RZY A;  3O1C A;  1KPA A;  3SPL A;  2FIT A;  4EQH A;  4FIT A;  1L9V A;  1GUP A;  2FHI A;  3BL7 A;  4YKL B;  4INI A;  3R6F A;  3SPD A;  4EQE A;  5ED3 A;  1GUQ A;  4EGU A;  2R7J A;  3N1S A;  3N1T A;  1EMS A;  3OJ7 A;  5IN3 A;  4G0J A;  3O1Z A;  1KPB A;  3OMF A;  3L7X A;  1ST0 A;  4NJZ A;  4NJY A;  3LB5 A;  2EO4 A;  4NDH A;  3BL9 A;  5IPB A;  2R8F A;  3ANO A;  4NJX A;  4I5T A;  3FIT A;  1ZWJ A;  1KPE A;  6RHN A;  1Z84 A;  3SZQ A;  2LJW A;  4I5V A;  3TW2 A;  5I2E A;  5IPC A;  1Y23 A;  3IMI A;  5IPE A;  5IPD A;  1KPC A;  4NDI A;  4QDV A;  4I5W A;  4NDG A;  4ZKV A;  2R7C A;  4NK0 A;  3P0T A;  1ST4 A;  3BLA A;  5EMT A;  2H39 A;  1HXP A;  3NRD A;  2GU0 A;  1XMM A;  5BV3 A;  4QDE A;  1VLR A;  3O1X A;  3QGZ A;  5CS2 A;  6FIT A;  5ED6 A;  5FIT A;  3I4S A;  3I24 A;  3KSV A;  4INC A;  1FHI A;  1FIT A;  4G0A A;  3OXK A;  4RHN A;  2R7P A;  2Q4L A;  3O0M A;  4ZKL A;  1KPF A;  1AV5 A;  3SP4 A;  2Q4H A;  5I2F A;  4EQG A;  3WO5 A;  4XBA A;  2POF A;  5RHN A;  4QEB A;  1XML A;  2OIK A;  1HXQ A;  3OHE A;  3RHN A;  4ZGL A;  4NDF A; 
#chains in the Genus database with same CATH homology
 1RZY A;  3O1C A;  1KPA A;  3SPL A;  2FIT A;  4EQH A;  4FIT A;  1GUP A;  2FHI A;  3BL7 A;  4YKL B;  4INI A;  3R6F A;  3SPD A;  4EQE A;  5ED3 A;  1GUQ A;  4EGU A;  3N1S A;  3N1T A;  1EMS A;  3OJ7 A;  5IN3 A;  3O1Z A;  1KPB A;  3OMF A;  3L7X A;  1ST0 A;  4NJZ A;  4NJY A;  3LB5 A;  2EO4 A;  4NDH A;  3BL9 A;  5IPB A;  3ANO A;  4NJX A;  3FIT A;  1ZWJ A;  1KPE A;  6RHN A;  1Z84 A;  3SZQ A;  3TW2 A;  5I2E A;  5IPC A;  1Y23 A;  3IMI A;  5IPE A;  5IPD A;  1KPC A;  4NDI A;  4QDV A;  4NDG A;  4ZKV A;  4NK0 A;  3P0T A;  1ST4 A;  3BLA A;  5EMT A;  2H39 A;  1HXP A;  3NRD A;  1XMM A;  5BV3 A;  4QDE A;  1VLR A;  3O1X A;  3QGZ A;  5CS2 A;  6FIT A;  5ED6 A;  5FIT A;  3I4S A;  3I24 A;  3KSV A;  4INC A;  1FHI A;  1FIT A;  3OXK A;  4RHN A;  2Q4L A;  3O0M A;  4ZKL A;  1KPF A;  1AV5 A;  3SP4 A;  2Q4H A;  5I2F A;  4EQG A;  3WO5 A;  4XBA A;  5RHN A;  4QEB A;  1XML A;  2OIK A;  1HXQ A;  3OHE A;  3RHN A;  4ZGL A;  4NDF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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