2KQPA

Nmr structure of proinsulin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
86
structure length
86
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTKPTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Insulin
publication title Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
pubmed doi rcsb
source organism Homo sapiens
total genus 11
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 2009-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2kqpA00
5L3MA 2DSRI 1ZEIA 4XSSB 1BQTA 1EFEA 1PMXA 2KJIA 2LWZA 1GZZB 2DSQC 3GF1A 2KQPA 1SJUA 2L29B 6INSE 5L3LA 1H02B 1TGRA 2GF1A 3KR3D 1B9GA 1IGLA 3LRIA 2DSPI 1WQJI 2JZQA 1GZYB 5L3NA 1GZRB 1H59A 1IMXA
chains in the Genus database with same CATH superfamily
5L3MA 2DSRI 1ZEIA 4XSSB 1BQTA 1EFEA 1PMXA 3F2BA 3F2DA 2KJIA 2LWZA 1GZZB 2DSQC 2L14B 3F2CA 3GF1A 2KQPA 1SJUA 2L29B 6INSE 5L3LA 1H02B 1TGRA 2GF1A 3KR3D 1B9GA 1IGLA 3LRIA 2DSPI 1WQJI 2JZQA 1GZYB 5L3NA 1GZRB 1H59A 1IMXA
chains in the Genus database with same CATH topology
5L3MA 2DSRI 1ZEIA 4XSSB 1BQTA 1EFEA 1PMXA 2KJIA 2LWZA 1GZZB 2DSQC 3GF1A 2KQPA 1SJUA 2L29B 6INSE 5L3LA 1H02B 1TGRA 2GF1A 3KR3D 1B9GA 1IGLA 3LRIA 2DSPI 1WQJI 2JZQA 1GZYB 5L3NA 1GZRB 1H59A 1IMXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L3M A;  2DSR I;  1ZEI A;  4XSS B;  1BQT A;  1EFE A;  1PMX A;  2KJI A;  2LWZ A;  1GZZ B;  2DSQ C;  3GF1 A;  2KQP A;  1SJU A;  2L29 B;  6INS E;  5L3L A;  1H02 B;  1TGR A;  2GF1 A;  3KR3 D;  1B9G A;  1IGL A;  3LRI A;  2DSP I;  1WQJ I;  2JZQ A;  1GZY B;  5L3N A;  1GZR B;  1H59 A;  1IMX A; 
#chains in the Genus database with same CATH topology
 5L3M A;  2DSR I;  1ZEI A;  4XSS B;  1BQT A;  1EFE A;  1PMX A;  3F2B A;  3F2D A;  2KJI A;  2LWZ A;  1GZZ B;  2DSQ C;  2L14 B;  3F2C A;  3GF1 A;  2KQP A;  1SJU A;  2L29 B;  6INS E;  5L3L A;  1H02 B;  1TGR A;  2GF1 A;  3KR3 D;  1B9G A;  1IGL A;  3LRI A;  2DSP I;  1WQJ I;  2JZQ A;  1GZY B;  5L3N A;  1GZR B;  1H59 A;  1IMX A; 
#chains in the Genus database with same CATH homology
 5L3M A;  2DSR I;  1ZEI A;  4XSS B;  1BQT A;  1EFE A;  1PMX A;  2KJI A;  2LWZ A;  1GZZ B;  2DSQ C;  3GF1 A;  2KQP A;  1SJU A;  2L29 B;  6INS E;  5L3L A;  1H02 B;  1TGR A;  2GF1 A;  3KR3 D;  1B9G A;  1IGL A;  3LRI A;  2DSP I;  1WQJ I;  2JZQ A;  1GZY B;  5L3N A;  1GZR B;  1H59 A;  1IMX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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