2DSQC

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
51
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/hormone/growth factor
molecule keywords Insulin-like growth factor-binding protein 4
publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
source organism Homo sapiens
total genus 15
structure length 51
sequence length 62
chains with identical sequence I
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dsqC00
3LRIA 2DSPI 2JZQA 5L3MA 1ZEIA 1GZRB 1GZYB 5L3NA 1BQTA 2GF1A 4XSSB 3KR3D 2DSRI 1IMXA 1GZZB 5L3LA 1PMXA 1WQJI 2KQPA 2L29B 1SJUA 1B9GA 2LWZA 1EFEA 1IGLA 1TGRA 3GF1A 2KJIA 1H02B 1H59A 2DSQC 6INSE
chains in the Genus database with same CATH superfamily
3LRIA 2DSPI 2JZQA 5L3MA 3F2DA 1ZEIA 1GZRB 1GZYB 5L3NA 3F2BA 1BQTA 2GF1A 4XSSB 2L14B 3KR3D 2DSRI 3F2CA 1IMXA 1GZZB 5L3LA 1PMXA 1WQJI 2KQPA 2L29B 1SJUA 1B9GA 2LWZA 1EFEA 1IGLA 1TGRA 3GF1A 2KJIA 1H02B 1H59A 2DSQC 6INSE
chains in the Genus database with same CATH topology
3LRIA 2DSPI 2JZQA 5L3MA 1ZEIA 1GZRB 1GZYB 5L3NA 1BQTA 2GF1A 4XSSB 3KR3D 2DSRI 1IMXA 1GZZB 5L3LA 1PMXA 1WQJI 2KQPA 2L29B 1SJUA 1B9GA 2LWZA 1EFEA 1IGLA 1TGRA 3GF1A 2KJIA 1H02B 1H59A 2DSQC 6INSE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LRI A;  2DSP I;  2JZQ A;  5L3M A;  1ZEI A;  1GZR B;  1GZY B;  5L3N A;  1BQT A;  2GF1 A;  4XSS B;  3KR3 D;  2DSR I;  1IMX A;  1GZZ B;  5L3L A;  1PMX A;  1WQJ I;  2KQP A;  2L29 B;  1SJU A;  1B9G A;  2LWZ A;  1EFE A;  1IGL A;  1TGR A;  3GF1 A;  2KJI A;  1H02 B;  1H59 A;  2DSQ C;  6INS E; 
#chains in the Genus database with same CATH topology
 3LRI A;  2DSP I;  2JZQ A;  5L3M A;  3F2D A;  1ZEI A;  1GZR B;  1GZY B;  5L3N A;  3F2B A;  1BQT A;  2GF1 A;  4XSS B;  2L14 B;  3KR3 D;  2DSR I;  3F2C A;  1IMX A;  1GZZ B;  5L3L A;  1PMX A;  1WQJ I;  2KQP A;  2L29 B;  1SJU A;  1B9G A;  2LWZ A;  1EFE A;  1IGL A;  1TGR A;  3GF1 A;  2KJI A;  1H02 B;  1H59 A;  2DSQ C;  6INS E; 
#chains in the Genus database with same CATH homology
 3LRI A;  2DSP I;  2JZQ A;  5L3M A;  1ZEI A;  1GZR B;  1GZY B;  5L3N A;  1BQT A;  2GF1 A;  4XSS B;  3KR3 D;  2DSR I;  1IMX A;  1GZZ B;  5L3L A;  1PMX A;  1WQJ I;  2KQP A;  2L29 B;  1SJU A;  1B9G A;  2LWZ A;  1EFE A;  1IGL A;  1TGR A;  3GF1 A;  2KJI A;  1H02 B;  1H59 A;  2DSQ C;  6INS E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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