3QXLA

Crystal structure of the cdc25 domain from ral-specific guanine-nucleotide exchange factor ralgps1a
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
245
structure length
245
Chain Sequence
FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Ras-specific guanine nucleotide-releasing factor RalGPS1
publication title Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 245
sequence length 245
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3qxlA00
2II0A 4NYJS 4URWS 5CM9A 4US0S 4URYS 2BYVE 1BKDS 1NVUS 3CF6E 4MGIE 4JGWA 5CM8A 1XD2C 4URUS 1NVXS 3QXLA 3KSYA 1NVVS 4MGZE 4NYIS 2IJES 4URZS 4F7ZA 4NYMS 1XD4A 1NVWS 4MH0E 4L9MA 4MGYE 3T6GA 4US1S 4US2S 4URVS 3T6AA 4MGKE 4URXS
chains in the Genus database with same CATH superfamily
2II0A 4NYJS 4URWS 5CM9A 4US0S 4URYS 2BYVE 1BKDS 1NVUS 3CF6E 4MGIE 4JGWA 5CM8A 1XD2C 4URUS 1NVXS 3QXLA 3KSYA 1NVVS 4MGZE 4NYIS 2IJES 4URZS 4F7ZA 4NYMS 1XD4A 1NVWS 4MH0E 4L9MA 4MGYE 3T6GA 4US1S 4US2S 4URVS 3T6AA 4MGKE 4URXS
chains in the Genus database with same CATH topology
2II0A 4NYJS 4URWS 5CM9A 4US0S 4URYS 2BYVE 1BKDS 1NVUS 3CF6E 4MGIE 4JGWA 5CM8A 1XD2C 4URUS 1NVXS 3QXLA 3KSYA 1NVVS 4MGZE 4NYIS 2IJES 4URZS 4F7ZA 4NYMS 1XD4A 1NVWS 4MH0E 4L9MA 4MGYE 3T6GA 4US1S 4US2S 4URVS 3T6AA 4MGKE 4URXS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2II0 A;  4NYJ S;  4URW S;  5CM9 A;  4US0 S;  4URY S;  2BYV E;  1BKD S;  1NVU S;  3CF6 E;  4MGI E;  4JGW A;  5CM8 A;  1XD2 C;  4URU S;  1NVX S;  3QXL A;  3KSY A;  1NVV S;  4MGZ E;  4NYI S;  2IJE S;  4URZ S;  4F7Z A;  4NYM S;  1XD4 A;  1NVW S;  4MH0 E;  4L9M A;  4MGY E;  3T6G A;  4US1 S;  4US2 S;  4URV S;  3T6A A;  4MGK E;  4URX S; 
#chains in the Genus database with same CATH topology
 2II0 A;  4NYJ S;  4URW S;  5CM9 A;  4US0 S;  4URY S;  2BYV E;  1BKD S;  1NVU S;  3CF6 E;  4MGI E;  4JGW A;  5CM8 A;  1XD2 C;  4URU S;  1NVX S;  3QXL A;  3KSY A;  1NVV S;  4MGZ E;  4NYI S;  2IJE S;  4URZ S;  4F7Z A;  4NYM S;  1XD4 A;  1NVW S;  4MH0 E;  4L9M A;  4MGY E;  3T6G A;  4US1 S;  4US2 S;  4URV S;  3T6A A;  4MGK E;  4URX S; 
#chains in the Genus database with same CATH homology
 2II0 A;  4NYJ S;  4URW S;  5CM9 A;  4US0 S;  4URY S;  2BYV E;  1BKD S;  1NVU S;  3CF6 E;  4MGI E;  4JGW A;  5CM8 A;  1XD2 C;  4URU S;  1NVX S;  3QXL A;  3KSY A;  1NVV S;  4MGZ E;  4NYI S;  2IJE S;  4URZ S;  4F7Z A;  4NYM S;  1XD4 A;  1NVW S;  4MH0 E;  4L9M A;  4MGY E;  3T6G A;  4US1 S;  4US2 S;  4URV S;  3T6A A;  4MGK E;  4URX S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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