4ZKLA

Crystal structure of human histidine triad nucleotide-binding protein 1 (hhint1) complexed with jb419 (ap4a analog)
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
112
structure length
112
Chain Sequence
GDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 27
structure length 112
sequence length 112
chains with identical sequence B, C, D
ec nomenclature ec 3.-.-.-:
pdb deposition date 2015-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4zklA00
2FITA 1XMMA 3ANOA 4QDEA 3N1TA 3P0TA 3I24A 1KPBA 6RHNA 1FHIA 6FITA 5ED6A 3N1SA 4NJYA 4RHNA 2OIKA 1XMLA 4NDGA 1RZYA 3KSVA 3BL7A 5I2EA 1KPAA 1ST0A 1Y23A 4INCA 4NDFA 2Q4LA 3O1XA 3OJ7A 4EQEA 3L7XA 4NDIA 4EQHA 4YKLB 5IN3A 5FITA 3IMIA 3FITA 1GUPA 5IPDA 4QDVA 1Z84A 4XBAA 2Q4HA 5I2FA 5IPCA 3LB5A 3I4SA 4ZKVA 1GUQA 4NJZA 5BV3A 5EMTA 2EO4A 3OMFA 1ZWJA 3QGZA 1HXPA 3SPDA 5CS2A 1EMSA 3TW2A 4INIA 3NRDA 3OXKA 5RHNA 3O1ZA 5IPBA 5IPEA 3SZQA 1KPEA 5ED3A 2FHIA 1ST4A 1AV5A 3BL9A 4ZGLA 1FITA 3R6FA 4QEBA 4EQGA 3RHNA 2H39A 3SP4A 3O1CA 1HXQA 1KPCA 4EGUA 4NK0A 4ZKLA 3BLAA 4NDHA 3OHEA 3WO5A 3SPLA 3O0MA 1KPFA 1VLRA 4FITA 4NJXA
chains in the Genus database with same CATH superfamily
2FITA 1XMMA 3ANOA 4QDEA 3N1TA 3P0TA 3I24A 1KPBA 6RHNA 1FHIA 6FITA 5ED6A 3N1SA 4NJYA 4RHNA 2OIKA 1XMLA 4NDGA 1RZYA 3KSVA 3BL7A 5I2EA 1KPAA 1ST0A 1Y23A 4I5VA 4INCA 4NDFA 2Q4LA 3O1XA 3OJ7A 4EQEA 3L7XA 4NDIA 4EQHA 4YKLB 2LJWA 1L9VA 5IN3A 5FITA 3IMIA 3FITA 1GUPA 5IPDA 2R8FA 2GU0A 4QDVA 1Z84A 4XBAA 2Q4HA 5I2FA 4I5WA 5IPCA 3LB5A 3I4SA 4ZKVA 1GUQA 4NJZA 5BV3A 5EMTA 2EO4A 3OMFA 4G0JA 1ZWJA 3QGZA 1HXPA 3SPDA 5CS2A 1EMSA 3TW2A 4INIA 3NRDA 3OXKA 5RHNA 3O1ZA 5IPBA 5IPEA 3SZQA 1KPEA 5ED3A 2FHIA 1ST4A 1AV5A 4G0AA 3BL9A 4ZGLA 1FITA 3R6FA 4QEBA 4I5TA 4EQGA 2R7CA 3RHNA 2H39A 3SP4A 3O1CA 1HXQA 2R7JA 1KPCA 4EGUA 4NK0A 4ZKLA 2POFA 3BLAA 4NDHA 3OHEA 3WO5A 3SPLA 3O0MA 1KPFA 1VLRA 4FITA 4NJXA 2R7PA
chains in the Genus database with same CATH topology
2FITA 1XMMA 3ANOA 4QDEA 3N1TA 3P0TA 3I24A 1KPBA 6RHNA 1FHIA 6FITA 5ED6A 3N1SA 4NJYA 4RHNA 2OIKA 1XMLA 4NDGA 1RZYA 3KSVA 3BL7A 5I2EA 1KPAA 1ST0A 1Y23A 4INCA 4NDFA 2Q4LA 3O1XA 3OJ7A 4EQEA 3L7XA 4NDIA 4EQHA 4YKLB 5IN3A 5FITA 3IMIA 3FITA 1GUPA 5IPDA 4QDVA 1Z84A 4XBAA 2Q4HA 5I2FA 5IPCA 3LB5A 3I4SA 4ZKVA 1GUQA 4NJZA 5BV3A 5EMTA 2EO4A 3OMFA 1ZWJA 3QGZA 1HXPA 3SPDA 5CS2A 1EMSA 3TW2A 4INIA 3NRDA 3OXKA 5RHNA 3O1ZA 5IPBA 5IPEA 3SZQA 1KPEA 5ED3A 2FHIA 1ST4A 1AV5A 3BL9A 4ZGLA 1FITA 3R6FA 4QEBA 4EQGA 3RHNA 2H39A 3SP4A 3O1CA 1HXQA 1KPCA 4EGUA 4NK0A 4ZKLA 3BLAA 4NDHA 3OHEA 3WO5A 3SPLA 3O0MA 1KPFA 1VLRA 4FITA 4NJXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FIT A;  1XMM A;  3ANO A;  4QDE A;  3N1T A;  3P0T A;  3I24 A;  1KPB A;  6RHN A;  1FHI A;  6FIT A;  5ED6 A;  3N1S A;  4NJY A;  4RHN A;  2OIK A;  1XML A;  4NDG A;  1RZY A;  3KSV A;  3BL7 A;  5I2E A;  1KPA A;  1ST0 A;  1Y23 A;  4INC A;  4NDF A;  2Q4L A;  3O1X A;  3OJ7 