2FHIA

Substrate analog (ib2) complex with the his 96 asn substitution of the fragile histidine triad protein, fhit
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
146
structure length
124
Chain Sequence
SFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVNVHVLPRKAGDWRSEEEMAAEAAALRVYFQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
pubmed doi rcsb
molecule tags Nucleotide-binding protein
source organism Homo sapiens
molecule keywords FRAGILE HISTIDINE TRIAD PROTEIN
total genus 32
structure length 124
sequence length 146
ec nomenclature ec 3.6.1.29: Bis(5'-adenosyl)-triphosphatase.
pdb deposition date 1998-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 2fhiA00
4INCA 3RHNA 5I2FA 1FHIA 5IPEA 1AV5A 3OHEA 6RHNA 3SP4A 5IPDA 3I24A 1FITA 3OMFA 1ST4A 3O0MA 3BL9A 4FITA 5FITA 1GUPA 3QGZA 4NDFA 5IPCA 4ZGLA 4EQHA 2Q4HA 1KPFA 1HXPA 1HXQA 5IN3A 1XMMA 4NDHA 1ZWJA 1Z84A 3O1CA 1KPCA 1GUQA 3P0TA 3N1SA 4EGUA 3KSVA 3O1ZA 2Q4LA 2H39A 2FHIA 5BV3A 2FITA 3I4SA 5EMTA 3SPLA 4NJYA 4NJXA 5ED6A 1KPAA 3L7XA 6FITA 5IPBA 3LB5A 3WO5A 1KPBA 4EQGA 4ZKVA 1Y23A 4XBAA 5CS2A 5I2EA 3SZQA 3SPDA 4RHNA 4NJZA 4NDGA 1EMSA 4INIA 1KPEA 4QDEA 4ZKLA 3N1TA 3NRDA 3BLAA 1VLRA 3R6FA 3TW2A 3BL7A 1RZYA 2OIKA 3OXKA 4QEBA 3FITA 5ED3A 4EQEA 3ANOA 3IMIA 4NK0A 5RHNA 3OJ7A 1XMLA 4NDIA 1ST0A 2EO4A 4QDVA 4YKLB 3O1XA
chains in the Genus database with same CATH superfamily
4INCA 3RHNA 5I2FA 1FHIA 5IPEA 4G0JA 1AV5A 2R7CA 3OHEA 6RHNA 3SP4A 2R8FA 5IPDA 3I24A 1FITA 3OMFA 1ST4A 3O0MA 3BL9A 2GU0A 4FITA 5FITA 1GUPA 3QGZA 4NDFA 5IPCA 4ZGLA 4EQHA 2Q4HA 1KPFA 1HXPA 1HXQA 5IN3A 4I5VA 1XMMA 4NDHA 1ZWJA 1Z84A 3O1CA 2R7PA 1KPCA 1GUQA 3P0TA 3N1SA 4EGUA 3KSVA 3O1ZA 2Q4LA 2H39A 2FHIA 5BV3A 2FITA 3I4SA 5EMTA 3SPLA 2R7JA 4NJYA 1L9VA 2POFA 4G0AA 4NJXA 2LJWA 5ED6A 1KPAA 3L7XA 6FITA 5IPBA 3LB5A 3WO5A 1KPBA 4EQGA 4ZKVA 1Y23A 4XBAA 5CS2A 5I2EA 3SZQA 3SPDA 4RHNA 4NJZA 4NDGA 1EMSA 4INIA 1KPEA 4I5WA 4QDEA 4ZKLA 3N1TA 3NRDA 3BLAA 1VLRA 3R6FA 3TW2A 3BL7A 1RZYA 2OIKA 3OXKA 4QEBA 3FITA 5ED3A 4EQEA 3ANOA 3IMIA 4NK0A 5RHNA 3OJ7A 1XMLA 4NDIA 1ST0A 2EO4A 4I5TA 4QDVA 4YKLB 3O1XA
chains in the Genus database with same CATH topology
4INCA 3RHNA 5I2FA 1FHIA 5IPEA 1AV5A 3OHEA 6RHNA 3SP4A 5IPDA 3I24A 1FITA 3OMFA 1ST4A 3O0MA 3BL9A 4FITA 5FITA 1GUPA 3QGZA 4NDFA 5IPCA 4ZGLA 4EQHA 2Q4HA 1KPFA 1HXPA 1HXQA 5IN3A 1XMMA 4NDHA 1ZWJA 1Z84A 3O1CA 1KPCA 1GUQA 3P0TA 3N1SA 4EGUA 3KSVA 3O1ZA 2Q4LA 2H39A 2FHIA 5BV3A 2FITA 3I4SA 5EMTA 3SPLA 4NJYA 4NJXA 5ED6A 1KPAA 3L7XA 6FITA 5IPBA 3LB5A 3WO5A 1KPBA 4EQGA 4ZKVA 1Y23A 4XBAA 5CS2A 5I2EA 3SZQA 3SPDA 4RHNA 4NJZA 4NDGA 1EMSA 4INIA 1KPEA 4QDEA 4ZKLA 3N1TA 3NRDA 3BLAA 1VLRA 3R6FA 3TW2A 3BL7A 1RZYA 2OIKA 3OXKA 4QEBA 3FITA 5ED3A 4EQEA 3ANOA 3IMIA 4NK0A 5RHNA 3OJ7A 1XMLA 4NDIA 1ST0A 2EO4A 4QDVA 4YKLB 3O1XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4INC A;  3RHN A;  5I2F A;  1FHI A;  5IPE A;  1AV5 A;  3OHE A;  6RHN A;  3SP4 A;  5IPD A;  3I24 A;  1FIT A;  3OMF A;  1ST4 A;  3O0M A;  3BL9 A;  4FIT A;  