4US2S

The crystal structure of h-ras and sos in complex with ligands
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
481
structure length
453
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 175
structure length 453
sequence length 481
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4us2S02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4us2S01
4MGIE 4US2S 3CF6E 3KSYA 4URVS 5CM9A 3T6AA 4MGKE 4US0S 4NYMS 4MGZE 1XD2C 4L9MA 1BKDS 4MGYE 3QXLA 1NVUS 4NYIS 2II0A 4URWS 4NYJS 2IJES 1NVXS 4F7ZA 4URYS 2BYVE 4URXS 4MH0E 3T6GA 4URZS 1NVWS 4JGWA 5CM8A 1NVVS 1XD4A 4US1S 4URUS
chains in the Genus database with same CATH superfamily
4MGIE 4US2S 3CF6E 3KSYA 4URVS 5CM9A 3T6AA 4MGKE 4US0S 4NYMS 4MGZE 1XD2C 4L9MA 1BKDS 4MGYE 3QXLA 1NVUS 4NYIS 2II0A 4URWS 4NYJS 2IJES 1NVXS 4F7ZA 4URYS 2BYVE 4URXS 4MH0E 3T6GA 4URZS 1NVWS 4JGWA 5CM8A 1NVVS 1XD4A 4US1S 4URUS
chains in the Genus database with same CATH topology
4MGIE 4US2S 3CF6E 3KSYA 4URVS 5CM9A 3T6AA 4MGKE 4US0S 4NYMS 4MGZE 1XD2C 4L9MA 1BKDS 4MGYE 3QXLA 1NVUS 4NYIS 2II0A 4URWS 4NYJS 2IJES 1NVXS 4F7ZA 4URYS 2BYVE 4URXS 4MH0E 3T6GA 4URZS 1NVWS 4JGWA 5CM8A 1NVVS 1XD4A 4US1S 4URUS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MGI E;  4US2 S;  3CF6 E;  3KSY A;  4URV S;  5CM9 A;  3T6A A;  4MGK E;  4US0 S;  4NYM S;  4MGZ E;  1XD2 C;  4L9M A;  1BKD S;  4MGY E;  3QXL A;  1NVU S;  4NYI S;  2II0 A;  4URW S;  4NYJ S;  2IJE S;  1NVX S;  4F7Z A;  4URY S;  2BYV E;  4URX S;  4MH0 E;  3T6G A;  4URZ S;  1NVW S;  4JGW A;  5CM8 A;  1NVV S;  1XD4 A;  4US1 S;  4URU S; 
#chains in the Genus database with same CATH topology
 4MGI E;  4US2 S;  3CF6 E;  3KSY A;  4URV S;  5CM9 A;  3T6A A;  4MGK E;  4US0 S;  4NYM S;  4MGZ E;  1XD2 C;  4L9M A;  1BKD S;  4MGY E;  3QXL A;  1NVU S;  4NYI S;  2II0 A;  4URW S;  4NYJ S;  2IJE S;  1NVX S;  4F7Z A;  4URY S;  2BYV E;  4URX S;  4MH0 E;  3T6G A;  4URZ S;  1NVW S;  4JGW A;  5CM8 A;  1NVV S;  1XD4 A;  4US1 S;  4URU S; 
#chains in the Genus database with same CATH homology
 4MGI E;  4US2 S;  3CF6 E;  3KSY A;  4URV S;  5CM9 A;  3T6A A;  4MGK E;  4US0 S;  4NYM S;  4MGZ E;  1XD2 C;  4L9M A;  1BKD S;  4MGY E;  3QXL A;  1NVU S;  4NYI S;  2II0 A;  4URW S;  4NYJ S;  2IJE S;  1NVX S;  4F7Z A;  4URY S;  2BYV E;  4URX S;  4MH0 E;  3T6G A;  4URZ S;  1NVW S;  4JGW A;  5CM8 A;  1NVV S;  1XD4 A;  4US1 S;  4URU S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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