3QXLA

Crystal structure of the cdc25 domain from ral-specific guanine-nucleotide exchange factor ralgps1a
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
245
structure length
245
Chain Sequence
FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Ras-specific guanine nucleotide-releasing factor RalGPS1
total genus 102
structure length 245
sequence length 245
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3qxlA00
4URZS 2IJES 1NVVS 1XD4A 4URWS 3T6AA 5CM9A 4L9MA 4US1S 3T6GA 4US0S 4NYJS 2BYVE 3QXLA 1BKDS 4NYMS 1NVXS 1NVWS 3CF6E 1NVUS 4F7ZA 4URUS 4US2S 4URVS 2II0A 4MGYE 4NYIS 3KSYA 4URYS 4MGZE 4MGIE 4MGKE 4MH0E 5CM8A 4URXS 1XD2C 4JGWA
chains in the Genus database with same CATH superfamily
4URZS 2IJES 1NVVS 1XD4A 4URWS 3T6AA 5CM9A 4L9MA 4US1S 3T6GA 4US0S 4NYJS 2BYVE 3QXLA 1BKDS 4NYMS 1NVXS 1NVWS 3CF6E 1NVUS 4F7ZA 4URUS 4US2S 4URVS 2II0A 4MGYE 4NYIS 3KSYA 4URYS 4MGZE 4MGIE 4MGKE 4MH0E 5CM8A 4URXS 1XD2C 4JGWA
chains in the Genus database with same CATH topology
4URZS 2IJES 1NVVS 1XD4A 4URWS 3T6AA 5CM9A 4L9MA 4US1S 3T6GA 4US0S 4NYJS 2BYVE 3QXLA 1BKDS 4NYMS 1NVXS 1NVWS 3CF6E 1NVUS 4F7ZA 4URUS 4US2S 4URVS 2II0A 4MGYE 4NYIS 3KSYA 4URYS 4MGZE 4MGIE 4MGKE 4MH0E 5CM8A 4URXS 1XD2C 4JGWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4URZ S;  2IJE S;  1NVV S;  1XD4 A;  4URW S;  3T6A A;  5CM9 A;  4L9M A;  4US1 S;  3T6G A;  4US0 S;  4NYJ S;  2BYV E;  3QXL A;  1BKD S;  4NYM S;  1NVX S;  1NVW S;  3CF6 E;  1NVU S;  4F7Z A;  4URU S;  4US2 S;  4URV S;  2II0 A;  4MGY E;  4NYI S;  3KSY A;  4URY S;  4MGZ E;  4MGI E;  4MGK E;  4MH0 E;  5CM8 A;  4URX S;  1XD2 C;  4JGW A; 
#chains in the Genus database with same CATH topology
 4URZ S;  2IJE S;  1NVV S;  1XD4 A;  4URW S;  3T6A A;  5CM9 A;  4L9M A;  4US1 S;  3T6G A;  4US0 S;  4NYJ S;  2BYV E;  3QXL A;  1BKD S;  4NYM S;  1NVX S;  1NVW S;  3CF6 E;  1NVU S;  4F7Z A;  4URU S;  4US2 S;  4URV S;  2II0 A;  4MGY E;  4NYI S;  3KSY A;  4URY S;  4MGZ E;  4MGI E;  4MGK E;  4MH0 E;  5CM8 A;  4URX S;  1XD2 C;  4JGW A; 
#chains in the Genus database with same CATH homology
 4URZ S;  2IJE S;  1NVV S;  1XD4 A;  4URW S;  3T6A A;  5CM9 A;  4L9M A;  4US1 S;  3T6G A;  4US0 S;  4NYJ S;  2BYV E;  3QXL A;  1BKD S;  4NYM S;  1NVX S;  1NVW S;  3CF6 E;  1NVU S;  4F7Z A;  4URU S;  4US2 S;  4URV S;  2II0 A;  4MGY E;  4NYI S;  3KSY A;  4URY S;  4MGZ E;  4MGI E;  4MGK E;  4MH0 E;  5CM8 A;  4URX S;  1XD2 C;  4JGW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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