5FIT A;  1GUP A;  3QGZ A;  4NDF A;  5IPC A;  4ZGL A;  4EQH A;  2Q4H A;  1KPF A;  1HXP A;  1HXQ A;  5IN3 A;  1XMM A;  4NDH A;  1ZWJ A;  1Z84 A;  3O1C A;  1KPC A;  1GUQ A;  3P0T A;  3N1S A;  4EGU A;  3KSV A;  3O1Z A;  2Q4L A;  2H39 A;  2FHI A;  5BV3 A;  2FIT A;  3I4S A;  5EMT A;  3SPL A;  4NJY A;  4NJX A;  5ED6 A;  1KPA A;  3L7X A;  6FIT A;  5IPB A;  3LB5 A;  3WO5 A;  1KPB A;  4EQG A;  4ZKV A;  1Y23 A;  4XBA A;  5CS2 A;  5I2E A;  3SZQ A;  3SPD A;  4RHN A;  4NJZ A;  4NDG A;  1EMS A;  4INI A;  1KPE A;  4QDE A;  4ZKL A;  3N1T A;  3NRD A;  3BLA A;  1VLR A;  3R6F A;  3TW2 A;  3BL7 A;  1RZY A;  2OIK A;  3OXK A;  4QEB A;  3FIT A;  5ED3 A;  4EQE A;  3ANO A;  3IMI A;  4NK0 A;  5RHN A;  3OJ7 A;  1XML A;  4NDI A;  1ST0 A;  2EO4 A;  4QDV A;  4YKL B;  3O1X A; 
#chains in the Genus database with same CATH topology
 4INC A;  3RHN A;  5I2F A;  1FHI A;  5IPE A;  4G0J A;  1AV5 A;  2R7C A;  3OHE A;  6RHN A;  3SP4 A;  2R8F A;  5IPD A;  3I24 A;  1FIT A;  3OMF A;  1ST4 A;  3O0M A;  3BL9 A;  2GU0 A;  4FIT A;  5FIT A;  1GUP A;  3QGZ A;  4NDF A;  5IPC A;  4ZGL A;  4EQH A;  2Q4H A;  1KPF A;  1HXP A;  1HXQ A;  5IN3 A;  4I5V A;  1XMM A;  4NDH A;  1ZWJ A;  1Z84 A;  3O1C A;  2R7P A;  1KPC A;  1GUQ A;  3P0T A;  3N1S A;  4EGU A;  3KSV A;  3O1Z A;  2Q4L A;  2H39 A;  2FHI A;  5BV3 A;  2FIT A;  3I4S A;  5EMT A;  3SPL A;  2R7J A;  4NJY A;  1L9V A;  2POF A;  4G0A A;  4NJX A;  2LJW A;  5ED6 A;  1KPA A;  3L7X A;  6FIT A;  5IPB A;  3LB5 A;  3WO5 A;  1KPB A;  4EQG A;  4ZKV A;  1Y23 A;  4XBA A;  5CS2 A;  5I2E A;  3SZQ A;  3SPD A;  4RHN A;  4NJZ A;  4NDG A;  1EMS A;  4INI A;  1KPE A;  4I5W A;  4QDE A;  4ZKL A;  3N1T A;  3NRD A;  3BLA A;  1VLR A;  3R6F A;  3TW2 A;  3BL7 A;  1RZY A;  2OIK A;  3OXK A;  4QEB A;  3FIT A;  5ED3 A;  4EQE A;  3ANO A;  3IMI A;  4NK0 A;  5RHN A;  3OJ7 A;  1XML A;  4NDI A;  1ST0 A;  2EO4 A;  4I5T A;  4QDV A;  4YKL B;  3O1X A; 
#chains in the Genus database with same CATH homology
 4INC A;  3RHN A;  5I2F A;  1FHI A;  5IPE A;  1AV5 A;  3OHE A;  6RHN A;  3SP4 A;  5IPD A;  3I24 A;  1FIT A;  3OMF A;  1ST4 A;  3O0M A;  3BL9 A;  4FIT A;  5FIT A;  1GUP A;  3QGZ A;  4NDF A;  5IPC A;  4ZGL A;  4EQH A;  2Q4H A;  1KPF A;  1HXP A;  1HXQ A;  5IN3 A;  1XMM A;  4NDH A;  1ZWJ A;  1Z84 A;  3O1C A;  1KPC A;  1GUQ A;  3P0T A;  3N1S A;  4EGU A;  3KSV A;  3O1Z A;  2Q4L A;  2H39 A;  2FHI A;  5BV3 A;  2FIT A;  3I4S A;  5EMT A;  3SPL A;  4NJY A;  4NJX A;  5ED6 A;  1KPA A;  3L7X A;  6FIT A;  5IPB A;  3LB5 A;  3WO5 A;  1KPB A;  4EQG A;  4ZKV A;  1Y23 A;  4XBA A;  5CS2 A;  5I2E A;  3SZQ A;  3SPD A;  4RHN A;  4NJZ A;  4NDG A;  1EMS A;  4INI A;  1KPE A;  4QDE A;  4ZKL A;  3N1T A;  3NRD A;  3BLA A;  1VLR A;  3R6F A;  3TW2 A;  3BL7 A;  1RZY A;  2OIK A;  3OXK A;  4QEB A;  3FIT A;  5ED3 A;  4EQE A;  3ANO A;  3IMI A;  4NK0 A;  5RHN A;  3OJ7 A;  1XML A;  4NDI A;  1ST0 A;  2EO4 A;  4QDV A;  4YKL B;  3O1X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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