3QXLA

Crystal structure of the cdc25 domain from ral-specific guanine-nucleotide exchange factor ralgps1a
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
245
structure length
245
Chain Sequence
FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords Ras-specific guanine nucleotide-releasing factor RalGPS1
total genus 102
structure length 245
sequence length 245
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3qxlA00
4URUS 4MGZE 4NYJS 3QXLA 1XD2C 4F7ZA 4URVS 4MH0E 4NYMS 2IJES 4MGIE 1NVXS 1NVVS 1NVUS 1NVWS 4URWS 3CF6E 1XD4A 4MGYE 3KSYA 4US2S 5CM9A 3T6GA 4URZS 2BYVE 4US1S 4URYS 4URXS 4US0S 4MGKE 4NYIS 2II0A 5CM8A 3T6AA 4JGWA 1BKDS 4L9MA
chains in the Genus database with same CATH superfamily
4URUS 4MGZE 4NYJS 3QXLA 1XD2C 4F7ZA 4URVS 4MH0E 4NYMS 2IJES 4MGIE 1NVXS 1NVVS 1NVUS 1NVWS 4URWS 3CF6E 1XD4A 4MGYE 3KSYA 4US2S 5CM9A 3T6GA 4URZS 2BYVE 4US1S 4URYS 4URXS 4US0S 4MGKE 4NYIS 2II0A 5CM8A 3T6AA 4JGWA 1BKDS 4L9MA
chains in the Genus database with same CATH topology
4URUS 4MGZE 4NYJS 3QXLA 1XD2C 4F7ZA 4URVS 4MH0E 4NYMS 2IJES 4MGIE 1NVXS 1NVVS 1NVUS 1NVWS 4URWS 3CF6E 1XD4A 4MGYE 3KSYA 4US2S 5CM9A 3T6GA 4URZS 2BYVE 4US1S 4URYS 4URXS 4US0S 4MGKE 4NYIS 2II0A 5CM8A 3T6AA 4JGWA 1BKDS 4L9MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4URU S;  4MGZ E;  4NYJ S;  3QXL A;  1XD2 C;  4F7Z A;  4URV S;  4MH0 E;  4NYM S;  2IJE S;  4MGI E;  1NVX S;  1NVV S;  1NVU S;  1NVW S;  4URW S;  3CF6 E;  1XD4 A;  4MGY E;  3KSY A;  4US2 S;  5CM9 A;  3T6G A;  4URZ S;  2BYV E;  4US1 S;  4URY S;  4URX S;  4US0 S;  4MGK E;  4NYI S;  2II0 A;  5CM8 A;  3T6A A;  4JGW A;  1BKD S;  4L9M A; 
#chains in the Genus database with same CATH topology
 4URU S;  4MGZ E;  4NYJ S;  3QXL A;  1XD2 C;  4F7Z A;  4URV S;  4MH0 E;  4NYM S;  2IJE S;  4MGI E;  1NVX S;  1NVV S;  1NVU S;  1NVW S;  4URW S;  3CF6 E;  1XD4 A;  4MGY E;  3KSY A;  4US2 S;  5CM9 A;  3T6G A;  4URZ S;  2BYV E;  4US1 S;  4URY S;  4URX S;  4US0 S;  4MGK E;  4NYI S;  2II0 A;  5CM8 A;  3T6A A;  4JGW A;  1BKD S;  4L9M A; 
#chains in the Genus database with same CATH homology
 4URU S;  4MGZ E;  4NYJ S;  3QXL A;  1XD2 C;  4F7Z A;  4URV S;  4MH0 E;  4NYM S;  2IJE S;  4MGI E;  1NVX S;  1NVV S;  1NVU S;  1NVW S;  4URW S;  3CF6 E;  1XD4 A;  4MGY E;  3KSY A;  4US2 S;  5CM9 A;  3T6G A;  4URZ S;  2BYV E;  4US1 S;  4URY S;  4URX S;  4US0 S;  4MGK E;  4NYI S;  2II0 A;  5CM8 A;  3T6A A;  4JGW A;  1BKD S;  4L9M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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