4NDGA

Human aprataxin (aptx) bound to rna-dna and zn - adenosine vanadate transition state mimic complex
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
178
structure length
178
Chain Sequence
MGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein/rna/dna
source organism Homo sapiens
publication title Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
pubmed doi rcsb
molecule keywords Aprataxin
total genus 48
structure length 178
sequence length 178
chains with identical sequence B
ec nomenclature ec 3.1.11.7: Adenosine-5'-diphospho-5'-(DNA) diphosphatase.
pdb deposition date 2013-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF11969 DcpS_C Scavenger mRNA decapping enzyme C-term binding
A PF16278 zf-C2HE C2HE / C2H2 / C2HC zinc-binding finger
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4ndgA00
1XMMA 1KPAA 2OIKA 3L7XA 4NDHA 5BV3A 4EQHA 2FITA 1Y23A 4QDVA 3N1TA 3SPDA 3OMFA 3OHEA 4EQGA 1KPBA 4YKLB 6RHNA 1GUPA 5ED6A 1ZWJA 4ZGLA 5IN3A 5IPEA 4NJXA 1GUQA 2FHIA 2H39A 3O0MA 4QEBA 1RZYA 3OJ7A 1AV5A 4NDIA 4ZKLA 3BL7A 4INIA 4EQEA 3BL9A 1FHIA 1HXPA 3BLAA 4FITA 2Q4LA 1HXQA 1XMLA 3ANOA 4QDEA 3LB5A 4NJYA 3TW2A 3SZQA 3O1ZA 3QGZA 2Q4HA 2EO4A 3P0TA 3SP4A 3R6FA 3O1XA 5IPBA 5IPDA 3I24A 1ST4A 5RHNA 3RHNA 4NDFA 4EGUA 6FITA 4XBAA 3KSVA 4INCA 1VLRA 4NJZA 3FITA 4NDGA 5IPCA 1KPEA 3OXKA 1EMSA 4NK0A 5EMTA 3NRDA 3N1SA 3I4SA 3WO5A 3O1CA 5FITA 5CS2A 1FITA 1KPFA 1KPCA 4ZKVA 1ST0A 3SPLA 1Z84A 3IMIA 5ED3A 5I2FA 5I2EA 4RHNA
chains in the Genus database with same CATH superfamily
1XMMA 1KPAA 2OIKA 3L7XA 4NDHA 5BV3A 4EQHA 2FITA 1Y23A 4I5TA 4QDVA 3N1TA 3SPDA 3OMFA 3OHEA 4EQGA 1KPBA 4YKLB 6RHNA 1GUPA 5ED6A 1ZWJA 4ZGLA 5IN3A 5IPEA 4NJXA 1GUQA 2FHIA 2H39A 3O0MA 4QEBA 1RZYA 3OJ7A 1AV5A 2POFA 4NDIA 4ZKLA 3BL7A 4INIA 4EQEA 3BL9A 1FHIA 1HXPA 3BLAA 4FITA 2Q4LA 1HXQA 1XMLA 3ANOA 4QDEA 3LB5A 2R7JA 4I5WA 4NJYA 3TW2A 3SZQA 3O1ZA 3QGZA 2Q4HA 2EO4A 2LJWA 3P0TA 3SP4A 3R6FA 3O1XA 2R8FA 5IPBA 5IPDA 3I24A 1ST4A 1L9VA 5RHNA 3RHNA 4NDFA 4EGUA 6FITA 4XBAA 3KSVA 4INCA 1VLRA 4G0AA 4NJZA 3FITA 2GU0A 4NDGA 5IPCA 1KPEA 3OXKA 1EMSA 4NK0A 5EMTA 2R7PA 3NRDA 3N1SA 3I4SA 3WO5A 3O1CA 5FITA 5CS2A 2R7CA 1FITA 1KPFA 4I5VA 1KPCA 4ZKVA 1ST0A 3SPLA 1Z84A 3IMIA 4G0JA 5ED3A 5I2FA 5I2EA 4RHNA
chains in the Genus database with same CATH topology
1XMMA 1KPAA 2OIKA 3L7XA 4NDHA 5BV3A 4EQHA 2FITA 1Y23A 4QDVA 3N1TA 3SPDA 3OMFA 3OHEA 4EQGA 1KPBA 4YKLB 6RHNA 1GUPA 5ED6A 1ZWJA 4ZGLA 5IN3A 5IPEA 4NJXA 1GUQA 2FHIA 2H39A 3O0MA 4QEBA 1RZYA 3OJ7A 1AV5A 4NDIA 4ZKLA 3BL7A 4INIA 4EQEA 3BL9A 1FHIA 1HXPA 3BLAA 4FITA 2Q4LA 1HXQA 1XMLA 3ANOA 4QDEA 3LB5A 4NJYA 3TW2A 3SZQA 3O1ZA 3QGZA 2Q4HA 2EO4A 3P0TA 3SP4A 3R6FA 3O1XA 5IPBA 5IPDA 3I24A 1ST4A 5RHNA 3RHNA 4NDFA 4EGUA 6FITA 4XBAA 3KSVA 4INCA 1VLRA 4NJZA 3FITA 4NDGA 5IPCA 1KPEA 3OXKA 1EMSA 4NK0A 5EMTA 3NRDA 3N1SA 3I4SA 3WO5A 3O1CA 5FITA 5CS2A 1FITA 1KPFA 1KPCA 4ZKVA 1ST0A 3SPLA 1Z84A 3IMIA 5ED3A 5I2FA 5I2EA 4RHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XMM A;  1KPA A;  2OIK A;  3L7X A;  4NDH A;  5BV3 A;  4EQH A;  2FIT A;  1Y23 A;  