5IN3A

Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
339
structure length
324
Chain Sequence
DHQHIRYNPLQDEWVLVSAHRTVPRHDPLNPLCPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAKSARGVCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWLVLVPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFETSFPYSMGWHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Galactose-1-phosphate uridylyltransferase
total genus 96
structure length 324
sequence length 339
chains with identical sequence B
ec nomenclature ec 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
pdb deposition date 2016-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01087 GalP_UDP_transf Galactose-1-phosphate uridyl transferase, N-terminal domain
A PF02744 GalP_UDP_tr_C Galactose-1-phosphate uridyl transferase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5in3A01
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5in3A02
5IN3A 4EQGA 5IPBA 2OIKA 4FITA 4ZKLA 3TW2A 6RHNA 3I24A 3O1XA 3KSVA 4NDHA 4QDEA 1ST0A 1XMMA 4NDFA 4NK0A 3O0MA 3FITA 1EMSA 1GUPA 3RHNA 5IPEA 4NDIA 4QDVA 3N1TA 3L7XA 3NRDA 3SP4A 6FITA 4NJYA 5EMTA 3P0TA 4NJXA 5I2EA 4EQEA 5FITA 1KPFA 1ZWJA 3I4SA 2EO4A 1AV5A 3R6FA 3BL7A 3OJ7A 4ZGLA 4EQHA 3SZQA 4ZKVA 5IPCA 4NJZA 3QGZA 4RHNA 4QEBA 5RHNA 3O1CA 3OMFA 5ED3A 1RZYA 1Z84A 1ST4A 3BLAA 1HXPA 5ED6A 3ANOA 5BV3A 5I2FA 3OXKA 4YKLB 1FHIA 1Y23A 2Q4LA 3O1ZA 4INCA 2H39A 4NDGA 1VLRA 3LB5A 4INIA 4XBAA 5IPDA 3N1SA 2FITA 1XMLA 1GUQA 3IMIA 1KPCA 5CS2A 3OHEA 3BL9A 3SPLA 2FHIA 1HXQA 4EGUA 1KPAA 3WO5A 3SPDA 1KPEA 1KPBA 1FITA 2Q4HA
chains in the Genus database with same CATH superfamily
5IN3A 4EQGA 5IPBA 2OIKA 4FITA 4ZKLA 3TW2A 6RHNA 3I24A 3O1XA 3KSVA 4NDHA 4QDEA 1ST0A 2LJWA 1XMMA 4NDFA 4NK0A 3O0MA 3FITA 1EMSA 1GUPA 3RHNA 5IPEA 4NDIA 4QDVA 3N1TA 2GU0A 3L7XA 3NRDA 3SP4A 6FITA 2POFA 4NJYA 5EMTA 3P0TA 4NJXA 5I2EA 4EQEA 5FITA 1KPFA 1ZWJA 3I4SA 2EO4A 1AV5A 3R6FA 3BL7A 3OJ7A 4G0JA 4ZGLA 4EQHA 3SZQA 4ZKVA 5IPCA 4NJZA 3QGZA 4RHNA 4QEBA 2R7JA 5RHNA 3O1CA 3OMFA 4I5VA 4I5TA 5ED3A 1RZYA 1Z84A 1ST4A 3BLAA 1HXPA 5ED6A 3ANOA 5BV3A 5I2FA 3OXKA 4YKLB 1FHIA 1Y23A 2Q4LA 3O1ZA 4INCA 2H39A 4NDGA 1VLRA 3LB5A 4INIA 4XBAA 5IPDA 3N1SA 2FITA 1XMLA 1GUQA 3IMIA 1KPCA 5CS2A 4I5WA 4G0AA 2R8FA 3OHEA 2R7PA 3BL9A 3SPLA 2FHIA 1HXQA 4EGUA 1KPAA 3WO5A 2R7CA 3SPDA 1KPEA 1L9VA 1KPBA 1FITA 2Q4HA
chains in the Genus database with same CATH topology
5IN3A 4EQGA 5IPBA 2OIKA 4FITA 4ZKLA 3TW2A 6RHNA 3I24A 3O1XA 3KSVA 4NDHA 4QDEA 1ST0A 1XMMA 4NDFA 4NK0A 3O0MA 3FITA 1EMSA 1GUPA 3RHNA 5IPEA 4NDIA 4QDVA 3N1TA 3L7XA 3NRDA 3SP4A 6FITA 4NJYA 5EMTA 3P0TA 4NJXA 5I2EA 4EQEA 5FITA 1KPFA 1ZWJA 3I4SA 2EO4A 1AV5A 3R6FA 3BL7A 3OJ7A 4ZGLA 4EQHA 3SZQA 4ZKVA 5IPCA 4NJZA 3QGZA 4RHNA 4QEBA 5RHNA 3O1CA 3OMFA 5ED3A 1RZYA 1Z84A 1ST4A 3BLAA 1HXPA 5ED6A 3ANOA 5BV3A 5I2FA 3OXKA 4YKLB 1FHIA 1Y23A 2Q4LA 3O1ZA 4INCA 2H39A 4NDGA 1VLRA 3LB5A 4INIA 4XBAA 5IPDA 3N1SA 2FITA 1XMLA 1GUQA 3IMIA 1KPCA 5CS2A 3OHEA 3BL9A 3SPLA 2FHIA 1HXQA 4EGUA 1KPAA 3WO5A 3SPDA 1KPEA 1KPBA 1FITA 2Q4HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IN3 A;  4EQG A;  5IPB A;  2OIK A;  