5IPEA

Human histidine triad nucleotide binding protein 1 (hhint1) nucleoside thiophosphoramidate catalytic product complex
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Histidine triad nucleotide-binding protein 1
total genus 29
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5ipeA00
3LB5A 4NJXA 4EGUA 4FITA 3I24A 4NJZA 4QDVA 4INIA 3BL9A 4EQEA 1KPBA 4NDFA 6RHNA 5FITA 3SZQA 3NRDA 3WO5A 5IPEA 1KPCA 3P0TA 4QEBA 5BV3A 5I2FA 1KPEA 4YKLB 2FHIA 1EMSA 1ST4A 4NJYA 3IMIA 6FITA 1FITA 3RHNA 4RHNA 3QGZA 2FITA 3O1CA 3SP4A 3OJ7A 4NDHA 3O1ZA 1HXPA 1FHIA 3L7XA 5RHNA 1KPAA 1KPFA 3ANOA 1Z84A 5IPDA 3FITA 2H39A 5CS2A 2Q4HA 1GUQA 4XBAA 5IN3A 1ST0A 3OXKA 3BL7A 3TW2A 2Q4LA 5IPBA 1HXQA 5IPCA 3N1TA 3SPLA 1ZWJA 3R6FA 3SPDA 3O1XA 5ED6A 5ED3A 3OHEA 1GUPA 3I4SA 1Y23A 1XMLA 4NK0A 1RZYA 1XMMA 2OIKA 4NDIA 4EQHA 2EO4A 5I2EA 3O0MA 3N1SA 3KSVA 4INCA 4ZGLA 4ZKLA 4ZKVA 1VLRA 3OMFA 4NDGA 3BLAA 1AV5A 4EQGA 5EMTA 4QDEA
chains in the Genus database with same CATH superfamily
3LB5A 4NJXA 4EGUA 4I5TA 4FITA 3I24A 1L9VA 4NJZA 4QDVA 4INIA 3BL9A 4EQEA 1KPBA 4NDFA 6RHNA 5FITA 3SZQA 3NRDA 2R7PA 4G0JA 3WO5A 5IPEA 1KPCA 3P0TA 4QEBA 5BV3A 5I2FA 1KPEA 4YKLB 2FHIA 1EMSA 1ST4A 4NJYA 3IMIA 6FITA 1FITA 3RHNA 4I5WA 4RHNA 4G0AA 3QGZA 2FITA 3O1CA 3SP4A 3OJ7A 4NDHA 2R8FA 3O1ZA 1HXPA 2R7CA 1FHIA 3L7XA 5RHNA 1KPAA 1KPFA 3ANOA 1Z84A 2R7JA 5IPDA 3FITA 2H39A 5CS2A 2Q4HA 1GUQA 4XBAA 5IN3A 1ST0A 3OXKA 3BL7A 3TW2A 2POFA 2Q4LA 5IPBA 1HXQA 2GU0A 5IPCA 2LJWA 3N1TA 3SPLA 1ZWJA 3R6FA 3SPDA 3O1XA 5ED6A 5ED3A 3OHEA 1GUPA 3I4SA 1Y23A 1XMLA 4NK0A 1RZYA 1XMMA 2OIKA 4NDIA 4EQHA 2EO4A 5I2EA 3O0MA 3N1SA 3KSVA 4INCA 4I5VA 4ZGLA 4ZKLA 4ZKVA 1VLRA 3OMFA 4NDGA 3BLAA 1AV5A 4EQGA 5EMTA 4QDEA
chains in the Genus database with same CATH topology
3LB5A 4NJXA 4EGUA 4FITA 3I24A 4NJZA 4QDVA 4INIA 3BL9A 4EQEA 1KPBA 4NDFA 6RHNA 5FITA 3SZQA 3NRDA 3WO5A 5IPEA 1KPCA 3P0TA 4QEBA 5BV3A 5I2FA 1KPEA 4YKLB 2FHIA 1EMSA 1ST4A 4NJYA 3IMIA 6FITA 1FITA 3RHNA 4RHNA 3QGZA 2FITA 3O1CA 3SP4A 3OJ7A 4NDHA 3O1ZA 1HXPA 1FHIA 3L7XA 5RHNA 1KPAA 1KPFA 3ANOA 1Z84A 5IPDA 3FITA 2H39A 5CS2A 2Q4HA 1GUQA 4XBAA 5IN3A 1ST0A 3OXKA 3BL7A 3TW2A 2Q4LA 5IPBA 1HXQA 5IPCA 3N1TA 3SPLA 1ZWJA 3R6FA 3SPDA 3O1XA 5ED6A 5ED3A 3OHEA 1GUPA 3I4SA 1Y23A 1XMLA 4NK0A 1RZYA 1XMMA 2OIKA 4NDIA 4EQHA 2EO4A 5I2EA 3O0MA 3N1SA 3KSVA 4INCA 4ZGLA 4ZKLA 4ZKVA 1VLRA 3OMFA 4NDGA 3BLAA 1AV5A 4EQGA 5EMTA 4QDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LB5 A;  4NJX A;  4EGU A;  4FIT A;  3I24 A;  4NJZ A;  4QDV A;  4INI A;  3BL9 A;  4EQE A;  1KPB A;  4NDF A;  6RHN A;  5FIT A;  3SZQ A;  3NRD A;  3WO5 A;  5IPE A;  1KPC A;  3P0T A;  4QEB A;  5BV3 A;  5I2F A;  1KPE A;  4YKL B;  2FHI A;  1EMS A;  1ST4 A;  4NJY A;  3IMI A;  6FIT A;  1FIT A;  3RHN A;  4RHN A;  3QGZ A;  2FIT A;  3O1C A;  3SP4 A;  3OJ7 A;  