1NVUS

Structural evidence for feedback activation by rasgtp of the ras-specific nucleotide exchange factor sos
Total Genus 174
50100150200250300350400450050100150
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
481
structure length
469
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Signaling protein
source organism Homo sapiens
publication title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
pubmed doi rcsb
molecule keywords Transforming protein p21/H-RAS-1
total genus 174
structure length 469
sequence length 481
ec nomenclature
pdb deposition date 2003-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 1nvuS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 1nvuS01
1BKDS 5CM9A 4F7ZA 1NVVS 4URXS 1NVXS 4L9MA 2IJES 1NVWS 2BYVE 3QXLA 1XD4A 4URYS 4MGZE 5CM8A 4NYMS 3KSYA 4MH0E 3CF6E 4URVS 4MGYE 4US1S 4NYIS 4MGIE 4URZS 4URWS 4JGWA 1NVUS 4NYJS 3T6AA 4URUS 1XD2C 4MGKE 4US2S 3T6GA 2II0A 4US0S
chains in the Genus database with same CATH superfamily
1BKDS 5CM9A 4F7ZA 1NVVS 4URXS 1NVXS 4L9MA 2IJES 1NVWS 2BYVE 3QXLA 1XD4A 4URYS 4MGZE 5CM8A 4NYMS 3KSYA 4MH0E 3CF6E 4URVS 4MGYE 4US1S 4NYIS 4MGIE 4URZS 4URWS 4JGWA 1NVUS 4NYJS 3T6AA 4URUS 1XD2C 4MGKE 4US2S 3T6GA 2II0A 4US0S
chains in the Genus database with same CATH topology
1BKDS 5CM9A 4F7ZA 1NVVS 4URXS 1NVXS 4L9MA 2IJES 1NVWS 2BYVE 3QXLA 1XD4A 4URYS 4MGZE 5CM8A 4NYMS 3KSYA 4MH0E 3CF6E 4URVS 4MGYE 4US1S 4NYIS 4MGIE 4URZS 4URWS 4JGWA 1NVUS 4NYJS 3T6AA 4URUS 1XD2C 4MGKE 4US2S 3T6GA 2II0A 4US0S
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1BKD S;  5CM9 A;  4F7Z A;  1NVV S;  4URX S;  1NVX S;  4L9M A;  2IJE S;  1NVW S;  2BYV E;  3QXL A;  1XD4 A;  4URY S;  4MGZ E;  5CM8 A;  4NYM S;  3KSY A;  4MH0 E;  3CF6 E;  4URV S;  4MGY E;  4US1 S;  4NYI S;  4MGI E;  4URZ S;  4URW S;  4JGW A;  1NVU S;  4NYJ S;  3T6A A;  4URU S;  1XD2 C;  4MGK E;  4US2 S;  3T6G A;  2II0 A;  4US0 S; 
#chains in the Genus database with same CATH topology
 1BKD S;  5CM9 A;  4F7Z A;  1NVV S;  4URX S;  1NVX S;  4L9M A;  2IJE S;  1NVW S;  2BYV E;  3QXL A;  1XD4 A;  4URY S;  4MGZ E;  5CM8 A;  4NYM S;  3KSY A;  4MH0 E;  3CF6 E;  4URV S;  4MGY E;  4US1 S;  4NYI S;  4MGI E;  4URZ S;  4URW S;  4JGW A;  1NVU S;  4NYJ S;  3T6A A;  4URU S;  1XD2 C;  4MGK E;  4US2 S;  3T6G A;  2II0 A;  4US0 S; 
#chains in the Genus database with same CATH homology
 1BKD S;  5CM9 A;  4F7Z A;  1NVV S;  4URX S;  1NVX S;  4L9M A;  2IJE S;  1NVW S;  2BYV E;  3QXL A;  1XD4 A;  4URY S;  4MGZ E;  5CM8 A;  4NYM S;  3KSY A;  4MH0 E;  3CF6 E;  4URV S;  4MGY E;  4US1 S;  4NYI S;  4MGI E;  4URZ S;  4URW S;  4JGW A;  1NVU S;  4NYJ S;  3T6A A;  4URU S;  1XD2 C;  4MGK E;  4US2 S;  3T6G A;  2II0 A;  4US0 S;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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