2FHIA

Substrate analog (ib2) complex with the his 96 asn substitution of the fragile histidine triad protein, fhit
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
146
structure length
124
Chain Sequence
SFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVNVHVLPRKAGDWRSEEEMAAEAAALRVYFQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Nucleotide-binding protein
source organism Homo sapiens
publication title Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
pubmed doi rcsb
molecule keywords FRAGILE HISTIDINE TRIAD PROTEIN
total genus 32
structure length 124
sequence length 146
ec nomenclature ec 3.6.1.29: Bis(5'-adenosyl)-triphosphatase.
pdb deposition date 1998-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 2fhiA00
1ZWJA 3ANOA 3FITA 3NRDA 3OJ7A 1RZYA 3OHEA 5BV3A 4INCA 4QDEA 1KPBA 1XMLA 5CS2A 1KPCA 5FITA 5IPDA 4NJYA 1Y23A 3WO5A 3SPLA 3KSVA 1FITA 4EQEA 3SPDA 2FHIA 1HXQA 4EQHA 3SZQA 3OXKA 3P0TA 3O1CA 2FITA 4INIA 4EQGA 6FITA 3IMIA 3RHNA 5IPCA 1GUPA 5RHNA 4XBAA 4NDGA 1GUQA 4ZGLA 5ED6A 4EGUA 1Z84A 3SP4A 3R6FA 6RHNA 4NJXA 3O1ZA 5I2FA 4QDVA 4NK0A 4ZKVA 4YKLB 1KPFA 3O1XA 4NJZA 1XMMA 4NDFA 2OIKA 2Q4HA 4NDHA 3BL9A 1KPAA 3TW2A 5I2EA 3I24A 3LB5A 2EO4A 2H39A 3OMFA 3I4SA 1AV5A 4FITA 4RHNA 1FHIA 3QGZA 5IN3A 3N1TA 4QEBA 4NDIA 4ZKLA 1VLRA 5EMTA 2Q4LA 1KPEA 3L7XA 5ED3A 1HXPA 1ST0A 3N1SA 1EMSA 5IPBA 5IPEA 3BLAA 3O0MA 1ST4A 3BL7A
chains in the Genus database with same CATH superfamily
1ZWJA 3ANOA 3FITA 3NRDA 2R8FA 3OJ7A 1RZYA 3OHEA 5BV3A 4INCA 4QDEA 1KPBA 1XMLA 5CS2A 1KPCA 5FITA 5IPDA 4NJYA 1Y23A 3WO5A 4G0JA 3SPLA 3KSVA 1FITA 2LJWA 4EQEA 3SPDA 2FHIA 1HXQA 4EQHA 3SZQA 3OXKA 3P0TA 2GU0A 2POFA 3O1CA 2R7CA 2FITA 4INIA 4EQGA 6FITA 3IMIA 3RHNA 5IPCA 1GUPA 5RHNA 4XBAA 4NDGA 1GUQA 4ZGLA 5ED6A 2R7JA 4I5VA 4G0AA 4EGUA 1Z84A 3SP4A 3R6FA 2R7PA 6RHNA 4NJXA 3O1ZA 5I2FA 4QDVA 4NK0A 4ZKVA 4YKLB 1KPFA 3O1XA 4NJZA 1XMMA 4NDFA 2OIKA 2Q4HA 4NDHA 3BL9A 1KPAA 3TW2A 5I2EA 3I24A 3LB5A 2EO4A 2H39A 4I5WA 3OMFA 3I4SA 1AV5A 4FITA 4RHNA 1FHIA 3QGZA 4I5TA 5IN3A 3N1TA 4QEBA 4NDIA 4ZKLA 1VLRA 5EMTA 2Q4LA 1KPEA 3L7XA 5ED3A 1HXPA 1ST0A 3N1SA 1EMSA 5IPBA 5IPEA 3BLAA 3O0MA 1L9VA 1ST4A 3BL7A
chains in the Genus database with same CATH topology
1ZWJA 3ANOA 3FITA 3NRDA 3OJ7A 1RZYA 3OHEA 5BV3A 4INCA 4QDEA 1KPBA 1XMLA 5CS2A 1KPCA 5FITA 5IPDA 4NJYA 1Y23A 3WO5A 3SPLA 3KSVA 1FITA 4EQEA 3SPDA 2FHIA 1HXQA 4EQHA 3SZQA 3OXKA 3P0TA 3O1CA 2FITA 4INIA 4EQGA 6FITA 3IMIA 3RHNA 5IPCA 1GUPA 5RHNA 4XBAA 4NDGA 1GUQA 4ZGLA 5ED6A 4EGUA 1Z84A 3SP4A 3R6FA 6RHNA 4NJXA 3O1ZA 5I2FA 4QDVA 4NK0A 4ZKVA 4YKLB 1KPFA 3O1XA 4NJZA 1XMMA 4NDFA 2OIKA 2Q4HA 4NDHA 3BL9A 1KPAA 3TW2A 5I2EA 3I24A 3LB5A 2EO4A 2H39A 3OMFA 3I4SA 1AV5A 4FITA 4RHNA 1FHIA 3QGZA 5IN3A 3N1TA 4QEBA 4NDIA 4ZKLA 1VLRA 5EMTA 2Q4LA 1KPEA 3L7XA 5ED3A 1HXPA 1ST0A 3N1SA 1EMSA 5IPBA 5IPEA 3BLAA 3O0MA 1ST4A 3BL7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZWJ A;  3ANO A;  3FIT A;  3NRD A;  3OJ7 A;  1RZY A;  3OHE A;  5BV3 A;  4INC A;  4QDE A;  1KPB A;  1XML A;  5CS2 A;  1KPC A;  