4NDFA

Human aprataxin (aptx) bound to rna-dna, amp, and zn - product complex
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
180
structure length
180
Chain Sequence
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
pubmed doi rcsb
molecule tags Dna binding protein/rna/dna
source organism Homo sapiens
molecule keywords Aprataxin
total genus 55
structure length 180
sequence length 180
chains with identical sequence B
ec nomenclature ec 3.1.11.7: Adenosine-5'-diphospho-5'-(DNA) diphosphatase.
pdb deposition date 2013-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF11969 DcpS_C Scavenger mRNA decapping enzyme C-term binding
A PF16278 zf-C2HE C2HE / C2H2 / C2HC zinc-binding finger
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4ndfA00
1HXPA 1ST0A 1ST4A 3L7XA 1KPEA 2FITA 4QDEA 3SZQA 1KPFA 3R6FA 3OXKA 4NK0A 1XMMA 3IMIA 3N1SA 1Y23A 3WO5A 4NJXA 3LB5A 4EQEA 6RHNA 2EO4A 4QDVA 4NDFA 4ZGLA 4NDIA 5I2FA 1EMSA 5ED6A 5FITA 3TW2A 3N1TA 3SPDA 4NDHA 4FITA 1GUQA 3OMFA 1HXQA 1KPBA 4INCA 3P0TA 3O1XA 4EQHA 3OJ7A 4ZKVA 1XMLA 3FITA 5ED3A 3SP4A 2OIKA 3KSVA 4RHNA 4INIA 4NDGA 4YKLB 3SPLA 5CS2A 1VLRA 2Q4LA 1KPCA 5RHNA 1Z84A 3OHEA 3I4SA 3NRDA 2H39A 5IPCA 4ZKLA 4XBAA 3BL7A 5IPBA 5IN3A 1FITA 2FHIA 3BL9A 2Q4HA 4QEBA 3I24A 3O1CA 1KPAA 1RZYA 5IPEA 4EGUA 1AV5A 5EMTA 3O1ZA 5IPDA 5BV3A 3O0MA 5I2EA 4NJYA 1ZWJA 3RHNA 4EQGA 6FITA 3ANOA 1GUPA 3QGZA 3BLAA 4NJZA 1FHIA
chains in the Genus database with same CATH superfamily
1HXPA 1ST0A 1ST4A 3L7XA 1KPEA 2FITA 4QDEA 3SZQA 1KPFA 3R6FA 3OXKA 4NK0A 1XMMA 3IMIA 3N1SA 1L9VA 1Y23A 3WO5A 4NJXA 3LB5A 4EQEA 6RHNA 2EO4A 4QDVA 2GU0A 2R7PA 4NDFA 4ZGLA 4NDIA 4I5VA 5I2FA 1EMSA 5ED6A 5FITA 3TW2A 3N1TA 3SPDA 4NDHA 4FITA 1GUQA 3OMFA 2R8FA 1HXQA 1KPBA 4INCA 3P0TA 3O1XA 4EQHA 3OJ7A 4ZKVA 1XMLA 3FITA 5ED3A 3SP4A 2OIKA 3KSVA 4RHNA 4INIA 4NDGA 4YKLB 4G0JA 3SPLA 5CS2A 1VLRA 2Q4LA 2R7JA 1KPCA 5RHNA 1Z84A 3OHEA 3I4SA 3NRDA 2H39A 5IPCA 2POFA 4ZKLA 4XBAA 3BL7A 5IPBA 5IN3A 1FITA 2FHIA 4I5WA 3BL9A 2LJWA 2Q4HA 4QEBA 3I24A 3O1CA 1KPAA 1RZYA 5IPEA 4EGUA 1AV5A 5EMTA 3O1ZA 5IPDA 5BV3A 3O0MA 5I2EA 4G0AA 2R7CA 1ZWJA 4NJYA 3RHNA 4EQGA 6FITA 3ANOA 1GUPA 4I5TA 3QGZA 3BLAA 4NJZA 1FHIA
chains in the Genus database with same CATH topology
1HXPA 1ST0A 1ST4A 3L7XA 1KPEA 2FITA 4QDEA 3SZQA 1KPFA 3R6FA 3OXKA 4NK0A 1XMMA 3IMIA 3N1SA 1Y23A 3WO5A 4NJXA 3LB5A 4EQEA 6RHNA 2EO4A 4QDVA 4NDFA 4ZGLA 4NDIA 5I2FA 1EMSA 5ED6A 5FITA 3TW2A 3N1TA 3SPDA 4NDHA 4FITA 1GUQA 3OMFA 1HXQA 1KPBA 4INCA 3P0TA 3O1XA 4EQHA 3OJ7A 4ZKVA 1XMLA 3FITA 5ED3A 3SP4A 2OIKA 3KSVA 4RHNA 4INIA 4NDGA 4YKLB 3SPLA 5CS2A 1VLRA 2Q4LA 1KPCA 5RHNA 1Z84A 3OHEA 3I4SA 3NRDA 2H39A 5IPCA 4ZKLA 4XBAA 3BL7A 5IPBA 5IN3A 1FITA 2FHIA 3BL9A 2Q4HA 4QEBA 3I24A 3O1CA 1KPAA 1RZYA 5IPEA 4EGUA 1AV5A 5EMTA 3O1ZA 5IPDA 5BV3A 3O0MA 5I2EA 4NJYA 1ZWJA 3RHNA 4EQGA 6FITA 3ANOA 1GUPA 3QGZA 3BLAA 4NJZA 1FHIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HXP A;  1ST0 A;  1ST4 A;  3L7X A;  1KPE A;  2FIT A;  4QDE A;  3SZQ A;  1KPF A;  3R6F A;  3OXK A;  4NK0 A;  1XMM A;  