1GZYB

Human insulin-like growth factor; in-house data
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
64
structure length
57
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNKPTGYPQTGIVDECCFRSCDLRRLEMYCAPLKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
pubmed doi rcsb
molecule tags Growth factor
source organism Homo sapiens
molecule keywords INSULIN-LIKE GROWTH FACTOR I
total genus 15
structure length 57
sequence length 64
ec nomenclature
pdb deposition date 2002-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1gzyB00
5L3LA 1H02B 1ZEIA 1BQTA 1GZYB 6INSE 1GZZB 5L3NA 1GZRB 3KR3D 2L29B 2DSRI 2KQPA 1IGLA 3LRIA 2DSQC 5L3MA 1H59A 2KJIA 1PMXA 1B9GA 4XSSB 1EFEA 1WQJI 3GF1A 1IMXA 1SJUA 2DSPI 2GF1A 2JZQA 1TGRA 2LWZA
chains in the Genus database with same CATH superfamily
5L3LA 1H02B 1ZEIA 1BQTA 1GZYB 6INSE 1GZZB 5L3NA 1GZRB 3KR3D 2L29B 2DSRI 2KQPA 1IGLA 3LRIA 2L14B 2DSQC 3F2DA 3F2CA 5L3MA 1H59A 2KJIA 1PMXA 1B9GA 4XSSB 1EFEA 1WQJI 3GF1A 1IMXA 1SJUA 2DSPI 2GF1A 2JZQA 1TGRA 3F2BA 2LWZA
chains in the Genus database with same CATH topology
5L3LA 1H02B 1ZEIA 1BQTA 1GZYB 6INSE 1GZZB 5L3NA 1GZRB 3KR3D 2L29B 2DSRI 2KQPA 1IGLA 3LRIA 2DSQC 5L3MA 1H59A 2KJIA 1PMXA 1B9GA 4XSSB 1EFEA 1WQJI 3GF1A 1IMXA 1SJUA 2DSPI 2GF1A 2JZQA 1TGRA 2LWZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L3L A;  1H02 B;  1ZEI A;  1BQT A;  1GZY B;  6INS E;  1GZZ B;  5L3N A;  1GZR B;  3KR3 D;  2L29 B;  2DSR I;  2KQP A;  1IGL A;  3LRI A;  2DSQ C;  5L3M A;  1H59 A;  2KJI A;  1PMX A;  1B9G A;  4XSS B;  1EFE A;  1WQJ I;  3GF1 A;  1IMX A;  1SJU A;  2DSP I;  2GF1 A;  2JZQ A;  1TGR A;  2LWZ A; 
#chains in the Genus database with same CATH topology
 5L3L A;  1H02 B;  1ZEI A;  1BQT A;  1GZY B;  6INS E;  1GZZ B;  5L3N A;  1GZR B;  3KR3 D;  2L29 B;  2DSR I;  2KQP A;  1IGL A;  3LRI A;  2L14 B;  2DSQ C;  3F2D A;  3F2C A;  5L3M A;  1H59 A;  2KJI A;  1PMX A;  1B9G A;  4XSS B;  1EFE A;  1WQJ I;  3GF1 A;  1IMX A;  1SJU A;  2DSP I;  2GF1 A;  2JZQ A;  1TGR A;  3F2B A;  2LWZ A; 
#chains in the Genus database with same CATH homology
 5L3L A;  1H02 B;  1ZEI A;  1BQT A;  1GZY B;  6INS E;  1GZZ B;  5L3N A;  1GZR B;  3KR3 D;  2L29 B;  2DSR I;  2KQP A;  1IGL A;  3LRI A;  2DSQ C;  5L3M A;  1H59 A;  2KJI A;  1PMX A;  1B9G A;  4XSS B;  1EFE A;  1WQJ I;  3GF1 A;  1IMX A;  1SJU A;  2DSP I;  2GF1 A;  2JZQ A;  1TGR A;  2LWZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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