5IPDA

Human histidine triad nucleotide binding protein 1 (hhint1) nucleoside thiophosphoramidate covalent intermediate complex
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 28
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5ipdA00
1HXPA 4RHNA 5IPEA 1KPFA 3O1ZA 2Q4LA 4QDVA 4INIA 3SPDA 1XMMA 4NJXA 3N1SA 5RHNA 1HXQA 6FITA 4ZKLA 4ZGLA 5I2FA 4NDHA 1KPAA 3R6FA 4FITA 2H39A 4ZKVA 2OIKA 1VLRA 4QDEA 3FITA 1ST4A 3NRDA 5ED3A 4NDIA 4NJZA 1RZYA 1ZWJA 4EQHA 3RHNA 3LB5A 4YKLB 3OJ7A 4NDFA 5EMTA 3OXKA 5BV3A 1KPEA 1Y23A 1FHIA 1GUQA 1AV5A 3BL7A 3BL9A 5FITA 1EMSA 3KSVA 2FITA 3IMIA 4INCA 2FHIA 3I24A 5CS2A 5ED6A 2EO4A 1GUPA 4EQEA 4NDGA 1KPCA 3BLAA 4NJYA 1ST0A 4XBAA 4NK0A 4QEBA 3O1CA 6RHNA 3OHEA 4EGUA 3OMFA 5IPCA 2Q4HA 3P0TA 1FITA 3SPLA 3SP4A 1Z84A 4EQGA 3TW2A 3ANOA 3WO5A 1KPBA 5I2EA 3N1TA 5IPDA 5IPBA 3I4SA 5IN3A 1XMLA 3QGZA 3L7XA 3SZQA 3O1XA 3O0MA
chains in the Genus database with same CATH superfamily
1HXPA 4RHNA 5IPEA 1KPFA 3O1ZA 2Q4LA 2R8FA 4QDVA 4INIA 3SPDA 1XMMA 4NJXA 3N1SA 5RHNA 1HXQA 2GU0A 6FITA 4ZKLA 4ZGLA 5I2FA 4NDHA 1KPAA 3R6FA 4FITA 2H39A 4G0AA 4ZKVA 2OIKA 1VLRA 4QDEA 3FITA 1ST4A 3NRDA 5ED3A 2LJWA 4NDIA 4NJZA 1RZYA 1ZWJA 4EQHA 3RHNA 3LB5A 4YKLB 3OJ7A 2R7CA 4NDFA 5EMTA 3OXKA 5BV3A 1KPEA 1Y23A 1FHIA 1GUQA 4I5VA 1AV5A 3BL7A 2POFA 1L9VA 2R7JA 3BL9A 5FITA 1EMSA 3KSVA 2FITA 3IMIA 4INCA 2FHIA 3I24A 5CS2A 5ED6A 2EO4A 1GUPA 4EQEA 4NDGA 4G0JA 1KPCA 4I5TA 2R7PA 3BLAA 4NJYA 1ST0A 4XBAA 4NK0A 4QEBA 3O1CA 6RHNA 3OHEA 4EGUA 3OMFA 5IPCA 2Q4HA 3P0TA 1FITA 3SPLA 3SP4A 1Z84A 4EQGA 3TW2A 3ANOA 3WO5A 1KPBA 5I2EA 3N1TA 4I5WA 5IPDA 5IPBA 3I4SA 5IN3A 1XMLA 3QGZA 3L7XA 3SZQA 3O1XA 3O0MA
chains in the Genus database with same CATH topology
1HXPA 4RHNA 5IPEA 1KPFA 3O1ZA 2Q4LA 4QDVA 4INIA 3SPDA 1XMMA 4NJXA 3N1SA 5RHNA 1HXQA 6FITA 4ZKLA 4ZGLA 5I2FA 4NDHA 1KPAA 3R6FA 4FITA 2H39A 4ZKVA 2OIKA 1VLRA 4QDEA 3FITA 1ST4A 3NRDA 5ED3A 4NDIA 4NJZA 1RZYA 1ZWJA 4EQHA 3RHNA 3LB5A 4YKLB 3OJ7A 4NDFA 5EMTA 3OXKA 5BV3A 1KPEA 1Y23A 1FHIA 1GUQA 1AV5A 3BL7A 3BL9A 5FITA 1EMSA 3KSVA 2FITA 3IMIA 4INCA 2FHIA 3I24A 5CS2A 5ED6A 2EO4A 1GUPA 4EQEA 4NDGA 1KPCA 3BLAA 4NJYA 1ST0A 4XBAA 4NK0A 4QEBA 3O1CA 6RHNA 3OHEA 4EGUA 3OMFA 5IPCA 2Q4HA 3P0TA 1FITA 3SPLA 3SP4A 1Z84A 4EQGA 3TW2A 3ANOA 3WO5A 1KPBA 5I2EA 3N1TA 5IPDA 5IPBA 3I4SA 5IN3A 1XMLA 3QGZA 3L7XA 3SZQA 3O1XA 3O0MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HXP A;  4RHN A;  5IPE A;  1KPF A;  3O1Z A;  2Q4L A;  4QDV A;  4INI A;  3SPD A;  1XMM A;  4NJX A;  3N1S A;  5RHN A;  1HXQ A;  6FIT A;  4ZKL A;  4ZGL A;  5I2F A;  4NDH A;  1KPA A;  3R6F A;  4FIT A;  2H39 A;  4ZKV A;  2OIK A;  1VLR A;  4QDE A;  3FIT A;  1ST4 A;  3NRD A;  5ED3 A;  4NDI A;  4NJZ A;  1RZY A;  1ZWJ A;  4EQH A;  3RHN A;  3LB5 A;  4YKL B;  3OJ7 A;  4NDF A;  5EMT A;  