5IPBA

Human histidine triad nucleotide binding protein 1 (hhint1) h112n mutant
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVNLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 28
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5ipbA00
1KPAA 3IMIA 5I2FA 4QEBA 4NJXA 5I2EA 3P0TA 5ED6A 5IPEA 4RHNA 3L7XA 1ST4A 3QGZA 4NK0A 4NJZA 1VLRA 1FHIA 5CS2A 4QDVA 1KPBA 2FHIA 3SPLA 1ST0A 3BL9A 3O1ZA 1HXQA 5BV3A 6RHNA 3O1CA 3OHEA 3OMFA 4QDEA 3ANOA 1AV5A 3I4SA 4XBAA 2EO4A 3O0MA 3BLAA 3N1SA 5ED3A 3RHNA 1XMLA 5EMTA 4NDHA 5IPCA 4INCA 1KPCA 3OXKA 3SPDA 3BL7A 4ZKVA 1KPEA 5FITA 4EQGA 5IN3A 4EGUA 2H39A 4NDFA 3WO5A 3LB5A 3TW2A 3KSVA 4NDGA 1RZYA 4INIA 6FITA 1XMMA 1EMSA 1FITA 1KPFA 1ZWJA 5IPBA 3SZQA 5IPDA 1Z84A 3FITA 4EQHA 4YKLB 3R6FA 3SP4A 4NJYA 3OJ7A 2Q4LA 4ZGLA 4ZKLA 3O1XA 3I24A 1GUPA 4EQEA 1GUQA 3NRDA 4FITA 5RHNA 2Q4HA 1HXPA 2OIKA 4NDIA 2FITA 3N1TA 1Y23A
chains in the Genus database with same CATH superfamily
1KPAA 3IMIA 5I2FA 4G0JA 4QEBA 4NJXA 5I2EA 4G0AA 3P0TA 5ED6A 2LJWA 5IPEA 2R8FA 4RHNA 3L7XA 1ST4A 3QGZA 4NK0A 4NJZA 1VLRA 1FHIA 5CS2A 4QDVA 1KPBA 2FHIA 3SPLA 1ST0A 3BL9A 3O1ZA 1HXQA 5BV3A 6RHNA 3O1CA 3OHEA 3OMFA 4QDEA 3ANOA 1AV5A 3I4SA 4XBAA 2EO4A 3O0MA 3BLAA 3N1SA 5ED3A 4I5TA 3RHNA 1XMLA 5EMTA 4NDHA 5IPCA 4INCA 1KPCA 3OXKA 3SPDA 4I5WA 1L9VA 3BL7A 2R7PA 4ZKVA 1KPEA 5FITA 4EQGA 5IN3A 2GU0A 4EGUA 2H39A 4NDFA 3WO5A 2R7JA 3LB5A 3TW2A 3KSVA 4NDGA 1RZYA 4INIA 6FITA 2POFA 1XMMA 1EMSA 1FITA 1KPFA 1ZWJA 5IPBA 3SZQA 5IPDA 1Z84A 3FITA 4EQHA 2R7CA 4YKLB 3R6FA 3SP4A 4NJYA 3OJ7A 2Q4LA 4ZGLA 4ZKLA 3O1XA 4I5VA 3I24A 1GUPA 4EQEA 1GUQA 3NRDA 4FITA 5RHNA 2Q4HA 1HXPA 2OIKA 4NDIA 2FITA 3N1TA 1Y23A
chains in the Genus database with same CATH topology
1KPAA 3IMIA 5I2FA 4QEBA 4NJXA 5I2EA 3P0TA 5ED6A 5IPEA 4RHNA 3L7XA 1ST4A 3QGZA 4NK0A 4NJZA 1VLRA 1FHIA 5CS2A 4QDVA 1KPBA 2FHIA 3SPLA 1ST0A 3BL9A 3O1ZA 1HXQA 5BV3A 6RHNA 3O1CA 3OHEA 3OMFA 4QDEA 3ANOA 1AV5A 3I4SA 4XBAA 2EO4A 3O0MA 3BLAA 3N1SA 5ED3A 3RHNA 1XMLA 5EMTA 4NDHA 5IPCA 4INCA 1KPCA 3OXKA 3SPDA 3BL7A 4ZKVA 1KPEA 5FITA 4EQGA 5IN3A 4EGUA 2H39A 4NDFA 3WO5A 3LB5A 3TW2A 3KSVA 4NDGA 1RZYA 4INIA 6FITA 1XMMA 1EMSA 1FITA 1KPFA 1ZWJA 5IPBA 3SZQA 5IPDA 1Z84A 3FITA 4EQHA 4YKLB 3R6FA 3SP4A 4NJYA 3OJ7A 2Q4LA 4ZGLA 4ZKLA 3O1XA 3I24A 1GUPA 4EQEA 1GUQA 3NRDA 4FITA 5RHNA 2Q4HA 1HXPA 2OIKA 4NDIA 2FITA 3N1TA 1Y23A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KPA A;  3IMI A;  5I2F A;  4QEB A;  4NJX A;  5I2E A;  3P0T A;  5ED6 A;  5IPE A;  4RHN A;  3L7X A;  1ST4 A;  3QGZ A;  4NK0 A;  4NJZ A;  1VLR A;  1FHI A;  5CS2 A;  4QDV A;  1KPB A;  2FHI A;  3SPL A;  1ST0 A;  3BL9 A;  3O1Z A;  1HXQ A;  5BV3 A;  6RHN A;  3O1C A;  3OHE A;  3OMF A;  4QDE A;  3ANO A;  1AV5 A;  3I4S A;  4XBA A;  2EO4 A;  3O0M A;  3BLA A;  3N1S A;  5ED3 A;  3RHN