1SJUA

Mini-proinsulin, single chain insulin analog mutant: des b30, his(b 10)asp, pro(b 28)asp and peptide bond between lys b 29 and gly a 1, nmr, 20 structures
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
50
structure length
50
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTDKGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords PROINSULIN
total genus 5
structure length 50
sequence length 50
ec nomenclature
pdb deposition date 1997-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1sjuA00
1SJUA 1B9GA 2KQPA 1GZZB 2KJIA 1IMXA 5L3NA 1ZEIA 2GF1A 2DSRI 1GZYB 2JZQA 4XSSB 1IGLA 1H59A 3LRIA 2LWZA 6INSE 5L3LA 5L3MA 2DSQC 1H02B 2DSPI 1TGRA 2L29B 1EFEA 3KR3D 1WQJI 1PMXA 3GF1A 1GZRB 1BQTA
chains in the Genus database with same CATH superfamily
1SJUA 1B9GA 2KQPA 1GZZB 3F2BA 2KJIA 3F2CA 1IMXA 5L3NA 1ZEIA 2GF1A 2DSRI 1GZYB 2JZQA 4XSSB 3F2DA 1IGLA 1H59A 3LRIA 2L14B 2LWZA 6INSE 5L3LA 5L3MA 2DSQC 1H02B 2DSPI 1TGRA 2L29B 1EFEA 3KR3D 1WQJI 1PMXA 3GF1A 1GZRB 1BQTA
chains in the Genus database with same CATH topology
1SJUA 1B9GA 2KQPA 1GZZB 2KJIA 1IMXA 5L3NA 1ZEIA 2GF1A 2DSRI 1GZYB 2JZQA 4XSSB 1IGLA 1H59A 3LRIA 2LWZA 6INSE 5L3LA 5L3MA 2DSQC 1H02B 2DSPI 1TGRA 2L29B 1EFEA 3KR3D 1WQJI 1PMXA 3GF1A 1GZRB 1BQTA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1SJU A;  1B9G A;  2KQP A;  1GZZ B;  2KJI A;  1IMX A;  5L3N A;  1ZEI A;  2GF1 A;  2DSR I;  1GZY B;  2JZQ A;  4XSS B;  1IGL A;  1H59 A;  3LRI A;  2LWZ A;  6INS E;  5L3L A;  5L3M A;  2DSQ C;  1H02 B;  2DSP I;  1TGR A;  2L29 B;  1EFE A;  3KR3 D;  1WQJ I;  1PMX A;  3GF1 A;  1GZR B;  1BQT A; 
#chains in the Genus database with same CATH topology
 1SJU A;  1B9G A;  2KQP A;  1GZZ B;  3F2B A;  2KJI A;  3F2C A;  1IMX A;  5L3N A;  1ZEI A;  2GF1 A;  2DSR I;  1GZY B;  2JZQ A;  4XSS B;  3F2D A;  1IGL A;  1H59 A;  3LRI A;  2L14 B;  2LWZ A;  6INS E;  5L3L A;  5L3M A;  2DSQ C;  1H02 B;  2DSP I;  1TGR A;  2L29 B;  1EFE A;  3KR3 D;  1WQJ I;  1PMX A;  3GF1 A;  1GZR B;  1BQT A; 
#chains in the Genus database with same CATH homology
 1SJU A;  1B9G A;  2KQP A;  1GZZ B;  2KJI A;  1IMX A;  5L3N A;  1ZEI A;  2GF1 A;  2DSR I;  1GZY B;  2JZQ A;  4XSS B;  1IGL A;  1H59 A;  3LRI A;  2LWZ A;  6INS E;  5L3L A;  5L3M A;  2DSQ C;  1H02 B;  2DSP I;  1TGR A;  2L29 B;  1EFE A;  3KR3 D;  1WQJ I;  1PMX A;  3GF1 A;  1GZR B;  1BQT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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