5I2EA

Human histidine triad nucleotide binding protein 1 (hint1) with bound sulfamate inhibitor 3a:3-(5-o-{[3-(1h-indol-3-yl)propanoyl]sulfamoyl}-beta-d-ribofuranosyl)-3h-imidazo[2,1-i]purine
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
molecule keywords Histidine triad nucleotide-binding protein 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 29
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2eA00
5BV3A 3RHNA 1EMSA 3ANOA 5IN3A 1ZWJA 5ED3A 4EQHA 3SP4A 4NDIA 4RHNA 3OXKA 6FITA 4QDVA 3P0TA 1KPCA 4NK0A 1KPEA 1ST0A 4EQGA 3BL9A 2Q4HA 3LB5A 1KPBA 3I24A 3IMIA 5I2FA 3BLAA 3WO5A 4EGUA 5I2EA 3N1SA 1KPFA 3BL7A 5IPDA 3FITA 4INCA 5RHNA 4NDHA 3O1XA 5ED6A 3QGZA 1XMMA 5IPBA 2OIKA 2FITA 2FHIA 5FITA 3SPDA 3TW2A 5EMTA 3L7XA 1HXPA 4YKLB 4NDFA 1FHIA 3OHEA 3KSVA 4XBAA 4ZGLA 1GUQA 1Y23A 1VLRA 4NJZA 1HXQA 1FITA 3SZQA 2EO4A 4NJXA 4NDGA 1KPAA 3O0MA 1ST4A 4QEBA 3R6FA 5IPCA 4QDEA 4NJYA 3N1TA 1RZYA 3OJ7A 2H39A 3OMFA 5CS2A 3NRDA 1Z84A 3I4SA 4EQEA 1XMLA 4INIA 4ZKLA 4FITA 5IPEA 6RHNA 1GUPA 1AV5A 4ZKVA 2Q4LA 3O1ZA 3SPLA 3O1CA
chains in the Genus database with same CATH superfamily
5BV3A 3RHNA 1EMSA 4G0JA 3ANOA 5IN3A 1ZWJA 5ED3A 4EQHA 2R7PA 2GU0A 2R8FA 3SP4A 4NDIA 4RHNA 3OXKA 6FITA 4QDVA 3P0TA 1KPCA 4NK0A 2POFA 1KPEA 1ST0A 4EQGA 3BL9A 2Q4HA 3LB5A 1KPBA 3I24A 3IMIA 4G0AA 5I2FA 3BLAA 3WO5A 4EGUA 5I2EA 3N1SA 1KPFA 3BL7A 1L9VA 5IPDA 3FITA 4INCA 5RHNA 4NDHA 3O1XA 5ED6A 3QGZA 1XMMA 5IPBA 2OIKA 2FITA 4I5VA 2FHIA 5FITA 3SPDA 3TW2A 5EMTA 3L7XA 1HXPA 4YKLB 4NDFA 1FHIA 3OHEA 3KSVA 4XBAA 2LJWA 4ZGLA 1GUQA 1Y23A 1VLRA 4I5WA 4NJZA 1HXQA 1FITA 3SZQA 2EO4A 4NJXA 4NDGA 1KPAA 3O0MA 1ST4A 4QEBA 3R6FA 5IPCA 4QDEA 4NJYA 3N1TA 1RZYA 3OJ7A 2H39A 3OMFA 5CS2A 3NRDA 1Z84A 3I4SA 4I5TA 4EQEA 1XMLA 4INIA 4ZKLA 4FITA 2R7CA 5IPEA 6RHNA 1GUPA 1AV5A 4ZKVA 2Q4LA 3O1ZA 3SPLA 2R7JA 3O1CA
chains in the Genus database with same CATH topology
5BV3A 3RHNA 1EMSA 3ANOA 5IN3A 1ZWJA 5ED3A 4EQHA 3SP4A 4NDIA 4RHNA 3OXKA 6FITA 4QDVA 3P0TA 1KPCA 4NK0A 1KPEA 1ST0A 4EQGA 3BL9A 2Q4HA 3LB5A 1KPBA 3I24A 3IMIA 5I2FA 3BLAA 3WO5A 4EGUA 5I2EA 3N1SA 1KPFA 3BL7A 5IPDA 3FITA 4INCA 5RHNA 4NDHA 3O1XA 5ED6A 3QGZA 1XMMA 5IPBA 2OIKA 2FITA 2FHIA 5FITA 3SPDA 3TW2A 5EMTA 3L7XA 1HXPA 4YKLB 4NDFA 1FHIA 3OHEA 3KSVA 4XBAA 4ZGLA 1GUQA 1Y23A 1VLRA 4NJZA 1HXQA 1FITA 3SZQA 2EO4A 4NJXA 4NDGA 1KPAA 3O0MA 1ST4A 4QEBA 3R6FA 5IPCA 4QDEA 4NJYA 3N1TA 1RZYA 3OJ7A 2H39A 3OMFA 5CS2A 3NRDA 1Z84A 3I4SA 4EQEA 1XMLA 4INIA 4ZKLA 4FITA 5IPEA 6RHNA 1GUPA 1AV5A 4ZKVA 2Q4LA 3O1ZA 3SPLA 3O1CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BV3 A;  3RHN A;  1EMS A;  3ANO A;  5IN3 A;  1ZWJ A;  5ED3 A;  4EQH A;  3SP4 A;  4NDI A;  4RHN A;  3OXK A;  6FIT A;  4QDV A;  3P0T A;  1KPC A;  4NK0 A;  1KPE A;  1ST0 A;  4EQG A;  3BL9 A;  2Q4H A;  3LB5 A;  1KPB A;  3I24 A;  3IMI A;  5I2F A;  3BLA A;  3WO5 A;  4EGU A;  5I2E A;  3N1S A;  