4US0S

The crystal structure of h-ras and sos in complex with ligands
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
480
structure length
454
Chain Sequence
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPESAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords GTPASE HRAS
total genus 175
structure length 454
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4us0S02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4us0S01
1BKDS 4URYS 4NYIS 5CM8A 4MGZE 4URUS 1NVVS 4URVS 4MGYE 4F7ZA 4JGWA 1NVXS 4URZS 2II0A 2BYVE 3QXLA 3T6AA 3T6GA 4NYMS 4L9MA 1NVWS 1XD2C 4NYJS 4URXS 3KSYA 4MGKE 1XD4A 4US0S 5CM9A 1NVUS 2IJES 4US1S 4US2S 3CF6E 4MGIE 4URWS 4MH0E
chains in the Genus database with same CATH superfamily
1BKDS 4URYS 4NYIS 5CM8A 4MGZE 4URUS 1NVVS 4URVS 4MGYE 4F7ZA 4JGWA 1NVXS 4URZS 2II0A 2BYVE 3QXLA 3T6AA 3T6GA 4NYMS 4L9MA 1NVWS 1XD2C 4NYJS 4URXS 3KSYA 4MGKE 1XD4A 4US0S 5CM9A 1NVUS 2IJES 4US1S 4US2S 3CF6E 4MGIE 4URWS 4MH0E
chains in the Genus database with same CATH topology
1BKDS 4URYS 4NYIS 5CM8A 4MGZE 4URUS 1NVVS 4URVS 4MGYE 4F7ZA 4JGWA 1NVXS 4URZS 2II0A 2BYVE 3QXLA 3T6AA 3T6GA 4NYMS 4L9MA 1NVWS 1XD2C 4NYJS 4URXS 3KSYA 4MGKE 1XD4A 4US0S 5CM9A 1NVUS 2IJES 4US1S 4US2S 3CF6E 4MGIE 4URWS 4MH0E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BKD S;  4URY S;  4NYI S;  5CM8 A;  4MGZ E;  4URU S;  1NVV S;  4URV S;  4MGY E;  4F7Z A;  4JGW A;  1NVX S;  4URZ S;  2II0 A;  2BYV E;  3QXL A;  3T6A A;  3T6G A;  4NYM S;  4L9M A;  1NVW S;  1XD2 C;  4NYJ S;  4URX S;  3KSY A;  4MGK E;  1XD4 A;  4US0 S;  5CM9 A;  1NVU S;  2IJE S;  4US1 S;  4US2 S;  3CF6 E;  4MGI E;  4URW S;  4MH0 E; 
#chains in the Genus database with same CATH topology
 1BKD S;  4URY S;  4NYI S;  5CM8 A;  4MGZ E;  4URU S;  1NVV S;  4URV S;  4MGY E;  4F7Z A;  4JGW A;  1NVX S;  4URZ S;  2II0 A;  2BYV E;  3QXL A;  3T6A A;  3T6G A;  4NYM S;  4L9M A;  1NVW S;  1XD2 C;  4NYJ S;  4URX S;  3KSY A;  4MGK E;  1XD4 A;  4US0 S;  5CM9 A;  1NVU S;  2IJE S;  4US1 S;  4US2 S;  3CF6 E;  4MGI E;  4URW S;  4MH0 E; 
#chains in the Genus database with same CATH homology
 1BKD S;  4URY S;  4NYI S;  5CM8 A;  4MGZ E;  4URU S;  1NVV S;  4URV S;  4MGY E;  4F7Z A;  4JGW A;  1NVX S;  4URZ S;  2II0 A;  2BYV E;  3QXL A;  3T6A A;  3T6G A;  4NYM S;  4L9M A;  1NVW S;  1XD2 C;  4NYJ S;  4URX S;  3KSY A;  4MGK E;  1XD4 A;  4US0 S;  5CM9 A;  1NVU S;  2IJE S;  4US1 S;  4US2 S;  3CF6 E;  4MGI E;  4URW S;  4MH0 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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