4URWS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
480
structure length
453
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPASE HRAS
publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
total genus 173
structure length 453
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urwS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urwS01
4JGWA 1NVWS 4URYS 4NYIS 4URUS 2BYVE 1NVUS 1NVVS 4URZS 4MGZE 4L9MA 4MGIE 3QXLA 4US1S 4F7ZA 1BKDS 3T6GA 4MGKE 4MGYE 4URXS 3CF6E 4US0S 2II0A 4NYJS 4NYMS 5CM8A 5CM9A 1XD2C 4URVS 2IJES 3KSYA 4MH0E 4URWS 4US2S 1XD4A 3T6AA 1NVXS
chains in the Genus database with same CATH superfamily
4JGWA 1NVWS 4URYS 4NYIS 4URUS 2BYVE 1NVUS 1NVVS 4URZS 4MGZE 4L9MA 4MGIE 3QXLA 4US1S 4F7ZA 1BKDS 3T6GA 4MGKE 4MGYE 4URXS 3CF6E 4US0S 2II0A 4NYJS 4NYMS 5CM8A 5CM9A 1XD2C 4URVS 2IJES 3KSYA 4MH0E 4URWS 4US2S 1XD4A 3T6AA 1NVXS
chains in the Genus database with same CATH topology
4JGWA 1NVWS 4URYS 4NYIS 4URUS 2BYVE 1NVUS 1NVVS 4URZS 4MGZE 4L9MA 4MGIE 3QXLA 4US1S 4F7ZA 1BKDS 3T6GA 4MGKE 4MGYE 4URXS 3CF6E 4US0S 2II0A 4NYJS 4NYMS 5CM8A 5CM9A 1XD2C 4URVS 2IJES 3KSYA 4MH0E 4URWS 4US2S 1XD4A 3T6AA 1NVXS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JGW A;  1NVW S;  4URY S;  4NYI S;  4URU S;  2BYV E;  1NVU S;  1NVV S;  4URZ S;  4MGZ E;  4L9M A;  4MGI E;  3QXL A;  4US1 S;  4F7Z A;  1BKD S;  3T6G A;  4MGK E;  4MGY E;  4URX S;  3CF6 E;  4US0 S;  2II0 A;  4NYJ S;  4NYM S;  5CM8 A;  5CM9 A;  1XD2 C;  4URV S;  2IJE S;  3KSY A;  4MH0 E;  4URW S;  4US2 S;  1XD4 A;  3T6A A;  1NVX S; 
#chains in the Genus database with same CATH topology
 4JGW A;  1NVW S;  4URY S;  4NYI S;  4URU S;  2BYV E;  1NVU S;  1NVV S;  4URZ S;  4MGZ E;  4L9M A;  4MGI E;  3QXL A;  4US1 S;  4F7Z A;  1BKD S;  3T6G A;  4MGK E;  4MGY E;  4URX S;  3CF6 E;  4US0 S;  2II0 A;  4NYJ S;  4NYM S;  5CM8 A;  5CM9 A;  1XD2 C;  4URV S;  2IJE S;  3KSY A;  4MH0 E;  4URW S;  4US2 S;  1XD4 A;  3T6A A;  1NVX S; 
#chains in the Genus database with same CATH homology
 4JGW A;  1NVW S;  4URY S;  4NYI S;  4URU S;  2BYV E;  1NVU S;  1NVV S;  4URZ S;  4MGZ E;  4L9M A;  4MGI E;  3QXL A;  4US1 S;  4F7Z A;  1BKD S;  3T6G A;  4MGK E;  4MGY E;  4URX S;  3CF6 E;  4US0 S;  2II0 A;  4NYJ S;  4NYM S;  5CM8 A;  5CM9 A;  1XD2 C;  4URV S;  2IJE S;  3KSY A;  4MH0 E;  4URW S;  4US2 S;  1XD4 A;  3T6A A;  1NVX S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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