5ED3A

Crystal structure of human hint1 complexing with ap5a
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
113
structure length
113
Chain Sequence
GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Convergent Regulation of Transcriptional Repression by a Second Messenger and Post-translation Modifications
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 30
structure length 113
sequence length 113
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2015-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5ed3A00
2Q4HA 4FITA 3OJ7A 1GUPA 3O1CA 3SPDA 5ED3A 3SP4A 1XMLA 1GUQA 2Q4LA 4ZGLA 3O1ZA 3QGZA 2H39A 3LB5A 5I2EA 5EMTA 4NDIA 5BV3A 5IPEA 4QEBA 4EGUA 1RZYA 4YKLB 3BL9A 4EQHA 5I2FA 5ED6A 4NK0A 4NDFA 1ZWJA 4QDEA 1KPCA 3TW2A 3OMFA 1AV5A 2EO4A 3FITA 4NDGA 3IMIA 1ST0A 4QDVA 3O1XA 1EMSA 3N1TA 5CS2A 4EQGA 1KPEA 3OHEA 5IN3A 3ANOA 5IPDA 1HXQA 3WO5A 1KPAA 5IPCA 5FITA 3BLAA 3O0MA 3L7XA 4XBAA 4NDHA 3P0TA 4RHNA 3R6FA 4INCA 2FHIA 4EQEA 1KPBA 3BL7A 4ZKLA 1XMMA 4NJZA 4ZKVA 3SPLA 5RHNA 4NJXA 1HXPA 1Y23A 3N1SA 2OIKA 1ST4A 1Z84A 4INIA 4NJYA 1KPFA 5IPBA 6FITA 2FITA 3RHNA 3SZQA 6RHNA 1VLRA 3I24A 3NRDA 3KSVA 1FHIA 1FITA 3I4SA 3OXKA
chains in the Genus database with same CATH superfamily
1L9VA 2Q4HA 4FITA 3OJ7A 1GUPA 4I5VA 3O1CA 3SPDA 5ED3A 3SP4A 1GUQA 1XMLA 2Q4LA 4ZGLA 3O1ZA 3QGZA 2H39A 2LJWA 3LB5A 5I2EA 4G0AA 5EMTA 4NDIA 5BV3A 5IPEA 4QEBA 4EGUA 1RZYA 4YKLB 3BL9A 4EQHA 2GU0A 5I2FA 5ED6A 4NK0A 4NDFA 1ZWJA 4QDEA 1KPCA 2R7PA 3TW2A 3OMFA 1AV5A 2EO4A 3FITA 4NDGA 3IMIA 1ST0A 4QDVA 3O1XA 2POFA 1EMSA 3N1TA 5CS2A 4EQGA 4G0JA 1KPEA 3OHEA 2R7CA 5IN3A 3ANOA 5IPDA 1HXQA 3WO5A 1KPAA 5IPCA 5FITA 3BLAA 3O0MA 3L7XA 4XBAA 4NDHA 3P0TA 4RHNA 3R6FA 4INCA 2FHIA 4EQEA 1KPBA 3BL7A 4ZKLA 1XMMA 2R7JA 4NJZA 4ZKVA 3SPLA 5RHNA 4NJXA 1HXPA 1Y23A 4I5TA 4I5WA 3N1SA 2OIKA 1ST4A 1Z84A 4INIA 4NJYA 1KPFA 2R8FA 5IPBA 6FITA 2FITA 3RHNA 3SZQA 6RHNA 1VLRA 3I24A 3NRDA 3KSVA 1FHIA 1FITA 3I4SA 3OXKA
chains in the Genus database with same CATH topology
2Q4HA 4FITA 3OJ7A 1GUPA 3O1CA 3SPDA 5ED3A 3SP4A 1XMLA 1GUQA 2Q4LA 4ZGLA 3O1ZA 3QGZA 2H39A 3LB5A 5I2EA 5EMTA 4NDIA 5BV3A 5IPEA 4QEBA 4EGUA 1RZYA 4YKLB 3BL9A 4EQHA 5I2FA 5ED6A 4NK0A 4NDFA 1ZWJA 4QDEA 1KPCA 3TW2A 3OMFA 1AV5A 2EO4A 3FITA 4NDGA 3IMIA 1ST0A 4QDVA 3O1XA 1EMSA 3N1TA 5CS2A 4EQGA 1KPEA 3OHEA 5IN3A 3ANOA 5IPDA 1HXQA 3WO5A 1KPAA 5IPCA 5FITA 3BLAA 3O0MA 3L7XA 4XBAA 4NDHA 3P0TA 4RHNA 3R6FA 4INCA 2FHIA 4EQEA 1KPBA 3BL7A 4ZKLA 1XMMA 4NJZA 4ZKVA 3SPLA 5RHNA 4NJXA 1HXPA 1Y23A 3N1SA 2OIKA 1ST4A 1Z84A 4INIA 4NJYA 1KPFA 5IPBA 6FITA 2FITA 3RHNA 3SZQA 6RHNA 1VLRA 3I24A 3NRDA 3KSVA 1FHIA 1FITA 3I4SA 3OXKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q4H A;  4FIT A;  3OJ7 A;  1GUP A;  3O1C A;  3SPD A;  5ED3 A;  3SP4 A;  1XML A;  1GUQ A;  2Q4L A;  4ZGL A;  3O1Z A;  3QGZ A;  2H39 A;  3LB5 A;  5I2E A;  5EMT A;  4NDI A;  5BV3 A;  5IPE A;  4QEB A;  4EGU A;  1RZY A;  4YKL B;  3BL9 A;  