4NDGA

Human aprataxin (aptx) bound to rna-dna and zn - adenosine vanadate transition state mimic complex
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
178
structure length
178
Chain Sequence
MGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
pubmed doi rcsb
molecule tags Dna binding protein/rna/dna
source organism Homo sapiens
molecule keywords Aprataxin
total genus 48
structure length 178
sequence length 178
chains with identical sequence B
ec nomenclature ec 3.1.11.7: Adenosine-5'-diphospho-5'-(DNA) diphosphatase.
pdb deposition date 2013-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF11969 DcpS_C Scavenger mRNA decapping enzyme C-term binding
A PF16278 zf-C2HE C2HE / C2H2 / C2HC zinc-binding finger
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4ndgA00
4EGUA 1ST0A 3QGZA 1XMMA 1KPAA 3OHEA 4YKLB 2FHIA 4NJZA 4EQHA 4ZKLA 1HXQA 4RHNA 1VLRA 3O1XA 2Q4LA 1ST4A 1KPBA 3FITA 5IPDA 4NDIA 3SPDA 4NK0A 3OJ7A 5EMTA 3I24A 1HXPA 3BLAA 2EO4A 5I2FA 3O1ZA 5IPCA 5CS2A 5FITA 3WO5A 4ZGLA 3N1SA 3P0TA 3IMIA 1KPFA 5IPBA 3L7XA 4QDEA 3O1CA 4QDVA 3SP4A 5ED6A 1KPCA 3SPLA 4INCA 4ZKVA 3ANOA 1Y23A 3O0MA 4QEBA 3KSVA 3LB5A 1FHIA 6FITA 4NDGA 3RHNA 1EMSA 4EQEA 4XBAA 4INIA 5IPEA 1Z84A 5RHNA 3N1TA 3BL7A 3I4SA 5I2EA 3NRDA 1GUPA 1KPEA 1ZWJA 1RZYA 4NDHA 3SZQA 3R6FA 4FITA 5ED3A 2FITA 5BV3A 2H39A 1AV5A 3BL9A 2Q4HA 4NJXA 3TW2A 4NDFA 4NJYA 3OMFA 3OXKA 4EQGA 6RHNA 1GUQA 5IN3A 1XMLA 2OIKA 1FITA
chains in the Genus database with same CATH superfamily
4EGUA 1ST0A 3QGZA 1XMMA 1KPAA 3OHEA 4YKLB 2FHIA 4NJZA 4EQHA 4ZKLA 1HXQA 4RHNA 1VLRA 2R7PA 3O1XA 2Q4LA 1ST4A 1KPBA 3FITA 5IPDA 4NDIA 3SPDA 4NK0A 3OJ7A 5EMTA 3I24A 1HXPA 3BLAA 2EO4A 5I2FA 3O1ZA 5IPCA 5CS2A 5FITA 3WO5A 4ZGLA 3N1SA 3P0TA 3IMIA 1KPFA 5IPBA 4I5TA 3L7XA 4QDEA 3O1CA 4QDVA 3SP4A 5ED6A 1KPCA 3SPLA 4INCA 2POFA 4ZKVA 3ANOA 1Y23A 3O0MA 4QEBA 4G0JA 2R7JA 3KSVA 3LB5A 1FHIA 4I5WA 6FITA 4NDGA 3RHNA 1EMSA 4EQEA 4XBAA 4INIA 2GU0A 5IPEA 1Z84A 5RHNA 3N1TA 3BL7A 3I4SA 5I2EA 4I5VA 3NRDA 2R7CA 1GUPA 1KPEA 1ZWJA 1RZYA 4NDHA 2LJWA 1L9VA 3SZQA 3R6FA 4FITA 5ED3A 2FITA 5BV3A 2H39A 1AV5A 3BL9A 2R8FA 2Q4HA 4NJXA 3TW2A 4NDFA 4NJYA 3OMFA 3OXKA 4EQGA 6RHNA 1GUQA 5IN3A 1XMLA 4G0AA 2OIKA 1FITA
chains in the Genus database with same CATH topology
4EGUA 1ST0A 3QGZA 1XMMA 1KPAA 3OHEA 4YKLB 2FHIA 4NJZA 4EQHA 4ZKLA 1HXQA 4RHNA 1VLRA 3O1XA 2Q4LA 1ST4A 1KPBA 3FITA 5IPDA 4NDIA 3SPDA 4NK0A 3OJ7A 5EMTA 3I24A 1HXPA 3BLAA 2EO4A 5I2FA 3O1ZA 5IPCA 5CS2A 5FITA 3WO5A 4ZGLA 3N1SA 3P0TA 3IMIA 1KPFA 5IPBA 3L7XA 4QDEA 3O1CA 4QDVA 3SP4A 5ED6A 1KPCA 3SPLA 4INCA 4ZKVA 3ANOA 1Y23A 3O0MA 4QEBA 3KSVA 3LB5A 1FHIA 6FITA 4NDGA 3RHNA 1EMSA 4EQEA 4XBAA 4INIA 5IPEA 1Z84A 5RHNA 3N1TA 3BL7A 3I4SA 5I2EA 3NRDA 1GUPA 1KPEA 1ZWJA 1RZYA 4NDHA 3SZQA 3R6FA 4FITA 5ED3A 2FITA 5BV3A 2H39A 1AV5A 3BL9A 2Q4HA 4NJXA 3TW2A 4NDFA 4NJYA 3OMFA 3OXKA 4EQGA 6RHNA 1GUQA 5IN3A 1XMLA 2OIKA 1FITA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EGU A;  1ST0 A;  3QGZ A;  1XMM A;  1KPA A;  3OHE A;  4YKL B;  2FHI A;  4NJZ A;  4EQH A;  4ZKL A;  1HXQ A;  4RHN A;  1VLR A;  3O1X A;  2Q4L A;  1ST4 A;  1KPB A;  3FIT A;  5IPD A;  4NDI A;  3SPD A;  4NK0 A;  3OJ7 A;  5EMT A;  3I24 A;  1HXP A;  3BLA A;  2EO4 A;  5I2F A;  3O1Z A;  5IPC A;  5CS2 A;  5FIT A;  3WO5 A;  4ZGL A;  3N1S A;  3P0T A;  3IMI A;  1KPF A;  5IPB A;  3L7X A;  4QDE A;  3O1C A;  4QDV A;  3SP4 A;  5ED6 A;  1KPC A;  3SPL A;  4INC A;  4ZKV A;  3ANO A;  1Y23 A;  3O0M A;  4QEB A;  3KSV A;  3LB5 A;  1FHI A;  6FIT A;  4NDG A;  3RHN A;  1EMS A;  4EQE A;  4XBA A;  4INI A;  5IPE A;  1Z84 A;  5RHN A;  3N1T A;  3BL7 A;  3I4S A;  5I2E A;  3NRD A;  1GUP A;  1KPE A;  1ZWJ A;  1RZY A;  4NDH A;  3SZQ A;  3R6F A;  4FIT A;  5ED3 A;  2FIT A;  5BV3 A;  2H39 A;  1AV5 A;  3BL9 A;  2Q4H A;  4NJX A;  3TW2 A;  4NDF A;  4NJY A;  3OMF A;  3OXK A;  4EQG A;  6RHN A;  1GUQ A;  5IN3 A;  1XML A;  2OIK A;  1FIT A; 
#chains in the Genus database with same CATH topology
 4EGU A;  1ST0 A;  3QGZ A;  1XMM A;  1KPA A;  3OHE A;  4YKL B;  2FHI A;  4NJZ A;  4EQH A;  4ZKL A;  1HXQ A;  4RHN A;  1VLR A;  2R7P A;  3O1X A;  2Q4L A;  1ST4 A;  1KPB A;  3FIT A;  5IPD A;  4NDI A;  3SPD A;  4NK0 A;  3OJ7 A;  5EMT A;  3I24 A;  1HXP A;  3BLA A;  2EO4 A;  5I2F A;  3O1Z A;  5IPC A;  5CS2 A;  5FIT A;  3WO5 A;  4ZGL A;  3N1S A;  3P0T A;  3IMI A;  1KPF A;  5IPB A;  4I5T A;  3L7X A;  4QDE A;  3O1C A;  4QDV A;  3SP4 A;  5ED6 A;  1KPC A;  3SPL A;  4INC A;  2POF A;  4ZKV A;  3ANO A;  1Y23 A;  3O0M A;  4QEB A;  4G0J A;  2R7J A;  3KSV A;  3LB5 A;  1FHI A;  4I5W A;  6FIT A;  4NDG A;  3RHN A;  1EMS A;  4EQE A;  4XBA A;  4INI A;  2GU0 A;  5IPE A;  1Z84 A;  5RHN A;  3N1T A;  3BL7 A;  3I4S A;  5I2E A;  4I5V A;  3NRD A;  2R7C A;  1GUP A;  1KPE A;  1ZWJ A;  1RZY A;  4NDH A;  2LJW A;  1L9V A;  3SZQ A;  3R6F A;  4FIT A;  5ED3 A;  2FIT A;  5BV3 A;  2H39 A;  1AV5 A;  3BL9 A;  2R8F A;  2Q4H A;  4NJX A;  3TW2 A;  4NDF A;  4NJY A;  3OMF A;  3OXK A;  4EQG A;  6RHN A;  1GUQ A;  5IN3 A;  1XML A;  4G0A A;  2OIK A;  1FIT A; 
#chains in the Genus database with same CATH homology
 4EGU A;  1ST0 A;  3QGZ A;  1XMM A;  1KPA A;  3OHE A;  4YKL B;  2FHI A;  4NJZ A;  4EQH A;  4ZKL A;  1HXQ A;  4RHN A;  1VLR A;  3O1X A;  2Q4L A;  1ST4 A;  1KPB A;  3FIT A;  5IPD A;  4NDI A;  3SPD A;  4NK0 A;  3OJ7 A;  5EMT A;  3I24 A;  1HXP A;  3BLA A;  2EO4 A;  5I2F A;  3O1Z A;  5IPC A;  5CS2 A;  5FIT A;  3WO5 A;  4ZGL A;  3N1S A;  3P0T A;  3IMI A;  1KPF A;  5IPB A;  3L7X A;  4QDE A;  3O1C A;  4QDV A;  3SP4 A;  5ED6 A;  1KPC A;  3SPL A;  4INC A;  4ZKV A;  3ANO A;  1Y23 A;  3O0M A;  4QEB A;  3KSV A;  3LB5 A;  1FHI A;  6FIT A;  4NDG A;  3RHN A;  1EMS A;  4EQE A;  4XBA A;  4INI A;  5IPE A;  1Z84 A;  5RHN A;  3N1T A;  3BL7 A;  3I4S A;  5I2E A;  3NRD A;  1GUP A;  1KPE A;  1ZWJ A;  1RZY A;  4NDH A;  3SZQ A;  3R6F A;  4FIT A;  5ED3 A;  2FIT A;  5BV3 A;  2H39 A;  1AV5 A;  3BL9 A;  2Q4H A;  4NJX A;  3TW2 A;  4NDF A;  4NJY A;  3OMF A;  3OXK A;  4EQG A;  6RHN A;  1GUQ A;  5IN3 A;  1XML A;  2OIK A;  1FIT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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