4URUS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
479
structure length
452
Chain Sequence
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 176
structure length 452
sequence length 479
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4uruS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4uruS01
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH superfamily
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH topology
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH topology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH homology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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