5I2FA

Human histidine triad nucleotide binding protein 1 (hhint1) with bound sulfamide inhibitor bio-ams
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
116
structure length
116
Chain Sequence
ARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
molecule keywords Histidine triad nucleotide-binding protein 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 28
structure length 116
sequence length 116
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2fA00
3BLAA 5ED6A 2Q4LA 4ZKVA 1AV5A 1GUPA 1KPEA 4ZGLA 1Z84A 3IMIA 3OMFA 5RHNA 3KSVA 4INCA 5IPBA 3SPDA 3SZQA 3O1ZA 1KPFA 3SP4A 1ZWJA 3FITA 5IPCA 3ANOA 1FHIA 1KPBA 1GUQA 3P0TA 3I24A 3NRDA 3R6FA 1KPCA 2OIKA 5IPDA 3WO5A 1HXQA 2FHIA 3QGZA 5EMTA 3I4SA 3LB5A 4NDIA 4YKLB 1ST0A 2EO4A 1VLRA 5IN3A 5FITA 5BV3A 6FITA 4EQHA 3SPLA 3OHEA 4EGUA 4FITA 4XBAA 4NDHA 1FITA 5I2EA 1ST4A 4QDEA 3N1TA 3OXKA 3OJ7A 4NK0A 3N1SA 2Q4HA 2H39A 6RHNA 2FITA 4NJXA 5IPEA 4RHNA 4QDVA 4EQGA 1HXPA 4NJZA 4NJYA 3TW2A 5ED3A 3RHNA 4INIA 3O1XA 1RZYA 3BL9A 3O0MA 3L7XA 5I2FA 3BL7A 5CS2A 1XMLA 1KPAA 4QEBA 4EQEA 1Y23A 4NDFA 1EMSA 4ZKLA 4NDGA 1XMMA 3O1CA
chains in the Genus database with same CATH superfamily
3BLAA 5ED6A 2Q4LA 4I5TA 4ZKVA 1AV5A 1GUPA 1KPEA 4I5WA 4ZGLA 1Z84A 3IMIA 3OMFA 5RHNA 3KSVA 4INCA 5IPBA 3SPDA 3SZQA 3O1ZA 1KPFA 3SP4A 1ZWJA 3FITA 5IPCA 3ANOA 1FHIA 1KPBA 4G0AA 1GUQA 3P0TA 3I24A 3NRDA 2R7CA 3R6FA 1KPCA 2OIKA 5IPDA 3WO5A 1HXQA 2FHIA 3QGZA 5EMTA 3I4SA 3LB5A 4NDIA 2R7JA 4YKLB 1ST0A 2EO4A 1VLRA 5IN3A 5FITA 2GU0A 5BV3A 4EQHA 6FITA 3SPLA 3OHEA 4EGUA 2R7PA 4FITA 2POFA 4I5VA 4XBAA 4NDHA 1FITA 1L9VA 5I2EA 1ST4A 4QDEA 3N1TA 3OXKA 3OJ7A 4NK0A 3N1SA 2Q4HA 2H39A 6RHNA 2FITA 4NJXA 5IPEA 4RHNA 4QDVA 4EQGA 1HXPA 2LJWA 4NJZA 4NJYA 3TW2A 5ED3A 3RHNA 4INIA 3O1XA 1RZYA 3BL9A 3O0MA 4G0JA 3L7XA 5I2FA 3BL7A 5CS2A 1XMLA 1KPAA 2R8FA 4QEBA 4EQEA 1Y23A 4NDFA 1EMSA 4ZKLA 4NDGA 1XMMA 3O1CA
chains in the Genus database with same CATH topology
3BLAA 5ED6A 2Q4LA 4ZKVA 1AV5A 1GUPA 1KPEA 4ZGLA 1Z84A 3IMIA 3OMFA 5RHNA 3KSVA 4INCA 5IPBA 3SPDA 3SZQA 3O1ZA 1KPFA 3SP4A 1ZWJA 3FITA 5IPCA 3ANOA 1FHIA 1KPBA 1GUQA 3P0TA 3I24A 3NRDA 3R6FA 1KPCA 2OIKA 5IPDA 3WO5A 1HXQA 2FHIA 3QGZA 5EMTA 3I4SA 3LB5A 4NDIA 4YKLB 1ST0A 2EO4A 1VLRA 5IN3A 5FITA 5BV3A 6FITA 4EQHA 3SPLA 3OHEA 4EGUA 4FITA 4XBAA 4NDHA 1FITA 5I2EA 1ST4A 4QDEA 3N1TA 3OXKA 3OJ7A 4NK0A 3N1SA 2Q4HA 2H39A 6RHNA 2FITA 4NJXA 5IPEA 4RHNA 4QDVA 4EQGA 1HXPA 4NJZA 4NJYA 3TW2A 5ED3A 3RHNA 4INIA 3O1XA 1RZYA 3BL9A 3O0MA 3L7XA 5I2FA 3BL7A 5CS2A 1XMLA 1KPAA 4QEBA 4EQEA 1Y23A 4NDFA 1EMSA 4ZKLA 4NDGA 1XMMA 3O1CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BLA A;  5ED6 A;  2Q4L A;  4ZKV A;  1AV5 A;  1GUP A;  1KPE A;  4ZGL A;  1Z84 A;  3IMI A;  3OMF A;  5RHN A;  3KSV A;  4INC A;  5IPB A;  3SPD A;  3SZQ A;  3O1Z A;  1KPF A;  3SP4 A;  1ZWJ A;  3FIT A;  5IPC A;  3ANO A;  1FHI A;  1KPB A;  1GUQ A;  3P0T A;  3I24 A;  