4FIT A;  4ZKL A;  3TW2 A;  6RHN A;  3I24 A;  3O1X A;  3KSV A;  4NDH A;  4QDE A;  1ST0 A;  1XMM A;  4NDF A;  4NK0 A;  3O0M A;  3FIT A;  1EMS A;  1GUP A;  3RHN A;  5IPE A;  4NDI A;  4QDV A;  3N1T A;  3L7X A;  3NRD A;  3SP4 A;  6FIT A;  4NJY A;  5EMT A;  3P0T A;  4NJX A;  5I2E A;  4EQE A;  5FIT A;  1KPF A;  1ZWJ A;  3I4S A;  2EO4 A;  1AV5 A;  3R6F A;  3BL7 A;  3OJ7 A;  4ZGL A;  4EQH A;  3SZQ A;  4ZKV A;  5IPC A;  4NJZ A;  3QGZ A;  4RHN A;  4QEB A;  5RHN A;  3O1C A;  3OMF A;  5ED3 A;  1RZY A;  1Z84 A;  1ST4 A;  3BLA A;  1HXP A;  5ED6 A;  3ANO A;  5BV3 A;  5I2F A;  3OXK A;  4YKL B;  1FHI A;  1Y23 A;  2Q4L A;  3O1Z A;  4INC A;  2H39 A;  4NDG A;  1VLR A;  3LB5 A;  4INI A;  4XBA A;  5IPD A;  3N1S A;  2FIT A;  1XML A;  1GUQ A;  3IMI A;  1KPC A;  5CS2 A;  3OHE A;  3BL9 A;  3SPL A;  2FHI A;  1HXQ A;  4EGU A;  1KPA A;  3WO5 A;  3SPD A;  1KPE A;  1KPB A;  1FIT A;  2Q4H A; 
#chains in the Genus database with same CATH topology
 5IN3 A;  4EQG A;  5IPB A;  2OIK A;  4FIT A;  4ZKL A;  3TW2 A;  6RHN A;  3I24 A;  3O1X A;  3KSV A;  4NDH A;  4QDE A;  1ST0 A;  2LJW A;  1XMM A;  4NDF A;  4NK0 A;  3O0M A;  3FIT A;  1EMS A;  1GUP A;  3RHN A;  5IPE A;  4NDI A;  4QDV A;  3N1T A;  2GU0 A;  3L7X A;  3NRD A;  3SP4 A;  6FIT A;  2POF A;  4NJY A;  5EMT A;  3P0T A;  4NJX A;  5I2E A;  4EQE A;  5FIT A;  1KPF A;  1ZWJ A;  3I4S A;  2EO4 A;  1AV5 A;  3R6F A;  3BL7 A;  3OJ7 A;  4G0J A;  4ZGL A;  4EQH A;  3SZQ A;  4ZKV A;  5IPC A;  4NJZ A;  3QGZ A;  4RHN A;  4QEB A;  2R7J A;  5RHN A;  3O1C A;  3OMF A;  4I5V A;  4I5T A;  5ED3 A;  1RZY A;  1Z84 A;  1ST4 A;  3BLA A;  1HXP A;  5ED6 A;  3ANO A;  5BV3 A;  5I2F A;  3OXK A;  4YKL B;  1FHI A;  1Y23 A;  2Q4L A;  3O1Z A;  4INC A;  2H39 A;  4NDG A;  1VLR A;  3LB5 A;  4INI A;  4XBA A;  5IPD A;  3N1S A;  2FIT A;  1XML A;  1GUQ A;  3IMI A;  1KPC A;  5CS2 A;  4I5W A;  4G0A A;  2R8F A;  3OHE A;  2R7P A;  3BL9 A;  3SPL A;  2FHI A;  1HXQ A;  4EGU A;  1KPA A;  3WO5 A;  2R7C A;  3SPD A;  1KPE A;  1L9V A;  1KPB A;  1FIT A;  2Q4H A; 
#chains in the Genus database with same CATH homology
 5IN3 A;  4EQG A;  5IPB A;  2OIK A;  4FIT A;  4ZKL A;  3TW2 A;  6RHN A;  3I24 A;  3O1X A;  3KSV A;  4NDH A;  4QDE A;  1ST0 A;  1XMM A;  4NDF A;  4NK0 A;  3O0M A;  3FIT A;  1EMS A;  1GUP A;  3RHN A;  5IPE A;  4NDI A;  4QDV A;  3N1T A;  3L7X A;  3NRD A;  3SP4 A;  6FIT A;  4NJY A;  5EMT A;  3P0T A;  4NJX A;  5I2E A;  4EQE A;  5FIT A;  1KPF A;  1ZWJ A;  3I4S A;  2EO4 A;  1AV5 A;  3R6F A;  3BL7 A;  3OJ7 A;  4ZGL A;  4EQH A;  3SZQ A;  4ZKV A;  5IPC A;  4NJZ A;  3QGZ A;  4RHN A;  4QEB A;  5RHN A;  3O1C A;  3OMF A;  5ED3 A;  1RZY A;  1Z84 A;  1ST4 A;  3BLA A;  1HXP A;  5ED6 A;  3ANO A;  5BV3 A;  5I2F A;  3OXK A;  4YKL B;  1FHI A;  1Y23 A;  2Q4L A;  3O1Z A;  4INC A;  2H39 A;  4NDG A;  1VLR A;  3LB5 A;  4INI A;  4XBA A;  5IPD A;  3N1S A;  2FIT A;  1XML A;  1GUQ A;  3IMI A;  1KPC A;  5CS2 A;  3OHE A;  3BL9 A;  3SPL A;  2FHI A;  1HXQ A;  4EGU A;  1KPA A;  3WO5 A;  3SPD A;  1KPE A;  1KPB A;  1FIT A;  2Q4H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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