1KPEA

Pkci-transition state analog
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
113
structure length
113
Chain Sequence
GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-based analysis of catalysis and substrate definition in the HIT protein family.
pubmed doi rcsb
molecule tags Protein kinase inhibitor
source organism Homo sapiens
molecule keywords PROTEIN KINASE C INTERACTING PROTEIN
total genus 27
structure length 113
sequence length 113
chains with identical sequence B
ec nomenclature
pdb deposition date 1997-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1kpeA00
4NJZA 3FITA 3O1CA 4QDEA 3O0MA 1ST0A 5RHNA 4ZGLA 1KPCA 3R6FA 1HXQA 4INCA 4EQGA 1FHIA 3OMFA 3P0TA 3QGZA 1Y23A 4ZKVA 5CS2A 4NJYA 3I24A 3SPLA 1ST4A 1XMMA 2Q4HA 6FITA 4XBAA 3BL9A 5BV3A 3SZQA 1KPFA 5EMTA 4NDFA 4ZKLA 5FITA 1EMSA 3RHNA 2EO4A 3ANOA 3WO5A 5IPDA 4RHNA 1KPAA 3SPDA 4EGUA 5I2EA 1KPBA 3I4SA 3NRDA 1AV5A 1KPEA 3L7XA 3SP4A 1VLRA 4NDHA 4QDVA 2OIKA 4NJXA 3OXKA 5ED6A 5IPCA 3O1XA 4EQEA 3BL7A 5I2FA 6RHNA 1FITA 2FITA 3BLAA 3KSVA 5IPBA 4EQHA 2FHIA 3N1TA 1XMLA 1ZWJA 1RZYA 1GUQA 4NDIA 3O1ZA 4INIA 4NDGA 5ED3A 3IMIA 3LB5A 4FITA 3OJ7A 1GUPA 1HXPA 1Z84A 3OHEA 5IPEA 2H39A 4QEBA 3N1SA 4YKLB 2Q4LA 4NK0A 5IN3A 3TW2A
chains in the Genus database with same CATH superfamily
4NJZA 3FITA 3O1CA 4QDEA 3O0MA 1ST0A 5RHNA 2POFA 4ZGLA 1KPCA 3R6FA 1HXQA 4INCA 4EQGA 1FHIA 2R7JA 3OMFA 3P0TA 3QGZA 1Y23A 4ZKVA 4I5TA 5CS2A 4NJYA 2R7PA 3I24A 3SPLA 1ST4A 1XMMA 2Q4HA 6FITA 4XBAA 3BL9A 5BV3A 3SZQA 1KPFA 5EMTA 4NDFA 4ZKLA 5FITA 1EMSA 3RHNA 2EO4A 3ANOA 3WO5A 5IPDA 4RHNA 1KPAA 3SPDA 4EGUA 5I2EA 1KPBA 3I4SA 3NRDA 1AV5A 4I5VA 1KPEA 3L7XA 3SP4A 1VLRA 4NDHA 4QDVA 2OIKA 4NJXA 4G0AA 3OXKA 5ED6A 5IPCA 3O1XA 4EQEA 3BL7A 5I2FA 4I5WA 6RHNA 1FITA 2FITA 3BLAA 2R8FA 2LJWA 3KSVA 5IPBA 4EQHA 2FHIA 4G0JA 3N1TA 1XMLA 1ZWJA 1RZYA 1GUQA 4NDIA 3O1ZA 4INIA 4NDGA 3IMIA 3LB5A 5ED3A 4FITA 3OJ7A 1GUPA 1HXPA 1Z84A 2GU0A 3OHEA 5IPEA 2H39A 1L9VA 4QEBA 3N1SA 4YKLB 2Q4LA 4NK0A 5IN3A 2R7CA 3TW2A
chains in the Genus database with same CATH topology
4NJZA 3FITA 3O1CA 4QDEA 3O0MA 1ST0A 5RHNA 4ZGLA 1KPCA 3R6FA 1HXQA 4INCA 4EQGA 1FHIA 3OMFA 3P0TA 3QGZA 1Y23A 4ZKVA 5CS2A 4NJYA 3I24A 3SPLA 1ST4A 1XMMA 2Q4HA 6FITA 4XBAA 3BL9A 5BV3A 3SZQA 1KPFA 5EMTA 4NDFA 4ZKLA 5FITA 1EMSA 3RHNA 2EO4A 3ANOA 3WO5A 5IPDA 4RHNA 1KPAA 3SPDA 4EGUA 5I2EA 1KPBA 3I4SA 3NRDA 1AV5A 1KPEA 3L7XA 3SP4A 1VLRA 4NDHA 4QDVA 2OIKA 4NJXA 3OXKA 5ED6A 5IPCA 3O1XA 4EQEA 3BL7A 5I2FA 6RHNA 1FITA 2FITA 3BLAA 3KSVA 5IPBA 4EQHA 2FHIA 3N1TA 1XMLA 1ZWJA 1RZYA 1GUQA 4NDIA 3O1ZA 4INIA 4NDGA 5ED3A 3IMIA 3LB5A 4FITA 3OJ7A 1GUPA 1HXPA 1Z84A 3OHEA 5IPEA 2H39A 4QEBA 3N1SA 4YKLB 2Q4LA 4NK0A 5IN3A 3TW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NJZ A;  3FIT A;  3O1C A;  4QDE A;  3O0M A;  1ST0 A;  5RHN A;  4ZGL A;  1KPC A;  3R6F A;  1HXQ A;  4INC A;  4EQG A;  1FHI A;  3OMF A;  3P0T A;  3QGZ A;  1Y23 A;  4ZKV A;  5CS2 A;  4NJY A;  3I24 A;  3SPL