2II0A

Crystal structure of catalytic domain of son of sevenless (rem-cdc25) in the absence of ras
Total Genus 170
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
480
structure length
463
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Ras-induced conformational switch in the Ras activator Son of sevenless.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords Son of sevenless homolog 1
total genus 170
structure length 463
sequence length 480
ec nomenclature
pdb deposition date 2006-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
A PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 2ii0A02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 2ii0A01
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH superfamily
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH topology
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH topology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH homology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...