4ZKLA

Crystal structure of human histidine triad nucleotide-binding protein 1 (hhint1) complexed with jb419 (ap4a analog)
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
112
structure length
112
Chain Sequence
GDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 27
structure length 112
sequence length 112
chains with identical sequence B, C, D
ec nomenclature ec 3.-.-.-:
pdb deposition date 2015-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4zklA00
4YKLB 4EGUA 4EQGA 1GUPA 4NJXA 4NK0A 5ED6A 2OIKA 1KPBA 3FITA 3R6FA 1ZWJA 4QEBA 4INCA 4QDEA 1XMLA 3ANOA 4QDVA 3WO5A 3TW2A 5IPDA 5RHNA 3OMFA 5IPEA 5ED3A 3O1CA 3O1ZA 1KPFA 3BL9A 1Y23A 4FITA 3SP4A 5I2FA 3KSVA 2H39A 1ST0A 1GUQA 4EQEA 3OXKA 2FITA 5BV3A 1ST4A 4NJYA 4RHNA 1KPAA 3BLAA 3N1TA 4ZKVA 3I4SA 3BL7A 6FITA 1FITA 3RHNA 4NDFA 3IMIA 3SPDA 5I2EA 2Q4HA 3NRDA 4ZGLA 1HXQA 1AV5A 1RZYA 3LB5A 4NJZA 2FHIA 1VLRA 3O1XA 5EMTA 1Z84A 2EO4A 4EQHA 6RHNA 4INIA 4XBAA 1HXPA 1KPEA 5IPCA 4NDGA 3O0MA 3SZQA 4NDIA 5FITA 3QGZA 1EMSA 1XMMA 3N1SA 3OHEA 5IN3A 4NDHA 3I24A 2Q4LA 3L7XA 5CS2A 3OJ7A 4ZKLA 3P0TA 1KPCA 5IPBA 1FHIA 3SPLA
chains in the Genus database with same CATH superfamily
4YKLB 4EGUA 4EQGA 1GUPA 4NJXA 4NK0A 5ED6A 2OIKA 1KPBA 3FITA 3R6FA 1ZWJA 4QEBA 4INCA 2R7PA 4QDEA 1XMLA 3ANOA 4QDVA 3WO5A 3TW2A 5IPDA 5RHNA 3OMFA 2POFA 4I5WA 5IPEA 5ED3A 3O1CA 3O1ZA 1KPFA 2LJWA 3BL9A 1Y23A 4FITA 1L9VA 3SP4A 5I2FA 3KSVA 2H39A 1ST0A 1GUQA 4EQEA 3OXKA 2R7JA 2FITA 5BV3A 1ST4A 4NJYA 4RHNA 1KPAA 3BLAA 3N1TA 4ZKVA 3I4SA 3BL7A 6FITA 1FITA 3RHNA 2GU0A 3IMIA 4NDFA 3SPDA 5I2EA 2Q4HA 3NRDA 4ZGLA 1HXQA 1AV5A 1RZYA 3LB5A 4NJZA 2FHIA 2R8FA 1VLRA 3O1XA 4G0AA 5EMTA 1Z84A 2R7CA 2EO4A 4EQHA 6RHNA 4INIA 4XBAA 4I5TA 1HXPA 1KPEA 5IPCA 4NDGA 3O0MA 3SZQA 4NDIA 5FITA 3QGZA 1EMSA 1XMMA 3N1SA 3OHEA 5IN3A 4NDHA 3I24A 2Q4LA 3L7XA 4G0JA 5CS2A 3OJ7A 4ZKLA 3P0TA 4I5VA 1KPCA 5IPBA 1FHIA 3SPLA
chains in the Genus database with same CATH topology
4YKLB 4EGUA 4EQGA 1GUPA 4NJXA 4NK0A 5ED6A 2OIKA 1KPBA 3FITA 3R6FA 1ZWJA 4QEBA 4INCA 4QDEA 1XMLA 3ANOA 4QDVA 3WO5A 3TW2A 5IPDA 5RHNA 3OMFA 5IPEA 5ED3A 3O1CA 3O1ZA 1KPFA 3BL9A 1Y23A 4FITA 3SP4A 5I2FA 3KSVA 2H39A 1ST0A 1GUQA 4EQEA 3OXKA 2FITA 5BV3A 1ST4A 4NJYA 4RHNA 1KPAA 3BLAA 3N1TA 4ZKVA 3I4SA 3BL7A 6FITA 1FITA 3RHNA 4NDFA 3IMIA 3SPDA 5I2EA 2Q4HA 3NRDA 4ZGLA 1HXQA 1AV5A 1RZYA 3LB5A 4NJZA 2FHIA 1VLRA 3O1XA 5EMTA 1Z84A 2EO4A 4EQHA 6RHNA 4INIA 4XBAA 1HXPA 1KPEA 5IPCA 4NDGA 3O0MA 3SZQA 4NDIA 5FITA 3QGZA 1EMSA 1XMMA 3N1SA 3OHEA 5IN3A 4NDHA 3I24A 2Q4LA 3L7XA 5CS2A 3OJ7A 4ZKLA 3P0TA 1KPCA 5IPBA 1FHIA 3SPLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YKL B;  4EGU A;  4EQG A;  1GUP A;  4NJX A;  4NK0 A;  5ED6 A;  2OIK A;  1KPB A;  3FIT A;  3R6F A;  1ZWJ A;  4QEB A;  4INC A;  4QDE A;  1XML A;  3ANO A;  4QDV A;  3WO5 A;  3TW2 A;  5IPD A;  5RHN A;  3OMF A;  5IPE A;  5ED3 A;  3O1C A;  3O1Z A;  1KPF A;  3BL9 A;  1Y23 