3IMI A;  3N1S A;  1Y23 A;  3WO5 A;  4NJX A;  3LB5 A;  4EQE A;  6RHN A;  2EO4 A;  4QDV A;  4NDF A;  4ZGL A;  4NDI A;  5I2F A;  1EMS A;  5ED6 A;  5FIT A;  3TW2 A;  3N1T A;  3SPD A;  4NDH A;  4FIT A;  1GUQ A;  3OMF A;  1HXQ A;  1KPB A;  4INC A;  3P0T A;  3O1X A;  4EQH A;  3OJ7 A;  4ZKV A;  1XML A;  3FIT A;  5ED3 A;  3SP4 A;  2OIK A;  3KSV A;  4RHN A;  4INI A;  4NDG A;  4YKL B;  3SPL A;  5CS2 A;  1VLR A;  2Q4L A;  1KPC A;  5RHN A;  1Z84 A;  3OHE A;  3I4S A;  3NRD A;  2H39 A;  5IPC A;  4ZKL A;  4XBA A;  3BL7 A;  5IPB A;  5IN3 A;  1FIT A;  2FHI A;  3BL9 A;  2Q4H A;  4QEB A;  3I24 A;  3O1C A;  1KPA A;  1RZY A;  5IPE A;  4EGU A;  1AV5 A;  5EMT A;  3O1Z A;  5IPD A;  5BV3 A;  3O0M A;  5I2E A;  4NJY A;  1ZWJ A;  3RHN A;  4EQG A;  6FIT A;  3ANO A;  1GUP A;  3QGZ A;  3BLA A;  4NJZ A;  1FHI A; 
#chains in the Genus database with same CATH topology
 1HXP A;  1ST0 A;  1ST4 A;  3L7X A;  1KPE A;  2FIT A;  4QDE A;  3SZQ A;  1KPF A;  3R6F A;  3OXK A;  4NK0 A;  1XMM A;  3IMI A;  3N1S A;  1L9V A;  1Y23 A;  3WO5 A;  4NJX A;  3LB5 A;  4EQE A;  6RHN A;  2EO4 A;  4QDV A;  2GU0 A;  2R7P A;  4NDF A;  4ZGL A;  4NDI A;  4I5V A;  5I2F A;  1EMS A;  5ED6 A;  5FIT A;  3TW2 A;  3N1T A;  3SPD A;  4NDH A;  4FIT A;  1GUQ A;  3OMF A;  2R8F A;  1HXQ A;  1KPB A;  4INC A;  3P0T A;  3O1X A;  4EQH A;  3OJ7 A;  4ZKV A;  1XML A;  3FIT A;  5ED3 A;  3SP4 A;  2OIK A;  3KSV A;  4RHN A;  4INI A;  4NDG A;  4YKL B;  4G0J A;  3SPL A;  5CS2 A;  1VLR A;  2Q4L A;  2R7J A;  1KPC A;  5RHN A;  1Z84 A;  3OHE A;  3I4S A;  3NRD A;  2H39 A;  5IPC A;  2POF A;  4ZKL A;  4XBA A;  3BL7 A;  5IPB A;  5IN3 A;  1FIT A;  2FHI A;  4I5W A;  3BL9 A;  2LJW A;  2Q4H A;  4QEB A;  3I24 A;  3O1C A;  1KPA A;  1RZY A;  5IPE A;  4EGU A;  1AV5 A;  5EMT A;  3O1Z A;  5IPD A;  5BV3 A;  3O0M A;  5I2E A;  4G0A A;  2R7C A;  1ZWJ A;  4NJY A;  3RHN A;  4EQG A;  6FIT A;  3ANO A;  1GUP A;  4I5T A;  3QGZ A;  3BLA A;  4NJZ A;  1FHI A; 
#chains in the Genus database with same CATH homology
 1HXP A;  1ST0 A;  1ST4 A;  3L7X A;  1KPE A;  2FIT A;  4QDE A;  3SZQ A;  1KPF A;  3R6F A;  3OXK A;  4NK0 A;  1XMM A;  3IMI A;  3N1S A;  1Y23 A;  3WO5 A;  4NJX A;  3LB5 A;  4EQE A;  6RHN A;  2EO4 A;  4QDV A;  4NDF A;  4ZGL A;  4NDI A;  5I2F A;  1EMS A;  5ED6 A;  5FIT A;  3TW2 A;  3N1T A;  3SPD A;  4NDH A;  4FIT A;  1GUQ A;  3OMF A;  1HXQ A;  1KPB A;  4INC A;  3P0T A;  3O1X A;  4EQH A;  3OJ7 A;  4ZKV A;  1XML A;  3FIT A;  5ED3 A;  3SP4 A;  2OIK A;  3KSV A;  4RHN A;  4INI A;  4NDG A;  4YKL B;  3SPL A;  5CS2 A;  1VLR A;  2Q4L A;  1KPC A;  5RHN A;  1Z84 A;  3OHE A;  3I4S A;  3NRD A;  2H39 A;  5IPC A;  4ZKL A;  4XBA A;  3BL7 A;  5IPB A;  5IN3 A;  1FIT A;  2FHI A;  3BL9 A;  2Q4H A;  4QEB A;  3I24 A;  3O1C A;  1KPA A;  1RZY A;  5IPE A;  4EGU A;  1AV5 A;  5EMT A;  3O1Z A;  5IPD A;  5BV3 A;  3O0M A;  5I2E A;  4NJY A;  1ZWJ A;  3RHN A;  4EQG A;  6FIT A;  3ANO A;  1GUP A;  3QGZ A;  3BLA A;  4NJZ A;  1FHI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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