3OXK A;  5BV3 A;  1KPE A;  1Y23 A;  1FHI A;  1GUQ A;  1AV5 A;  3BL7 A;  3BL9 A;  5FIT A;  1EMS A;  3KSV A;  2FIT A;  3IMI A;  4INC A;  2FHI A;  3I24 A;  5CS2 A;  5ED6 A;  2EO4 A;  1GUP A;  4EQE A;  4NDG A;  1KPC A;  3BLA A;  4NJY A;  1ST0 A;  4XBA A;  4NK0 A;  4QEB A;  3O1C A;  6RHN A;  3OHE A;  4EGU A;  3OMF A;  5IPC A;  2Q4H A;  3P0T A;  1FIT A;  3SPL A;  3SP4 A;  1Z84 A;  4EQG A;  3TW2 A;  3ANO A;  3WO5 A;  1KPB A;  5I2E A;  3N1T A;  5IPD A;  5IPB A;  3I4S A;  5IN3 A;  1XML A;  3QGZ A;  3L7X A;  3SZQ A;  3O1X A;  3O0M A; 
#chains in the Genus database with same CATH topology
 1HXP A;  4RHN A;  5IPE A;  1KPF A;  3O1Z A;  2Q4L A;  2R8F A;  4QDV A;  4INI A;  3SPD A;  1XMM A;  4NJX A;  3N1S A;  5RHN A;  1HXQ A;  2GU0 A;  6FIT A;  4ZKL A;  4ZGL A;  5I2F A;  4NDH A;  1KPA A;  3R6F A;  4FIT A;  2H39 A;  4G0A A;  4ZKV A;  2OIK A;  1VLR A;  4QDE A;  3FIT A;  1ST4 A;  3NRD A;  5ED3 A;  2LJW A;  4NDI A;  4NJZ A;  1RZY A;  1ZWJ A;  4EQH A;  3RHN A;  3LB5 A;  4YKL B;  3OJ7 A;  2R7C A;  4NDF A;  5EMT A;  3OXK A;  5BV3 A;  1KPE A;  1Y23 A;  1FHI A;  1GUQ A;  4I5V A;  1AV5 A;  3BL7 A;  2POF A;  1L9V A;  2R7J A;  3BL9 A;  5FIT A;  1EMS A;  3KSV A;  2FIT A;  3IMI A;  4INC A;  2FHI A;  3I24 A;  5CS2 A;  5ED6 A;  2EO4 A;  1GUP A;  4EQE A;  4NDG A;  4G0J A;  1KPC A;  4I5T A;  2R7P A;  3BLA A;  4NJY A;  1ST0 A;  4XBA A;  4NK0 A;  4QEB A;  3O1C A;  6RHN A;  3OHE A;  4EGU A;  3OMF A;  5IPC A;  2Q4H A;  3P0T A;  1FIT A;  3SPL A;  3SP4 A;  1Z84 A;  4EQG A;  3TW2 A;  3ANO A;  3WO5 A;  1KPB A;  5I2E A;  3N1T A;  4I5W A;  5IPD A;  5IPB A;  3I4S A;  5IN3 A;  1XML A;  3QGZ A;  3L7X A;  3SZQ A;  3O1X A;  3O0M A; 
#chains in the Genus database with same CATH homology
 1HXP A;  4RHN A;  5IPE A;  1KPF A;  3O1Z A;  2Q4L A;  4QDV A;  4INI A;  3SPD A;  1XMM A;  4NJX A;  3N1S A;  5RHN A;  1HXQ A;  6FIT A;  4ZKL A;  4ZGL A;  5I2F A;  4NDH A;  1KPA A;  3R6F A;  4FIT A;  2H39 A;  4ZKV A;  2OIK A;  1VLR A;  4QDE A;  3FIT A;  1ST4 A;  3NRD A;  5ED3 A;  4NDI A;  4NJZ A;  1RZY A;  1ZWJ A;  4EQH A;  3RHN A;  3LB5 A;  4YKL B;  3OJ7 A;  4NDF A;  5EMT A;  3OXK A;  5BV3 A;  1KPE A;  1Y23 A;  1FHI A;  1GUQ A;  1AV5 A;  3BL7 A;  3BL9 A;  5FIT A;  1EMS A;  3KSV A;  2FIT A;  3IMI A;  4INC A;  2FHI A;  3I24 A;  5CS2 A;  5ED6 A;  2EO4 A;  1GUP A;  4EQE A;  4NDG A;  1KPC A;  3BLA A;  4NJY A;  1ST0 A;  4XBA A;  4NK0 A;  4QEB A;  3O1C A;  6RHN A;  3OHE A;  4EGU A;  3OMF A;  5IPC A;  2Q4H A;  3P0T A;  1FIT A;  3SPL A;  3SP4 A;  1Z84 A;  4EQG A;  3TW2 A;  3ANO A;  3WO5 A;  1KPB A;  5I2E A;  3N1T A;  5IPD A;  5IPB A;  3I4S A;  5IN3 A;  1XML A;  3QGZ A;  3L7X A;  3SZQ A;  3O1X A;  3O0M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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