4US0S

The crystal structure of h-ras and sos in complex with ligands
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
480
structure length
454
Chain Sequence
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPESAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 175
structure length 454
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4us0S02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4us0S01
4URZS 4URVS 4US1S 3T6AA 1NVVS 5CM9A 4URXS 4MH0E 3CF6E 1NVUS 1XD4A 1NVWS 2II0A 4MGKE 4US2S 2BYVE 4URYS 3T6GA 4NYMS 4NYIS 4MGYE 4L9MA 4JGWA 1BKDS 1XD2C 3KSYA 4F7ZA 4MGIE 4US0S 2IJES 5CM8A 1NVXS 4URUS 4NYJS 3QXLA 4URWS 4MGZE
chains in the Genus database with same CATH superfamily
4URZS 4URVS 4US1S 3T6AA 1NVVS 5CM9A 4URXS 4MH0E 3CF6E 1NVUS 1XD4A 1NVWS 2II0A 4MGKE 4US2S 2BYVE 4URYS 3T6GA 4NYMS 4NYIS 4MGYE 4L9MA 4JGWA 1BKDS 1XD2C 3KSYA 4F7ZA 4MGIE 4US0S 2IJES 5CM8A 1NVXS 4URUS 4NYJS 3QXLA 4URWS 4MGZE
chains in the Genus database with same CATH topology
4URZS 4URVS 4US1S 3T6AA 1NVVS 5CM9A 4URXS 4MH0E 3CF6E 1NVUS 1XD4A 1NVWS 2II0A 4MGKE 4US2S 2BYVE 4URYS 3T6GA 4NYMS 4NYIS 4MGYE 4L9MA 4JGWA 1BKDS 1XD2C 3KSYA 4F7ZA 4MGIE 4US0S 2IJES 5CM8A 1NVXS 4URUS 4NYJS 3QXLA 4URWS 4MGZE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4URZ S;  4URV S;  4US1 S;  3T6A A;  1NVV S;  5CM9 A;  4URX S;  4MH0 E;  3CF6 E;  1NVU S;  1XD4 A;  1NVW S;  2II0 A;  4MGK E;  4US2 S;  2BYV E;  4URY S;  3T6G A;  4NYM S;  4NYI S;  4MGY E;  4L9M A;  4JGW A;  1BKD S;  1XD2 C;  3KSY A;  4F7Z A;  4MGI E;  4US0 S;  2IJE S;  5CM8 A;  1NVX S;  4URU S;  4NYJ S;  3QXL A;  4URW S;  4MGZ E; 
#chains in the Genus database with same CATH topology
 4URZ S;  4URV S;  4US1 S;  3T6A A;  1NVV S;  5CM9 A;  4URX S;  4MH0 E;  3CF6 E;  1NVU S;  1XD4 A;  1NVW S;  2II0 A;  4MGK E;  4US2 S;  2BYV E;  4URY S;  3T6G A;  4NYM S;  4NYI S;  4MGY E;  4L9M A;  4JGW A;  1BKD S;  1XD2 C;  3KSY A;  4F7Z A;  4MGI E;  4US0 S;  2IJE S;  5CM8 A;  1NVX S;  4URU S;  4NYJ S;  3QXL A;  4URW S;  4MGZ E; 
#chains in the Genus database with same CATH homology
 4URZ S;  4URV S;  4US1 S;  3T6A A;  1NVV S;  5CM9 A;  4URX S;  4MH0 E;  3CF6 E;  1NVU S;  1XD4 A;  1NVW S;  2II0 A;  4MGK E;  4US2 S;  2BYV E;  4URY S;  3T6G A;  4NYM S;  4NYI S;  4MGY E;  4L9M A;  4JGW A;  1BKD S;  1XD2 C;  3KSY A;  4F7Z A;  4MGI E;  4US0 S;  2IJE S;  5CM8 A;  1NVX S;  4URU S;  4NYJ S;  3QXL A;  4URW S;  4MGZ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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