3NRD A;  3R6F A;  1KPC A;  2OIK A;  5IPD A;  3WO5 A;  1HXQ A;  2FHI A;  3QGZ A;  5EMT A;  3I4S A;  3LB5 A;  4NDI A;  4YKL B;  1ST0 A;  2EO4 A;  1VLR A;  5IN3 A;  5FIT A;  5BV3 A;  6FIT A;  4EQH A;  3SPL A;  3OHE A;  4EGU A;  4FIT A;  4XBA A;  4NDH A;  1FIT A;  5I2E A;  1ST4 A;  4QDE A;  3N1T A;  3OXK A;  3OJ7 A;  4NK0 A;  3N1S A;  2Q4H A;  2H39 A;  6RHN A;  2FIT A;  4NJX A;  5IPE A;  4RHN A;  4QDV A;  4EQG A;  1HXP A;  4NJZ A;  4NJY A;  3TW2 A;  5ED3 A;  3RHN A;  4INI A;  3O1X A;  1RZY A;  3BL9 A;  3O0M A;  3L7X A;  5I2F A;  3BL7 A;  5CS2 A;  1XML A;  1KPA A;  4QEB A;  4EQE A;  1Y23 A;  4NDF A;  1EMS A;  4ZKL A;  4NDG A;  1XMM A;  3O1C A; 
#chains in the Genus database with same CATH topology
 3BLA A;  5ED6 A;  2Q4L A;  4I5T A;  4ZKV A;  1AV5 A;  1GUP A;  1KPE A;  4I5W A;  4ZGL A;  1Z84 A;  3IMI A;  3OMF A;  5RHN A;  3KSV A;  4INC A;  5IPB A;  3SPD A;  3SZQ A;  3O1Z A;  1KPF A;  3SP4 A;  1ZWJ A;  3FIT A;  5IPC A;  3ANO A;  1FHI A;  1KPB A;  4G0A A;  1GUQ A;  3P0T A;  3I24 A;  3NRD A;  2R7C A;  3R6F A;  1KPC A;  2OIK A;  5IPD A;  3WO5 A;  1HXQ A;  2FHI A;  3QGZ A;  5EMT A;  3I4S A;  3LB5 A;  4NDI A;  2R7J A;  4YKL B;  1ST0 A;  2EO4 A;  1VLR A;  5IN3 A;  5FIT A;  2GU0 A;  5BV3 A;  4EQH A;  6FIT A;  3SPL A;  3OHE A;  4EGU A;  2R7P A;  4FIT A;  2POF A;  4I5V A;  4XBA A;  4NDH A;  1FIT A;  1L9V A;  5I2E A;  1ST4 A;  4QDE A;  3N1T A;  3OXK A;  3OJ7 A;  4NK0 A;  3N1S A;  2Q4H A;  2H39 A;  6RHN A;  2FIT A;  4NJX A;  5IPE A;  4RHN A;  4QDV A;  4EQG A;  1HXP A;  2LJW A;  4NJZ A;  4NJY A;  3TW2 A;  5ED3 A;  3RHN A;  4INI A;  3O1X A;  1RZY A;  3BL9 A;  3O0M A;  4G0J A;  3L7X A;  5I2F A;  3BL7 A;  5CS2 A;  1XML A;  1KPA A;  2R8F A;  4QEB A;  4EQE A;  1Y23 A;  4NDF A;  1EMS A;  4ZKL A;  4NDG A;  1XMM A;  3O1C A; 
#chains in the Genus database with same CATH homology
 3BLA A;  5ED6 A;  2Q4L A;  4ZKV A;  1AV5 A;  1GUP A;  1KPE A;  4ZGL A;  1Z84 A;  3IMI A;  3OMF A;  5RHN A;  3KSV A;  4INC A;  5IPB A;  3SPD A;  3SZQ A;  3O1Z A;  1KPF A;  3SP4 A;  1ZWJ A;  3FIT A;  5IPC A;  3ANO A;  1FHI A;  1KPB A;  1GUQ A;  3P0T A;  3I24 A;  3NRD A;  3R6F A;  1KPC A;  2OIK A;  5IPD A;  3WO5 A;  1HXQ A;  2FHI A;  3QGZ A;  5EMT A;  3I4S A;  3LB5 A;  4NDI A;  4YKL B;  1ST0 A;  2EO4 A;  1VLR A;  5IN3 A;  5FIT A;  5BV3 A;  6FIT A;  4EQH A;  3SPL A;  3OHE A;  4EGU A;  4FIT A;  4XBA A;  4NDH A;  1FIT A;  5I2E A;  1ST4 A;  4QDE A;  3N1T A;  3OXK A;  3OJ7 A;  4NK0 A;  3N1S A;  2Q4H A;  2H39 A;  6RHN A;  2FIT A;  4NJX A;  5IPE A;  4RHN A;  4QDV A;  4EQG A;  1HXP A;  4NJZ A;  4NJY A;  3TW2 A;  5ED3 A;  3RHN A;  4INI A;  3O1X A;  1RZY A;  3BL9 A;  3O0M A;  3L7X A;  5I2F A;  3BL7 A;  5CS2 A;  1XML A;  1KPA A;  4QEB A;  4EQE A;  1Y23 A;  4NDF A;  1EMS A;  4ZKL A;  4NDG A;  1XMM A;  3O1C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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