4NYMS

Approach for targeting ras with small molecules that activate sos-mediated nucleotide exchange
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
sequence length
481
structure length
469
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPase HRas
total genus 164
structure length 469
sequence length 481
ec nomenclature
pdb deposition date 2013-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4nymS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4nymS01
4MH0E 4NYMS 2BYVE 4US0S 4F7ZA 4US1S 1NVWS 5CM9A 3T6AA 1XD4A 4MGKE 3CF6E 4MGIE 1NVXS 4MGYE 3KSYA 4NYJS 5CM8A 1XD2C 1BKDS 4URWS 4URVS 1NVVS 3QXLA 4URYS 4JGWA 4L9MA 4US2S 4URUS 4URXS 2IJES 4URZS 3T6GA 2II0A 1NVUS 4NYIS 4MGZE
chains in the Genus database with same CATH superfamily
4MH0E 4NYMS 2BYVE 4US0S 4F7ZA 4US1S 1NVWS 5CM9A 3T6AA 1XD4A 4MGKE 3CF6E 4MGIE 1NVXS 4MGYE 3KSYA 4NYJS 5CM8A 1XD2C 1BKDS 4URWS 4URVS 1NVVS 3QXLA 4URYS 4JGWA 4L9MA 4US2S 4URUS 4URXS 2IJES 4URZS 3T6GA 2II0A 1NVUS 4NYIS 4MGZE
chains in the Genus database with same CATH topology
4MH0E 4NYMS 2BYVE 4US0S 4F7ZA 4US1S 1NVWS 5CM9A 3T6AA 1XD4A 4MGKE 3CF6E 4MGIE 1NVXS 4MGYE 3KSYA 4NYJS 5CM8A 1XD2C 1BKDS 4URWS 4URVS 1NVVS 3QXLA 4URYS 4JGWA 4L9MA 4US2S 4URUS 4URXS 2IJES 4URZS 3T6GA 2II0A 1NVUS 4NYIS 4MGZE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MH0 E;  4NYM S;  2BYV E;  4US0 S;  4F7Z A;  4US1 S;  1NVW S;  5CM9 A;  3T6A A;  1XD4 A;  4MGK E;  3CF6 E;  4MGI E;  1NVX S;  4MGY E;  3KSY A;  4NYJ S;  5CM8 A;  1XD2 C;  1BKD S;  4URW S;  4URV S;  1NVV S;  3QXL A;  4URY S;  4JGW A;  4L9M A;  4US2 S;  4URU S;  4URX S;  2IJE S;  4URZ S;  3T6G A;  2II0 A;  1NVU S;  4NYI S;  4MGZ E; 
#chains in the Genus database with same CATH topology
 4MH0 E;  4NYM S;  2BYV E;  4US0 S;  4F7Z A;  4US1 S;  1NVW S;  5CM9 A;  3T6A A;  1XD4 A;  4MGK E;  3CF6 E;  4MGI E;  1NVX S;  4MGY E;  3KSY A;  4NYJ S;  5CM8 A;  1XD2 C;  1BKD S;  4URW S;  4URV S;  1NVV S;  3QXL A;  4URY S;  4JGW A;  4L9M A;  4US2 S;  4URU S;  4URX S;  2IJE S;  4URZ S;  3T6G A;  2II0 A;  1NVU S;  4NYI S;  4MGZ E; 
#chains in the Genus database with same CATH homology
 4MH0 E;  4NYM S;  2BYV E;  4US0 S;  4F7Z A;  4US1 S;  1NVW S;  5CM9 A;  3T6A A;  1XD4 A;  4MGK E;  3CF6 E;  4MGI E;  1NVX S;  4MGY E;  3KSY A;  4NYJ S;  5CM8 A;  1XD2 C;  1BKD S;  4URW S;  4URV S;  1NVV S;  3QXL A;  4URY S;  4JGW A;  4L9M A;  4US2 S;  4URU S;  4URX S;  2IJE S;  4URZ S;  3T6G A;  2II0 A;  1NVU S;  4NYI S;  4MGZ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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