A;  4FIT A;  3SP4 A;  5I2F A;  3KSV A;  2H39 A;  1ST0 A;  1GUQ A;  4EQE A;  3OXK A;  2FIT A;  5BV3 A;  1ST4 A;  4NJY A;  4RHN A;  1KPA A;  3BLA A;  3N1T A;  4ZKV A;  3I4S A;  3BL7 A;  6FIT A;  1FIT A;  3RHN A;  4NDF A;  3IMI A;  3SPD A;  5I2E A;  2Q4H A;  3NRD A;  4ZGL A;  1HXQ A;  1AV5 A;  1RZY A;  3LB5 A;  4NJZ A;  2FHI A;  1VLR A;  3O1X A;  5EMT A;  1Z84 A;  2EO4 A;  4EQH A;  6RHN A;  4INI A;  4XBA A;  1HXP A;  1KPE A;  5IPC A;  4NDG A;  3O0M A;  3SZQ A;  4NDI A;  5FIT A;  3QGZ A;  1EMS A;  1XMM A;  3N1S A;  3OHE A;  5IN3 A;  4NDH A;  3I24 A;  2Q4L A;  3L7X A;  5CS2 A;  3OJ7 A;  4ZKL A;  3P0T A;  1KPC A;  5IPB A;  1FHI A;  3SPL A; 
#chains in the Genus database with same CATH topology
 4YKL B;  4EGU A;  4EQG A;  1GUP A;  4NJX A;  4NK0 A;  5ED6 A;  2OIK A;  1KPB A;  3FIT A;  3R6F A;  1ZWJ A;  4QEB A;  4INC A;  2R7P A;  4QDE A;  1XML A;  3ANO A;  4QDV A;  3WO5 A;  3TW2 A;  5IPD A;  5RHN A;  3OMF A;  2POF A;  4I5W A;  5IPE A;  5ED3 A;  3O1C A;  3O1Z A;  1KPF A;  2LJW A;  3BL9 A;  1Y23 A;  4FIT A;  1L9V A;  3SP4 A;  5I2F A;  3KSV A;  2H39 A;  1ST0 A;  1GUQ A;  4EQE A;  3OXK A;  2R7J A;  2FIT A;  5BV3 A;  1ST4 A;  4NJY A;  4RHN A;  1KPA A;  3BLA A;  3N1T A;  4ZKV A;  3I4S A;  3BL7 A;  6FIT A;  1FIT A;  3RHN A;  2GU0 A;  3IMI A;  4NDF A;  3SPD A;  5I2E A;  2Q4H A;  3NRD A;  4ZGL A;  1HXQ A;  1AV5 A;  1RZY A;  3LB5 A;  4NJZ A;  2FHI A;  2R8F A;  1VLR A;  3O1X A;  4G0A A;  5EMT A;  1Z84 A;  2R7C A;  2EO4 A;  4EQH A;  6RHN A;  4INI A;  4XBA A;  4I5T A;  1HXP A;  1KPE A;  5IPC A;  4NDG A;  3O0M A;  3SZQ A;  4NDI A;  5FIT A;  3QGZ A;  1EMS A;  1XMM A;  3N1S A;  3OHE A;  5IN3 A;  4NDH A;  3I24 A;  2Q4L A;  3L7X A;  4G0J A;  5CS2 A;  3OJ7 A;  4ZKL A;  3P0T A;  4I5V A;  1KPC A;  5IPB A;  1FHI A;  3SPL A; 
#chains in the Genus database with same CATH homology
 4YKL B;  4EGU A;  4EQG A;  1GUP A;  4NJX A;  4NK0 A;  5ED6 A;  2OIK A;  1KPB A;  3FIT A;  3R6F A;  1ZWJ A;  4QEB A;  4INC A;  4QDE A;  1XML A;  3ANO A;  4QDV A;  3WO5 A;  3TW2 A;  5IPD A;  5RHN A;  3OMF A;  5IPE A;  5ED3 A;  3O1C A;  3O1Z A;  1KPF A;  3BL9 A;  1Y23 A;  4FIT A;  3SP4 A;  5I2F A;  3KSV A;  2H39 A;  1ST0 A;  1GUQ A;  4EQE A;  3OXK A;  2FIT A;  5BV3 A;  1ST4 A;  4NJY A;  4RHN A;  1KPA A;  3BLA A;  3N1T A;  4ZKV A;  3I4S A;  3BL7 A;  6FIT A;  1FIT A;  3RHN A;  4NDF A;  3IMI A;  3SPD A;  5I2E A;  2Q4H A;  3NRD A;  4ZGL A;  1HXQ A;  1AV5 A;  1RZY A;  3LB5 A;  4NJZ A;  2FHI A;  1VLR A;  3O1X A;  5EMT A;  1Z84 A;  2EO4 A;  4EQH A;  6RHN A;  4INI A;  4XBA A;  1HXP A;  1KPE A;  5IPC A;  4NDG A;  3O0M A;  3SZQ A;  4NDI A;  5FIT A;  3QGZ A;  1EMS A;  1XMM A;  3N1S A;  3OHE A;  5IN3 A;  4NDH A;  3I24 A;  2Q4L A;  3L7X A;  5CS2 A;  3OJ7 A;  4ZKL A;  3P0T A;  1KPC A;  5IPB A;  1FHI A;  3SPL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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