4NYJS

Approach for targeting ras with small molecules that activate sos-mediated nucleotide exchange
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
481
structure length
468
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPase HRas
total genus 174
structure length 468
sequence length 481
ec nomenclature
pdb deposition date 2013-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4nyjS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4nyjS01
1XD2C 2BYVE 4URXS 5CM9A 2IJES 3QXLA 1NVUS 4URWS 5CM8A 1NVXS 4URZS 1XD4A 4URYS 4US1S 4MH0E 4F7ZA 4US2S 1NVWS 4MGIE 4NYMS 4MGZE 4URUS 1NVVS 4JGWA 4L9MA 4NYIS 1BKDS 4US0S 4NYJS 4MGYE 4URVS 3T6GA 4MGKE 2II0A 3T6AA 3CF6E 3KSYA
chains in the Genus database with same CATH superfamily
1XD2C 2BYVE 4URXS 5CM9A 2IJES 3QXLA 1NVUS 4URWS 5CM8A 1NVXS 4URZS 1XD4A 4URYS 4US1S 4MH0E 4F7ZA 4US2S 1NVWS 4MGIE 4NYMS 4MGZE 4URUS 1NVVS 4JGWA 4L9MA 4NYIS 1BKDS 4US0S 4NYJS 4MGYE 4URVS 3T6GA 4MGKE 2II0A 3T6AA 3CF6E 3KSYA
chains in the Genus database with same CATH topology
1XD2C 2BYVE 4URXS 5CM9A 2IJES 3QXLA 1NVUS 4URWS 5CM8A 1NVXS 4URZS 1XD4A 4URYS 4US1S 4MH0E 4F7ZA 4US2S 1NVWS 4MGIE 4NYMS 4MGZE 4URUS 1NVVS 4JGWA 4L9MA 4NYIS 1BKDS 4US0S 4NYJS 4MGYE 4URVS 3T6GA 4MGKE 2II0A 3T6AA 3CF6E 3KSYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XD2 C;  2BYV E;  4URX S;  5CM9 A;  2IJE S;  3QXL A;  1NVU S;  4URW S;  5CM8 A;  1NVX S;  4URZ S;  1XD4 A;  4URY S;  4US1 S;  4MH0 E;  4F7Z A;  4US2 S;  1NVW S;  4MGI E;  4NYM S;  4MGZ E;  4URU S;  1NVV S;  4JGW A;  4L9M A;  4NYI S;  1BKD S;  4US0 S;  4NYJ S;  4MGY E;  4URV S;  3T6G A;  4MGK E;  2II0 A;  3T6A A;  3CF6 E;  3KSY A; 
#chains in the Genus database with same CATH topology
 1XD2 C;  2BYV E;  4URX S;  5CM9 A;  2IJE S;  3QXL A;  1NVU S;  4URW S;  5CM8 A;  1NVX S;  4URZ S;  1XD4 A;  4URY S;  4US1 S;  4MH0 E;  4F7Z A;  4US2 S;  1NVW S;  4MGI E;  4NYM S;  4MGZ E;  4URU S;  1NVV S;  4JGW A;  4L9M A;  4NYI S;  1BKD S;  4US0 S;  4NYJ S;  4MGY E;  4URV S;  3T6G A;  4MGK E;  2II0 A;  3T6A A;  3CF6 E;  3KSY A; 
#chains in the Genus database with same CATH homology
 1XD2 C;  2BYV E;  4URX S;  5CM9 A;  2IJE S;  3QXL A;  1NVU S;  4URW S;  5CM8 A;  1NVX S;  4URZ S;  1XD4 A;  4URY S;  4US1 S;  4MH0 E;  4F7Z A;  4US2 S;  1NVW S;  4MGI E;  4NYM S;  4MGZ E;  4URU S;  1NVV S;  4JGW A;  4L9M A;  4NYI S;  1BKD S;  4US0 S;  4NYJ S;  4MGY E;  4URV S;  3T6G A;  4MGK E;  2II0 A;  3T6A A;  3CF6 E;  3KSY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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