A;  1XML A;  5EMT A;  4NDH A;  5IPC A;  4INC A;  1KPC A;  3OXK A;  3SPD A;  3BL7 A;  4ZKV A;  1KPE A;  5FIT A;  4EQG A;  5IN3 A;  4EGU A;  2H39 A;  4NDF A;  3WO5 A;  3LB5 A;  3TW2 A;  3KSV A;  4NDG A;  1RZY A;  4INI A;  6FIT A;  1XMM A;  1EMS A;  1FIT A;  1KPF A;  1ZWJ A;  5IPB A;  3SZQ A;  5IPD A;  1Z84 A;  3FIT A;  4EQH A;  4YKL B;  3R6F A;  3SP4 A;  4NJY A;  3OJ7 A;  2Q4L A;  4ZGL A;  4ZKL A;  3O1X A;  3I24 A;  1GUP A;  4EQE A;  1GUQ A;  3NRD A;  4FIT A;  5RHN A;  2Q4H A;  1HXP A;  2OIK A;  4NDI A;  2FIT A;  3N1T A;  1Y23 A; 
#chains in the Genus database with same CATH topology
 1KPA A;  3IMI A;  5I2F A;  4G0J A;  4QEB A;  4NJX A;  5I2E A;  4G0A A;  3P0T A;  5ED6 A;  2LJW A;  5IPE A;  2R8F A;  4RHN A;  3L7X A;  1ST4 A;  3QGZ A;  4NK0 A;  4NJZ A;  1VLR A;  1FHI A;  5CS2 A;  4QDV A;  1KPB A;  2FHI A;  3SPL A;  1ST0 A;  3BL9 A;  3O1Z A;  1HXQ A;  5BV3 A;  6RHN A;  3O1C A;  3OHE A;  3OMF A;  4QDE A;  3ANO A;  1AV5 A;  3I4S A;  4XBA A;  2EO4 A;  3O0M A;  3BLA A;  3N1S A;  5ED3 A;  4I5T A;  3RHN A;  1XML A;  5EMT A;  4NDH A;  5IPC A;  4INC A;  1KPC A;  3OXK A;  3SPD A;  4I5W A;  1L9V A;  3BL7 A;  2R7P A;  4ZKV A;  1KPE A;  5FIT A;  4EQG A;  5IN3 A;  2GU0 A;  4EGU A;  2H39 A;  4NDF A;  3WO5 A;  2R7J A;  3LB5 A;  3TW2 A;  3KSV A;  4NDG A;  1RZY A;  4INI A;  6FIT A;  2POF A;  1XMM A;  1EMS A;  1FIT A;  1KPF A;  1ZWJ A;  5IPB A;  3SZQ A;  5IPD A;  1Z84 A;  3FIT A;  4EQH A;  2R7C A;  4YKL B;  3R6F A;  3SP4 A;  4NJY A;  3OJ7 A;  2Q4L A;  4ZGL A;  4ZKL A;  3O1X A;  4I5V A;  3I24 A;  1GUP A;  4EQE A;  1GUQ A;  3NRD A;  4FIT A;  5RHN A;  2Q4H A;  1HXP A;  2OIK A;  4NDI A;  2FIT A;  3N1T A;  1Y23 A; 
#chains in the Genus database with same CATH homology
 1KPA A;  3IMI A;  5I2F A;  4QEB A;  4NJX A;  5I2E A;  3P0T A;  5ED6 A;  5IPE A;  4RHN A;  3L7X A;  1ST4 A;  3QGZ A;  4NK0 A;  4NJZ A;  1VLR A;  1FHI A;  5CS2 A;  4QDV A;  1KPB A;  2FHI A;  3SPL A;  1ST0 A;  3BL9 A;  3O1Z A;  1HXQ A;  5BV3 A;  6RHN A;  3O1C A;  3OHE A;  3OMF A;  4QDE A;  3ANO A;  1AV5 A;  3I4S A;  4XBA A;  2EO4 A;  3O0M A;  3BLA A;  3N1S A;  5ED3 A;  3RHN A;  1XML A;  5EMT A;  4NDH A;  5IPC A;  4INC A;  1KPC A;  3OXK A;  3SPD A;  3BL7 A;  4ZKV A;  1KPE A;  5FIT A;  4EQG A;  5IN3 A;  4EGU A;  2H39 A;  4NDF A;  3WO5 A;  3LB5 A;  3TW2 A;  3KSV A;  4NDG A;  1RZY A;  4INI A;  6FIT A;  1XMM A;  1EMS A;  1FIT A;  1KPF A;  1ZWJ A;  5IPB A;  3SZQ A;  5IPD A;  1Z84 A;  3FIT A;  4EQH A;  4YKL B;  3R6F A;  3SP4 A;  4NJY A;  3OJ7 A;  2Q4L A;  4ZGL A;  4ZKL A;  3O1X A;  3I24 A;  1GUP A;  4EQE A;  1GUQ A;  3NRD A;  4FIT A;  5RHN A;  2Q4H A;  1HXP A;  2OIK A;  4NDI A;  2FIT A;  3N1T A;  1Y23 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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