1GZYB

Human insulin-like growth factor; in-house data
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
64
structure length
57
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNKPTGYPQTGIVDECCFRSCDLRRLEMYCAPLKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
pubmed doi rcsb
molecule keywords INSULIN-LIKE GROWTH FACTOR I
molecule tags Growth factor
source organism Homo sapiens
total genus 15
structure length 57
sequence length 64
ec nomenclature
pdb deposition date 2002-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1gzyB00
1H59A 5L3LA 1B9GA 1BQTA 3LRIA 2GF1A 2DSRI 1ZEIA 1SJUA 2KQPA 2JZQA 6INSE 3GF1A 1GZYB 2L29B 1GZZB 1PMXA 1IMXA 5L3NA 2LWZA 1EFEA 2DSPI 2DSQC 4XSSB 5L3MA 1WQJI 1GZRB 1TGRA 2KJIA 3KR3D 1H02B 1IGLA
chains in the Genus database with same CATH superfamily
1H59A 5L3LA 1B9GA 1BQTA 3LRIA 2GF1A 2DSRI 1ZEIA 1SJUA 2KQPA 2L14B 2JZQA 6INSE 3F2CA 3GF1A 3F2DA 1GZYB 3F2BA 2L29B 1GZZB 1PMXA 1IMXA 5L3NA 2LWZA 1EFEA 2DSPI 2DSQC 4XSSB 5L3MA 1WQJI 1GZRB 1TGRA 2KJIA 3KR3D 1H02B 1IGLA
chains in the Genus database with same CATH topology
1H59A 5L3LA 1B9GA 1BQTA 3LRIA 2GF1A 2DSRI 1ZEIA 1SJUA 2KQPA 2JZQA 6INSE 3GF1A 1GZYB 2L29B 1GZZB 1PMXA 1IMXA 5L3NA 2LWZA 1EFEA 2DSPI 2DSQC 4XSSB 5L3MA 1WQJI 1GZRB 1TGRA 2KJIA 3KR3D 1H02B 1IGLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H59 A;  5L3L A;  1B9G A;  1BQT A;  3LRI A;  2GF1 A;  2DSR I;  1ZEI A;  1SJU A;  2KQP A;  2JZQ A;  6INS E;  3GF1 A;  1GZY B;  2L29 B;  1GZZ B;  1PMX A;  1IMX A;  5L3N A;  2LWZ A;  1EFE A;  2DSP I;  2DSQ C;  4XSS B;  5L3M A;  1WQJ I;  1GZR B;  1TGR A;  2KJI A;  3KR3 D;  1H02 B;  1IGL A; 
#chains in the Genus database with same CATH topology
 1H59 A;  5L3L A;  1B9G A;  1BQT A;  3LRI A;  2GF1 A;  2DSR I;  1ZEI A;  1SJU A;  2KQP A;  2L14 B;  2JZQ A;  6INS E;  3F2C A;  3GF1 A;  3F2D A;  1GZY B;  3F2B A;  2L29 B;  1GZZ B;  1PMX A;  1IMX A;  5L3N A;  2LWZ A;  1EFE A;  2DSP I;  2DSQ C;  4XSS B;  5L3M A;  1WQJ I;  1GZR B;  1TGR A;  2KJI A;  3KR3 D;  1H02 B;  1IGL A; 
#chains in the Genus database with same CATH homology
 1H59 A;  5L3L A;  1B9G A;  1BQT A;  3LRI A;  2GF1 A;  2DSR I;  1ZEI A;  1SJU A;  2KQP A;  2JZQ A;  6INS E;  3GF1 A;  1GZY B;  2L29 B;  1GZZ B;  1PMX A;  1IMX A;  5L3N A;  2LWZ A;  1EFE A;  2DSP I;  2DSQ C;  4XSS B;  5L3M A;  1WQJ I;  1GZR B;  1TGR A;  2KJI A;  3KR3 D;  1H02 B;  1IGL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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