1WQJI

Structural basis for the regulation of insulin-like growth factors (igfs) by igf binding proteins (igfbps)
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
62
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/hormone/growth factor
molecule keywords Insulin-like growth factor binding protein 4
publication title Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
pubmed doi rcsb
source organism Homo sapiens
total genus 15
structure length 62
sequence length 62
ec nomenclature
pdb deposition date 2004-09-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1wqjI00
1PMXA 1GZYB 1WQJI 1IMXA 6INSE 2LWZA 1EFEA 1TGRA 3LRIA 1BQTA 5L3NA 5L3LA 4XSSB 1H02B 3GF1A 1B9GA 2DSPI 2DSRI 1IGLA 1ZEIA 1H59A 2GF1A 5L3MA 2KJIA 2DSQC 1SJUA 1GZRB 2KQPA 3KR3D 1GZZB 2L29B 2JZQA
chains in the Genus database with same CATH superfamily
1PMXA 1GZYB 1WQJI 1IMXA 6INSE 2LWZA 1EFEA 1TGRA 3LRIA 1BQTA 5L3NA 5L3LA 4XSSB 1H02B 3GF1A 1B9GA 2DSPI 2DSRI 3F2BA 1IGLA 1ZEIA 1H59A 3F2DA 2GF1A 5L3MA 2KJIA 2DSQC 1SJUA 3F2CA 1GZRB 2L14B 2KQPA 3KR3D 1GZZB 2L29B 2JZQA
chains in the Genus database with same CATH topology
1PMXA 1GZYB 1WQJI 1IMXA 6INSE 2LWZA 1EFEA 1TGRA 3LRIA 1BQTA 5L3NA 5L3LA 4XSSB 1H02B 3GF1A 1B9GA 2DSPI 2DSRI 1IGLA 1ZEIA 1H59A 2GF1A 5L3MA 2KJIA 2DSQC 1SJUA 1GZRB 2KQPA 3KR3D 1GZZB 2L29B 2JZQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PMX A;  1GZY B;  1WQJ I;  1IMX A;  6INS E;  2LWZ A;  1EFE A;  1TGR A;  3LRI A;  1BQT A;  5L3N A;  5L3L A;  4XSS B;  1H02 B;  3GF1 A;  1B9G A;  2DSP I;  2DSR I;  1IGL A;  1ZEI A;  1H59 A;  2GF1 A;  5L3M A;  2KJI A;  2DSQ C;  1SJU A;  1GZR B;  2KQP A;  3KR3 D;  1GZZ B;  2L29 B;  2JZQ A; 
#chains in the Genus database with same CATH topology
 1PMX A;  1GZY B;  1WQJ I;  1IMX A;  6INS E;  2LWZ A;  1EFE A;  1TGR A;  3LRI A;  1BQT A;  5L3N A;  5L3L A;  4XSS B;  1H02 B;  3GF1 A;  1B9G A;  2DSP I;  2DSR I;  3F2B A;  1IGL A;  1ZEI A;  1H59 A;  3F2D A;  2GF1 A;  5L3M A;  2KJI A;  2DSQ C;  1SJU A;  3F2C A;  1GZR B;  2L14 B;  2KQP A;  3KR3 D;  1GZZ B;  2L29 B;  2JZQ A; 
#chains in the Genus database with same CATH homology
 1PMX A;  1GZY B;  1WQJ I;  1IMX A;  6INS E;  2LWZ A;  1EFE A;  1TGR A;  3LRI A;  1BQT A;  5L3N A;  5L3L A;  4XSS B;  1H02 B;  3GF1 A;  1B9G A;  2DSP I;  2DSR I;  1IGL A;  1ZEI A;  1H59 A;  2GF1 A;  5L3M A;  2KJI A;  2DSQ C;  1SJU A;  1GZR B;  2KQP A;  3KR3 D;  1GZZ B;  2L29 B;  2JZQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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