1KPF A;  3BL7 A;  5IPD A;  3FIT A;  4INC A;  5RHN A;  4NDH A;  3O1X A;  5ED6 A;  3QGZ A;  1XMM A;  5IPB A;  2OIK A;  2FIT A;  2FHI A;  5FIT A;  3SPD A;  3TW2 A;  5EMT A;  3L7X A;  1HXP A;  4YKL B;  4NDF A;  1FHI A;  3OHE A;  3KSV A;  4XBA A;  4ZGL A;  1GUQ A;  1Y23 A;  1VLR A;  4NJZ A;  1HXQ A;  1FIT A;  3SZQ A;  2EO4 A;  4NJX A;  4NDG A;  1KPA A;  3O0M A;  1ST4 A;  4QEB A;  3R6F A;  5IPC A;  4QDE A;  4NJY A;  3N1T A;  1RZY A;  3OJ7 A;  2H39 A;  3OMF A;  5CS2 A;  3NRD A;  1Z84 A;  3I4S A;  4EQE A;  1XML A;  4INI A;  4ZKL A;  4FIT A;  5IPE A;  6RHN A;  1GUP A;  1AV5 A;  4ZKV A;  2Q4L A;  3O1Z A;  3SPL A;  3O1C A; 
#chains in the Genus database with same CATH topology
 5BV3 A;  3RHN A;  1EMS A;  4G0J A;  3ANO A;  5IN3 A;  1ZWJ A;  5ED3 A;  4EQH A;  2R7P A;  2GU0 A;  2R8F A;  3SP4 A;  4NDI A;  4RHN A;  3OXK A;  6FIT A;  4QDV A;  3P0T A;  1KPC A;  4NK0 A;  2POF A;  1KPE A;  1ST0 A;  4EQG A;  3BL9 A;  2Q4H A;  3LB5 A;  1KPB A;  3I24 A;  3IMI A;  4G0A A;  5I2F A;  3BLA A;  3WO5 A;  4EGU A;  5I2E A;  3N1S A;  1KPF A;  3BL7 A;  1L9V A;  5IPD A;  3FIT A;  4INC A;  5RHN A;  4NDH A;  3O1X A;  5ED6 A;  3QGZ A;  1XMM A;  5IPB A;  2OIK A;  2FIT A;  4I5V A;  2FHI A;  5FIT A;  3SPD A;  3TW2 A;  5EMT A;  3L7X A;  1HXP A;  4YKL B;  4NDF A;  1FHI A;  3OHE A;  3KSV A;  4XBA A;  2LJW A;  4ZGL A;  1GUQ A;  1Y23 A;  1VLR A;  4I5W A;  4NJZ A;  1HXQ A;  1FIT A;  3SZQ A;  2EO4 A;  4NJX A;  4NDG A;  1KPA A;  3O0M A;  1ST4 A;  4QEB A;  3R6F A;  5IPC A;  4QDE A;  4NJY A;  3N1T A;  1RZY A;  3OJ7 A;  2H39 A;  3OMF A;  5CS2 A;  3NRD A;  1Z84 A;  3I4S A;  4I5T A;  4EQE A;  1XML A;  4INI A;  4ZKL A;  4FIT A;  2R7C A;  5IPE A;  6RHN A;  1GUP A;  1AV5 A;  4ZKV A;  2Q4L A;  3O1Z A;  3SPL A;  2R7J A;  3O1C A; 
#chains in the Genus database with same CATH homology
 5BV3 A;  3RHN A;  1EMS A;  3ANO A;  5IN3 A;  1ZWJ A;  5ED3 A;  4EQH A;  3SP4 A;  4NDI A;  4RHN A;  3OXK A;  6FIT A;  4QDV A;  3P0T A;  1KPC A;  4NK0 A;  1KPE A;  1ST0 A;  4EQG A;  3BL9 A;  2Q4H A;  3LB5 A;  1KPB A;  3I24 A;  3IMI A;  5I2F A;  3BLA A;  3WO5 A;  4EGU A;  5I2E A;  3N1S A;  1KPF A;  3BL7 A;  5IPD A;  3FIT A;  4INC A;  5RHN A;  4NDH A;  3O1X A;  5ED6 A;  3QGZ A;  1XMM A;  5IPB A;  2OIK A;  2FIT A;  2FHI A;  5FIT A;  3SPD A;  3TW2 A;  5EMT A;  3L7X A;  1HXP A;  4YKL B;  4NDF A;  1FHI A;  3OHE A;  3KSV A;  4XBA A;  4ZGL A;  1GUQ A;  1Y23 A;  1VLR A;  4NJZ A;  1HXQ A;  1FIT A;  3SZQ A;  2EO4 A;  4NJX A;  4NDG A;  1KPA A;  3O0M A;  1ST4 A;  4QEB A;  3R6F A;  5IPC A;  4QDE A;  4NJY A;  3N1T A;  1RZY A;  3OJ7 A;  2H39 A;  3OMF A;  5CS2 A;  3NRD A;  1Z84 A;  3I4S A;  4EQE A;  1XML A;  4INI A;  4ZKL A;  4FIT A;  5IPE A;  6RHN A;  1GUP A;  1AV5 A;  4ZKV A;  2Q4L A;  3O1Z A;  3SPL A;  3O1C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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