1NVVS

Structural evidence for feedback activation by rasgtp of the ras-specific nucleotide exchange factor sos
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
sequence length
481
structure length
469
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords Transforming protein p21/H-RAS-1
total genus 167
structure length 469
sequence length 481
ec nomenclature
pdb deposition date 2003-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 1nvvS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 1nvvS01
4MGIE 4URXS 4F7ZA 4URYS 3CF6E 4NYIS 5CM9A 4NYMS 2II0A 4NYJS 1NVUS 4L9MA 1NVXS 1XD4A 2BYVE 1XD2C 3KSYA 4URZS 4URVS 5CM8A 3T6AA 1NVVS 4MGYE 4US0S 4MGZE 4US2S 3T6GA 4URUS 4MGKE 4URWS 4US1S 4MH0E 2IJES 4JGWA 3QXLA 1NVWS 1BKDS
chains in the Genus database with same CATH superfamily
4MGIE 4URXS 4F7ZA 4URYS 3CF6E 4NYIS 5CM9A 4NYMS 2II0A 4NYJS 1NVUS 4L9MA 1NVXS 1XD4A 2BYVE 1XD2C 3KSYA 4URZS 4URVS 5CM8A 3T6AA 1NVVS 4MGYE 4US0S 4MGZE 4US2S 3T6GA 4URUS 4MGKE 4URWS 4US1S 4MH0E 2IJES 4JGWA 3QXLA 1NVWS 1BKDS
chains in the Genus database with same CATH topology
4MGIE 4URXS 4F7ZA 4URYS 3CF6E 4NYIS 5CM9A 4NYMS 2II0A 4NYJS 1NVUS 4L9MA 1NVXS 1XD4A 2BYVE 1XD2C 3KSYA 4URZS 4URVS 5CM8A 3T6AA 1NVVS 4MGYE 4US0S 4MGZE 4US2S 3T6GA 4URUS 4MGKE 4URWS 4US1S 4MH0E 2IJES 4JGWA 3QXLA 1NVWS 1BKDS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MGI E;  4URX S;  4F7Z A;  4URY S;  3CF6 E;  4NYI S;  5CM9 A;  4NYM S;  2II0 A;  4NYJ S;  1NVU S;  4L9M A;  1NVX S;  1XD4 A;  2BYV E;  1XD2 C;  3KSY A;  4URZ S;  4URV S;  5CM8 A;  3T6A A;  1NVV S;  4MGY E;  4US0 S;  4MGZ E;  4US2 S;  3T6G A;  4URU S;  4MGK E;  4URW S;  4US1 S;  4MH0 E;  2IJE S;  4JGW A;  3QXL A;  1NVW S;  1BKD S; 
#chains in the Genus database with same CATH topology
 4MGI E;  4URX S;  4F7Z A;  4URY S;  3CF6 E;  4NYI S;  5CM9 A;  4NYM S;  2II0 A;  4NYJ S;  1NVU S;  4L9M A;  1NVX S;  1XD4 A;  2BYV E;  1XD2 C;  3KSY A;  4URZ S;  4URV S;  5CM8 A;  3T6A A;  1NVV S;  4MGY E;  4US0 S;  4MGZ E;  4US2 S;  3T6G A;  4URU S;  4MGK E;  4URW S;  4US1 S;  4MH0 E;  2IJE S;  4JGW A;  3QXL A;  1NVW S;  1BKD S; 
#chains in the Genus database with same CATH homology
 4MGI E;  4URX S;  4F7Z A;  4URY S;  3CF6 E;  4NYI S;  5CM9 A;  4NYM S;  2II0 A;  4NYJ S;  1NVU S;  4L9M A;  1NVX S;  1XD4 A;  2BYV E;  1XD2 C;  3KSY A;  4URZ S;  4URV S;  5CM8 A;  3T6A A;  1NVV S;  4MGY E;  4US0 S;  4MGZ E;  4US2 S;  3T6G A;  4URU S;  4MGK E;  4URW S;  4US1 S;  4MH0 E;  2IJE S;  4JGW A;  3QXL A;  1NVW S;  1BKD S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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