4ZKVA

Crystal structure of human histidine triad nucleotide-binding protein 1 (hhint1) refined to 1.92a at p21 space group
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 28
structure length 115
sequence length 115
chains with identical sequence B, C, D
ec nomenclature ec 3.-.-.-:
pdb deposition date 2015-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 4zkvA00
3SPDA 1FHIA 1VLRA 3RHNA 4INCA 3QGZA 1ST0A 5ED3A 4NDFA 4QDEA 3O1ZA 4EQGA 4NDIA 4QDVA 4NJYA 3R6FA 3BLAA 5EMTA 1HXQA 1KPBA 5RHNA 1RZYA 1GUPA 3I24A 1XMLA 5I2FA 3OHEA 2Q4LA 4EQEA 3SPLA 4ZGLA 3I4SA 4NDGA 3KSVA 3LB5A 5IPDA 1ZWJA 3IMIA 3SP4A 4NDHA 4EQHA 1EMSA 3O1XA 5IPCA 3OMFA 3N1TA 5IN3A 3BL7A 4YKLB 3O0MA 1KPEA 2OIKA 4INIA 3OJ7A 4EGUA 3BL9A 3SZQA 1GUQA 2FHIA 4NJXA 4ZKVA 4RHNA 4FITA 2Q4HA 5CS2A 5FITA 5IPBA 1XMMA 6FITA 1Z84A 5BV3A 3N1SA 5IPEA 2FITA 2H39A 4NJZA 1KPAA 5I2EA 2EO4A 3TW2A 1HXPA 3O1CA 4QEBA 3OXKA 1Y23A 3P0TA 6RHNA 1KPFA 4XBAA 1FITA 3L7XA 3FITA 1ST4A 5ED6A 1AV5A 3ANOA 3NRDA 3WO5A 1KPCA 4ZKLA 4NK0A
chains in the Genus database with same CATH superfamily
3SPDA 1FHIA 1VLRA 3RHNA 4INCA 3QGZA 1ST0A 5ED3A 4NDFA 4QDEA 3O1ZA 4EQGA 4NDIA 4QDVA 4NJYA 3R6FA 3BLAA 5EMTA 1HXQA 2POFA 1KPBA 5RHNA 4G0AA 1RZYA 1GUPA 3I24A 1XMLA 5I2FA 3OHEA 2Q4LA 4EQEA 3SPLA 4ZGLA 2R7PA 3I4SA 4NDGA 3KSVA 3LB5A 5IPDA 1ZWJA 3IMIA 3SP4A 4NDHA 4EQHA 1EMSA 3O1XA 2R8FA 4G0JA 5IPCA 2R7JA 3OMFA 2GU0A 4I5TA 3N1TA 5IN3A 2LJWA 3BL7A 4YKLB 3O0MA 4ZKLA 1KPEA 2OIKA 4INIA 3OJ7A 4EGUA 3BL9A 3SZQA 1GUQA 2FHIA 4NJXA 4ZKVA 4RHNA 4FITA 1L9VA 2Q4HA 5CS2A 5FITA 5IPBA 1XMMA 6FITA 1Z84A 5BV3A 3N1SA 5IPEA 2FITA 2H39A 4NJZA 1KPAA 5I2EA 2EO4A 3TW2A 1HXPA 3O1CA 4QEBA 3OXKA 1Y23A 3P0TA 6RHNA 1KPFA 4XBAA 1FITA 4I5WA 3L7XA 3FITA 1ST4A 5ED6A 1AV5A 3ANOA 3NRDA 3WO5A 1KPCA 4I5VA 2R7CA 4NK0A
chains in the Genus database with same CATH topology
3SPDA 1FHIA 1VLRA 3RHNA 4INCA 3QGZA 1ST0A 5ED3A 4NDFA 4QDEA 3O1ZA 4EQGA 4NDIA 4QDVA 4NJYA 3R6FA 3BLAA 5EMTA 1HXQA 1KPBA 5RHNA 1RZYA 1GUPA 3I24A 1XMLA 5I2FA 3OHEA 2Q4LA 4EQEA 3SPLA 4ZGLA 3I4SA 4NDGA 3KSVA 3LB5A 5IPDA 1ZWJA 3IMIA 3SP4A 4NDHA 4EQHA 1EMSA 3O1XA 5IPCA 3OMFA 3N1TA 5IN3A 3BL7A 4YKLB 3O0MA 1KPEA 2OIKA 4INIA 3OJ7A 4EGUA 3BL9A 3SZQA 1GUQA 2FHIA 4NJXA 4ZKVA 4RHNA 4FITA 2Q4HA 5CS2A 5FITA 5IPBA 1XMMA 6FITA 1Z84A 5BV3A 3N1SA 5IPEA 2FITA 2H39A 4NJZA 1KPAA 5I2EA 2EO4A 3TW2A 1HXPA 3O1CA 4QEBA 3OXKA 1Y23A 3P0TA 6RHNA 1KPFA 4XBAA 1FITA 3L7XA 3FITA 1ST4A 5ED6A 1AV5A 3ANOA 3NRDA 3WO5A 1KPCA 4ZKLA 4NK0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SPD A;  1FHI A;  1VLR A;  3RHN A;  4INC A;  3QGZ A;  1ST0 A;  5ED3 A;  4NDF A;  4QDE A;  3O1Z A;  4EQG A;  4NDI A;  4QDV A;  4NJY A;  3R6F A;  3BLA A;  5EMT A;  1HXQ A;  1KPB A;  5RHN A;  1RZY A;  1GUP A;  3I24 A;  1XML A;  5I2F A;  3OHE A;  2Q4L A;  4EQE A;  3SPL A;  4ZGL A;  3I4S A;  4NDG A;  3KSV A;  3LB5 