4NYJS

Approach for targeting ras with small molecules that activate sos-mediated nucleotide exchange
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
481
structure length
468
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPase HRas
publication title Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb
source organism Homo sapiens
total genus 174
structure length 468
sequence length 481
ec nomenclature
pdb deposition date 2013-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4nyjS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4nyjS01
4MH0E 4URVS 3KSYA 4US2S 4US1S 1NVXS 1XD2C 1BKDS 4MGYE 2BYVE 4MGIE 3T6GA 3T6AA 4F7ZA 5CM9A 4URXS 3QXLA 4URUS 3CF6E 4NYMS 1NVVS 4JGWA 4L9MA 5CM8A 1NVWS 1NVUS 4MGKE 2II0A 4URZS 4NYIS 4NYJS 4URWS 4URYS 4MGZE 1XD4A 4US0S 2IJES
chains in the Genus database with same CATH superfamily
4MH0E 4URVS 3KSYA 4US2S 4US1S 1NVXS 1XD2C 1BKDS 4MGYE 2BYVE 4MGIE 3T6GA 3T6AA 4F7ZA 5CM9A 4URXS 3QXLA 4URUS 3CF6E 4NYMS 1NVVS 4JGWA 4L9MA 5CM8A 1NVWS 1NVUS 4MGKE 2II0A 4URZS 4NYIS 4NYJS 4URWS 4URYS 4MGZE 1XD4A 4US0S 2IJES
chains in the Genus database with same CATH topology
4MH0E 4URVS 3KSYA 4US2S 4US1S 1NVXS 1XD2C 1BKDS 4MGYE 2BYVE 4MGIE 3T6GA 3T6AA 4F7ZA 5CM9A 4URXS 3QXLA 4URUS 3CF6E 4NYMS 1NVVS 4JGWA 4L9MA 5CM8A 1NVWS 1NVUS 4MGKE 2II0A 4URZS 4NYIS 4NYJS 4URWS 4URYS 4MGZE 1XD4A 4US0S 2IJES
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MH0 E;  4URV S;  3KSY A;  4US2 S;  4US1 S;  1NVX S;  1XD2 C;  1BKD S;  4MGY E;  2BYV E;  4MGI E;  3T6G A;  3T6A A;  4F7Z A;  5CM9 A;  4URX S;  3QXL A;  4URU S;  3CF6 E;  4NYM S;  1NVV S;  4JGW A;  4L9M A;  5CM8 A;  1NVW S;  1NVU S;  4MGK E;  2II0 A;  4URZ S;  4NYI S;  4NYJ S;  4URW S;  4URY S;  4MGZ E;  1XD4 A;  4US0 S;  2IJE S; 
#chains in the Genus database with same CATH topology
 4MH0 E;  4URV S;  3KSY A;  4US2 S;  4US1 S;  1NVX S;  1XD2 C;  1BKD S;  4MGY E;  2BYV E;  4MGI E;  3T6G A;  3T6A A;  4F7Z A;  5CM9 A;  4URX S;  3QXL A;  4URU S;  3CF6 E;  4NYM S;  1NVV S;  4JGW A;  4L9M A;  5CM8 A;  1NVW S;  1NVU S;  4MGK E;  2II0 A;  4URZ S;  4NYI S;  4NYJ S;  4URW S;  4URY S;  4MGZ E;  1XD4 A;  4US0 S;  2IJE S; 
#chains in the Genus database with same CATH homology
 4MH0 E;  4URV S;  3KSY A;  4US2 S;  4US1 S;  1NVX S;  1XD2 C;  1BKD S;  4MGY E;  2BYV E;  4MGI E;  3T6G A;  3T6A A;  4F7Z A;  5CM9 A;  4URX S;  3QXL A;  4URU S;  3CF6 E;  4NYM S;  1NVV S;  4JGW A;  4L9M A;  5CM8 A;  1NVW S;  1NVU S;  4MGK E;  2II0 A;  4URZ S;  4NYI S;  4NYJ S;  4URW S;  4URY S;  4MGZ E;  1XD4 A;  4US0 S;  2IJE S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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