5IN3A

Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
339
structure length
324
Chain Sequence
DHQHIRYNPLQDEWVLVSAHRTVPRHDPLNPLCPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAKSARGVCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWLVLVPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFETSFPYSMGWHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Galactose-1-phosphate uridylyltransferase
total genus 96
structure length 324
sequence length 339
chains with identical sequence B
ec nomenclature ec 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
pdb deposition date 2016-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01087 GalP_UDP_transf Galactose-1-phosphate uridyl transferase, N-terminal domain
A PF02744 GalP_UDP_tr_C Galactose-1-phosphate uridyl transferase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5in3A01
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5in3A02
3NRDA 4NDGA 1RZYA 3R6FA 3I24A 2FHIA 6RHNA 1ST4A 3N1TA 3O1ZA 5ED3A 4NDFA 1AV5A 1FHIA 3ANOA 5IPEA 4NJXA 4ZKLA 5IPBA 3L7XA 5BV3A 4XBAA 3OHEA 3RHNA 1FITA 4INCA 1KPBA 3TW2A 5EMTA 5I2EA 1KPAA 3N1SA 4RHNA 4ZKVA 5RHNA 1HXPA 3SPDA 1VLRA 1GUPA 5I2FA 4QEBA 1GUQA 2Q4LA 3BL9A 4NJZA 4QDEA 4ZGLA 3KSVA 3IMIA 3BL7A 6FITA 1XMMA 2H39A 2Q4HA 3SZQA 3LB5A 5IN3A 5ED6A 4QDVA 4EQEA 3OMFA 4NK0A 2EO4A 1Z84A 1EMSA 3BLAA 3QGZA 3O0MA 3P0TA 2FITA 3O1XA 5IPDA 4FITA 4INIA 1Y23A 3OXKA 2OIKA 3SP4A 4NDIA 4NJYA 1XMLA 4YKLB 4EQGA 1ZWJA 3SPLA 5CS2A 4NDHA 1KPCA 4EGUA 1KPFA 5IPCA 1HXQA 1ST0A 3I4SA 5FITA 1KPEA 3FITA 3WO5A 4EQHA 3O1CA 3OJ7A
chains in the Genus database with same CATH superfamily
3NRDA 4NDGA 1RZYA 3R6FA 3I24A 2FHIA 6RHNA 1ST4A 4I5TA 3N1TA 3O1ZA 5ED3A 4NDFA 1AV5A 1FHIA 3ANOA 5IPEA 4NJXA 2R7CA 4ZKLA 5IPBA 3L7XA 5BV3A 4XBAA 3OHEA 4G0AA 2POFA 3RHNA 1FITA 4INCA 1KPBA 3TW2A 1L9VA 5EMTA 5I2EA 1KPAA 3O1CA 4G0JA 3N1SA 4RHNA 4ZKVA 5RHNA 1HXPA 3SPDA 1VLRA 1GUPA 5I2FA 4QEBA 1GUQA 2Q4LA 3BL9A 4NJZA 2LJWA 4QDEA 4ZGLA 3KSVA 3IMIA 3BL7A 6FITA 1XMMA 2H39A 2Q4HA 3SZQA 3LB5A 5IN3A 5ED6A 4QDVA 4EQEA 3OMFA 4NK0A 2EO4A 1Z84A 4I5VA 1EMSA 3BLAA 3QGZA 3O0MA 3P0TA 2FITA 3O1XA 5IPDA 4FITA 4INIA 1Y23A 3OXKA 2OIKA 3SP4A 4NDIA 2R7JA 4NJYA 1XMLA 4YKLB 2R7PA 4EQGA 1ZWJA 3SPLA 5CS2A 4NDHA 1KPCA 4EGUA 1KPFA 5IPCA 1HXQA 1ST0A 3I4SA 2GU0A 1KPEA 3FITA 5FITA 3WO5A 4EQHA 4I5WA 3OJ7A 2R8FA
chains in the Genus database with same CATH topology
3NRDA 4NDGA 1RZYA 3R6FA 3I24A 2FHIA 6RHNA 1ST4A 3N1TA 3O1ZA 5ED3A 4NDFA 1AV5A 1FHIA 3ANOA 5IPEA 4NJXA 4ZKLA 5IPBA 3L7XA 5BV3A 4XBAA 3OHEA 3RHNA 1FITA 4INCA 1KPBA 3TW2A 5EMTA 5I2EA 1KPAA 3N1SA 4RHNA 4ZKVA 5RHNA 1HXPA 3SPDA 1VLRA 1GUPA 5I2FA 4QEBA 1GUQA 2Q4LA 3BL9A 4NJZA 4QDEA 4ZGLA 3KSVA 3IMIA 3BL7A 6FITA 1XMMA 2H39A 2Q4HA 3SZQA 3LB5A 5IN3A 5ED6A 4QDVA 4EQEA 3OMFA 4NK0A 2EO4A 1Z84A 1EMSA 3BLAA 3QGZA 3O0MA 3P0TA 2FITA 3O1XA 5IPDA 4FITA 4INIA 1Y23A 3OXKA 2OIKA 3SP4A 4NDIA 4NJYA 1XMLA 4YKLB 4EQGA 1ZWJA 3SPLA 5CS2A 4NDHA 1KPCA 4EGUA 1KPFA 5IPCA 1HXQA 1ST0A 3I4SA 5FITA 1KPEA 3FITA 3WO5A 4EQHA 3O1CA 3OJ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NRD A;  4NDG A;  1RZY A;  3R6F A;  