4EQH A;  5I2F A;  5ED6 A;  4NK0 A;  4NDF A;  1ZWJ A;  4QDE A;  1KPC A;  3TW2 A;  3OMF A;  1AV5 A;  2EO4 A;  3FIT A;  4NDG A;  3IMI A;  1ST0 A;  4QDV A;  3O1X A;  1EMS A;  3N1T A;  5CS2 A;  4EQG A;  1KPE A;  3OHE A;  5IN3 A;  3ANO A;  5IPD A;  1HXQ A;  3WO5 A;  1KPA A;  5IPC A;  5FIT A;  3BLA A;  3O0M A;  3L7X A;  4XBA A;  4NDH A;  3P0T A;  4RHN A;  3R6F A;  4INC A;  2FHI A;  4EQE A;  1KPB A;  3BL7 A;  4ZKL A;  1XMM A;  4NJZ A;  4ZKV A;  3SPL A;  5RHN A;  4NJX A;  1HXP A;  1Y23 A;  3N1S A;  2OIK A;  1ST4 A;  1Z84 A;  4INI A;  4NJY A;  1KPF A;  5IPB A;  6FIT A;  2FIT A;  3RHN A;  3SZQ A;  6RHN A;  1VLR A;  3I24 A;  3NRD A;  3KSV A;  1FHI A;  1FIT A;  3I4S A;  3OXK A; 
#chains in the Genus database with same CATH topology
 1L9V A;  2Q4H A;  4FIT A;  3OJ7 A;  1GUP A;  4I5V A;  3O1C A;  3SPD A;  5ED3 A;  3SP4 A;  1GUQ A;  1XML A;  2Q4L A;  4ZGL A;  3O1Z A;  3QGZ A;  2H39 A;  2LJW A;  3LB5 A;  5I2E A;  4G0A A;  5EMT A;  4NDI A;  5BV3 A;  5IPE A;  4QEB A;  4EGU A;  1RZY A;  4YKL B;  3BL9 A;  4EQH A;  2GU0 A;  5I2F A;  5ED6 A;  4NK0 A;  4NDF A;  1ZWJ A;  4QDE A;  1KPC A;  2R7P A;  3TW2 A;  3OMF A;  1AV5 A;  2EO4 A;  3FIT A;  4NDG A;  3IMI A;  1ST0 A;  4QDV A;  3O1X A;  2POF A;  1EMS A;  3N1T A;  5CS2 A;  4EQG A;  4G0J A;  1KPE A;  3OHE A;  2R7C A;  5IN3 A;  3ANO A;  5IPD A;  1HXQ A;  3WO5 A;  1KPA A;  5IPC A;  5FIT A;  3BLA A;  3O0M A;  3L7X A;  4XBA A;  4NDH A;  3P0T A;  4RHN A;  3R6F A;  4INC A;  2FHI A;  4EQE A;  1KPB A;  3BL7 A;  4ZKL A;  1XMM A;  2R7J A;  4NJZ A;  4ZKV A;  3SPL A;  5RHN A;  4NJX A;  1HXP A;  1Y23 A;  4I5T A;  4I5W A;  3N1S A;  2OIK A;  1ST4 A;  1Z84 A;  4INI A;  4NJY A;  1KPF A;  2R8F A;  5IPB A;  6FIT A;  2FIT A;  3RHN A;  3SZQ A;  6RHN A;  1VLR A;  3I24 A;  3NRD A;  3KSV A;  1FHI A;  1FIT A;  3I4S A;  3OXK A; 
#chains in the Genus database with same CATH homology
 2Q4H A;  4FIT A;  3OJ7 A;  1GUP A;  3O1C A;  3SPD A;  5ED3 A;  3SP4 A;  1XML A;  1GUQ A;  2Q4L A;  4ZGL A;  3O1Z A;  3QGZ A;  2H39 A;  3LB5 A;  5I2E A;  5EMT A;  4NDI A;  5BV3 A;  5IPE A;  4QEB A;  4EGU A;  1RZY A;  4YKL B;  3BL9 A;  4EQH A;  5I2F A;  5ED6 A;  4NK0 A;  4NDF A;  1ZWJ A;  4QDE A;  1KPC A;  3TW2 A;  3OMF A;  1AV5 A;  2EO4 A;  3FIT A;  4NDG A;  3IMI A;  1ST0 A;  4QDV A;  3O1X A;  1EMS A;  3N1T A;  5CS2 A;  4EQG A;  1KPE A;  3OHE A;  5IN3 A;  3ANO A;  5IPD A;  1HXQ A;  3WO5 A;  1KPA A;  5IPC A;  5FIT A;  3BLA A;  3O0M A;  3L7X A;  4XBA A;  4NDH A;  3P0T A;  4RHN A;  3R6F A;  4INC A;  2FHI A;  4EQE A;  1KPB A;  3BL7 A;  4ZKL A;  1XMM A;  4NJZ A;  4ZKV A;  3SPL A;  5RHN A;  4NJX A;  1HXP A;  1Y23 A;  3N1S A;  2OIK A;  1ST4 A;  1Z84 A;  4INI A;  4NJY A;  1KPF A;  5IPB A;  6FIT A;  2FIT A;  3RHN A;  3SZQ A;  6RHN A;  1VLR A;  3I24 A;  3NRD A;  3KSV A;  1FHI A;  1FIT A;  3I4S A;  3OXK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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