A;  1ST4 A;  1XMM A;  2Q4H A;  6FIT A;  4XBA A;  3BL9 A;  5BV3 A;  3SZQ A;  1KPF A;  5EMT A;  4NDF A;  4ZKL A;  5FIT A;  1EMS A;  3RHN A;  2EO4 A;  3ANO A;  3WO5 A;  5IPD A;  4RHN A;  1KPA A;  3SPD A;  4EGU A;  5I2E A;  1KPB A;  3I4S A;  3NRD A;  1AV5 A;  1KPE A;  3L7X A;  3SP4 A;  1VLR A;  4NDH A;  4QDV A;  2OIK A;  4NJX A;  3OXK A;  5ED6 A;  5IPC A;  3O1X A;  4EQE A;  3BL7 A;  5I2F A;  6RHN A;  1FIT A;  2FIT A;  3BLA A;  3KSV A;  5IPB A;  4EQH A;  2FHI A;  3N1T A;  1XML A;  1ZWJ A;  1RZY A;  1GUQ A;  4NDI A;  3O1Z A;  4INI A;  4NDG A;  5ED3 A;  3IMI A;  3LB5 A;  4FIT A;  3OJ7 A;  1GUP A;  1HXP A;  1Z84 A;  3OHE A;  5IPE A;  2H39 A;  4QEB A;  3N1S A;  4YKL B;  2Q4L A;  4NK0 A;  5IN3 A;  3TW2 A; 
#chains in the Genus database with same CATH topology
 4NJZ A;  3FIT A;  3O1C A;  4QDE A;  3O0M A;  1ST0 A;  5RHN A;  2POF A;  4ZGL A;  1KPC A;  3R6F A;  1HXQ A;  4INC A;  4EQG A;  1FHI A;  2R7J A;  3OMF A;  3P0T A;  3QGZ A;  1Y23 A;  4ZKV A;  4I5T A;  5CS2 A;  4NJY A;  2R7P A;  3I24 A;  3SPL A;  1ST4 A;  1XMM A;  2Q4H A;  6FIT A;  4XBA A;  3BL9 A;  5BV3 A;  3SZQ A;  1KPF A;  5EMT A;  4NDF A;  4ZKL A;  5FIT A;  1EMS A;  3RHN A;  2EO4 A;  3ANO A;  3WO5 A;  5IPD A;  4RHN A;  1KPA A;  3SPD A;  4EGU A;  5I2E A;  1KPB A;  3I4S A;  3NRD A;  1AV5 A;  4I5V A;  1KPE A;  3L7X A;  3SP4 A;  1VLR A;  4NDH A;  4QDV A;  2OIK A;  4NJX A;  4G0A A;  3OXK A;  5ED6 A;  5IPC A;  3O1X A;  4EQE A;  3BL7 A;  5I2F A;  4I5W A;  6RHN A;  1FIT A;  2FIT A;  3BLA A;  2R8F A;  2LJW A;  3KSV A;  5IPB A;  4EQH A;  2FHI A;  4G0J A;  3N1T A;  1XML A;  1ZWJ A;  1RZY A;  1GUQ A;  4NDI A;  3O1Z A;  4INI A;  4NDG A;  3IMI A;  3LB5 A;  5ED3 A;  4FIT A;  3OJ7 A;  1GUP A;  1HXP A;  1Z84 A;  2GU0 A;  3OHE A;  5IPE A;  2H39 A;  1L9V A;  4QEB A;  3N1S A;  4YKL B;  2Q4L A;  4NK0 A;  5IN3 A;  2R7C A;  3TW2 A; 
#chains in the Genus database with same CATH homology
 4NJZ A;  3FIT A;  3O1C A;  4QDE A;  3O0M A;  1ST0 A;  5RHN A;  4ZGL A;  1KPC A;  3R6F A;  1HXQ A;  4INC A;  4EQG A;  1FHI A;  3OMF A;  3P0T A;  3QGZ A;  1Y23 A;  4ZKV A;  5CS2 A;  4NJY A;  3I24 A;  3SPL A;  1ST4 A;  1XMM A;  2Q4H A;  6FIT A;  4XBA A;  3BL9 A;  5BV3 A;  3SZQ A;  1KPF A;  5EMT A;  4NDF A;  4ZKL A;  5FIT A;  1EMS A;  3RHN A;  2EO4 A;  3ANO A;  3WO5 A;  5IPD A;  4RHN A;  1KPA A;  3SPD A;  4EGU A;  5I2E A;  1KPB A;  3I4S A;  3NRD A;  1AV5 A;  1KPE A;  3L7X A;  3SP4 A;  1VLR A;  4NDH A;  4QDV A;  2OIK A;  4NJX A;  3OXK A;  5ED6 A;  5IPC A;  3O1X A;  4EQE A;  3BL7 A;  5I2F A;  6RHN A;  1FIT A;  2FIT A;  3BLA A;  3KSV A;  5IPB A;  4EQH A;  2FHI A;  3N1T A;  1XML A;  1ZWJ A;  1RZY A;  1GUQ A;  4NDI A;  3O1Z A;  4INI A;  4NDG A;  5ED3 A;  3IMI A;  3LB5 A;  4FIT A;  3OJ7 A;  1GUP A;  1HXP A;  1Z84 A;  3OHE A;  5IPE A;  2H39 A;  4QEB A;  3N1S A;  4YKL B;  2Q4L A;  4NK0 A;  5IN3 A;  3TW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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