3I24 A;  2FHI A;  6RHN A;  1ST4 A;  3N1T A;  3O1Z A;  5ED3 A;  4NDF A;  1AV5 A;  1FHI A;  3ANO A;  5IPE A;  4NJX A;  4ZKL A;  5IPB A;  3L7X A;  5BV3 A;  4XBA A;  3OHE A;  3RHN A;  1FIT A;  4INC A;  1KPB A;  3TW2 A;  5EMT A;  5I2E A;  1KPA A;  3N1S A;  4RHN A;  4ZKV A;  5RHN A;  1HXP A;  3SPD A;  1VLR A;  1GUP A;  5I2F A;  4QEB A;  1GUQ A;  2Q4L A;  3BL9 A;  4NJZ A;  4QDE A;  4ZGL A;  3KSV A;  3IMI A;  3BL7 A;  6FIT A;  1XMM A;  2H39 A;  2Q4H A;  3SZQ A;  3LB5 A;  5IN3 A;  5ED6 A;  4QDV A;  4EQE A;  3OMF A;  4NK0 A;  2EO4 A;  1Z84 A;  1EMS A;  3BLA A;  3QGZ A;  3O0M A;  3P0T A;  2FIT A;  3O1X A;  5IPD A;  4FIT A;  4INI A;  1Y23 A;  3OXK A;  2OIK A;  3SP4 A;  4NDI A;  4NJY A;  1XML A;  4YKL B;  4EQG A;  1ZWJ A;  3SPL A;  5CS2 A;  4NDH A;  1KPC A;  4EGU A;  1KPF A;  5IPC A;  1HXQ A;  1ST0 A;  3I4S A;  5FIT A;  1KPE A;  3FIT A;  3WO5 A;  4EQH A;  3O1C A;  3OJ7 A; 
#chains in the Genus database with same CATH topology
 3NRD A;  4NDG A;  1RZY A;  3R6F A;  3I24 A;  2FHI A;  6RHN A;  1ST4 A;  4I5T A;  3N1T A;  3O1Z A;  5ED3 A;  4NDF A;  1AV5 A;  1FHI A;  3ANO A;  5IPE A;  4NJX A;  2R7C A;  4ZKL A;  5IPB A;  3L7X A;  5BV3 A;  4XBA A;  3OHE A;  4G0A A;  2POF A;  3RHN A;  1FIT A;  4INC A;  1KPB A;  3TW2 A;  1L9V A;  5EMT A;  5I2E A;  1KPA A;  3O1C A;  4G0J A;  3N1S A;  4RHN A;  4ZKV A;  5RHN A;  1HXP A;  3SPD A;  1VLR A;  1GUP A;  5I2F A;  4QEB A;  1GUQ A;  2Q4L A;  3BL9 A;  4NJZ A;  2LJW A;  4QDE A;  4ZGL A;  3KSV A;  3IMI A;  3BL7 A;  6FIT A;  1XMM A;  2H39 A;  2Q4H A;  3SZQ A;  3LB5 A;  5IN3 A;  5ED6 A;  4QDV A;  4EQE A;  3OMF A;  4NK0 A;  2EO4 A;  1Z84 A;  4I5V A;  1EMS A;  3BLA A;  3QGZ A;  3O0M A;  3P0T A;  2FIT A;  3O1X A;  5IPD A;  4FIT A;  4INI A;  1Y23 A;  3OXK A;  2OIK A;  3SP4 A;  4NDI A;  2R7J A;  4NJY A;  1XML A;  4YKL B;  2R7P A;  4EQG A;  1ZWJ A;  3SPL A;  5CS2 A;  4NDH A;  1KPC A;  4EGU A;  1KPF A;  5IPC A;  1HXQ A;  1ST0 A;  3I4S A;  2GU0 A;  1KPE A;  3FIT A;  5FIT A;  3WO5 A;  4EQH A;  4I5W A;  3OJ7 A;  2R8F A; 
#chains in the Genus database with same CATH homology
 3NRD A;  4NDG A;  1RZY A;  3R6F A;  3I24 A;  2FHI A;  6RHN A;  1ST4 A;  3N1T A;  3O1Z A;  5ED3 A;  4NDF A;  1AV5 A;  1FHI A;  3ANO A;  5IPE A;  4NJX A;  4ZKL A;  5IPB A;  3L7X A;  5BV3 A;  4XBA A;  3OHE A;  3RHN A;  1FIT A;  4INC A;  1KPB A;  3TW2 A;  5EMT A;  5I2E A;  1KPA A;  3N1S A;  4RHN A;  4ZKV A;  5RHN A;  1HXP A;  3SPD A;  1VLR A;  1GUP A;  5I2F A;  4QEB A;  1GUQ A;  2Q4L A;  3BL9 A;  4NJZ A;  4QDE A;  4ZGL A;  3KSV A;  3IMI A;  3BL7 A;  6FIT A;  1XMM A;  2H39 A;  2Q4H A;  3SZQ A;  3LB5 A;  5IN3 A;  5ED6 A;  4QDV A;  4EQE A;  3OMF A;  4NK0 A;  2EO4 A;  1Z84 A;  1EMS A;  3BLA A;  3QGZ A;  3O0M A;  3P0T A;  2FIT A;  3O1X A;  5IPD A;  4FIT A;  4INI A;  1Y23 A;  3OXK A;  2OIK A;  3SP4 A;  4NDI A;  4NJY A;  1XML A;  4YKL B;  4EQG A;  1ZWJ A;  3SPL A;  5CS2 A;  4NDH A;  1KPC A;  4EGU A;  1KPF A;  5IPC A;  1HXQ A;  1ST0 A;  3I4S A;  5FIT A;  1KPE A;  3FIT A;  3WO5 A;  4EQH A;  3O1C A;  3OJ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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