4QDV A;  3N1T A;  3SPD A;  3OMF A;  3OHE A;  4EQG A;  1KPB A;  4YKL B;  6RHN A;  1GUP A;  5ED6 A;  1ZWJ A;  4ZGL A;  5IN3 A;  5IPE A;  4NJX A;  1GUQ A;  2FHI A;  2H39 A;  3O0M A;  4QEB A;  1RZY A;  3OJ7 A;  1AV5 A;  4NDI A;  4ZKL A;  3BL7 A;  4INI A;  4EQE A;  3BL9 A;  1FHI A;  1HXP A;  3BLA A;  4FIT A;  2Q4L A;  1HXQ A;  1XML A;  3ANO A;  4QDE A;  3LB5 A;  4NJY A;  3TW2 A;  3SZQ A;  3O1Z A;  3QGZ A;  2Q4H A;  2EO4 A;  3P0T A;  3SP4 A;  3R6F A;  3O1X A;  5IPB A;  5IPD A;  3I24 A;  1ST4 A;  5RHN A;  3RHN A;  4NDF A;  4EGU A;  6FIT A;  4XBA A;  3KSV A;  4INC A;  1VLR A;  4NJZ A;  3FIT A;  4NDG A;  5IPC A;  1KPE A;  3OXK A;  1EMS A;  4NK0 A;  5EMT A;  3NRD A;  3N1S A;  3I4S A;  3WO5 A;  3O1C A;  5FIT A;  5CS2 A;  1FIT A;  1KPF A;  1KPC A;  4ZKV A;  1ST0 A;  3SPL A;  1Z84 A;  3IMI A;  5ED3 A;  5I2F A;  5I2E A;  4RHN A; 
#chains in the Genus database with same CATH topology
 1XMM A;  1KPA A;  2OIK A;  3L7X A;  4NDH A;  5BV3 A;  4EQH A;  2FIT A;  1Y23 A;  4I5T A;  4QDV A;  3N1T A;  3SPD A;  3OMF A;  3OHE A;  4EQG A;  1KPB A;  4YKL B;  6RHN A;  1GUP A;  5ED6 A;  1ZWJ A;  4ZGL A;  5IN3 A;  5IPE A;  4NJX A;  1GUQ A;  2FHI A;  2H39 A;  3O0M A;  4QEB A;  1RZY A;  3OJ7 A;  1AV5 A;  2POF A;  4NDI A;  4ZKL A;  3BL7 A;  4INI A;  4EQE A;  3BL9 A;  1FHI A;  1HXP A;  3BLA A;  4FIT A;  2Q4L A;  1HXQ A;  1XML A;  3ANO A;  4QDE A;  3LB5 A;  2R7J A;  4I5W A;  4NJY A;  3TW2 A;  3SZQ A;  3O1Z A;  3QGZ A;  2Q4H A;  2EO4 A;  2LJW A;  3P0T A;  3SP4 A;  3R6F A;  3O1X A;  2R8F A;  5IPB A;  5IPD A;  3I24 A;  1ST4 A;  1L9V A;  5RHN A;  3RHN A;  4NDF A;  4EGU A;  6FIT A;  4XBA A;  3KSV A;  4INC A;  1VLR A;  4G0A A;  4NJZ A;  3FIT A;  2GU0 A;  4NDG A;  5IPC A;  1KPE A;  3OXK A;  1EMS A;  4NK0 A;  5EMT A;  2R7P A;  3NRD A;  3N1S A;  3I4S A;  3WO5 A;  3O1C A;  5FIT A;  5CS2 A;  2R7C A;  1FIT A;  1KPF A;  4I5V A;  1KPC A;  4ZKV A;  1ST0 A;  3SPL A;  1Z84 A;  3IMI A;  4G0J A;  5ED3 A;  5I2F A;  5I2E A;  4RHN A; 
#chains in the Genus database with same CATH homology
 1XMM A;  1KPA A;  2OIK A;  3L7X A;  4NDH A;  5BV3 A;  4EQH A;  2FIT A;  1Y23 A;  4QDV A;  3N1T A;  3SPD A;  3OMF A;  3OHE A;  4EQG A;  1KPB A;  4YKL B;  6RHN A;  1GUP A;  5ED6 A;  1ZWJ A;  4ZGL A;  5IN3 A;  5IPE A;  4NJX A;  1GUQ A;  2FHI A;  2H39 A;  3O0M A;  4QEB A;  1RZY A;  3OJ7 A;  1AV5 A;  4NDI A;  4ZKL A;  3BL7 A;  4INI A;  4EQE A;  3BL9 A;  1FHI A;  1HXP A;  3BLA A;  4FIT A;  2Q4L A;  1HXQ A;  1XML A;  3ANO A;  4QDE A;  3LB5 A;  4NJY A;  3TW2 A;  3SZQ A;  3O1Z A;  3QGZ A;  2Q4H A;  2EO4 A;  3P0T A;  3SP4 A;  3R6F A;  3O1X A;  5IPB A;  5IPD A;  3I24 A;  1ST4 A;  5RHN A;  3RHN A;  4NDF A;  4EGU A;  6FIT A;  4XBA A;  3KSV A;  4INC A;  1VLR A;  4NJZ A;  3FIT A;  4NDG A;  5IPC A;  1KPE A;  3OXK A;  1EMS A;  4NK0 A;  5EMT A;  3NRD A;  3N1S A;  3I4S A;  3WO5 A;  3O1C A;  5FIT A;  5CS2 A;  1FIT A;  1KPF A;  1KPC A;  4ZKV A;  1ST0 A;  3SPL A;  1Z84 A;  3IMI A;  5ED3 A;  5I2F A;  5I2E A;  4RHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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