1GZRB

Human insulin-like growth factor; esrf data
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
64
structure length
61
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSPQTGIVDECCFRSCDLRRLEMYCAPLKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
pubmed doi rcsb
molecule tags Growth factor
source organism Homo sapiens
molecule keywords INSULIN-LIKE GROWTH FACTOR I
total genus 14
structure length 61
sequence length 64
ec nomenclature
pdb deposition date 2002-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1gzrB00
1SJUA 1PMXA 1IGLA 1B9GA 1GZYB 1TGRA 2DSRI 1IMXA 2L29B 2LWZA 5L3NA 2JZQA 1H59A 1GZZB 2GF1A 4XSSB 3LRIA 2DSPI 3GF1A 5L3MA 5L3LA 2KJIA 1H02B 1BQTA 1WQJI 2DSQC 2KQPA 1EFEA 1GZRB 3KR3D 1ZEIA 6INSE
chains in the Genus database with same CATH superfamily
1SJUA 1PMXA 1IGLA 3F2CA 1B9GA 1GZYB 1TGRA 2DSRI 1IMXA 2L29B 2LWZA 5L3NA 3F2BA 3F2DA 2JZQA 1H59A 1GZZB 2GF1A 4XSSB 3LRIA 2DSPI 3GF1A 5L3MA 5L3LA 2KJIA 1H02B 2L14B 1BQTA 1WQJI 2DSQC 2KQPA 1EFEA 1GZRB 3KR3D 1ZEIA 6INSE
chains in the Genus database with same CATH topology
1SJUA 1PMXA 1IGLA 1B9GA 1GZYB 1TGRA 2DSRI 1IMXA 2L29B 2LWZA 5L3NA 2JZQA 1H59A 1GZZB 2GF1A 4XSSB 3LRIA 2DSPI 3GF1A 5L3MA 5L3LA 2KJIA 1H02B 1BQTA 1WQJI 2DSQC 2KQPA 1EFEA 1GZRB 3KR3D 1ZEIA 6INSE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SJU A;  1PMX A;  1IGL A;  1B9G A;  1GZY B;  1TGR A;  2DSR I;  1IMX A;  2L29 B;  2LWZ A;  5L3N A;  2JZQ A;  1H59 A;  1GZZ B;  2GF1 A;  4XSS B;  3LRI A;  2DSP I;  3GF1 A;  5L3M A;  5L3L A;  2KJI A;  1H02 B;  1BQT A;  1WQJ I;  2DSQ C;  2KQP A;  1EFE A;  1GZR B;  3KR3 D;  1ZEI A;  6INS E; 
#chains in the Genus database with same CATH topology
 1SJU A;  1PMX A;  1IGL A;  3F2C A;  1B9G A;  1GZY B;  1TGR A;  2DSR I;  1IMX A;  2L29 B;  2LWZ A;  5L3N A;  3F2B A;  3F2D A;  2JZQ A;  1H59 A;  1GZZ B;  2GF1 A;  4XSS B;  3LRI A;  2DSP I;  3GF1 A;  5L3M A;  5L3L A;  2KJI A;  1H02 B;  2L14 B;  1BQT A;  1WQJ I;  2DSQ C;  2KQP A;  1EFE A;  1GZR B;  3KR3 D;  1ZEI A;  6INS E; 
#chains in the Genus database with same CATH homology
 1SJU A;  1PMX A;  1IGL A;  1B9G A;  1GZY B;  1TGR A;  2DSR I;  1IMX A;  2L29 B;  2LWZ A;  5L3N A;  2JZQ A;  1H59 A;  1GZZ B;  2GF1 A;  4XSS B;  3LRI A;  2DSP I;  3GF1 A;  5L3M A;  5L3L A;  2KJI A;  1H02 B;  1BQT A;  1WQJ I;  2DSQ C;  2KQP A;  1EFE A;  1GZR B;  3KR3 D;  1ZEI A;  6INS E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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