2IJES

Crystal structure of the cdc25 domain of rasgrf1
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
237
structure length
237
Chain Sequence
GPLGSALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Ras-induced conformational switch in the Ras activator Son of sevenless.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
molecule keywords Guanine nucleotide-releasing protein
total genus 98
structure length 237
sequence length 237
ec nomenclature
pdb deposition date 2006-09-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 2ijeS00
4US0S 4URYS 3T6AA 4US2S 3CF6E 4L9MA 4MGYE 1XD4A 3KSYA 4URWS 4MGIE 3T6GA 5CM9A 1NVWS 2II0A 4URUS 5CM8A 4NYMS 1NVXS 2BYVE 4US1S 4URXS 3QXLA 4F7ZA 1BKDS 4JGWA 4MGZE 4MH0E 4URZS 4NYJS 1NVUS 1NVVS 4MGKE 2IJES 1XD2C 4URVS 4NYIS
chains in the Genus database with same CATH superfamily
4US0S 4URYS 3T6AA 4US2S 3CF6E 4L9MA 4MGYE 1XD4A 3KSYA 4URWS 4MGIE 3T6GA 5CM9A 1NVWS 2II0A 4URUS 5CM8A 4NYMS 1NVXS 2BYVE 4US1S 4URXS 3QXLA 4F7ZA 1BKDS 4JGWA 4MGZE 4MH0E 4URZS 4NYJS 1NVUS 1NVVS 4MGKE 2IJES 1XD2C 4URVS 4NYIS
chains in the Genus database with same CATH topology
4US0S 4URYS 3T6AA 4US2S 3CF6E 4L9MA 4MGYE 1XD4A 3KSYA 4URWS 4MGIE 3T6GA 5CM9A 1NVWS 2II0A 4URUS 5CM8A 4NYMS 1NVXS 2BYVE 4US1S 4URXS 3QXLA 4F7ZA 1BKDS 4JGWA 4MGZE 4MH0E 4URZS 4NYJS 1NVUS 1NVVS 4MGKE 2IJES 1XD2C 4URVS 4NYIS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4US0 S;  4URY S;  3T6A A;  4US2 S;  3CF6 E;  4L9M A;  4MGY E;  1XD4 A;  3KSY A;  4URW S;  4MGI E;  3T6G A;  5CM9 A;  1NVW S;  2II0 A;  4URU S;  5CM8 A;  4NYM S;  1NVX S;  2BYV E;  4US1 S;  4URX S;  3QXL A;  4F7Z A;  1BKD S;  4JGW A;  4MGZ E;  4MH0 E;  4URZ S;  4NYJ S;  1NVU S;  1NVV S;  4MGK E;  2IJE S;  1XD2 C;  4URV S;  4NYI S; 
#chains in the Genus database with same CATH topology
 4US0 S;  4URY S;  3T6A A;  4US2 S;  3CF6 E;  4L9M A;  4MGY E;  1XD4 A;  3KSY A;  4URW S;  4MGI E;  3T6G A;  5CM9 A;  1NVW S;  2II0 A;  4URU S;  5CM8 A;  4NYM S;  1NVX S;  2BYV E;  4US1 S;  4URX S;  3QXL A;  4F7Z A;  1BKD S;  4JGW A;  4MGZ E;  4MH0 E;  4URZ S;  4NYJ S;  1NVU S;  1NVV S;  4MGK E;  2IJE S;  1XD2 C;  4URV S;  4NYI S; 
#chains in the Genus database with same CATH homology
 4US0 S;  4URY S;  3T6A A;  4US2 S;  3CF6 E;  4L9M A;  4MGY E;  1XD4 A;  3KSY A;  4URW S;  4MGI E;  3T6G A;  5CM9 A;  1NVW S;  2II0 A;  4URU S;  5CM8 A;  4NYM S;  1NVX S;  2BYV E;  4US1 S;  4URX S;  3QXL A;  4F7Z A;  1BKD S;  4JGW A;  4MGZ E;  4MH0 E;  4URZ S;  4NYJ S;  1NVU S;  1NVV S;  4MGK E;  2IJE S;  1XD2 C;  4URV S;  4NYI S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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