5I2FA

Human histidine triad nucleotide binding protein 1 (hhint1) with bound sulfamide inhibitor bio-ams
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
116
structure length
116
Chain Sequence
ARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 28
structure length 116
sequence length 116
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2fA00
4QDVA 4NDIA 4FITA 4EQGA 3I24A 4ZKVA 3R6FA 6FITA 1Y23A 4RHNA 1GUQA 3O1CA 3OXKA 6RHNA 1ZWJA 3OJ7A 1XMLA 3SPDA 2Q4HA 1KPBA 4NJYA 4ZKLA 3I4SA 1FHIA 3IMIA 4XBAA 2FITA 2Q4LA 4NJZA 4EGUA 5CS2A 3O0MA 3BL7A 4NDGA 4INCA 4NK0A 5RHNA 3ANOA 1GUPA 3RHNA 1AV5A 1KPEA 5IPDA 3KSVA 1KPAA 3SP4A 3L7XA 4YKLB 2EO4A 4NDHA 3NRDA 3OMFA 5ED6A 1Z84A 1ST0A 3WO5A 3BL9A 4QEBA 2H39A 4EQHA 4NJXA 4INIA 4EQEA 3LB5A 3P0TA 4ZGLA 1HXPA 1EMSA 3O1XA 1KPFA 3BLAA 5IPBA 3QGZA 1RZYA 1ST4A 2FHIA 3N1SA 5EMTA 3OHEA 2OIKA 1HXQA 3N1TA 4QDEA 3O1ZA 1FITA 1KPCA 5BV3A 1VLRA 3SZQA 5IN3A 5I2FA 3SPLA 3TW2A 1XMMA 4NDFA 5I2EA 5ED3A 5FITA 5IPCA 5IPEA 3FITA
chains in the Genus database with same CATH superfamily
4QDVA 4NDIA 4FITA 4EQGA 3I24A 4ZKVA 3R6FA 2GU0A 6FITA 1Y23A 4RHNA 1GUQA 3O1CA 3OXKA 6RHNA 1L9VA 1ZWJA 3OJ7A 1XMLA 3SPDA 2Q4HA 1KPBA 4NJYA 4ZKLA 3I4SA 1FHIA 3IMIA 4XBAA 2FITA 2Q4LA 4NJZA 4EGUA 5CS2A 3O0MA 3BL7A 4I5TA 4NDGA 2R7CA 4INCA 4NK0A 5RHNA 3ANOA 1GUPA 3RHNA 1AV5A 1KPEA 5IPDA 3KSVA 1KPAA 3SP4A 3L7XA 4YKLB 2EO4A 4NDHA 3NRDA 3OMFA 5ED6A 1Z84A 1ST0A 3WO5A 3BL9A 4QEBA 4G0JA 2H39A 4EQHA 4NJXA 4INIA 4EQEA 2R8FA 3LB5A 3P0TA 4ZGLA 1HXPA 1EMSA 2LJWA 3O1XA 1KPFA 3BLAA 2POFA 5IPBA 3QGZA 1RZYA 1ST4A 2FHIA 3N1SA 5EMTA 4G0AA 4I5WA 3OHEA 2OIKA 1HXQA 3N1TA 4QDEA 3O1ZA 1FITA 1KPCA 5BV3A 1VLRA 3SZQA 5IN3A 5I2FA 2R7JA 3SPLA 3TW2A 1XMMA 4NDFA 5I2EA 4I5VA 5ED3A 5FITA 2R7PA 5IPCA 5IPEA 3FITA
chains in the Genus database with same CATH topology
4QDVA 4NDIA 4FITA 4EQGA 3I24A 4ZKVA 3R6FA 6FITA 1Y23A 4RHNA 1GUQA 3O1CA 3OXKA 6RHNA 1ZWJA 3OJ7A 1XMLA 3SPDA 2Q4HA 1KPBA 4NJYA 4ZKLA 3I4SA 1FHIA 3IMIA 4XBAA 2FITA 2Q4LA 4NJZA 4EGUA 5CS2A 3O0MA 3BL7A 4NDGA 4INCA 4NK0A 5RHNA 3ANOA 1GUPA 3RHNA 1AV5A 1KPEA 5IPDA 3KSVA 1KPAA 3SP4A 3L7XA 4YKLB 2EO4A 4NDHA 3NRDA 3OMFA 5ED6A 1Z84A 1ST0A 3WO5A 3BL9A 4QEBA 2H39A 4EQHA 4NJXA 4INIA 4EQEA 3LB5A 3P0TA 4ZGLA 1HXPA 1EMSA 3O1XA 1KPFA 3BLAA 5IPBA 3QGZA 1RZYA 1ST4A 2FHIA 3N1SA 5EMTA 3OHEA 2OIKA 1HXQA 3N1TA 4QDEA 3O1ZA 1FITA 1KPCA 5BV3A 1VLRA 3SZQA 5IN3A 5I2FA 3SPLA 3TW2A 1XMMA 4NDFA 5I2EA 5ED3A 5FITA 5IPCA 5IPEA 3FITA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QDV A;  4NDI A;  4FIT A;  4EQG A;  3I24 A;  4ZKV A;  3R6F A;  6FIT A;  1Y23 A;  4RHN A;  1GUQ A;  3O1C A;  3OXK A;  6RHN A;  1ZWJ A;  3OJ7 A;  1XML A;  3SPD A;  2Q4H A;  1KPB A;  4NJY A;  4ZKL A;  3I4S A;  1FHI A;  3IMI A;  4XBA A;  2FIT A;  2Q4L A;  4NJZ A;  4EGU A;  5CS2 A;  3O0M A;  3BL7 A;  4NDG A;  4INC A;  4NK0 