4NDIA

Human aprataxin (aptx) aoa1 variant k197q bound to rna-dna, amp, and zn - product complex
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
180
structure length
180
Chain Sequence
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPQARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
pubmed doi rcsb
molecule tags Dna binding protein/rna/dna
source organism Homo sapiens
molecule keywords Aprataxin
total genus 60
structure length 180
sequence length 180
chains with identical sequence B
ec nomenclature ec 3.1.11.7: Adenosine-5'-diphospho-5'-(DNA) diphosphatase.
pdb deposition date 2013-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF11969 DcpS_C Scavenger mRNA decapping enzyme C-term binding
A PF16278 zf-C2HE C2HE / C2H2 / C2HC zinc-binding finger
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4ndiA00
3OMFA 5IPCA 3KSVA 3WO5A 1FITA 5BV3A 5IPDA 1GUQA 1KPCA 3I24A 3L7XA 1EMSA 3O0MA 1KPBA 4ZKVA 5FITA 3BLAA 3N1TA 3NRDA 3OHEA 3O1XA 3QGZA 6FITA 5ED3A 1ST4A 1FHIA 4NJXA 1KPEA 3P0TA 5EMTA 4QDEA 4INIA 3OXKA 1RZYA 5RHNA 4NDGA 1Y23A 3BL9A 3SPDA 3SP4A 2EO4A 2OIKA 4NJYA 4ZKLA 4RHNA 4INCA 1HXPA 2H39A 3RHNA 1HXQA 2FHIA 4QEBA 5I2FA 5IPEA 5IN3A 3SPLA 1ZWJA 2Q4HA 5IPBA 1GUPA 3TW2A 1VLRA 4FITA 4EQHA 4ZGLA 4QDVA 1Z84A 4NJZA 3ANOA 2FITA 1XMLA 1KPFA 3SZQA 4EQEA 3I4SA 4XBAA 3O1CA 3IMIA 5CS2A 3OJ7A 3BL7A 5I2EA 4EGUA 3O1ZA 5ED6A 1XMMA 4EQGA 4NDFA 4NK0A 4YKLB 4NDIA 2Q4LA 1ST0A 1AV5A 6RHNA 3N1SA 3LB5A 3R6FA 1KPAA 4NDHA 3FITA
chains in the Genus database with same CATH superfamily
3OMFA 5IPCA 3KSVA 3WO5A 1FITA 5BV3A 5IPDA 1GUQA 2R8FA 2R7PA 1KPCA 3I24A 3L7XA 1EMSA 3O0MA 1KPBA 4ZKVA 5FITA 3BLAA 3N1TA 3NRDA 3OHEA 3O1XA 3QGZA 6FITA 1ST4A 5ED3A 1FHIA 4NJXA 1KPEA 2GU0A 3P0TA 4I5VA 5EMTA 4QDEA 4INIA 4G0JA 3OXKA 1RZYA 1L9VA 5RHNA 4NDGA 1Y23A 3BL9A 3SPDA 3SP4A 2EO4A 2OIKA 4NJYA 4ZKLA 4RHNA 4INCA 1HXPA 2H39A 3RHNA 1HXQA 2FHIA 4QEBA 5I2FA 2R7CA 5IPEA 5IN3A 3SPLA 1ZWJA 2Q4HA 5IPBA 2LJWA 1GUPA 3TW2A 4I5TA 1VLRA 4FITA 4EQHA 4ZGLA 4QDVA 1Z84A 4NJZA 3ANOA 2FITA 1XMLA 1KPFA 3SZQA 4EQEA 3I4SA 4XBAA 3O1CA 3IMIA 5CS2A 3OJ7A 3BL7A 5I2EA 4EGUA 3O1ZA 5ED6A 1XMMA 4G0AA 4EQGA 4NDFA 4NK0A 4YKLB 4NDIA 2POFA 2Q4LA 1ST0A 1AV5A 6RHNA 3N1SA 3LB5A 3R6FA 1KPAA 2R7JA 4NDHA 3FITA 4I5WA
chains in the Genus database with same CATH topology
3OMFA 5IPCA 3KSVA 3WO5A 1FITA 5BV3A 5IPDA 1GUQA 1KPCA 3I24A 3L7XA 1EMSA 3O0MA 1KPBA 4ZKVA 5FITA 3BLAA 3N1TA 3NRDA 3OHEA 3O1XA 3QGZA 6FITA 5ED3A 1ST4A 1FHIA 4NJXA 1KPEA 3P0TA 5EMTA 4QDEA 4INIA 3OXKA 1RZYA 5RHNA 4NDGA 1Y23A 3BL9A 3SPDA 3SP4A 2EO4A 2OIKA 4NJYA 4ZKLA 4RHNA 4INCA 1HXPA 2H39A 3RHNA 1HXQA 2FHIA 4QEBA 5I2FA 5IPEA 5IN3A 3SPLA 1ZWJA 2Q4HA 5IPBA 1GUPA 3TW2A 1VLRA 4FITA 4EQHA 4ZGLA 4QDVA 1Z84A 4NJZA 3ANOA 2FITA 1XMLA 1KPFA 3SZQA 4EQEA 3I4SA 4XBAA 3O1CA 3IMIA 5CS2A 3OJ7A 3BL7A 5I2EA 4EGUA 3O1ZA 5ED6A 1XMMA 4EQGA 4NDFA 4NK0A 4YKLB 4NDIA 2Q4LA 1ST0A 1AV5A 6RHNA 3N1SA 3LB5A 3R6FA 1KPAA 4NDHA 3FITA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OMF A;  5IPC A;  3KSV A;  3WO5 A;  1FIT A;  5BV3 A;  5IPD A;  1GUQ A;  1KPC A;  