5I2EA

Human histidine triad nucleotide binding protein 1 (hint1) with bound sulfamate inhibitor 3a:3-(5-o-{[3-(1h-indol-3-yl)propanoyl]sulfamoyl}-beta-d-ribofuranosyl)-3h-imidazo[2,1-i]purine
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
molecule keywords Histidine triad nucleotide-binding protein 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 29
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2eA00
2H39A 3L7XA 4NDGA 2OIKA 3WO5A 3TW2A 5IPDA 2FITA 3I24A 1XMMA 3SPDA 3RHNA 4NDHA 4QEBA 5BV3A 4NDFA 1Z84A 3OXKA 4NJXA 4EQGA 4INIA 1GUQA 3BLAA 3N1TA 4XBAA 1Y23A 6FITA 5IPEA 3LB5A 1VLRA 3ANOA 5IN3A 5ED3A 3IMIA 4EQEA 4NJYA 2Q4LA 4ZKLA 4QDVA 3OJ7A 4QDEA 4ZKVA 1KPAA 3N1SA 4FITA 1ST4A 1KPEA 3QGZA 4NDIA 4YKLB 1KPBA 2Q4HA 3OMFA 3SPLA 4ZGLA 3O1XA 5I2FA 6RHNA 5RHNA 4NJZA 2EO4A 3KSVA 3O0MA 4INCA 5EMTA 5IPBA 5CS2A 1KPCA 4NK0A 3FITA 3OHEA 4EGUA 1HXPA 3BL9A 1ST0A 3BL7A 1AV5A 1FITA 4EQHA 3O1ZA 5I2EA 3I4SA 4RHNA 3NRDA 1EMSA 1FHIA 1GUPA 1RZYA 1KPFA 5ED6A 1XMLA 3O1CA 3P0TA 1ZWJA 3SZQA 5IPCA 2FHIA 3SP4A 5FITA 1HXQA 3R6FA
chains in the Genus database with same CATH superfamily
2H39A 1L9VA 3L7XA 4NDGA 2OIKA 3WO5A 3TW2A 5IPDA 2R8FA 2FITA 3I24A 1XMMA 3SPDA 3RHNA 2GU0A 4NDHA 4QEBA 5BV3A 4NDFA 1Z84A 2LJWA 3OXKA 4NJXA 4EQGA 4INIA 1GUQA 3BLAA 3N1TA 4XBAA 1Y23A 6FITA 5IPEA 3LB5A 1VLRA 3ANOA 5IN3A 5ED3A 3IMIA 4EQEA 4NJYA 2Q4LA 4ZKLA 4QDVA 4G0JA 3OJ7A 4QDEA 4ZKVA 2R7CA 1KPAA 3N1SA 4FITA 1ST4A 1KPEA 3QGZA 4NDIA 4YKLB 1KPBA 2Q4HA 3OMFA 3SPLA 4ZGLA 4I5VA 3O1XA 5I2FA 6RHNA 5RHNA 4NJZA 2EO4A 3KSVA 3O0MA 4INCA 5EMTA 5IPBA 5CS2A 1KPCA 4I5TA 4NK0A 3FITA 3OHEA 2POFA 1HXPA 3BL9A 1ST0A 4EGUA 3BL7A 1AV5A 1FITA 4EQHA 3O1ZA 5I2EA 2R7PA 3I4SA 4RHNA 3NRDA 2R7JA 1EMSA 1FHIA 1GUPA 1RZYA 1KPFA 5ED6A 1XMLA 4G0AA 4I5WA 3O1CA 3P0TA 1ZWJA 3SZQA 5IPCA 2FHIA 3SP4A 5FITA 1HXQA 3R6FA
chains in the Genus database with same CATH topology
2H39A 3L7XA 4NDGA 2OIKA 3WO5A 3TW2A 5IPDA 2FITA 3I24A 1XMMA 3SPDA 3RHNA 4NDHA 4QEBA 5BV3A 4NDFA 1Z84A 3OXKA 4NJXA 4EQGA 4INIA 1GUQA 3BLAA 3N1TA 4XBAA 1Y23A 6FITA 5IPEA 3LB5A 1VLRA 3ANOA 5IN3A 5ED3A 3IMIA 4EQEA 4NJYA 2Q4LA 4ZKLA 4QDVA 3OJ7A 4QDEA 4ZKVA 1KPAA 3N1SA 4FITA 1ST4A 1KPEA 3QGZA 4NDIA 4YKLB 1KPBA 2Q4HA 3OMFA 3SPLA 4ZGLA 3O1XA 5I2FA 6RHNA 5RHNA 4NJZA 2EO4A 3KSVA 3O0MA 4INCA 5EMTA 5IPBA 5CS2A 1KPCA 4NK0A 3FITA 3OHEA 4EGUA 1HXPA 3BL9A 1ST0A 3BL7A 1AV5A 1FITA 4EQHA 3O1ZA 5I2EA 3I4SA 4RHNA 3NRDA 1EMSA 1FHIA 1GUPA 1RZYA 1KPFA 5ED6A 1XMLA 3O1CA 3P0TA 1ZWJA 3SZQA 5IPCA 2FHIA 3SP4A 5FITA 1HXQA 3R6FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H39 A;  3L7X A;  4NDG A;  2OIK A;  3WO5 A;  3TW2 A;  5IPD A;  2FIT A;  3I24 A;  1XMM A;  3SPD A;  3RHN A;  4NDH A;  4QEB A;  5BV3 A;  4NDF A;  1Z84 A;  3OXK A;  4NJX A;  4EQG A;  4INI A;  1GUQ A;  3BLA A;  3N1T A;  4XBA A;  1Y23 A;  6FIT A;  5IPE A;  3LB5 A;  1VLR A;  3ANO A;  5IN3 A;  