A;  5RHN A;  3ANO A;  1GUP A;  3RHN A;  1AV5 A;  1KPE A;  5IPD A;  3KSV A;  1KPA A;  3SP4 A;  3L7X A;  4YKL B;  2EO4 A;  4NDH A;  3NRD A;  3OMF A;  5ED6 A;  1Z84 A;  1ST0 A;  3WO5 A;  3BL9 A;  4QEB A;  2H39 A;  4EQH A;  4NJX A;  4INI A;  4EQE A;  3LB5 A;  3P0T A;  4ZGL A;  1HXP A;  1EMS A;  3O1X A;  1KPF A;  3BLA A;  5IPB A;  3QGZ A;  1RZY A;  1ST4 A;  2FHI A;  3N1S A;  5EMT A;  3OHE A;  2OIK A;  1HXQ A;  3N1T A;  4QDE A;  3O1Z A;  1FIT A;  1KPC A;  5BV3 A;  1VLR A;  3SZQ A;  5IN3 A;  5I2F A;  3SPL A;  3TW2 A;  1XMM A;  4NDF A;  5I2E A;  5ED3 A;  5FIT A;  5IPC A;  5IPE A;  3FIT A; 
#chains in the Genus database with same CATH topology
 4QDV A;  4NDI A;  4FIT A;  4EQG A;  3I24 A;  4ZKV A;  3R6F A;  2GU0 A;  6FIT A;  1Y23 A;  4RHN A;  1GUQ A;  3O1C A;  3OXK A;  6RHN A;  1L9V A;  1ZWJ A;  3OJ7 A;  1XML A;  3SPD A;  2Q4H A;  1KPB A;  4NJY A;  4ZKL A;  3I4S A;  1FHI A;  3IMI A;  4XBA A;  2FIT A;  2Q4L A;  4NJZ A;  4EGU A;  5CS2 A;  3O0M A;  3BL7 A;  4I5T A;  4NDG A;  2R7C A;  4INC A;  4NK0 A;  5RHN A;  3ANO A;  1GUP A;  3RHN A;  1AV5 A;  1KPE A;  5IPD A;  3KSV A;  1KPA A;  3SP4 A;  3L7X A;  4YKL B;  2EO4 A;  4NDH A;  3NRD A;  3OMF A;  5ED6 A;  1Z84 A;  1ST0 A;  3WO5 A;  3BL9 A;  4QEB A;  4G0J A;  2H39 A;  4EQH A;  4NJX A;  4INI A;  4EQE A;  2R8F A;  3LB5 A;  3P0T A;  4ZGL A;  1HXP A;  1EMS A;  2LJW A;  3O1X A;  1KPF A;  3BLA A;  2POF A;  5IPB A;  3QGZ A;  1RZY A;  1ST4 A;  2FHI A;  3N1S A;  5EMT A;  4G0A A;  4I5W A;  3OHE A;  2OIK A;  1HXQ A;  3N1T A;  4QDE A;  3O1Z A;  1FIT A;  1KPC A;  5BV3 A;  1VLR A;  3SZQ A;  5IN3 A;  5I2F A;  2R7J A;  3SPL A;  3TW2 A;  1XMM A;  4NDF A;  5I2E A;  4I5V A;  5ED3 A;  5FIT A;  2R7P A;  5IPC A;  5IPE A;  3FIT A; 
#chains in the Genus database with same CATH homology
 4QDV A;  4NDI A;  4FIT A;  4EQG A;  3I24 A;  4ZKV A;  3R6F A;  6FIT A;  1Y23 A;  4RHN A;  1GUQ A;  3O1C A;  3OXK A;  6RHN A;  1ZWJ A;  3OJ7 A;  1XML A;  3SPD A;  2Q4H A;  1KPB A;  4NJY A;  4ZKL A;  3I4S A;  1FHI A;  3IMI A;  4XBA A;  2FIT A;  2Q4L A;  4NJZ A;  4EGU A;  5CS2 A;  3O0M A;  3BL7 A;  4NDG A;  4INC A;  4NK0 A;  5RHN A;  3ANO A;  1GUP A;  3RHN A;  1AV5 A;  1KPE A;  5IPD A;  3KSV A;  1KPA A;  3SP4 A;  3L7X A;  4YKL B;  2EO4 A;  4NDH A;  3NRD A;  3OMF A;  5ED6 A;  1Z84 A;  1ST0 A;  3WO5 A;  3BL9 A;  4QEB A;  2H39 A;  4EQH A;  4NJX A;  4INI A;  4EQE A;  3LB5 A;  3P0T A;  4ZGL A;  1HXP A;  1EMS A;  3O1X A;  1KPF A;  3BLA A;  5IPB A;  3QGZ A;  1RZY A;  1ST4 A;  2FHI A;  3N1S A;  5EMT A;  3OHE A;  2OIK A;  1HXQ A;  3N1T A;  4QDE A;  3O1Z A;  1FIT A;  1KPC A;  5BV3 A;  1VLR A;  3SZQ A;  5IN3 A;  5I2F A;  3SPL A;  3TW2 A;  1XMM A;  4NDF A;  5I2E A;  5ED3 A;  5FIT A;  5IPC A;  5IPE A;  3FIT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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