3I24 A;  3L7X A;  1EMS A;  3O0M A;  1KPB A;  4ZKV A;  5FIT A;  3BLA A;  3N1T A;  3NRD A;  3OHE A;  3O1X A;  3QGZ A;  6FIT A;  5ED3 A;  1ST4 A;  1FHI A;  4NJX A;  1KPE A;  3P0T A;  5EMT A;  4QDE A;  4INI A;  3OXK A;  1RZY A;  5RHN A;  4NDG A;  1Y23 A;  3BL9 A;  3SPD A;  3SP4 A;  2EO4 A;  2OIK A;  4NJY A;  4ZKL A;  4RHN A;  4INC A;  1HXP A;  2H39 A;  3RHN A;  1HXQ A;  2FHI A;  4QEB A;  5I2F A;  5IPE A;  5IN3 A;  3SPL A;  1ZWJ A;  2Q4H A;  5IPB A;  1GUP A;  3TW2 A;  1VLR A;  4FIT A;  4EQH A;  4ZGL A;  4QDV A;  1Z84 A;  4NJZ A;  3ANO A;  2FIT A;  1XML A;  1KPF A;  3SZQ A;  4EQE A;  3I4S A;  4XBA A;  3O1C A;  3IMI A;  5CS2 A;  3OJ7 A;  3BL7 A;  5I2E A;  4EGU A;  3O1Z A;  5ED6 A;  1XMM A;  4EQG A;  4NDF A;  4NK0 A;  4YKL B;  4NDI A;  2Q4L A;  1ST0 A;  1AV5 A;  6RHN A;  3N1S A;  3LB5 A;  3R6F A;  1KPA A;  4NDH A;  3FIT A; 
#chains in the Genus database with same CATH topology
 3OMF A;  5IPC A;  3KSV A;  3WO5 A;  1FIT A;  5BV3 A;  5IPD A;  1GUQ A;  2R8F A;  2R7P A;  1KPC A;  3I24 A;  3L7X A;  1EMS A;  3O0M A;  1KPB A;  4ZKV A;  5FIT A;  3BLA A;  3N1T A;  3NRD A;  3OHE A;  3O1X A;  3QGZ A;  6FIT A;  1ST4 A;  5ED3 A;  1FHI A;  4NJX A;  1KPE A;  2GU0 A;  3P0T A;  4I5V A;  5EMT A;  4QDE A;  4INI A;  4G0J A;  3OXK A;  1RZY A;  1L9V A;  5RHN A;  4NDG A;  1Y23 A;  3BL9 A;  3SPD A;  3SP4 A;  2EO4 A;  2OIK A;  4NJY A;  4ZKL A;  4RHN A;  4INC A;  1HXP A;  2H39 A;  3RHN A;  1HXQ A;  2FHI A;  4QEB A;  5I2F A;  2R7C A;  5IPE A;  5IN3 A;  3SPL A;  1ZWJ A;  2Q4H A;  5IPB A;  2LJW A;  1GUP A;  3TW2 A;  4I5T A;  1VLR A;  4FIT A;  4EQH A;  4ZGL A;  4QDV A;  1Z84 A;  4NJZ A;  3ANO A;  2FIT A;  1XML A;  1KPF A;  3SZQ A;  4EQE A;  3I4S A;  4XBA A;  3O1C A;  3IMI A;  5CS2 A;  3OJ7 A;  3BL7 A;  5I2E A;  4EGU A;  3O1Z A;  5ED6 A;  1XMM A;  4G0A A;  4EQG A;  4NDF A;  4NK0 A;  4YKL B;  4NDI A;  2POF A;  2Q4L A;  1ST0 A;  1AV5 A;  6RHN A;  3N1S A;  3LB5 A;  3R6F A;  1KPA A;  2R7J A;  4NDH A;  3FIT A;  4I5W A; 
#chains in the Genus database with same CATH homology
 3OMF A;  5IPC A;  3KSV A;  3WO5 A;  1FIT A;  5BV3 A;  5IPD A;  1GUQ A;  1KPC A;  3I24 A;  3L7X A;  1EMS A;  3O0M A;  1KPB A;  4ZKV A;  5FIT A;  3BLA A;  3N1T A;  3NRD A;  3OHE A;  3O1X A;  3QGZ A;  6FIT A;  5ED3 A;  1ST4 A;  1FHI A;  4NJX A;  1KPE A;  3P0T A;  5EMT A;  4QDE A;  4INI A;  3OXK A;  1RZY A;  5RHN A;  4NDG A;  1Y23 A;  3BL9 A;  3SPD A;  3SP4 A;  2EO4 A;  2OIK A;  4NJY A;  4ZKL A;  4RHN A;  4INC A;  1HXP A;  2H39 A;  3RHN A;  1HXQ A;  2FHI A;  4QEB A;  5I2F A;  5IPE A;  5IN3 A;  3SPL A;  1ZWJ A;  2Q4H A;  5IPB A;  1GUP A;  3TW2 A;  1VLR A;  4FIT A;  4EQH A;  4ZGL A;  4QDV A;  1Z84 A;  4NJZ A;  3ANO A;  2FIT A;  1XML A;  1KPF A;  3SZQ A;  4EQE A;  3I4S A;  4XBA A;  3O1C A;  3IMI A;  5CS2 A;  3OJ7 A;  3BL7 A;  5I2E A;  4EGU A;  3O1Z A;  5ED6 A;  1XMM A;  4EQG A;  4NDF A;  4NK0 A;  4YKL B;  4NDI A;  2Q4L A;  1ST0 A;  1AV5 A;  6RHN A;  3N1S A;  3LB5 A;  3R6F A;  1KPA A;  4NDH A;  3FIT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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