5I2FA

Human histidine triad nucleotide binding protein 1 (hhint1) with bound sulfamide inhibitor bio-ams
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
116
structure length
116
Chain Sequence
ARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 28
structure length 116
sequence length 116
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2fA00
2H39A 2FITA 4QEBA 4EQEA 3KSVA 3R6FA 4NJXA 2Q4LA 3OHEA 1GUPA 1XMLA 3QGZA 5IPBA 5IPDA 1KPAA 1GUQA 4XBAA 3I24A 3OXKA 4YKLB 1ST4A 4NDGA 3O1XA 4NJZA 3BL9A 1XMMA 3OMFA 1FITA 1RZYA 4ZKVA 4EQHA 4INCA 3N1TA 3SPDA 4ZGLA 5I2FA 3TW2A 1KPCA 2OIKA 1Y23A 5ED6A 3LB5A 1HXQA 3ANOA 5RHNA 6FITA 3SP4A 3OJ7A 1EMSA 5BV3A 1ST0A 4ZKLA 4NDHA 3I4SA 3RHNA 1FHIA 4NK0A 4EGUA 3BL7A 5IN3A 2FHIA 4EQGA 4FITA 1KPEA 4RHNA 3L7XA 5FITA 3N1SA 4INIA 1AV5A 1KPBA 1HXPA 3IMIA 1ZWJA 5I2EA 3SPLA 6RHNA 3O1CA 2EO4A 1VLRA 5IPCA 3NRDA 3SZQA 4NJYA 3FITA 3BLAA 4QDVA 4QDEA 5IPEA 5EMTA 3O0MA 5ED3A 2Q4HA 3WO5A 5CS2A 1Z84A 3P0TA 4NDIA 3O1ZA 4NDFA 1KPFA
chains in the Genus database with same CATH superfamily
2R7PA 2GU0A 2H39A 2FITA 4QEBA 4EQEA 3KSVA 3R6FA 4NJXA 2Q4LA 3OHEA 1GUPA 1XMLA 3QGZA 5IPBA 5IPDA 1KPAA 1GUQA 4XBAA 3I24A 2POFA 3OXKA 4YKLB 1ST4A 4NDGA 3O1XA 4NJZA 3BL9A 1XMMA 3OMFA 1FITA 1RZYA 4ZKVA 4EQHA 4INCA 3N1TA 3SPDA 4ZGLA 5I2FA 3TW2A 1KPCA 2OIKA 1Y23A 5ED6A 3LB5A 4G0AA 1HXQA 3ANOA 5RHNA 6FITA 3SP4A 3OJ7A 1EMSA 5BV3A 1ST0A 4ZKLA 4NDHA 3I4SA 3RHNA 1FHIA 4NK0A 4EGUA 3BL7A 4I5VA 5IN3A 2FHIA 4EQGA 4FITA 1KPEA 4RHNA 3L7XA 2R8FA 5FITA 3N1SA 4G0JA 4I5TA 4INIA 1AV5A 1KPBA 1HXPA 3IMIA 1ZWJA 2R7JA 5I2EA 3SPLA 6RHNA 3O1CA 2EO4A 1VLRA 4I5WA 5IPCA 3NRDA 3SZQA 1L9VA 4NJYA 2LJWA 3FITA 3BLAA 4QDVA 4QDEA 5IPEA 5EMTA 3O0MA 5ED3A 2R7CA 2Q4HA 3WO5A 5CS2A 1Z84A 3P0TA 4NDIA 3O1ZA 4NDFA 1KPFA
chains in the Genus database with same CATH topology
2H39A 2FITA 4QEBA 4EQEA 3KSVA 3R6FA 4NJXA 2Q4LA 3OHEA 1GUPA 1XMLA 3QGZA 5IPBA 5IPDA 1KPAA 1GUQA 4XBAA 3I24A 3OXKA 4YKLB 1ST4A 4NDGA 3O1XA 4NJZA 3BL9A 1XMMA 3OMFA 1FITA 1RZYA 4ZKVA 4EQHA 4INCA 3N1TA 3SPDA 4ZGLA 5I2FA 3TW2A 1KPCA 2OIKA 1Y23A 5ED6A 3LB5A 1HXQA 3ANOA 5RHNA 6FITA 3SP4A 3OJ7A 1EMSA 5BV3A 1ST0A 4ZKLA 4NDHA 3I4SA 3RHNA 1FHIA 4NK0A 4EGUA 3BL7A 5IN3A 2FHIA 4EQGA 4FITA 1KPEA 4RHNA 3L7XA 5FITA 3N1SA 4INIA 1AV5A 1KPBA 1HXPA 3IMIA 1ZWJA 5I2EA 3SPLA 6RHNA 3O1CA 2EO4A 1VLRA 5IPCA 3NRDA 3SZQA 4NJYA 3FITA 3BLAA 4QDVA 4QDEA 5IPEA 5EMTA 3O0MA 5ED3A 2Q4HA 3WO5A 5CS2A 1Z84A 3P0TA 4NDIA 3O1ZA 4NDFA 1KPFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H39 A;  2FIT A;  4QEB A;  4EQE A;  3KSV A;  3R6F A;  4NJX A;  2Q4L A;  3OHE A;  1GUP A;  1XML A;  3QGZ A;  5IPB A;  5IPD A;  1KPA A;  1GUQ A;  4XBA A;  3I24 A;  3OXK A;  4YKL B;  1ST4 A;  4NDG A;  3O1X A;  4NJZ A;  3BL9 A;  1XMM A;  3OMF A;  1FIT A;  1RZY A;  4ZKV A;  4EQH A;  4INC A;  3N1T A;  3SPD A;  4ZGL A;  5I2F