4US0S

The crystal structure of h-ras and sos in complex with ligands
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
480
structure length
454
Chain Sequence
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPESAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 175
structure length 454
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4us0S02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4us0S01
3KSYA 4NYIS 4US2S 4JGWA 2BYVE 1NVUS 4L9MA 5CM8A 1XD2C 4US0S 2II0A 1BKDS 1NVXS 4NYJS 2IJES 4URXS 4MGZE 4NYMS 5CM9A 3T6AA 4MGIE 1NVWS 4F7ZA 4US1S 4URYS 4MGKE 4URZS 1XD4A 4MGYE 4URWS 3T6GA 3QXLA 4URVS 1NVVS 4MH0E 4URUS 3CF6E
chains in the Genus database with same CATH superfamily
3KSYA 4NYIS 4US2S 4JGWA 2BYVE 1NVUS 4L9MA 5CM8A 1XD2C 4US0S 2II0A 1BKDS 1NVXS 4NYJS 2IJES 4URXS 4MGZE 4NYMS 5CM9A 3T6AA 4MGIE 1NVWS 4F7ZA 4US1S 4URYS 4MGKE 4URZS 1XD4A 4MGYE 4URWS 3T6GA 3QXLA 4URVS 1NVVS 4MH0E 4URUS 3CF6E
chains in the Genus database with same CATH topology
3KSYA 4NYIS 4US2S 4JGWA 2BYVE 1NVUS 4L9MA 5CM8A 1XD2C 4US0S 2II0A 1BKDS 1NVXS 4NYJS 2IJES 4URXS 4MGZE 4NYMS 5CM9A 3T6AA 4MGIE 1NVWS 4F7ZA 4US1S 4URYS 4MGKE 4URZS 1XD4A 4MGYE 4URWS 3T6GA 3QXLA 4URVS 1NVVS 4MH0E 4URUS 3CF6E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KSY A;  4NYI S;  4US2 S;  4JGW A;  2BYV E;  1NVU S;  4L9M A;  5CM8 A;  1XD2 C;  4US0 S;  2II0 A;  1BKD S;  1NVX S;  4NYJ S;  2IJE S;  4URX S;  4MGZ E;  4NYM S;  5CM9 A;  3T6A A;  4MGI E;  1NVW S;  4F7Z A;  4US1 S;  4URY S;  4MGK E;  4URZ S;  1XD4 A;  4MGY E;  4URW S;  3T6G A;  3QXL A;  4URV S;  1NVV S;  4MH0 E;  4URU S;  3CF6 E; 
#chains in the Genus database with same CATH topology
 3KSY A;  4NYI S;  4US2 S;  4JGW A;  2BYV E;  1NVU S;  4L9M A;  5CM8 A;  1XD2 C;  4US0 S;  2II0 A;  1BKD S;  1NVX S;  4NYJ S;  2IJE S;  4URX S;  4MGZ E;  4NYM S;  5CM9 A;  3T6A A;  4MGI E;  1NVW S;  4F7Z A;  4US1 S;  4URY S;  4MGK E;  4URZ S;  1XD4 A;  4MGY E;  4URW S;  3T6G A;  3QXL A;  4URV S;  1NVV S;  4MH0 E;  4URU S;  3CF6 E; 
#chains in the Genus database with same CATH homology
 3KSY A;  4NYI S;  4US2 S;  4JGW A;  2BYV E;  1NVU S;  4L9M A;  5CM8 A;  1XD2 C;  4US0 S;  2II0 A;  1BKD S;  1NVX S;  4NYJ S;  2IJE S;  4URX S;  4MGZ E;  4NYM S;  5CM9 A;  3T6A A;  4MGI E;  1NVW S;  4F7Z A;  4US1 S;  4URY S;  4MGK E;  4URZ S;  1XD4 A;  4MGY E;  4URW S;  3T6G A;  3QXL A;  4URV S;  1NVV S;  4MH0 E;  4URU S;  3CF6 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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