A;  4EQE A;  3L7X A;  4NDI A;  4EQH A;  4YKL B;  5IN3 A;  5FIT A;  3IMI A;  3FIT A;  1GUP A;  5IPD A;  4QDV A;  1Z84 A;  4XBA A;  2Q4H A;  5I2F A;  5IPC A;  3LB5 A;  3I4S A;  4ZKV A;  1GUQ A;  4NJZ A;  5BV3 A;  5EMT A;  2EO4 A;  3OMF A;  1ZWJ A;  3QGZ A;  1HXP A;  3SPD A;  5CS2 A;  1EMS A;  3TW2 A;  4INI A;  3NRD A;  3OXK A;  5RHN A;  3O1Z A;  5IPB A;  5IPE A;  3SZQ A;  1KPE A;  5ED3 A;  2FHI A;  1ST4 A;  1AV5 A;  3BL9 A;  4ZGL A;  1FIT A;  3R6F A;  4QEB A;  4EQG A;  3RHN A;  2H39 A;  3SP4 A;  3O1C A;  1HXQ A;  1KPC A;  4EGU A;  4NK0 A;  4ZKL A;  3BLA A;  4NDH A;  3OHE A;  3WO5 A;  3SPL A;  3O0M A;  1KPF A;  1VLR A;  4FIT A;  4NJX A; 
#chains in the Genus database with same CATH topology
 2FIT A;  1XMM A;  3ANO A;  4QDE A;  3N1T A;  3P0T A;  3I24 A;  1KPB A;  6RHN A;  1FHI A;  6FIT A;  5ED6 A;  3N1S A;  4NJY A;  4RHN A;  2OIK A;  1XML A;  4NDG A;  1RZY A;  3KSV A;  3BL7 A;  5I2E A;  1KPA A;  1ST0 A;  1Y23 A;  4I5V A;  4INC A;  4NDF A;  2Q4L A;  3O1X A;  3OJ7 A;  4EQE A;  3L7X A;  4NDI A;  4EQH A;  4YKL B;  2LJW A;  1L9V A;  5IN3 A;  5FIT A;  3IMI A;  3FIT A;  1GUP A;  5IPD A;  2R8F A;  2GU0 A;  4QDV A;  1Z84 A;  4XBA A;  2Q4H A;  5I2F A;  4I5W A;  5IPC A;  3LB5 A;  3I4S A;  4ZKV A;  1GUQ A;  4NJZ A;  5BV3 A;  5EMT A;  2EO4 A;  3OMF A;  4G0J A;  1ZWJ A;  3QGZ A;  1HXP A;  3SPD A;  5CS2 A;  1EMS A;  3TW2 A;  4INI A;  3NRD A;  3OXK A;  5RHN A;  3O1Z A;  5IPB A;  5IPE A;  3SZQ A;  1KPE A;  5ED3 A;  2FHI A;  1ST4 A;  1AV5 A;  4G0A A;  3BL9 A;  4ZGL A;  1FIT A;  3R6F A;  4QEB A;  4I5T A;  4EQG A;  2R7C A;  3RHN A;  2H39 A;  3SP4 A;  3O1C A;  1HXQ A;  2R7J A;  1KPC A;  4EGU A;  4NK0 A;  4ZKL A;  2POF A;  3BLA A;  4NDH A;  3OHE A;  3WO5 A;  3SPL A;  3O0M A;  1KPF A;  1VLR A;  4FIT A;  4NJX A;  2R7P A; 
#chains in the Genus database with same CATH homology
 2FIT A;  1XMM A;  3ANO A;  4QDE A;  3N1T A;  3P0T A;  3I24 A;  1KPB A;  6RHN A;  1FHI A;  6FIT A;  5ED6 A;  3N1S A;  4NJY A;  4RHN A;  2OIK A;  1XML A;  4NDG A;  1RZY A;  3KSV A;  3BL7 A;  5I2E A;  1KPA A;  1ST0 A;  1Y23 A;  4INC A;  4NDF A;  2Q4L A;  3O1X A;  3OJ7 A;  4EQE A;  3L7X A;  4NDI A;  4EQH A;  4YKL B;  5IN3 A;  5FIT A;  3IMI A;  3FIT A;  1GUP A;  5IPD A;  4QDV A;  1Z84 A;  4XBA A;  2Q4H A;  5I2F A;  5IPC A;  3LB5 A;  3I4S A;  4ZKV A;  1GUQ A;  4NJZ A;  5BV3 A;  5EMT A;  2EO4 A;  3OMF A;  1ZWJ A;  3QGZ A;  1HXP A;  3SPD A;  5CS2 A;  1EMS A;  3TW2 A;  4INI A;  3NRD A;  3OXK A;  5RHN A;  3O1Z A;  5IPB A;  5IPE A;  3SZQ A;  1KPE A;  5ED3 A;  2FHI A;  1ST4 A;  1AV5 A;  3BL9 A;  4ZGL A;  1FIT A;  3R6F A;  4QEB A;  4EQG A;  3RHN A;  2H39 A;  3SP4 A;  3O1C A;  1HXQ A;  1KPC A;  4EGU A;  4NK0 A;  4ZKL A;  3BLA A;  4NDH A;  3OHE A;  3WO5 A;  3SPL A;  3O0M A;  1KPF A;  1VLR A;  4FIT A;  4NJX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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