A;  5IPD A;  1ZWJ A;  3IMI A;  3SP4 A;  4NDH A;  4EQH A;  1EMS A;  3O1X A;  5IPC A;  3OMF A;  3N1T A;  5IN3 A;  3BL7 A;  4YKL B;  3O0M A;  1KPE A;  2OIK A;  4INI A;  3OJ7 A;  4EGU A;  3BL9 A;  3SZQ A;  1GUQ A;  2FHI A;  4NJX A;  4ZKV A;  4RHN A;  4FIT A;  2Q4H A;  5CS2 A;  5FIT A;  5IPB A;  1XMM A;  6FIT A;  1Z84 A;  5BV3 A;  3N1S A;  5IPE A;  2FIT A;  2H39 A;  4NJZ A;  1KPA A;  5I2E A;  2EO4 A;  3TW2 A;  1HXP A;  3O1C A;  4QEB A;  3OXK A;  1Y23 A;  3P0T A;  6RHN A;  1KPF A;  4XBA A;  1FIT A;  3L7X A;  3FIT A;  1ST4 A;  5ED6 A;  1AV5 A;  3ANO A;  3NRD A;  3WO5 A;  1KPC A;  4ZKL A;  4NK0 A; 
#chains in the Genus database with same CATH topology
 3SPD A;  1FHI A;  1VLR A;  3RHN A;  4INC A;  3QGZ A;  1ST0 A;  5ED3 A;  4NDF A;  4QDE A;  3O1Z A;  4EQG A;  4NDI A;  4QDV A;  4NJY A;  3R6F A;  3BLA A;  5EMT A;  1HXQ A;  2POF A;  1KPB A;  5RHN A;  4G0A A;  1RZY A;  1GUP A;  3I24 A;  1XML A;  5I2F A;  3OHE A;  2Q4L A;  4EQE A;  3SPL A;  4ZGL A;  2R7P A;  3I4S A;  4NDG A;  3KSV A;  3LB5 A;  5IPD A;  1ZWJ A;  3IMI A;  3SP4 A;  4NDH A;  4EQH A;  1EMS A;  3O1X A;  2R8F A;  4G0J A;  5IPC A;  2R7J A;  3OMF A;  2GU0 A;  4I5T A;  3N1T A;  5IN3 A;  2LJW A;  3BL7 A;  4YKL B;  3O0M A;  4ZKL A;  1KPE A;  2OIK A;  4INI A;  3OJ7 A;  4EGU A;  3BL9 A;  3SZQ A;  1GUQ A;  2FHI A;  4NJX A;  4ZKV A;  4RHN A;  4FIT A;  1L9V A;  2Q4H A;  5CS2 A;  5FIT A;  5IPB A;  1XMM A;  6FIT A;  1Z84 A;  5BV3 A;  3N1S A;  5IPE A;  2FIT A;  2H39 A;  4NJZ A;  1KPA A;  5I2E A;  2EO4 A;  3TW2 A;  1HXP A;  3O1C A;  4QEB A;  3OXK A;  1Y23 A;  3P0T A;  6RHN A;  1KPF A;  4XBA A;  1FIT A;  4I5W A;  3L7X A;  3FIT A;  1ST4 A;  5ED6 A;  1AV5 A;  3ANO A;  3NRD A;  3WO5 A;  1KPC A;  4I5V A;  2R7C A;  4NK0 A; 
#chains in the Genus database with same CATH homology
 3SPD A;  1FHI A;  1VLR A;  3RHN A;  4INC A;  3QGZ A;  1ST0 A;  5ED3 A;  4NDF A;  4QDE A;  3O1Z A;  4EQG A;  4NDI A;  4QDV A;  4NJY A;  3R6F A;  3BLA A;  5EMT A;  1HXQ A;  1KPB A;  5RHN A;  1RZY A;  1GUP A;  3I24 A;  1XML A;  5I2F A;  3OHE A;  2Q4L A;  4EQE A;  3SPL A;  4ZGL A;  3I4S A;  4NDG A;  3KSV A;  3LB5 A;  5IPD A;  1ZWJ A;  3IMI A;  3SP4 A;  4NDH A;  4EQH A;  1EMS A;  3O1X A;  5IPC A;  3OMF A;  3N1T A;  5IN3 A;  3BL7 A;  4YKL B;  3O0M A;  1KPE A;  2OIK A;  4INI A;  3OJ7 A;  4EGU A;  3BL9 A;  3SZQ A;  1GUQ A;  2FHI A;  4NJX A;  4ZKV A;  4RHN A;  4FIT A;  2Q4H A;  5CS2 A;  5FIT A;  5IPB A;  1XMM A;  6FIT A;  1Z84 A;  5BV3 A;  3N1S A;  5IPE A;  2FIT A;  2H39 A;  4NJZ A;  1KPA A;  5I2E A;  2EO4 A;  3TW2 A;  1HXP A;  3O1C A;  4QEB A;  3OXK A;  1Y23 A;  3P0T A;  6RHN A;  1KPF A;  4XBA A;  1FIT A;  3L7X A;  3FIT A;  1ST4 A;  5ED6 A;  1AV5 A;  3ANO A;  3NRD A;  3WO5 A;  1KPC A;  4ZKL A;  4NK0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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