5FIT A;  5IPD A;  4NJY A;  1Y23 A;  3WO5 A;  3SPL A;  3KSV A;  1FIT A;  4EQE A;  3SPD A;  2FHI A;  1HXQ A;  4EQH A;  3SZQ A;  3OXK A;  3P0T A;  3O1C A;  2FIT A;  4INI A;  4EQG A;  6FIT A;  3IMI A;  3RHN A;  5IPC A;  1GUP A;  5RHN A;  4XBA A;  4NDG A;  1GUQ A;  4ZGL A;  5ED6 A;  4EGU A;  1Z84 A;  3SP4 A;  3R6F A;  6RHN A;  4NJX A;  3O1Z A;  5I2F A;  4QDV A;  4NK0 A;  4ZKV A;  4YKL B;  1KPF A;  3O1X A;  4NJZ A;  1XMM A;  4NDF A;  2OIK A;  2Q4H A;  4NDH A;  3BL9 A;  1KPA A;  3TW2 A;  5I2E A;  3I24 A;  3LB5 A;  2EO4 A;  2H39 A;  3OMF A;  3I4S A;  1AV5 A;  4FIT A;  4RHN A;  1FHI A;  3QGZ A;  5IN3 A;  3N1T A;  4QEB A;  4NDI A;  4ZKL A;  1VLR A;  5EMT A;  2Q4L A;  1KPE A;  3L7X A;  5ED3 A;  1HXP A;  1ST0 A;  3N1S A;  1EMS A;  5IPB A;  5IPE A;  3BLA A;  3O0M A;  1ST4 A;  3BL7 A; 
#chains in the Genus database with same CATH topology
 1ZWJ A;  3ANO A;  3FIT A;  3NRD A;  2R8F A;  3OJ7 A;  1RZY A;  3OHE A;  5BV3 A;  4INC A;  4QDE A;  1KPB A;  1XML A;  5CS2 A;  1KPC A;  5FIT A;  5IPD A;  4NJY A;  1Y23 A;  3WO5 A;  4G0J A;  3SPL A;  3KSV A;  1FIT A;  2LJW A;  4EQE A;  3SPD A;  2FHI A;  1HXQ A;  4EQH A;  3SZQ A;  3OXK A;  3P0T A;  2GU0 A;  2POF A;  3O1C A;  2R7C A;  2FIT A;  4INI A;  4EQG A;  6FIT A;  3IMI A;  3RHN A;  5IPC A;  1GUP A;  5RHN A;  4XBA A;  4NDG A;  1GUQ A;  4ZGL A;  5ED6 A;  2R7J A;  4I5V A;  4G0A A;  4EGU A;  1Z84 A;  3SP4 A;  3R6F A;  2R7P A;  6RHN A;  4NJX A;  3O1Z A;  5I2F A;  4QDV A;  4NK0 A;  4ZKV A;  4YKL B;  1KPF A;  3O1X A;  4NJZ A;  1XMM A;  4NDF A;  2OIK A;  2Q4H A;  4NDH A;  3BL9 A;  1KPA A;  3TW2 A;  5I2E A;  3I24 A;  3LB5 A;  2EO4 A;  2H39 A;  4I5W A;  3OMF A;  3I4S A;  1AV5 A;  4FIT A;  4RHN A;  1FHI A;  3QGZ A;  4I5T A;  5IN3 A;  3N1T A;  4QEB A;  4NDI A;  4ZKL A;  1VLR A;  5EMT A;  2Q4L A;  1KPE A;  3L7X A;  5ED3 A;  1HXP A;  1ST0 A;  3N1S A;  1EMS A;  5IPB A;  5IPE A;  3BLA A;  3O0M A;  1L9V A;  1ST4 A;  3BL7 A; 
#chains in the Genus database with same CATH homology
 1ZWJ A;  3ANO A;  3FIT A;  3NRD A;  3OJ7 A;  1RZY A;  3OHE A;  5BV3 A;  4INC A;  4QDE A;  1KPB A;  1XML A;  5CS2 A;  1KPC A;  5FIT A;  5IPD A;  4NJY A;  1Y23 A;  3WO5 A;  3SPL A;  3KSV A;  1FIT A;  4EQE A;  3SPD A;  2FHI A;  1HXQ A;  4EQH A;  3SZQ A;  3OXK A;  3P0T A;  3O1C A;  2FIT A;  4INI A;  4EQG A;  6FIT A;  3IMI A;  3RHN A;  5IPC A;  1GUP A;  5RHN A;  4XBA A;  4NDG A;  1GUQ A;  4ZGL A;  5ED6 A;  4EGU A;  1Z84 A;  3SP4 A;  3R6F A;  6RHN A;  4NJX A;  3O1Z A;  5I2F A;  4QDV A;  4NK0 A;  4ZKV A;  4YKL B;  1KPF A;  3O1X A;  4NJZ A;  1XMM A;  4NDF A;  2OIK A;  2Q4H A;  4NDH A;  3BL9 A;  1KPA A;  3TW2 A;  5I2E A;  3I24 A;  3LB5 A;  2EO4 A;  2H39 A;  3OMF A;  3I4S A;  1AV5 A;  4FIT A;  4RHN A;  1FHI A;  3QGZ A;  5IN3 A;  3N1T A;  4QEB A;  4NDI A;  4ZKL A;  1VLR A;  5EMT A;  2Q4L A;  1KPE A;  3L7X A;  5ED3 A;  1HXP A;  1ST0 A;  3N1S A;  1EMS A;  5IPB A;  5IPE A;  3BLA A;  3O0M A;  1ST4 A;  3BL7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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