5ED3 A;  3IMI A;  4EQE A;  4NJY A;  2Q4L A;  4ZKL A;  4QDV A;  3OJ7 A;  4QDE A;  4ZKV A;  1KPA A;  3N1S A;  4FIT A;  1ST4 A;  1KPE A;  3QGZ A;  4NDI A;  4YKL B;  1KPB A;  2Q4H A;  3OMF A;  3SPL A;  4ZGL A;  3O1X A;  5I2F A;  6RHN A;  5RHN A;  4NJZ A;  2EO4 A;  3KSV A;  3O0M A;  4INC A;  5EMT A;  5IPB A;  5CS2 A;  1KPC A;  4NK0 A;  3FIT A;  3OHE A;  4EGU A;  1HXP A;  3BL9 A;  1ST0 A;  3BL7 A;  1AV5 A;  1FIT A;  4EQH A;  3O1Z A;  5I2E A;  3I4S A;  4RHN A;  3NRD A;  1EMS A;  1FHI A;  1GUP A;  1RZY A;  1KPF A;  5ED6 A;  1XML A;  3O1C A;  3P0T A;  1ZWJ A;  3SZQ A;  5IPC A;  2FHI A;  3SP4 A;  5FIT A;  1HXQ A;  3R6F A; 
#chains in the Genus database with same CATH topology
 2H39 A;  1L9V A;  3L7X A;  4NDG A;  2OIK A;  3WO5 A;  3TW2 A;  5IPD A;  2R8F A;  2FIT A;  3I24 A;  1XMM A;  3SPD A;  3RHN A;  2GU0 A;  4NDH A;  4QEB A;  5BV3 A;  4NDF A;  1Z84 A;  2LJW A;  3OXK A;  4NJX A;  4EQG A;  4INI A;  1GUQ A;  3BLA A;  3N1T A;  4XBA A;  1Y23 A;  6FIT A;  5IPE A;  3LB5 A;  1VLR A;  3ANO A;  5IN3 A;  5ED3 A;  3IMI A;  4EQE A;  4NJY A;  2Q4L A;  4ZKL A;  4QDV A;  4G0J A;  3OJ7 A;  4QDE A;  4ZKV A;  2R7C A;  1KPA A;  3N1S A;  4FIT A;  1ST4 A;  1KPE A;  3QGZ A;  4NDI A;  4YKL B;  1KPB A;  2Q4H A;  3OMF A;  3SPL A;  4ZGL A;  4I5V A;  3O1X A;  5I2F A;  6RHN A;  5RHN A;  4NJZ A;  2EO4 A;  3KSV A;  3O0M A;  4INC A;  5EMT A;  5IPB A;  5CS2 A;  1KPC A;  4I5T A;  4NK0 A;  3FIT A;  3OHE A;  2POF A;  1HXP A;  3BL9 A;  1ST0 A;  4EGU A;  3BL7 A;  1AV5 A;  1FIT A;  4EQH A;  3O1Z A;  5I2E A;  2R7P A;  3I4S A;  4RHN A;  3NRD A;  2R7J A;  1EMS A;  1FHI A;  1GUP A;  1RZY A;  1KPF A;  5ED6 A;  1XML A;  4G0A A;  4I5W A;  3O1C A;  3P0T A;  1ZWJ A;  3SZQ A;  5IPC A;  2FHI A;  3SP4 A;  5FIT A;  1HXQ A;  3R6F A; 
#chains in the Genus database with same CATH homology
 2H39 A;  3L7X A;  4NDG A;  2OIK A;  3WO5 A;  3TW2 A;  5IPD A;  2FIT A;  3I24 A;  1XMM A;  3SPD A;  3RHN A;  4NDH A;  4QEB A;  5BV3 A;  4NDF A;  1Z84 A;  3OXK A;  4NJX A;  4EQG A;  4INI A;  1GUQ A;  3BLA A;  3N1T A;  4XBA A;  1Y23 A;  6FIT A;  5IPE A;  3LB5 A;  1VLR A;  3ANO A;  5IN3 A;  5ED3 A;  3IMI A;  4EQE A;  4NJY A;  2Q4L A;  4ZKL A;  4QDV A;  3OJ7 A;  4QDE A;  4ZKV A;  1KPA A;  3N1S A;  4FIT A;  1ST4 A;  1KPE A;  3QGZ A;  4NDI A;  4YKL B;  1KPB A;  2Q4H A;  3OMF A;  3SPL A;  4ZGL A;  3O1X A;  5I2F A;  6RHN A;  5RHN A;  4NJZ A;  2EO4 A;  3KSV A;  3O0M A;  4INC A;  5EMT A;  5IPB A;  5CS2 A;  1KPC A;  4NK0 A;  3FIT A;  3OHE A;  4EGU A;  1HXP A;  3BL9 A;  1ST0 A;  3BL7 A;  1AV5 A;  1FIT A;  4EQH A;  3O1Z A;  5I2E A;  3I4S A;  4RHN A;  3NRD A;  1EMS A;  1FHI A;  1GUP A;  1RZY A;  1KPF A;  5ED6 A;  1XML A;  3O1C A;  3P0T A;  1ZWJ A;  3SZQ A;  5IPC A;  2FHI A;  3SP4 A;  5FIT A;  1HXQ A;  3R6F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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