3QD6R

Crystal structure of the cd40 and cd154 (cd40l) complex
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
120
structure length
114
Chain Sequence
CREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCKQIATGVSDTICEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation
pubmed doi rcsb
molecule tags Cytokine/cytokine receptor
source organism Homo sapiens
molecule keywords CD40 ligand
total genus 14
structure length 114
sequence length 120
chains with identical sequence S, T, U
ec nomenclature
pdb deposition date 2011-01-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 3qd6R01
3.10.360.30 Alpha Beta Roll Antimicrobial Peptide, Beta-defensin 2; Chain A Antimicrobial Peptide, Beta-defensin 2; Chain A 3qd6R02
2HEYR 5DMJA 1D4VA 3ME2R 2X10A 4I9XC 3K51B 4BK5A 4E4DR 3QBQB 4FHQA 3U3VA 3QD6R 1JMAB 4OD2S 3WVTA 4MXWR 5BNQR 3TJEF 3QO4A 1TNRR 3URFZ 4RSUD 4J6GC 4KGQC 1EXTA 5L36B 3ME4A 4GIQR 1D0GR 1NCFA 5CIRE 1SG1X 4M4RA 3BUKC 1ZA3R 4N90R 3X3FA 3MI8D 4MSVB 2HEVR 3U3PA 1DU3A 3MHDD 2UWIA 3U3TA 3U3SA 3ALQR 4M4PA 3THMF 2AW2B 2H9GR 3FL7A 3IJ2X 4YN0A 4BK4A 5IHLA 4KGGC 3MBWA 1FT4A 3U3QA
chains in the Genus database with same CATH superfamily
2HEYR 5DMJA 2E4VA 1D4VA 3ME2R 2X10A 4I9XC 1FD3A 3K51B 2E4WA 4BK5A 2MJKA 4E4DR 3QBQB 4FHQA 3U3VA 3QD6R 1JMAB 4OD2S 3WVTA 4MXWR 5BNQR 2LXOA 3TJEF 3QO4A 2E4YA 1TNRR 3URFZ 4RSUD 4J6GC 4KGQC 1KJ6A 1EXTA 5L36B 3ME4A 4GIQR 2QR6A 1D0GR 1NCFA 5CIRE 1SG1X 4M4RA 3BUKC 1FD4A 1ZA3R 4N90R 3X3FA 1FQQA 3MI8D 4MSVB 2HEVR 3U3PA 1DU3A 2E4XA 3MHDD 2UWIA 3U3TA 3U3SA 3ALQR 4M4PA 3THMF 2LWLA 2AW2B 2H9GR 3FL7A 3IJ2X 2E4UA 4YN0A 4BK4A 4KGGC 5IHLA 3MBWA 1FT4A 3U3QA
chains in the Genus database with same CATH topology
2HEYR 5DMJA 1D4VA 3ME2R 2X10A 4I9XC 1FD3A 3K51B 4BK5A 2MJKA 4E4DR 3QBQB 4FHQA 3U3VA 3QD6R 1JMAB 4OD2S 3WVTA 4MXWR 5BNQR 2LXOA 3TJEF 3QO4A 1TNRR 3URFZ 4RSUD 4J6GC 4KGQC 1KJ6A 1EXTA 5L36B 3ME4A 4GIQR 1D0GR 1NCFA 5CIRE 1SG1X 4M4RA 3BUKC 1ZA3R 4N90R 3X3FA 1FQQA 3MI8D 4MSVB 2HEVR 3U3PA 1DU3A 3MHDD 2UWIA 3U3TA 3U3SA 3ALQR 4M4PA 3THMF 2LWLA 2AW2B 2H9GR 3FL7A 3IJ2X 4YN0A 4BK4A 5IHLA 4KGGC 1FD4A 3MBWA 1FT4A 3U3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HEY R;  5DMJ A;  1D4V A;  3ME2 R;  2X10 A;  4I9X C;  3K51 B;  4BK5 A;  4E4D R;  3QBQ B;  4FHQ A;  3U3V A;  3QD6 R;  1JMA B;  4OD2 S;  3WVT A;  4MXW R;  5BNQ R;  3TJE F;  3QO4 A;  1TNR R;  3URF Z;  4RSU D;  4J6G C;  4KGQ C;  1EXT A;  5L36 B;  3ME4 A;  4GIQ R;  1D0G R;  1NCF A;  5CIR E;  1SG1 X;  4M4R A;  3BUK C;  1ZA3 R;  4N90 R;  3X3F A;  3MI8 D;  4MSV B;  2HEV R;  3U3P A;  1DU3 A;  3MHD D;  2UWI A;  3U3T A;  3U3S A;  3ALQ R;  4M4P A;  3THM F;  2AW2 B;  2H9G R;  3FL7 A;  3IJ2 X;  4YN0 A;  4BK4 A;  5IHL A;  4KGG C;  3MBW A;  1FT4 A;  3U3Q A; 
#chains in the Genus database with same CATH topology
 2HEY R;  5DMJ A;  2E4V A;  1D4V A;  3ME2 R;  2X10 A;  4I9X C;  1FD3 A;  3K51 B;  2E4W A;  4BK5 A;  2MJK A;  4E4D R;  3QBQ B;  4FHQ A;  3U3V A;  3QD6 R;  1JMA B;  4OD2 S;  3WVT A;  4MXW R;  5BNQ R;  2LXO A;  3TJE F;  3QO4 A;  2E4Y A;  1TNR R;  3URF Z;  4RSU D;  4J6G C;  4KGQ C;  1KJ6 A;  1EXT A;  5L36 B;  3ME4 A;  4GIQ R;  2QR6 A;  1D0G R;  1NCF A;  5CIR E;  1SG1 X;  4M4R A;  3BUK C;  1FD4 A;  1ZA3 R;  4N90 R;  3X3F A;  1FQQ A;  3MI8 D;  4MSV B;  2HEV R;  3U3P A;  1DU3 A;  2E4X A;  3MHD D;  2UWI A;  3U3T A;  3U3S A;  3ALQ R;  4M4P A;  3THM F;  2LWL A;  2AW2 B;  2H9G R;  3FL7 A;  3IJ2 X;  2E4U A;  4YN0 A;  4BK4 A;  4KGG C;  5IHL A;  3MBW A;  1FT4 A;  3U3Q A; 
#chains in the Genus database with same CATH homology
 2HEY R;  5DMJ A;  1D4V A;  3ME2 R;  2X10 A;  4I9X C;  1FD3 A;  3K51 B;  4BK5 A;  2MJK A;  4E4D R;  3QBQ B;  4FHQ A;  3U3V A;  3QD6 R;  1JMA B;  4OD2 S;  3WVT A;  4MXW R;  5BNQ R;  2LXO A;  3TJE F;  3QO4 A;  1TNR R;  3URF Z;  4RSU D;  4J6G C;  4KGQ C;  1KJ6 A;  1EXT A;  5L36 B;  3ME4 A;  4GIQ R;  1D0G R;  1NCF A;  5CIR E;  1SG1 X;  4M4R A;  3BUK C;  1ZA3 R;  4N90 R;  3X3F A;  1FQQ A;  3MI8 D;  4MSV B;  2HEV R;  3U3P A;  1DU3 A;  3MHD D;  2UWI A;  3U3T A;  3U3S A;  3ALQ R;  4M4P A;  3THM F;  2LWL A;  2AW2 B;  2H9G R;  3FL7 A;  3IJ2 X;  4YN0 A;  4BK4 A;  5IHL A;  4KGG C;  1FD4 A;  3MBW A;  1FT4 A;  3U3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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