4NDH A;  3O1Z A;  1HXP A;  1FHI A;  3L7X A;  5RHN A;  1KPA A;  1KPF A;  3ANO A;  1Z84 A;  5IPD A;  3FIT A;  2H39 A;  5CS2 A;  2Q4H A;  1GUQ A;  4XBA A;  5IN3 A;  1ST0 A;  3OXK A;  3BL7 A;  3TW2 A;  2Q4L A;  5IPB A;  1HXQ A;  5IPC A;  3N1T A;  3SPL A;  1ZWJ A;  3R6F A;  3SPD A;  3O1X A;  5ED6 A;  5ED3 A;  3OHE A;  1GUP A;  3I4S A;  1Y23 A;  1XML A;  4NK0 A;  1RZY A;  1XMM A;  2OIK A;  4NDI A;  4EQH A;  2EO4 A;  5I2E A;  3O0M A;  3N1S A;  3KSV A;  4INC A;  4ZGL A;  4ZKL A;  4ZKV A;  1VLR A;  3OMF A;  4NDG A;  3BLA A;  1AV5 A;  4EQG A;  5EMT A;  4QDE A; 
#chains in the Genus database with same CATH topology
 3LB5 A;  4NJX A;  4EGU A;  4I5T A;  4FIT A;  3I24 A;  1L9V A;  4NJZ A;  4QDV A;  4INI A;  3BL9 A;  4EQE A;  1KPB A;  4NDF A;  6RHN A;  5FIT A;  3SZQ A;  3NRD A;  2R7P A;  4G0J A;  3WO5 A;  5IPE A;  1KPC A;  3P0T A;  4QEB A;  5BV3 A;  5I2F A;  1KPE A;  4YKL B;  2FHI A;  1EMS A;  1ST4 A;  4NJY A;  3IMI A;  6FIT A;  1FIT A;  3RHN A;  4I5W A;  4RHN A;  4G0A A;  3QGZ A;  2FIT A;  3O1C A;  3SP4 A;  3OJ7 A;  4NDH A;  2R8F A;  3O1Z A;  1HXP A;  2R7C A;  1FHI A;  3L7X A;  5RHN A;  1KPA A;  1KPF A;  3ANO A;  1Z84 A;  2R7J A;  5IPD A;  3FIT A;  2H39 A;  5CS2 A;  2Q4H A;  1GUQ A;  4XBA A;  5IN3 A;  1ST0 A;  3OXK A;  3BL7 A;  3TW2 A;  2POF A;  2Q4L A;  5IPB A;  1HXQ A;  2GU0 A;  5IPC A;  2LJW A;  3N1T A;  3SPL A;  1ZWJ A;  3R6F A;  3SPD A;  3O1X A;  5ED6 A;  5ED3 A;  3OHE A;  1GUP A;  3I4S A;  1Y23 A;  1XML A;  4NK0 A;  1RZY A;  1XMM A;  2OIK A;  4NDI A;  4EQH A;  2EO4 A;  5I2E A;  3O0M A;  3N1S A;  3KSV A;  4INC A;  4I5V A;  4ZGL A;  4ZKL A;  4ZKV A;  1VLR A;  3OMF A;  4NDG A;  3BLA A;  1AV5 A;  4EQG A;  5EMT A;  4QDE A; 
#chains in the Genus database with same CATH homology
 3LB5 A;  4NJX A;  4EGU A;  4FIT A;  3I24 A;  4NJZ A;  4QDV A;  4INI A;  3BL9 A;  4EQE A;  1KPB A;  4NDF A;  6RHN A;  5FIT A;  3SZQ A;  3NRD A;  3WO5 A;  5IPE A;  1KPC A;  3P0T A;  4QEB A;  5BV3 A;  5I2F A;  1KPE A;  4YKL B;  2FHI A;  1EMS A;  1ST4 A;  4NJY A;  3IMI A;  6FIT A;  1FIT A;  3RHN A;  4RHN A;  3QGZ A;  2FIT A;  3O1C A;  3SP4 A;  3OJ7 A;  4NDH A;  3O1Z A;  1HXP A;  1FHI A;  3L7X A;  5RHN A;  1KPA A;  1KPF A;  3ANO A;  1Z84 A;  5IPD A;  3FIT A;  2H39 A;  5CS2 A;  2Q4H A;  1GUQ A;  4XBA A;  5IN3 A;  1ST0 A;  3OXK A;  3BL7 A;  3TW2 A;  2Q4L A;  5IPB A;  1HXQ A;  5IPC A;  3N1T A;  3SPL A;  1ZWJ A;  3R6F A;  3SPD A;  3O1X A;  5ED6 A;  5ED3 A;  3OHE A;  1GUP A;  3I4S A;  1Y23 A;  1XML A;  4NK0 A;  1RZY A;  1XMM A;  2OIK A;  4NDI A;  4EQH A;  2EO4 A;  5I2E A;  3O0M A;  3N1S A;  3KSV A;  4INC A;  4ZGL A;  4ZKL A;  4ZKV A;  1VLR A;  3OMF A;  4NDG A;  3BLA A;  1AV5 A;  4EQG A;  5EMT A;  4QDE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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