4URWS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
480
structure length
453
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 173
structure length 453
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urwS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urwS01
2BYVE 4URZS 3T6AA 4MGKE 1BKDS 4URWS 4NYMS 4F7ZA 4URXS 3CF6E 1NVVS 4MH0E 3T6GA 4URVS 1XD4A 1XD2C 4JGWA 1NVXS 4US0S 4L9MA 2II0A 4US2S 5CM8A 3KSYA 2IJES 1NVUS 5CM9A 4MGZE 3QXLA 4URUS 4NYIS 1NVWS 4MGYE 4MGIE 4NYJS 4URYS 4US1S
chains in the Genus database with same CATH superfamily
2BYVE 4URZS 3T6AA 4MGKE 1BKDS 4URWS 4NYMS 4F7ZA 4URXS 3CF6E 1NVVS 4MH0E 3T6GA 4URVS 1XD4A 1XD2C 4JGWA 1NVXS 4US0S 4L9MA 2II0A 4US2S 5CM8A 3KSYA 2IJES 1NVUS 5CM9A 4MGZE 3QXLA 4URUS 4NYIS 1NVWS 4MGYE 4MGIE 4NYJS 4URYS 4US1S
chains in the Genus database with same CATH topology
2BYVE 4URZS 3T6AA 4MGKE 1BKDS 4URWS 4NYMS 4F7ZA 4URXS 3CF6E 1NVVS 4MH0E 3T6GA 4URVS 1XD4A 1XD2C 4JGWA 1NVXS 4US0S 4L9MA 2II0A 4US2S 5CM8A 3KSYA 2IJES 1NVUS 5CM9A 4MGZE 3QXLA 4URUS 4NYIS 1NVWS 4MGYE 4MGIE 4NYJS 4URYS 4US1S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BYV E;  4URZ S;  3T6A A;  4MGK E;  1BKD S;  4URW S;  4NYM S;  4F7Z A;  4URX S;  3CF6 E;  1NVV S;  4MH0 E;  3T6G A;  4URV S;  1XD4 A;  1XD2 C;  4JGW A;  1NVX S;  4US0 S;  4L9M A;  2II0 A;  4US2 S;  5CM8 A;  3KSY A;  2IJE S;  1NVU S;  5CM9 A;  4MGZ E;  3QXL A;  4URU S;  4NYI S;  1NVW S;  4MGY E;  4MGI E;  4NYJ S;  4URY S;  4US1 S; 
#chains in the Genus database with same CATH topology
 2BYV E;  4URZ S;  3T6A A;  4MGK E;  1BKD S;  4URW S;  4NYM S;  4F7Z A;  4URX S;  3CF6 E;  1NVV S;  4MH0 E;  3T6G A;  4URV S;  1XD4 A;  1XD2 C;  4JGW A;  1NVX S;  4US0 S;  4L9M A;  2II0 A;  4US2 S;  5CM8 A;  3KSY A;  2IJE S;  1NVU S;  5CM9 A;  4MGZ E;  3QXL A;  4URU S;  4NYI S;  1NVW S;  4MGY E;  4MGI E;  4NYJ S;  4URY S;  4US1 S; 
#chains in the Genus database with same CATH homology
 2BYV E;  4URZ S;  3T6A A;  4MGK E;  1BKD S;  4URW S;  4NYM S;  4F7Z A;  4URX S;  3CF6 E;  1NVV S;  4MH0 E;  3T6G A;  4URV S;  1XD4 A;  1XD2 C;  4JGW A;  1NVX S;  4US0 S;  4L9M A;  2II0 A;  4US2 S;  5CM8 A;  3KSY A;  2IJE S;  1NVU S;  5CM9 A;  4MGZ E;  3QXL A;  4URU S;  4NYI S;  1NVW S;  4MGY E;  4MGI E;  4NYJ S;  4URY S;  4US1 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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