1GZZB

Human insulin-like growth factor; hamburg data
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
66
structure length
60
Chain Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYAPQTGIVDECCFRSCDLRRLEMYCAPLKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
pubmed doi rcsb
molecule tags Growth factor
source organism Homo sapiens
molecule keywords INSULIN-LIKE GROWTH FACTOR I
total genus 11
structure length 60
sequence length 66
ec nomenclature
pdb deposition date 2002-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1gzzB00
1WQJI 3LRIA 2DSQC 2JZQA 2DSRI 4XSSB 2GF1A 1GZRB 2KQPA 5L3LA 1IMXA 6INSE 1H02B 1IGLA 3GF1A 2LWZA 1GZZB 1B9GA 1EFEA 2KJIA 2L29B 5L3NA 2DSPI 3KR3D 1ZEIA 1SJUA 1H59A 5L3MA 1TGRA 1BQTA 1PMXA 1GZYB
chains in the Genus database with same CATH superfamily
1WQJI 3LRIA 2DSQC 2JZQA 2DSRI 4XSSB 2GF1A 1GZRB 2KQPA 5L3LA 1IMXA 6INSE 1H02B 1IGLA 3GF1A 3F2BA 2LWZA 1GZZB 1B9GA 1EFEA 2KJIA 2L14B 2L29B 5L3NA 2DSPI 3KR3D 1ZEIA 1SJUA 1H59A 3F2CA 5L3MA 1TGRA 1BQTA 1PMXA 1GZYB 3F2DA
chains in the Genus database with same CATH topology
1WQJI 3LRIA 2DSQC 2JZQA 2DSRI 4XSSB 2GF1A 1GZRB 2KQPA 5L3LA 1IMXA 6INSE 1H02B 1IGLA 3GF1A 2LWZA 1GZZB 1B9GA 1EFEA 2KJIA 2L29B 5L3NA 2DSPI 3KR3D 1ZEIA 1SJUA 1H59A 5L3MA 1TGRA 1BQTA 1PMXA 1GZYB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WQJ I;  3LRI A;  2DSQ C;  2JZQ A;  2DSR I;  4XSS B;  2GF1 A;  1GZR B;  2KQP A;  5L3L A;  1IMX A;  6INS E;  1H02 B;  1IGL A;  3GF1 A;  2LWZ A;  1GZZ B;  1B9G A;  1EFE A;  2KJI A;  2L29 B;  5L3N A;  2DSP I;  3KR3 D;  1ZEI A;  1SJU A;  1H59 A;  5L3M A;  1TGR A;  1BQT A;  1PMX A;  1GZY B; 
#chains in the Genus database with same CATH topology
 1WQJ I;  3LRI A;  2DSQ C;  2JZQ A;  2DSR I;  4XSS B;  2GF1 A;  1GZR B;  2KQP A;  5L3L A;  1IMX A;  6INS E;  1H02 B;  1IGL A;  3GF1 A;  3F2B A;  2LWZ A;  1GZZ B;  1B9G A;  1EFE A;  2KJI A;  2L14 B;  2L29 B;  5L3N A;  2DSP I;  3KR3 D;  1ZEI A;  1SJU A;  1H59 A;  3F2C A;  5L3M A;  1TGR A;  1BQT A;  1PMX A;  1GZY B;  3F2D A; 
#chains in the Genus database with same CATH homology
 1WQJ I;  3LRI A;  2DSQ C;  2JZQ A;  2DSR I;  4XSS B;  2GF1 A;  1GZR B;  2KQP A;  5L3L A;  1IMX A;  6INS E;  1H02 B;  1IGL A;  3GF1 A;  2LWZ A;  1GZZ B;  1B9G A;  1EFE A;  2KJI A;  2L29 B;  5L3N A;  2DSP I;  3KR3 D;  1ZEI A;  1SJU A;  1H59 A;  5L3M A;  1TGR A;  1BQT A;  1PMX A;  1GZY B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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