A;  3TW2 A;  1KPC A;  2OIK A;  1Y23 A;  5ED6 A;  3LB5 A;  1HXQ A;  3ANO A;  5RHN A;  6FIT A;  3SP4 A;  3OJ7 A;  1EMS A;  5BV3 A;  1ST0 A;  4ZKL A;  4NDH A;  3I4S A;  3RHN A;  1FHI A;  4NK0 A;  4EGU A;  3BL7 A;  5IN3 A;  2FHI A;  4EQG A;  4FIT A;  1KPE A;  4RHN A;  3L7X A;  5FIT A;  3N1S A;  4INI A;  1AV5 A;  1KPB A;  1HXP A;  3IMI A;  1ZWJ A;  5I2E A;  3SPL A;  6RHN A;  3O1C A;  2EO4 A;  1VLR A;  5IPC A;  3NRD A;  3SZQ A;  4NJY A;  3FIT A;  3BLA A;  4QDV A;  4QDE A;  5IPE A;  5EMT A;  3O0M A;  5ED3 A;  2Q4H A;  3WO5 A;  5CS2 A;  1Z84 A;  3P0T A;  4NDI A;  3O1Z A;  4NDF A;  1KPF A; 
#chains in the Genus database with same CATH topology
 2R7P A;  2GU0 A;  2H39 A;  2FIT A;  4QEB A;  4EQE A;  3KSV A;  3R6F A;  4NJX A;  2Q4L A;  3OHE A;  1GUP A;  1XML A;  3QGZ A;  5IPB A;  5IPD A;  1KPA A;  1GUQ A;  4XBA A;  3I24 A;  2POF A;  3OXK A;  4YKL B;  1ST4 A;  4NDG A;  3O1X A;  4NJZ A;  3BL9 A;  1XMM A;  3OMF A;  1FIT A;  1RZY A;  4ZKV A;  4EQH A;  4INC A;  3N1T A;  3SPD A;  4ZGL A;  5I2F A;  3TW2 A;  1KPC A;  2OIK A;  1Y23 A;  5ED6 A;  3LB5 A;  4G0A A;  1HXQ A;  3ANO A;  5RHN A;  6FIT A;  3SP4 A;  3OJ7 A;  1EMS A;  5BV3 A;  1ST0 A;  4ZKL A;  4NDH A;  3I4S A;  3RHN A;  1FHI A;  4NK0 A;  4EGU A;  3BL7 A;  4I5V A;  5IN3 A;  2FHI A;  4EQG A;  4FIT A;  1KPE A;  4RHN A;  3L7X A;  2R8F A;  5FIT A;  3N1S A;  4G0J A;  4I5T A;  4INI A;  1AV5 A;  1KPB A;  1HXP A;  3IMI A;  1ZWJ A;  2R7J A;  5I2E A;  3SPL A;  6RHN A;  3O1C A;  2EO4 A;  1VLR A;  4I5W A;  5IPC A;  3NRD A;  3SZQ A;  1L9V A;  4NJY A;  2LJW A;  3FIT A;  3BLA A;  4QDV A;  4QDE A;  5IPE A;  5EMT A;  3O0M A;  5ED3 A;  2R7C A;  2Q4H A;  3WO5 A;  5CS2 A;  1Z84 A;  3P0T A;  4NDI A;  3O1Z A;  4NDF A;  1KPF A; 
#chains in the Genus database with same CATH homology
 2H39 A;  2FIT A;  4QEB A;  4EQE A;  3KSV A;  3R6F A;  4NJX A;  2Q4L A;  3OHE A;  1GUP A;  1XML A;  3QGZ A;  5IPB A;  5IPD A;  1KPA A;  1GUQ A;  4XBA A;  3I24 A;  3OXK A;  4YKL B;  1ST4 A;  4NDG A;  3O1X A;  4NJZ A;  3BL9 A;  1XMM A;  3OMF A;  1FIT A;  1RZY A;  4ZKV A;  4EQH A;  4INC A;  3N1T A;  3SPD A;  4ZGL A;  5I2F A;  3TW2 A;  1KPC A;  2OIK A;  1Y23 A;  5ED6 A;  3LB5 A;  1HXQ A;  3ANO A;  5RHN A;  6FIT A;  3SP4 A;  3OJ7 A;  1EMS A;  5BV3 A;  1ST0 A;  4ZKL A;  4NDH A;  3I4S A;  3RHN A;  1FHI A;  4NK0 A;  4EGU A;  3BL7 A;  5IN3 A;  2FHI A;  4EQG A;  4FIT A;  1KPE A;  4RHN A;  3L7X A;  5FIT A;  3N1S A;  4INI A;  1AV5 A;  1KPB A;  1HXP A;  3IMI A;  1ZWJ A;  5I2E A;  3SPL A;  6RHN A;  3O1C A;  2EO4 A;  1VLR A;  5IPC A;  3NRD A;  3SZQ A;  4NJY A;  3FIT A;  3BLA A;  4QDV A;  4QDE A;  5IPE A;  5EMT A;  3O0M A;  5ED3 A;  2Q4H A;  3WO5 A;  5CS2 A;  1Z84 A;  3P0T A;  4NDI A;  3O1Z A;  4NDF A;  1KPF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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